Research Topics
Genomes and GenesSpecies | WILLIS LISummaryAffiliation: University of Rochester Country: USA Publications
Research Grants
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Detail Information
Publications
A novel function of Drosophila eIF4A as a negative regulator of Dpp/BMP signalling that mediates SMAD degradationJinghong Li
Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY 14642, USA
Nat Cell Biol 8:1407-14. 2006..Thus, in addition to being an obligatory component of the cap-dependent translation initiation complex, eIF4A has a novel function as a specific inhibitor of Dpp signalling that mediates the degradation of SMAD homologues...- Differential requirement for STAT by gain-of-function and wild-type receptor tyrosine kinase Torso in DrosophilaWillis X Li
Department of Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
Development 129:4241-8. 2002..Our findings indicate that the Ras/Raf/MEK/MAPK signaling pathway is sufficient to mediate the normal functions of wild-type RTK, whereas the effects of gain-of-function mutant RTK additionally require STAT activation... - Canonical and non-canonical JAK-STAT signalingWillis X Li
Department of Biomedical Genetics, University of Rochester Medical Center, 601 Elmwood Avenue, KMRB 2 9641, Rochester, NY 14642, USA
Trends Cell Biol 18:545-51. 2008..In this review, canonical versus non-canonical JAK-STAT signaling and the implications for gene regulation and cancer formation are discussed... - Functions and mechanisms of receptor tyrosine kinase Torso signaling: lessons from Drosophila embryonic terminal developmentWillis X Li
Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, New York 14642, USA
Dev Dyn 232:656-72. 2005..Genetic and biochemical studies of Torso signaling have provided valuable insights into the biological functions and mechanisms of RTK signaling during early Drosophila embryogenesis... - Receptor tyrosine kinase signaling and primordial germ cell developmentWillis X Li
Department of Biomedical Genetics, University of Rochester Medical Center, 601 Elmwood Ave, Box 633, Rochester, New York 14642, USA
Cell Cycle 3:249-51. 2004..The requirement for RTK suggests molecular conservation between flies and mice in PGC development and also suggests that germ cells and cancer cells share certain intracellular signaling strategies... - Coactivation of STAT and Ras is required for germ cell proliferation and invasive migration in DrosophilaJinghong Li
Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY 14642, USA
Dev Cell 5:787-98. 2003..A requirement for RTK in Drosophila PGC development is analogous to the mouse, in which the RTK c-kit is required, suggesting a conserved molecular mechanism governing PGC behavior in flies and mammals... - Drosophila gain-of-function mutant RTK torso triggers ectopic Dpp and STAT signalingJinghong Li
Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, New York 14642, USA
Genetics 164:247-58. 2003..These results demonstrate an essential requirement of noncanonical signaling pathways for a persistently activated RTK to cause pathological defects in an organism... - Patterns and functions of STAT activation during Drosophila embryogenesisJinghong Li
Department of Biomedical Genetics, University of Rochester Medical Center, 601 Elmwood Ave, Rochester, NY 14642, USA
Mech Dev 120:1455-68. 2003..These results suggest that STAT activation is involved in proper differentiation and morphogenesis of multiple tissues during Drosophila embryogenesis... - Drosophila STAT is required for directly maintaining HP1 localization and heterochromatin stabilitySong Shi
Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY 14642, USA
Nat Cell Biol 10:489-96. 2008..These results suggest that activation of STAT by phosphorylation controls both access to chromatin and activity of the transcription machinery... - Raf activation is regulated by tyrosine 510 phosphorylation in DrosophilaFan Xia
Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, New York, United States of America
PLoS Biol 6:e128. 2008..Together, these results suggest a novel mechanism of Raf activation via Src-mediated tyrosine phosphorylation. Since Y510 is a conserved residue in the kinase domain of all Raf proteins, this mechanism is likely evolutionarily conserved... - Bistability coordinates activation of the EGFR and DPP pathways in Drosophila vein differentiationShian Jang Yan
Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY 14642, USA
Mol Syst Biol 5:278. 2009..The joint activation of the EGFR and DPP signaling systems is ensured by a positive feedback loop, in which the two pathways stimulate each other at the level of ligand production... - Evidence for transgenerational transmission of epigenetic tumor susceptibility in DrosophilaYalan Xing
Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, New York, USA
PLoS Genet 3:1598-606. 2007.... - JAK signaling globally counteracts heterochromatic gene silencingSong Shi
Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, New York 14642, USA
Nat Genet 38:1071-6. 2006..These results demonstrate that the JAK/STAT pathway regulates cellular epigenetic status and that globally disrupting heterochromatin-mediated tumor suppression is essential for tumorigenesis induced by JAK overactivation... - Multiple signaling pathways and a selector protein sequentially regulate Drosophila wing developmentShian Jang Yan
Department of Biology, University of Rochester, Rochester, NY 14627, USA
Development 131:285-98. 2004..Such a mechanism is possibly conserved in the appendage outgrowth of other arthropods and vertebrates... - An intrinsic cell cycle checkpoint pathway mediated by MEK and ERK in DrosophilaVladic Mogila
Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, New York 14642, USA
Dev Cell 11:575-82. 2006..Thus, MEK/ERK activation is required for multiple checkpoints and is essential for orderly cell cycle progression... - Unphosphorylated STAT and heterochromatin protect genome stabilityShian Jang Yan
Department of Biomedical Genetics, University of Rochester Medical Center, 601 Elmwood Ave, KMRB 2 9654, Rochester, NY 14642, USA
FASEB J 25:232-41. 2011..These results suggest that maintaining genome stability by heterochromatin formation and correct chromosomal packaging is essential for normal cellular functions and for survival of animals under genotoxic stress... - A genetic screen for maternal-effect suppressors of decapentaplegic identifies the eukaryotic translation initiation factor 4A in DrosophilaJinghong Li
Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
Genetics 171:1629-41. 2005..This result provides an intriguing link between a component of the translation machinery and Dpp signaling...
Research Grants
- Network Interaction between EGFR and TGFbeta PathwaysWILLIS LI; Fiscal Year: 2009..abstract_text> ..
- Network Interaction between EGFR and TGFbeta PathwaysWILLIS LI; Fiscal Year: 2007....
- Genetic Analysis of Intracellular Signaling CrosstalkWILLIS LI; Fiscal Year: 2006..Results from this work should shed light on the mechanisms of signaling crosstalk that may be important for human pathogenesis as well as tumorigenesis. ..
- Epigenetic tumor induction by heterochromatin instabilityWillis X Li; Fiscal Year: 2010..Results from these studies should advance our knowledge of how genetic and epigenetic mechanisms cooperate in cancer formation in humans and could also lead to new therapeutic targets for cancer treatment. ..