S K Li

Summary

Affiliation: University of Utah
Country: USA

Publications

  1. ncbi In vitro and in vivo comparisons of constant resistance AC iontophoresis and DC iontophoresis
    S Kevin Li
    Pharmaceutics and Pharmaceutical Chemistry, University of Utah, 30 S 2000 E, Salt Lake City, UT 84112, USA
    J Control Release 91:327-43. 2003
  2. ncbi Magnetic resonance imaging study of current and ion delivery into the eye during transscleral and transcorneal iontophoresis
    S Kevin Li
    Department of Pharmaceutics, Utah Center for Advanced Imaging Research Radiology, University of Utah, Salt Lake City, Utah 84112, USA
    Invest Ophthalmol Vis Sci 45:1224-31. 2004
  3. ncbi Assessment of subconjunctival delivery with model ionic permeants and magnetic resonance imaging
    S Kevin Li
    Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, Utah 84112, USA
    Pharm Res 21:2175-84. 2004
  4. ncbi Influence of asymmetric donor-receiver ion concentration upon transscleral iontophoretic transport
    S Kevin Li
    Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, Utah 84112, USA
    J Pharm Sci 94:847-60. 2005
  5. ncbi Mechanistic studies of flux variability of neutral and ionic permeants during constant current dc iontophoresis with human epidermal membrane
    S Kevin Li
    Pharmaceutics and Pharmaceutical Chemistry, University of Utah, 30 S 2000 E, Rm 213 Skaggs Hall, Salt Lake City, UT 84112, USA
    Int J Pharm 273:9-22. 2004
  6. ncbi Iontophoretic transport of oligonucleotides across human epidermal membrane: a study of the Nernst-Planck model
    S K Li
    Department of Pharmaceutics and Pharmaceutical Chemistry, College of Pharmacy, University of Utah, Salt Lake City, Utah 84112, USA
    J Pharm Sci 90:915-31. 2001
  7. ncbi Pore charge distribution considerations in human epidermal membrane electroosmosis
    S K Li
    301 Skaggs Hall, Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, Utah 84112, USA
    J Pharm Sci 88:1044-9. 1999
  8. ncbi Pore induction in human epidermal membrane during low to moderate voltage iontophoresis: A study using AC iontophoresis
    S K Li
    Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, Utah 84112, USA
    J Pharm Sci 88:419-27. 1999
  9. ncbi Enhanced transscleral lontophoretic transport with ion-exchange membrane
    S Kevin Li
    Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, Utah 84112, USA
    Pharm Res 23:1857-67. 2006
  10. ncbi Evaluation of constant current alternating current iontophoresis for transdermal drug delivery
    Guang Yan
    Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, 84112, USA
    J Control Release 110:141-50. 2005

Collaborators

Detail Information

Publications50

  1. ncbi In vitro and in vivo comparisons of constant resistance AC iontophoresis and DC iontophoresis
    S Kevin Li
    Pharmaceutics and Pharmaceutical Chemistry, University of Utah, 30 S 2000 E, Salt Lake City, UT 84112, USA
    J Control Release 91:327-43. 2003
    ....
  2. ncbi Magnetic resonance imaging study of current and ion delivery into the eye during transscleral and transcorneal iontophoresis
    S Kevin Li
    Department of Pharmaceutics, Utah Center for Advanced Imaging Research Radiology, University of Utah, Salt Lake City, Utah 84112, USA
    Invest Ophthalmol Vis Sci 45:1224-31. 2004
    ....
  3. ncbi Assessment of subconjunctival delivery with model ionic permeants and magnetic resonance imaging
    S Kevin Li
    Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, Utah 84112, USA
    Pharm Res 21:2175-84. 2004
    ..The objective was to assess the permeation and clearance of model ionic permeants after subconjunctival injection with nuclear magnetic resonance imaging (MRI)...
  4. ncbi Influence of asymmetric donor-receiver ion concentration upon transscleral iontophoretic transport
    S Kevin Li
    Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, Utah 84112, USA
    J Pharm Sci 94:847-60. 2005
    ..The membrane ion concentrations were different from those in the chambers due to the requirement of charge neutrality in the membrane...
  5. ncbi Mechanistic studies of flux variability of neutral and ionic permeants during constant current dc iontophoresis with human epidermal membrane
    S Kevin Li
    Pharmaceutics and Pharmaceutical Chemistry, University of Utah, 30 S 2000 E, Rm 213 Skaggs Hall, Salt Lake City, UT 84112, USA
    Int J Pharm 273:9-22. 2004
    ....
  6. ncbi Iontophoretic transport of oligonucleotides across human epidermal membrane: a study of the Nernst-Planck model
    S K Li
    Department of Pharmaceutics and Pharmaceutical Chemistry, College of Pharmacy, University of Utah, Salt Lake City, Utah 84112, USA
    J Pharm Sci 90:915-31. 2001
    ..The oligonucleotide HEM flux data also suggest the existence of pores with effective pore radii greater than the effective radii estimated in previous studies with small molecular weight model permeants...
  7. ncbi Pore charge distribution considerations in human epidermal membrane electroosmosis
    S K Li
    301 Skaggs Hall, Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, Utah 84112, USA
    J Pharm Sci 88:1044-9. 1999
    ..Under the higher applied voltage conditions (>/approximately = 1.0 V), results from anodal and cathodal electroosmosis studies were consistent with the model in which the HEM has only pores that are net negatively charged...
  8. ncbi Pore induction in human epidermal membrane during low to moderate voltage iontophoresis: A study using AC iontophoresis
    S K Li
    Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, Utah 84112, USA
    J Pharm Sci 88:419-27. 1999
    ....
  9. ncbi Enhanced transscleral lontophoretic transport with ion-exchange membrane
    S Kevin Li
    Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, Utah 84112, USA
    Pharm Res 23:1857-67. 2006
    ....
  10. ncbi Evaluation of constant current alternating current iontophoresis for transdermal drug delivery
    Guang Yan
    Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, 84112, USA
    J Control Release 110:141-50. 2005
    ..2 ma)...
  11. ncbi Examination of penetration routes and distribution of ionic permeants during and after transscleral iontophoresis with magnetic resonance imaging
    Sarah A Molokhia
    Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, UT 84112, USA
    Int J Pharm 335:46-53. 2007
    ..These new findings continue to support the utility of MRI as a noninvasive technique in ocular drug delivery research and testing...
  12. ncbi Model analysis of flux enhancement across hairless mouse skin induced by chemical permeation enhancers
    Ning He
    Department of Pharmaceutics and Pharmaceutical Chemistry, College of Pharmacy, University of Utah, 30 S 2000 E, Rm 213, Salt Lake City, UT 84112, USA
    Int J Pharm 297:9-21. 2005
    ....
  13. ncbi Ion-exchange membrane assisted transdermal iontophoretic delivery of salicylate and acyclovir
    Qingfang Xu
    Division of Pharmaceutical Sciences, College of Pharmacy, University of Cincinnati, Cincinnati, OH 45267, USA
    Int J Pharm 369:105-13. 2009
    ..The present study has demonstrated the potential of a new approach using a positively charged ion-exchange membrane to enhance transdermal iontophoretic transport of negatively charged drugs...
  14. ncbi Flux enhancement effects of ionic surfactants upon passive and electroosmotic transdermal transport
    K D Peck
    Department of Pharmaceutics and Pharmaceutical Chemistry, 301 Skaggs Hall, University of Utah, Salt Lake City, Utah 84112, USA
    J Pharm Sci 87:1161-9. 1998
    ..Sodium dodecyl sulfate enhanced the intrinsic passive permeability of the HEM, and it also enhanced the contribution of electroosmosis to the flux during iontophoresis...
  15. ncbi Quantification of pore induction in human epidermal membrane during iontophoresis: the importance of background electrolyte selection
    H Zhu
    Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, 30 S 2000 E Rm 213, Salt Lake City, Utah 84112, USA
    J Pharm Sci 90:932-42. 2001
    ..The results of the present study illustrate that permeant flux enhancement can be predicted by the modified Nernst-Planck model even during moderate voltage iontophoresis when electroporation is operative...
  16. ncbi Silicone elastomer uptake method for determination of free 1-alkyl-2-pyrrolidone concentration in micelle and hydroxypropyl-beta-cyclodextrin systems used in skin transport studies
    Kevin S Warner
    ZARS Pharma, 1142 W 2320 S, Salt Lake City, UT 84119, USA
    J Pharm Sci 97:368-80. 2008
    ..This study shows that longer chain enhancers may be studied by employing a solubilizing system, and free enhancer concentration in these systems can be determined with the aid of the silicone elastomer uptake method...
  17. ncbi Alternating current (AC) iontophoretic transport across human epidermal membrane: effects of AC frequency and amplitude
    Guang Yan
    Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, Utah 84112, USA
    Pharm Res 25:616-24. 2008
    ....
  18. ncbi A systematic examination of the in vitro Ussing chamber and the in situ single-pass perfusion model systems in rat ileum permeation of model solutes
    Keiko Tsutsumi
    Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, 30 South 2000 East, Salt Lake City, Utah 84112, USA
    J Pharm Sci 92:344-59. 2003
    ..The in situ and in vitro pore radii of the paracellular route were 7.2 and 9.2 A, respectively, and the difference was likely the result of perturbation of the tight junctions during the in vitro preparation of the ileal tissue...
  19. ncbi Systematic studies on the paracellular permeation of model permeants and oligonucleotides in the rat small intestine with chenodeoxycholate as enhancer
    Keiko Tsutsumi
    Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, 30 South 2000 East, Salt Lake City, UT 84112, USA
    J Pharm Sci 97:350-67. 2008
    ..5 x 10(-6) and 6 x 10(-6) cm/s, whereas ON6 was enhanced up to twofold in the jejunum and fivefold in the ileum with permeabilities between 0.3 x 10(-6) and 2 x 10(-6) cm/s...
  20. ncbi Investigation of properties of human epidermal membrane under constant conductance alternating current iontophoresis
    Honggang Zhu
    Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, UT 84112, USA
    J Control Release 89:31-46. 2003
    ....
  21. ncbi Mechanistic studies of the effect of hydroxypropyl-beta-cyclodextrin on in vitro transdermal permeation of corticosterone through hairless mouse skin
    D S Shaker
    Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, 30 South 2000 East, 213 Skaggs Hall, Salt Lake City, UT 84112, USA
    Int J Pharm 253:1-11. 2003
    ....
  22. ncbi Effects of alternating current frequency and permeation enhancers upon human epidermal membrane
    Qingfang Xu
    Division of Pharmaceutical Sciences, College of Pharmacy, University of Cincinnati, Cincinnati, Ohio, USA
    Int J Pharm 372:24-32. 2009
    ..The enhancers reversibly reduced the AC voltage required to sustain a constant state of pore induction in HEM during AC iontophoresis, consistent with the mechanism of lipid lamellae electroporation in the stratum corneum...
  23. ncbi Effects of chemical enhancers on human epidermal membrane: Structure-enhancement relationship based on maximum enhancement (E(max))
    Sarah A Ibrahim
    Division of Pharmaceutical Sciences, College of Pharmacy, University of Cincinnati, Cincinnati, Ohio 45267, USA
    J Pharm Sci 98:926-44. 2009
    ..Based on the E(max) results, some common topical ingredients were found to be more potent enhancers than a number of well-known chemical enhancers...
  24. ncbi Noninvasive measurement of phenylalanine by iontophoretic extraction in patients with phenylketonuria
    N Longo
    Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah, USA
    J Inherit Metab Dis 30:910-5. 2007
    ..This correlation supports the feasibility of iontophoretic phenylalanine extraction for monitoring phenylketonuria...
  25. ncbi Influences of alkyl group chain length and polar head group on chemical skin permeation enhancement
    K S Warner
    Department of Pharmaceutics and Pharmaceutical Chemistry, 213 Skaggs Hall, University of Utah, 30 S 2000 E, Salt Lake City, UT 84112, USA
    J Pharm Sci 90:1143-53. 2001
    ....
  26. ncbi Transscleral iontophoretic and intravitreal delivery of a macromolecule: study of ocular distribution in vivo and postmortem with MRI
    Sarah A Molokhia
    Department of Pharmaceutics and Pharmaceutical Chemistry, College of Pharmacy, University of Utah, UT 84112, USA
    Exp Eye Res 88:418-25. 2009
    ..In the intravitreal injection study, the diffusion coefficient of Galbumin in the vitreous humor was estimated to be close to that of free aqueous diffusion...
  27. ncbi Iontophoretic transport across a multiple membrane system
    Sarah A Molokhia
    Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, UT 84112, USA
    J Pharm Sci 97:490-505. 2008
    ....
  28. ncbi Transungual iontophoretic transport of polar neutral and positively charged model permeants: effects of electrophoresis and electroosmosis
    Jinsong Hao
    Division of Pharmaceutical Sciences, College of Pharmacy, University of Cincinnati, Cincinnati, Ohio 45267, USA
    J Pharm Sci 97:893-905. 2008
    ..The present results with hydrated nail plates are consistent with electrophoresis-dominant (the direct field effect) transungual iontophoretic transport of small ionic permeants with small contribution from electroosmosis...
  29. ncbi Mechanistic study of alkyl azacycloheptanones as skin permeation enhancers by permeation and partition experiments with hairless mouse skin
    Ning He
    Pharmaceutics, University of Utah, 30 S 2000E Skaggs Hall, Room 213, Salt Lake City, Utah 84112 5820, USA
    J Pharm Sci 92:297-310. 2003
    ..c) 2003 Wiley-Liss, Inc. and the American Pharmaceutical Association J Pharm Sci 92:297-310, 2003..
  30. ncbi Structure-activity relationship for chemical skin permeation enhancers: probing the chemical microenvironment of the site of action
    Kevin S Warner
    Department of Pharmaceutics and Pharmaceutical Chemistry, 213 Skaggs Hall, University of Utah, 30 S 2000 E, Salt Lake City, Utah 84112, USA
    J Pharm Sci 92:1305-22. 2003
    ....
  31. ncbi Improvement on conventional constant current DC iontophoresis: a study using constant conductance AC iontophoresis
    Honggang Zhu
    30 S 2000 E, Rm 201, Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, UT 84112, USA
    J Control Release 82:249-61. 2002
    ....
  32. ncbi Correlation of transdermal iontophoretic phenylalanine and mannitol transport: test of the internal standard concept under DC iontophoresis and constant resistance AC iontophoresis conditions
    Guang Yan
    Department of Pharmaceutics and Pharmaceutical Chemistry, College of Pharmacy, University of Utah, 30 S 2000 E, Skaggs Hall 213, Salt Lake City 84112, USA
    J Control Release 98:127-38. 2004
    ....
  33. ncbi Quantitative study of electrophoretic and electroosmotic enhancement during alternating current iontophoresis across synthetic membranes
    Guang Yan
    Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, 30 S 2000 E, Skaggs Hall 213, Salt Lake City, Utah 84112, USA
    J Pharm Sci 93:2895-908. 2004
    ..Excellent agreement between model predictions and experimental data was observed when the data were compared with the simulations from the heterogeneous membrane model...
  34. ncbi Examination of barriers and barrier alteration in transscleral iontophoresis
    Sarah A Molokhia
    Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, Utah 84112, USA
    J Pharm Sci 97:831-44. 2008
    ..The different results observed in the in vivo and postmortem studies can be attributed to ocular clearance in ocular delivery...
  35. ncbi Effects of electrophoresis and electroosmosis during alternating current iontophoresis across human epidermal membrane
    Guang Yan
    University of Utah, Department of Pharmaceutics and Pharmaceutical Chemistry, 30 S 2000 E, Skaggs Hall 213, Salt Lake City, Utah 84112, USA
    J Pharm Sci 94:547-58. 2005
    ..When the DC offset voltage was increased, the AC component of the flux enhancement for the ionic permeant decreased, eventually appearing to contribute negligibly to the total flux enhancement at high DC offset voltages...
  36. ncbi Efficiency of fatty acids as chemical penetration enhancers: mechanisms and structure enhancement relationship
    Sarah A Ibrahim
    Division of Pharmaceutical Sciences, College of Pharmacy, University of Cincinnati, 3225 Eden Avenue, Rm 136 HPB, Cincinnati, Ohio 45267 0004, USA
    Pharm Res 27:115-25. 2010
    ....
  37. ncbi Chemical method to enhance transungual transport and iontophoresis efficiency
    Jinsong Hao
    Division of Pharmaceutical Sciences, College of Pharmacy, University of Cincinnati, Cincinnati, OH 45267, USA
    Int J Pharm 357:61-9. 2008
    ..The effect of TGA on the nail plates was irreversible. The present study shows the possibility of using a chemical enhancer to reduce transport hindrance in the nail plate and thus enhance passive and iontophoretic transungual transport...
  38. ncbi Human epidermal membrane constant conductance iontophoresis: alternating current to obtain reproducible enhanced permeation and reduced lag times of a nonionic polar permeant
    Yang Song
    Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, 30 S 2000 E, Rm 213, Salt Lake City, UT 84112, USA
    Int J Pharm 232:45-57. 2002
    ..These results suggest that constant fluxes can be achieved by keeping HEM electrical conductance constant during AC iontophoresis...
  39. ncbi Effects of solvent deposited enhancers on transdermal permeation and their relationship with Emax
    Sarah A Ibrahim
    Division of Pharmaceutical Sciences, College of Pharmacy, University of Cincinnati, Cincinnati, OH 45267, USA
    J Control Release 136:117-24. 2009
    ....
  40. ncbi Influence of pH on transungual passive and iontophoretic transport
    Kelly A Smith
    Division of Pharmaceutical Sciences, College of Pharmacy, University of Cincinnati, 3225 Eden Ave, 136 HPB, Cincinnati, Ohio 45267, USA
    J Pharm Sci 99:1955-67. 2010
    ..Hydronium and hydroxide ion competition in iontophoretic transport was generally negligible at pH 3-11 was significant at the extreme pH conditions studied...
  41. ncbi Chemical enhancer solubility in human stratum corneum lipids and enhancer mechanism of action on stratum corneum lipid domain
    Sarah A Ibrahim
    Division of Pharmaceutical Sciences, College of Pharmacy, University of Cincinnati, Cincinnati, OH 45267, USA
    Int J Pharm 383:89-98. 2010
    ..These results suggest that the enhancer mechanism of action is through enhancer intercalation into SC intercellular lipids and subsequent lipid lamellae fluidization related to enhancer lipid concentration...
  42. ncbi Iontophoretically enhanced ciclopirox delivery into and across human nail plate
    Jinsong Hao
    Division of Pharmaceutical Sciences, College of Pharmacy, University of Cincinnati, Cincinnati, Ohio 45267, USA
    J Pharm Sci 98:3608-16. 2009
    ..The results demonstrate that iontophoresis was able to deliver an effective amount of CIC into and across the nails, and this suggests the feasibility of a constant voltage battery-powered transungual iontophoretic device...
  43. ncbi Ocular pharmacokinetic study of a corticosteroid by 19F MR
    Xin Liu
    Department of Physics and Astronomy, University of Utah, 115 South 400 East, Salt Lake City, UT 84112, USA
    Exp Eye Res 91:347-52. 2010
    ..5 h in vivo and 17 and 6.0 h postmortem, respectively. The half-lives associated with clearance were 14 h for intravitreal injection and 0.5 h for subconjunctival injection...
  44. ncbi Passive and oxymetazoline-enhanced delivery with a lens device: pharmacokinetics and efficacy studies with rabbits
    David J Miller
    Aciont, Inc, Salt Lake City, UT, USA
    J Ocul Pharmacol Ther 24:385-91. 2008
    ....
  45. ncbi Electrically assisted delivery of macromolecules into the corneal epithelium
    Jinsong Hao
    Division of Pharmaceutical Sciences, College of Pharmacy, University of Cincinnati, 3225 Eden Ave, HPB 136, Cincinnati, OH 45267, USA
    Exp Eye Res 89:934-41. 2009
    ..These results illustrate the feasibility of electrically assisted delivery of macromolecules such as siRNA into the cornea...
  46. ncbi Mechanistic study of electroosmotic transport across hydrated nail plates: effects of pH and ionic strength
    Jinsong Hao
    Division of Pharmaceutical Sciences, College of Pharmacy, University of Cincinnati, Cincinnati, Ohio 45267, USA
    J Pharm Sci 97:5186-97. 2008
    ..Under the studied pH and ionic strength conditions, the effects of electroosmosis were small compared to the direct-field effects in transungual iontophoretic transport of small to moderate size permeants...
  47. ncbi MRI in ocular drug delivery
    S Kevin Li
    Division of Pharmaceutical Sciences, College of Pharmacy, University of Cincinnati, Cincinnati, OH 45267, USA
    NMR Biomed 21:941-56. 2008
    ..Different MR contrast agents and MRI techniques for ocular drug-delivery research are compared. Ocular drug-delivery studies using MRI are reviewed...
  48. ncbi Gene delivery to cornea
    Jinsong Hao
    Division of Pharmaceutical Sciences, College of Pharmacy, University of Cincinnati, Cincinnati, OH 45267, USA
    Brain Res Bull 81:256-61. 2010
    ..The combination of iontophoresis and electroporation was found to be effective in delivering siRNA but not plasmid DNA into the corneal epithelium. Nanocarriers such as polymeric micelles are promising methods of corneal gene delivery...
  49. ncbi Mechanistic studies of branched-chain alkanols as skin permeation enhancers
    Doungdaw Chantasart
    Department of Pharmacy, Faculty of Pharmacy, Mahidol University, Bangkok 10400, Thailand
    J Pharm Sci 93:762-79. 2004
    ....
  50. ncbi Comparison of the effects of chemical permeation enhancers on the lipoidal pathways of human epidermal membrane and hairless mouse skin and the mechanism of enhancer action
    Doungdaw Chantasart
    Department of Pharmacy, Faculty of Pharmacy, Mahidol University, Bangkok 10400, Thailand
    J Pharm Sci 96:2310-26. 2007
    ..Therefore, provided with proper experimental protocols, HMS can be a reliable model for the evaluation of the effects of skin permeation enhancers on the lipoidal pathway of HEM...