Research Topics
| James J LeydenSummaryAffiliation: University of Pennsylvania Country: USA Publications
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Publications
A review of the use of combination therapies for the treatment of acne vulgarisJames J Leyden
Department of Dermatology, University of Pennsylvania, Philadelphia 19104, USA
J Am Acad Dermatol 49:S200-10. 2003..Retinoids can also be used alone for long-term maintenance to prevent the reemergence of comedones and inflammatory acne lesions and to spare the use of antibiotics, thus helping to reduce the risk of bacterial resistance...- Irritation potential of tretinoin gel microsphere pump versus adapalene plus benzoyl peroxide gelJames J Leyden
Department of Dermatology, University of Pennsylvania, Philadelphia, USA
J Drugs Dermatol 9:998-1003. 2010..1%/2.5% gel. While both agents were well tolerated by most patients, TGM 0.04% pump demonstrated significantly better tolerance than ADA-BPO 0.1%/2.5% gel in both neurosensory parameters and signs of contact irritation... - New insights into the management of acne: an update from the Global Alliance to Improve Outcomes in Acne groupDiane Thiboutot
Department of Dermatology, Pennsylvania State University College of Medicine, Hershey, USA
J Am Acad Dermatol 60:S1-50. 2009..As in the original supplement, the authors have based recommendations on published evidence as much as possible... - Antibiotic use in acne vulgaris and rosacea: clinical considerations and resistance issues of significance to dermatologistsJames Q Del Rosso
Department of Dermatology, University of Nevada School of Medicine, Las Vegas, USA
Cutis 82:5-12. 2008.... - Two randomized, double-blind, controlled trials of 2219 subjects to compare the combination clindamycin/tretinoin hydrogel with each agent alone and vehicle for the treatment of acne vulgarisJames J Leyden
Department of Dermatology, University of Pennsylvania Hospital, Philadelphia, Pennsylvania, USA
J Am Acad Dermatol 54:73-81. 2006..The development of a hydrogel to stabilize and solubilize clindamycin and tretinoin provides a single, once-daily treatment for acne vulgaris... - Topical retinoids in inflammatory acne: a retrospective, investigator-blinded, vehicle-controlled, photographic assessmentJames J Leyden
Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Clin Ther 27:216-24. 2005..Despite published data showing the efficacy of topical retinoids in treating inflammatory acne, in clinical practice topical retinoids tend to be used most commonly for noninflammatory acne... - Antibiotic-resistant Propionibacterium acnes suppressed by a benzoyl peroxide cleanser 6%James J Leyden
Department of Dermatology, University of Pennsylvania, Philadelphia, USA
Cutis 82:417-21. 2008..Benzoyl peroxide cleanser 6% effectively reduced resistant P acnes populations and offers a useful therapy for controlling antibiotic resistance in patients receiving antibiotics... - Clinical considerations in the treatment of acne vulgaris and other inflammatory skin disorders: a status reportJames J Leyden
University of Pennsylvania, Philadelphia, PA 19104, USA
Dermatol Clin 27:1-15. 2009..It concludes that there are treatment strategies that can effectively minimize the potential for development of resistant P. acnes organisms... - Guidelines of care for acne vulgaris managementJohn S Strauss
Department of Dermatology, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, USA
J Am Acad Dermatol 56:651-63. 2007..The ultimate judgment regarding the propriety of any specific therapy must be made by the physician and the patient in light of all the circumstances presented by the individual patient... - Clinical considerations in the treatment of acne vulgaris and other inflammatory skin disorders: focus on antibiotic resistanceJames J Leyden
Department of Dermatology, University of Pennsylvania, Philadelphia, USA
Cutis 79:9-25. 2007..By increasing our understanding of the multifaceted actions of antibiotics and the known clinical implications of antibiotic resistance, physicians can improve their decision making in prescribing these agents... - Cumulative irritation potential of topical retinoid formulationsJames J Leyden
Department of Dermatology, University of Pennsylvania Hospital, Philadelphia, PA, USA
J Drugs Dermatol 7:s14-8. 2008..The factors that influence irritant reactions have been shown to include individual skin sensitivity, the particular retinoid and concentration used, and the vehicle formulation... - Body dysmorphic disorder symptoms among patients with acne vulgarisWhitney P Bowe
Department of Dermatology, The Children s Hospital of Philadelphia, USA
J Am Acad Dermatol 57:222-30. 2007.... - Efficacy of benzoyl peroxide (5.3%) emollient foam and benzoyl peroxide (8%) wash in reducing Propionibacterium acnes on the backJames J Leyden
Department of Dermatology, University of Pennsylvania, Philadelphia, PA, USA
J Drugs Dermatol 9:622-5. 2010..Prior to this trial, no data on Propionibacterium acnes (P. acnes) reduction on the back has existed for any benzoyl peroxide (BP) formulations or other acne treatments... - Effect of antibiotics on the oropharyngeal flora in patients with acneRoss M Levy
Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
Arch Dermatol 139:467-71. 2003..CONCLUSIONS: Streptococcus pyogenes colonization and resistance in the oropharynx are associated with antibiotic therapy in patients with acne. The clinical and long-term effects of this finding need to be studied further... - Treating photodamage of the décolletage area with a novel copper zinc malonate complex plus hydroquinone and tretinoinJames J Leyden
University of Pennsylvania, Philadelphia, PA, USA
J Drugs Dermatol 9:220-6. 2010..Treatment was generally well tolerated and 94% of subjects were satisfied or very satisfied with the overall improvement in their décolletage at week 24... - Meta-analysis of topical tazarotene in the treatment of mild to moderate acneJames J Leyden
Department of Dermatology, University of Pennsylvania Hospital, Philadelphia, USA
Cutis 74:9-15. 2004..These results indicate that topical tazarotene 0.1% gel and cream are efficacious and well-tolerated treatment options for clearing acne vulgaris across a broad range of patients... - Introduction. Contemporary perspectives on topical retinoidsJames J Leyden
Department of Dermatology, University of Pennsylvania Hospital, Philadelphia, USA
Cutis 75:4. 2005 - Effect of topical benzoyl peroxide/clindamycin versus topical clindamycin and vehicle in the reduction of Propionibacterium acnesJames J Leyden
Department of Dermatology, University of Pennsylvania School of Medicine and Hospital of the University of Pennsylvania, Philadelphia 19104 4283, USA
Cutis 69:475-80. 2002..This activity is likely responsible for the quick onset of clinical efficacy produced by this combination regimen... - Acne vulgaris is a multifactorial diseaseJames J Leyden
J Am Acad Dermatol 49:S199. 2003 - Management of acne: a report from a Global Alliance to Improve Outcomes in AcneHarald Gollnick
American Academy of Dermatology, Inc
J Am Acad Dermatol 49:S1-37. 2003 - Topical treatment for the inflamed lesion in acne, rosacea, and pseudofolliculitis barbaeJames J Leyden
Skin Study Center, Broomall, Pennsylvania, USA
Cutis 73:4-5. 2004 - Current concepts in the treatment of acne: report from a clinical roundtableDiane S Berson
Cornell University Medical College, New York, New York, USA
Cutis 72:5-13. 2003..Clinical experience has shown that combination therapies, which affect multiple aspects of pathophysiology, are most likely to achieve this goal and help in its long-term management and resolution... - Antibiotic resistance in the topical treatment of acne vulgarisJames J Leyden
Skin Study Center, Broomall, Pennsylvania, USA
Cutis 73:6-10. 2004.... - Photographic review of results from a clinical study comparing benzoyl peroxide 5%/clindamycin 1% topical gel with vehicle in the treatment of rosaceaJames J Leyden
Skin Study Center, Broomall, Pennsylvania, USA
Cutis 73:11-7. 2004..647 (BP/C) and 0.722 (vehicle) on the OGI scale (P < .001). These results showed that BP/C was significantly more effective than vehicle in improving papules and pustules associated with rosacea... - Bacterial resistance and therapeutic outcome following three months of topical acne therapy with 2% erythromycin gel versus its vehicleOtto Mills
Hill Top Research, East Brunswick, New Jersey, USA
Acta Derm Venereol 82:260-5. 2002..Nearly all of the resistant isolates were highly resistant (minimal inhibitory concentrations > 128 microg/ml). Resistance development was confined to the macrolide class of antibiotics. No anti-acne efficacy was observed... - Once-daily tazarotene 0.1 % gel versus once-daily tretinoin 0.1 % microsponge gel for the treatment of facial acne vulgaris: a double-blind randomized trialJames J Leyden
University of Pennsylvania Hospital, Philadelphia, USA
Cutis 69:12-9. 2002..24 per treatment success with tretinoin microsponge. Tazarotene was observed to have greater efficacy and comparable tolerability and to be a cost-effective alternative to tretinoin 0.1% microsponge gel... - Efficacy of 0.1% tazarotene cream for the treatment of photodamage: a 12-month multicenter, randomized trialTania J Phillips
Boston University School of Medicine, Boston, MA 02118, USA
Arch Dermatol 138:1486-93. 2002..To determine the efficacy and safety of 0.1% tazarotene cream for the treatment of photodamage... - A novel gel formulation of clindamycin phosphate-tretinoin is not associated with acne flaringJames J Leyden
KGL, Inc, Broomall, Pennsylvania 19008, USA
Cutis 82:151-6. 2008..Lack of flaring may result from either the novel vehicle formulation or the antiinflammatory effects of CLIN... - A double-blinded, randomized, vehicle-controlled, multicenter, parallel-group study to assess the safety and efficacy of tretinoin gel microsphere 0.04% in the treatment of acne vulgaris in adultsRichard Berger
Hill Top Research, Inc, East Brunswick, New Jersey, USA
Cutis 80:152-7. 2007..At week 12, there were no statistically significant differences between treatment groups for any measured tolerability parameter... - Status report on antibiotic resistance: implications for the dermatologistJames Q Del Rosso
Valley Hospital Medical Center, PMB 531, 3230 E Flamingo Rad 8, Las Vegas, NV 89121, USA
Dermatol Clin 25:127-32, v. 2007..The common use of systemic antibiotic therapy in dermatology warrants a closer look at how prescribing patterns impact on the development of antibiotic resistant bacteria and outcomes in clinical practice... - Effects of tazarotene 0.1 % cream in the treatment of facial acne vulgaris: pooled results from two multicenter, double-blind, randomized, vehicle-controlled, parallel-group trialsAlan R Shalita
State University of New York Health Sciences Center, Brooklyn, New York, USA
Clin Ther 26:1865-73. 2004..CONCLUSIONS: In these 2 studies in adolescent and adult patients with facial acne vulgaris, tazarotene 0.1%cream QD for 12 weeks was effective and well tolerated. Systemic exposure to tazarotenic acid was limited... - Safety of doxycycline and minocycline: a systematic reviewKelly Smith
Warner Chilcott Laboratories, Rockaway, NJ 07866, USA
Clin Ther 27:1329-42. 2005..The goal of this review was to summarize the available literature covering the safety profiles of oral doxycycline and minocycline...