Research Topics
| Beth LevineSummaryAffiliation: University of Texas Southwestern Medical Center Country: USA Publications
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Detail Information
Publications
Autophagy in cell death: an innocent convict?Beth Levine
Division of Infectious Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9113, USA
J Clin Invest 115:2679-88. 2005..This review summarizes the evidence linking autophagy to cell survival and cell death, the complex interplay between autophagy and apoptosis pathways, and the role of autophagy-dependent survival and death pathways in clinical diseases...- HSV-1 ICP34.5 confers neurovirulence by targeting the Beclin 1 autophagy proteinAnthony Orvedahl
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Cell Host Microbe 1:23-35. 2007..Our findings suggest that autophagy inhibition is a novel molecular mechanism by which viruses evade innate immunity and cause fatal disease... - Autophagy in immunity and inflammationBeth Levine
Department of Microbiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9113, USA
Nature 469:323-35. 2011..They balance the beneficial and detrimental effects of immunity and inflammation, and thereby may protect against infectious, autoimmune and inflammatory diseases... - Unveiling the roles of autophagy in innate and adaptive immunityBeth Levine
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
Nat Rev Immunol 7:767-77. 2007..This Review describes the mechanisms of autophagy and highlights recent advances relevant to the role of autophagy in innate and adaptive immunity... - Bcl-2 family members: dual regulators of apoptosis and autophagyBeth Levine
Howard Hughes Medical Institute, Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9113, USA
Autophagy 4:600-6. 2008..This hitherto neglected crosstalk between the core machineries regulating autophagy and apoptosis may redefine the role of Bcl-2 family proteins in oncogenesis and tumor progression... - HIV and CXCR4 in a kiss of autophagic deathBeth Levine
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9113, USA
J Clin Invest 116:2078-80. 2006..The HIV envelope glycoprotein interacts with CXC chemokine receptor 4 to activate the lysosomal degradation pathway of autophagy, which is necessary for both apoptotic and nonapoptotic cell death... - Unraveling the role of autophagy in cancerBeth Levine
Department of Internal Medicine and Microbiology, UT Southwestern Medical Center at Dallas, Texas 75390, USA
Autophagy 2:65-6. 2006 - Molecular basis of the regulation of Beclin 1-dependent autophagy by the gamma-herpesvirus 68 Bcl-2 homolog M11Sangita Sinha
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9113, USA
Autophagy 4:989-97. 2008..Thus, our results suggest that M11 inhibits autophagy through a mechanism that involves the binding of the Beclin 1 BH3 domain in the M11 hydrophobic surface groove... - Autophagy in the pathogenesis of diseaseBeth Levine
Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
Cell 132:27-42. 2008..This Review summarizes recent advances in understanding the physiological functions of autophagy and its possible roles in the causation and prevention of human diseases... - Eating oneself and uninvited guests: autophagy-related pathways in cellular defenseBeth Levine
Department of Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75330, USA
Cell 120:159-62. 2005..2005). Other recent studies indicate that the autophagy machinery is also used to degrade foreign microbial invaders (xenophagy)... - Bcl-2 inhibition of autophagy: a new route to cancer?Sophie Pattingre
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9113, USA
Cancer Res 66:2885-8. 2006..These findings raise the possibility that Bcl-2 family members may function as oncogenes not only by blocking apoptosis but also by blocking autophagy... - JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagyYongjie Wei
Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Mol Cell 30:678-88. 2008..These findings define a mechanism that cells use to regulate autophagic activity in response to nutrient status... - Autophagy protects against Sindbis virus infection of the central nervous systemAnthony Orvedahl
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, 75390, USA
Cell Host Microbe 7:115-27. 2010..These results suggest a function for autophagy in mammalian antiviral defense: a cell-autonomous mechanism in which p62 adaptor-mediated autophagic viral protein clearance promotes cell survival... - Autophagy genes protect against Salmonella typhimurium infection and mediate insulin signaling-regulated pathogen resistanceKailiang Jia
Department of Internal Medicine, The Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Proc Natl Acad Sci U S A 106:14564-9. 2009..Thus, autophagy genes play an essential role in host defense in vivo against an intracellular bacterial pathogen and mediate pathogen resistance in long-lived mutant nematodes... - The Beclin 1 interactomeCongcong He
Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, United States
Curr Opin Cell Biol 22:140-9. 2010.... - Cardiac autophagy is a maladaptive response to hemodynamic stressHongxin Zhu
Department of Internal Medicine and Donald W Reynolds Cardiovascular Clinical Research Center, University of Texas Southwestern Medical Center, Dallas, TX 75390 8573, USA
J Clin Invest 117:1782-93. 2007..Taken together, these findings implicate autophagy in the pathogenesis of load-induced heart failure and suggest it may be a target for novel therapeutic intervention... - Autophagy in cellular growth controlRichard C Wang
Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
FEBS Lett 584:1417-26. 2010..Here we give an overview of how TOR signaling and autophagy integrate nutritional status to regulate cell growth, how these pathways are coordinately regulated, and how dysfunction of this regulation might result in tumorigenesis... - Autophagy fights disease through cellular self-digestionNoboru Mizushima
Department of Physiology and Cell Biology, Tokyo Medical and Dental University, Tokyo 113 8519, Japan
Nature 451:1069-75. 2008..Understanding autophagy may ultimately allow scientists and clinicians to harness this process for the purpose of improving human health... - The role of autophagy in mammalian development: cell makeover rather than cell deathFrancesco Cecconi
Dulbecco Telethon Institute at the Department of Biology, University of Rome Tor Vergata, 00133 Rome, Italy
Dev Cell 15:344-57. 2008..Thus, autophagy is a process of cytosolic "renovation," crucial in cell fate decisions... - 4th International Symposium on Autophagy: exploiting the frontiers of autophagy researchEeva Liisa Eskelinen
Department of Biological and Environmental Sciences, Division of Biochemistry, University of Helsinki, Helsinki, Finland
Autophagy 3:166-73. 2007..Two themes were discussed in many sessions during the symposium: the role of autophagy in the degradation of aggregate-prone proteins and protein aggregates, and the possible role of p62 in autophagy... - Dual role of JNK1-mediated phosphorylation of Bcl-2 in autophagy and apoptosis regulationYongjie Wei
Howard Hughes Medical Institute, USA
Autophagy 4:949-51. 2008..At a certain point when autophagy is no longer able to keep the cell alive, Bcl-2 phosphorylation might then serve to inactivate its antiapoptotic function... - p53: The Janus of autophagy?Beth Levine
Nat Cell Biol 10:637-9. 2008..The p53 tumour suppressor, previously thought to positively regulate autophagy, may also inhibit it. This dual interplay between p53 and autophagy regulation is enigmatic, but may underlie key aspects of metabolism and cancer biology... - Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotesDaniel J Klionsky
Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109 2216, USA
Autophagy 4:151-75. 2008..In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to verify an autophagic response... - Autophagy genes are essential for dauer development and life-span extension in C. elegansAlicia Melendez
Department of Medicine, Columbia University College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA
Science 301:1387-91. 2003..elegans orthologs of the yeast autophagy genes APG1, APG7, APG8, and AUT10. Thus, autophagy is a cellular pathway essential for dauer development and life-span extension in C. elegans... - Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy geneXueping Qu
Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
J Clin Invest 112:1809-20. 2003..Thus, mutation of beclin 1 or other autophagy genes may contribute to the pathogenesis of human cancers... - Development by self-digestion: molecular mechanisms and biological functions of autophagyBeth Levine
Department of Medicine, Columbia University, New York, NY 10032, USA
Dev Cell 6:463-77. 2004..In this review, we summarize our current knowledge about the molecular machinery of autophagy and the role of the autophagic machinery in eukaryotic development... - Autophagy regulates programmed cell death during the plant innate immune responseYule Liu
Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06520, USA
Cell 121:567-77. 2005..Thus, the evolutionarily conserved autophagy pathway plays an essential role in plant innate immunity and negatively regulates PCD... - Autophagy in development, tumor suppression, and innate immunityBeth Levine
Department of Medicine, Columbia University College of Physicians and Surgeons, USA
Harvey Lect 99:47-76. 2003 - Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagySophie Pattingre
Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
Cell 122:927-39. 2005..This antiautophagy function of Bcl-2 may help maintain autophagy at levels that are compatible with cell survival, rather than cell death... - Identification of interferon-stimulated gene 15 as an antiviral molecule during Sindbis virus infection in vivoDeborah J Lenschow
Department of Pathology, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Virol 79:13974-83. 2005..Finally, we demonstrate that ISG15's LRLRGG motif is also required for its antiviral activity. We conclude that ISG15 can be directly antiviral... - IFN-stimulated gene 15 functions as a critical antiviral molecule against influenza, herpes, and Sindbis virusesDeborah J Lenschow
Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
Proc Natl Acad Sci U S A 104:1371-6. 2007..The demonstration of ISG15 as a novel antiviral molecule with activity against both RNA and DNA viruses provides a target for the development of therapies against important human pathogens... - Distinct roles of autophagy in the heart during ischemia and reperfusion: roles of AMP-activated protein kinase and Beclin 1 in mediating autophagyYutaka Matsui
Department of Cell Biology and Molecular Medicine, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ 07103, USA
Circ Res 100:914-22. 2007..Furthermore, autophagy plays distinct roles during ischemia and reperfusion: autophagy may be protective during ischemia, whereas it may be detrimental during reperfusion... - Cell biology: autophagy and cancerBeth Levine
Nature 446:745-7. 2007 - How shall I eat thee?Daniel J Klionsky
Life Sciences Institute and Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, Michigan 48109-2216, USA
Autophagy 3:413-6. 2007 - Age-dependent resistance to lethal alphavirus encephalitis in mice: analysis of gene expression in the central nervous system and identification of a novel interferon-inducible protective gene, mouse ISG12Lucia Labrada
Department of Medicine, Columbia University College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
J Virol 76:11688-703. 2002..Together, our data identify genes that are developmentally regulated in the CNS and genes that are differentially regulated in the brains of different aged mice in response to Sindbis virus infection...