Research Topics
| Nicholas William LercheSummaryAffiliation: University of California Country: USA Publications
Research Grants
| Collaborators
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Detail Information
Publications
Evidence of infection with simian type D retrovirus in persons occupationally exposed to nonhuman primatesN W Lerche
Simian Retrovirus Laboratory, California Regional Primate Research Center, University of California, Davis, Davis, California 95616 8542, USA
J Virol 75:1783-9. 2001....- Simian retroviruses: infection and disease--implications for immunotoxicology research in primatesNicholas W Lerche
California National Primate Research Center, University of California, Davis, CA 95616 8542, USA
J Immunotoxicol 7:93-101. 2010..Adequate pre-study retrovirus screening is essential to exclude retrovirus-infected primates from research protocols... - Simian retrovirus infections: potential confounding variables in primate toxicology studiesNicholas W Lerche
Simian Retrovirus Laboratory, California National Primate Research Center, University of California, Davis, CA 95616, USA
Toxicol Pathol 31:103-10. 2003..Adequate prestudy viral screening is critical to exclude retrovirus-infected primates from toxicologic research protocols and prevent potential confounding of research results... - New approaches to tuberculosis surveillance in nonhuman primatesNicholas W Lerche
Pathogen Detection Laboratory, California National Primate Research Center, University of California, Davis, CA 95616, USA
ILAR J 49:170-8. 2008..In this article we describe the characteristics of these newer screening tests and discuss their potential contributions to NHP tuberculosis surveillance programs... - DNA vaccination of infants in the presence of maternal antibody: a measles model in the primateMary Premenko-Lanier
California National Primate Research Center and Department of Pathology, School of Medicine, University of California-Davis, County Road 98, Davis, CA 95616-8542, USA
Virology 307:67-75. 2003..Further, the addition of a molecular IL-2 adjuvant augments this DNA vaccine... - Predictors of matrilineal overthrows in large captive breeding groups of rhesus macaques (Macaca mulatta)Rhonda Sue Oates-O'Brien
Campus Veterinary Service, University of California, Davis, CA, USA
J Am Assoc Lab Anim Sci 49:196-201. 2010..Our results suggest a possible association between the occurrence of a matrilineal overthrow and the following factors: absence of the alpha female, decreased housing density, number of juvenile males, and number of adolescent males... - Serologic evaluation of clinical and subclinical secondary hepatic amyloidosis in rhesus macaques (Macaca mulatta)Jamus G MacGuire
California National Primate Research Center, University of California, Davis, California, USA
Comp Med 59:168-73. 2009..The serologic parameters studied indicate a temporal relationship of these factors not previously described, show a clear pattern of disease progression, and could be useful in subclinical disease detection... - Development of a generic real-time PCR assay for simultaneous detection of proviral DNA of simian Betaretrovirus serotypes 1, 2, 3, 4 and 5 and secondary uniplex assays for specific serotype identificationJessica A White
California National Primate Research Center, University of California, Davis, CA 95616, USA
J Virol Methods 162:148-54. 2009..A panel of SRV serotype-specific uniplex real-time PCR assays for discrimination among the five recognized serotypes is also described... - Prevalence of viremia and oral shedding of rhesus rhadinovirus and retroperitoneal fibromatosis herpesvirus in large age-structured breeding groups of rhesus macaques (Macaca mulatta)Jessica A White
California National Primate Research Center, University of California, Davis, California, USA
Comp Med 59:383-90. 2009..Both RRV and RFHV are highly endemic in socially housed breeding colonies of rhesus macaques, and their patterns of infection are similar to that for the betaherpesvirus rhesus cytomegalovirus... - Beyond specific pathogen-free: biology and effect of common viruses in macaquesNicholas W Lerche
California National Primate Research Center, University of California, Davis, CA, USA
Comp Med 58:8-10. 2008..Featured articles also address the challenges of developing colonies of macaques and other nonhuman primates that are truly specific pathogen-free for these and other adventitious infectious agents... - Effects of the macrolide drug tylosin on chronic diarrhea in rhesus macaques (Macaca mulatta)Rebecca S Blackwood
California National Primate Research Center, University of California, Davis, CA, USA
Comp Med 58:81-7. 2008..In conclusion, tylosin significantly improved the fecal consistency score, significantly decreased colonic inflammation, and significantly decreased serum CRP levels post-treatment in rhesus macaques with chronic diarrhea... - Genetic characterization of specific pathogen-free rhesus macaque (Macaca mulatta) populations at the California National Primate Research Center (CNPRC)Sree Kanthaswamy
California National Primate Research Center, University of California Davis, CA 95616, USA
Am J Primatol 72:587-99. 2010..Together with demographic management, population genetic assessments of SPF colonies can curtail excessive phenotypic variation among the study stocks and facilitate successful production goals... - Comparative pathogenesis of epidemic and enzootic Chikungunya viruses in a pregnant Rhesus macaque modelChing I Chen
Department of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California, Davis, California 95616, USA
Am J Trop Med Hyg 83:1249-58. 2010..Our study establishes a non-human primate model for evaluating vaccines and antiviral therapies and indicates that Rhesus macaques could serve as a competent enzootic reservoir... - Simultaneous detection of antibodies to six nonhuman-primate viruses by multiplex microbead immunoassayImran H Khan
Center for Comparative Medicine, University of California, One Shields Ave, Davis, CA 95616, USA
Clin Vaccine Immunol 13:45-52. 2006..Thus, this multiplex microbead detection system is an efficient diagnostic modality for serosurveillance of nonhuman primates... - Microsatellite markers for standardized genetic management of captive colonies of rhesus macaques (Macaca mulatta)Sreetharan Kanthaswamy
Veterinary Genetics Laboratory, School of Veterinary Medicine, California National Primate Research Center, University of California Davis, California 95616, USA
Am J Primatol 68:73-95. 2006..We then assessed the effectiveness of these loci for providing high probabilities of individual identification and parentage resolution, and for estimating population genetic parameters that are useful for genetic management... - Polymorphism in the rhesus macaque (Macaca mulatta) NRAMP1 gene: lack of an allelic association to tuberculosis susceptibilityAmos S Deinard
School of Veterinary Medicine, and Department of Anthropology, University of California, Davis 95616, USA
J Med Primatol 31:8-16. 2002..These data represent the first study designed to examine the role that NRAMP1 may play in TB susceptibility among rhesus macaques... - Safety, antigenicity, and efficacy of a recombinant coccidioidomycosis vaccine in cynomolgus macaques (Macaca fascicularis)Suzanne M Johnson
D V M M P V M, California National Primate Research Center, University of California, Davis, CA 95616, USA
Ann N Y Acad Sci 1111:290-300. 2007..Additional experiments may be needed to optimize the vaccination and to confer greater protection against lethal challenge... - Comparative efficacy of a canine distemper-measles and a standard measles vaccine for immunization of rhesus macaques (Macaca mulatta)Kari L Christe
California Regional Primate Research Center, University of California, Davis 95616-8542, USA
Comp Med 52:467-72. 2002..The considerably lower cost of Vanguard makes vaccination against measles in large breeding colonies economically feasible... - Subsets of T cells in healthy rhesus macaques (Macaca mulatta) infected with simian T-lymphotropic virus type 1Laurie Brignolo
California National Primate Research Center, University of California, Davis 95616, USA
Comp Med 54:271-4. 2004..Parameters measured included CD3, CD4, CD8, CD25, CD28, CD38, and HLA-DR cell sets. Significant differences in T-cell subsets or hematologic parameters were not observed between healthy STLV-seropositive and seronegative groups... - Four preanesthetic oral sedation protocols for rhesus macaques (Macaca mulatta)Astrid C S Pulley
California National Primate Research Center, University of California, Davis, California 95616-8542, USA
J Zoo Wildl Med 35:497-502. 2004..Alternatively, oral midazolam syrup is well accepted by some animals and provides a mild sedative and calming effect, which may decrease stress associated with the induction of anesthesia via darting, pole syringes, etc... - Frequent simian foamy virus infection in persons occupationally exposed to nonhuman primatesWilliam M Switzer
HIV and Retrovirology Branch, Division of AIDS, STD, and TB Laboratory Research, National Center for HIV, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
J Virol 78:2780-9. 2004..Our data highlight the importance of studies to better define the public health implications of zoonotic SFV infections... - Immunological concepts in tuberculosis diagnostics for non-human primates: a reviewPhilana Ling Lin
Department of Pediatrics, Children s Hospital of Pittsburgh, 3705 Fifth Avenue, Pittsburgh, PA 15213, USA
J Med Primatol 37:44-51. 2008..Lastly, the risk and benefits to the primate colony, staff and resources must be carefully weighed when deciding to euthanize monkeys to make the diagnosis of tuberculosis... - Transmission dynamics of simian T-lymphotropic virus type 1 (STLV1) in a baboon breeding colony: predominance of female-to-female transmissionJean M d'Offay
Department of Veterinary Pathobiology, Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, USA
Comp Med 57:105-14. 2007.... - A family of variably expressed outer-membrane proteins (Vomp) mediates adhesion and autoaggregation in Bartonella quintanaPeng Zhang
Division of Infectious Diseases, Department of Medicine, University of California San Francisco, 521 Parnassus Avenue, San Francisco, CA 94143 0654
Proc Natl Acad Sci U S A 101:13630-5. 2004.... - Molecular epidemiology of simian immunodeficiency virus SIVsm in U.S. primate centers unravels the origin of SIVmac and SIVstmCristian Apetrei
Division of Microbiology and Immunology, Tulane National Primate Research Center, 18703 Three Rivers Road, Covington, LA 70433, USA
J Virol 79:8991-9005. 2005..The genetic variability of SIVsm strains among PCs may influence the diagnosis and monitoring of SIVsm infection and, consequently, may bias the results of pathogenesis studies... - Diagnosis of tuberculosis in macaques, using whole-blood in vitro interferon-gamma (PRIMAGAM) testingManuel A Garcia
Stanford University School of Medicine, Department of Comparative Medicine, RAF 1, Quad 7, Bldg. 330, Stanford, California 94305-5410, USA
Comp Med 54:86-92. 2004..Fortunately, they were different animals; therefore, we recommend the parallel use of the TST and PRIMAGAM test for maximal overall sensitivity in a tuberculosis screening program, especially for cynomolgus macaques... - Prevalence of antibodies to selected viruses in a long-term closed breeding colony of rhesus macaques (Macaca mulatta) in BrazilMarcia Ribeiro Andrade
Oswaldo Cruz Foundation, Centro de Criação de Animais de Loboratório, Rio de Janeiro, Brazil
Am J Primatol 59:123-8. 2003..All samples were negative for antibodies against the simian retroviruses. The overall prevalence of antibodies was 95% for RhCMV, 45% for B virus, 35% for HAV, and 1% for MV. Prevalence was found to vary by age group... - Kuru experiments triggered the emergence of pathogenic SIVmacCristian Apetrei
Division of Microbiology, Tulane National Primate Research Center, Covington, Louisiana 70433, USA
AIDS 20:317-21. 2006
Research Grants
- Training of Graduate Veterinarians in Clinical Primate MedicineNicholas Lerche; Fiscal Year: 2007..Participants will also benefit from the intellectual environment and training resources provided by the Schools of Medicine and Veterinary Medicine, and the Center for Comparative Medicine, co-located on the UCD campus. ..
- PRODUCTION OF PEDIGREED SPF RHESUS MACAQUESNicholas Lerche; Fiscal Year: 2009..The rhesus monkeys produced as part of this grant will provide valuable resources for AIDS-related research. These animals will be used for research related to vaccine development and anti-viral therapy. ..
- GENETICALLY DEFINED HERPES/RETROVIRUS SPF MACAQUESNicholas William Lerche; Fiscal Year: 2010..Genetic and immunologic data obtained from this project will better define and characterize the rhesus macaque model system in support of research on AIDS and other infectious diseases. ..
- GENETICALLY DEFINED HERPES/RETROVIRUS SPF MACAQUESNicholas Lerche; Fiscal Year: 2009..Genetic and immunologic data obtained from this project will better define and characterize the rhesus macaque model system in support of research on AIDS and other infectious diseases. ..
- PRODUCTION OF PEDIGREED SPF RHESUS MACAQUESNicholas Lerche; Fiscal Year: 2006..abstract_text> ..
- GENETICALLY DEFINED HERPES/RETROVIRUS SPF MACAQUESNicholas Lerche; Fiscal Year: 2006..This multiplex system will allow for high throughput screening at reduced cost and will be used in support of the SPF colony development. ..
- PRODUCTION OF PEDIGREED SPF RHESUS MACAQUESNicholas Lerche; Fiscal Year: 2004..abstract_text> ..
- PRODUCTION OF PEDIGREED SPF RHESUS MACAQUESNicholas Lerche; Fiscal Year: 2005..The rhesus monkeys produced as part of this grant will provide valuable resources for AIDS-related research. These animals will be used for research related to vaccine development and anti-viral therapy. ..
- GENETICALLY DEFINED HERPES/RETROVIRUS SPF MACAQUESNicholas Lerche; Fiscal Year: 2006..This multiplex system will allow for high throughput screening at reduced cost and will be used in support of the SPF colony development. ..
- GENETICALLY DEFINED HERPES/RETROVIRUS SPF MACAQUESNicholas Lerche; Fiscal Year: 2009..Genetic and immunologic data obtained from this project will better define and characterize the rhesus macaque model system in support of research on AIDS and other infectious diseases. ..