Christopher C Leonardo

Summary

Affiliation: University of South Florida
Country: USA

Publications

  1. ncbi Delayed administration of a matrix metalloproteinase inhibitor limits progressive brain injury after hypoxia-ischemia in the neonatal rat
    Christopher C Leonardo
    Department of Molecular Pharmacology and Physiology, School of Basic Biomedical Sciences, College of Medicine, University of South Florida, Tampa, FL 33612, USA
    J Neuroinflammation 5:34. 2008
  2. ncbi Neuroinflammation and MMPs: potential therapeutic targets in neonatal hypoxic-ischemic injury
    Christopher C Leonardo
    Department of Molecular Pharmacology and Physiology, School of Basic Biomedical Sciences, College of Medicine, University of South Florida, Tampa, FL 33612, USA
    J Neuroinflammation 6:13. 2009
  3. ncbi Human umbilical cord blood cell therapy blocks the morphological change and recruitment of CD11b-expressing, isolectin-binding proinflammatory cells after middle cerebral artery occlusion
    Christopher C Leonardo
    Department of Molecular Pharmacology and Physiology, College of Medicine, University of South Florida, Tampa, Florida 33612, USA
    J Neurosci Res 88:1213-22. 2010
  4. ncbi Human umbilical cord blood cells protect oligodendrocytes from brain ischemia through Akt signal transduction
    Derrick D Rowe
    Department of Molecular Pharmacology and Physiology, School of Basic Biomedical Sciences, College of Medicine, University of South Florida, Tampa, Florida 33612, USA
    J Biol Chem 287:4177-87. 2012
  5. ncbi Versican and brevican are expressed with distinct pathology in neonatal hypoxic-ischemic injury
    Christopher C Leonardo
    Department of Molecular Pharmacology and Physiology, School of Basic Biomedical Sciences, College of Medicine, University of South Florida, Tampa, Florida, USA
    J Neurosci Res 86:1106-14. 2008
  6. ncbi Multimodal signaling by the ADAMTSs (a disintegrin and metalloproteinase with thrombospondin motifs) promotes neurite extension
    Michelle G Hamel
    University of South Florida College of Medicine, Department of Molecular Pharmacology and Physiology, 12901 Bruce B Downs Boulevard, Tampa, FL 33612 4799, USA
    Exp Neurol 210:428-40. 2008
  7. ncbi Blockade of adrenoreceptors inhibits the splenic response to stroke
    Craig T Ajmo
    Department of Molecular Pharmacology and Physiology, School of Basic Biomedical Sciences, College of Medicine, University of South Florida, Tampa, FL 33612, USA
    Exp Neurol 218:47-55. 2009
  8. ncbi Lateral fluid percussion injury of the brain induces CCL20 inflammatory chemokine expression in rats
    Mahasweta Das
    Department of Internal Medicine, University of South Florida College of Medicine, 12901 Bruce B Downs Blvd, Tampa, FL 33612, USA
    J Neuroinflammation 8:148. 2011
  9. ncbi Dietary flavonoids are neuroprotective through Nrf2-coordinated induction of endogenous cytoprotective proteins
    Christopher C Leonardo
    Department of Anesthesiology, University of Florida, College of Medicine, Gainesville, FL, USA
    Nutr Neurosci 14:226-36. 2011

Collaborators

  • Joanne M Ajmo
  • SYLVAIN DORE
  • Javier Cuevas
  • Keith R Pennypacker
  • Derrick D Rowe
  • Mahasweta Das
  • Alison E Willing
  • Lisa A Collier
  • Craig T Ajmo
  • Michelle G Hamel
  • Jesus A Recio
  • Subhra Mohapatra
  • Saniya Rangooni
  • Shyam S Mohapatra
  • Aaron A Hall
  • Suzanne M Green
  • Tracy A Womble
  • John D Sandy
  • Paul E Gottschall
  • Fengrong Zuo

Detail Information

Publications9

  1. ncbi Delayed administration of a matrix metalloproteinase inhibitor limits progressive brain injury after hypoxia-ischemia in the neonatal rat
    Christopher C Leonardo
    Department of Molecular Pharmacology and Physiology, School of Basic Biomedical Sciences, College of Medicine, University of South Florida, Tampa, FL 33612, USA
    J Neuroinflammation 5:34. 2008
    ..AG3340 (prinomastat) is an MMP inhibitor with high selectivity for the gelatinases. The purpose of this study was to determine whether these compounds could limit H-I--induced injury when administered at a delayed time point...
  2. ncbi Neuroinflammation and MMPs: potential therapeutic targets in neonatal hypoxic-ischemic injury
    Christopher C Leonardo
    Department of Molecular Pharmacology and Physiology, School of Basic Biomedical Sciences, College of Medicine, University of South Florida, Tampa, FL 33612, USA
    J Neuroinflammation 6:13. 2009
    ..Finally, we discuss data that supports the potential to target these neuroinflammatory signals at clinically relevant time points...
  3. ncbi Human umbilical cord blood cell therapy blocks the morphological change and recruitment of CD11b-expressing, isolectin-binding proinflammatory cells after middle cerebral artery occlusion
    Christopher C Leonardo
    Department of Molecular Pharmacology and Physiology, College of Medicine, University of South Florida, Tampa, Florida 33612, USA
    J Neurosci Res 88:1213-22. 2010
    ....
  4. ncbi Human umbilical cord blood cells protect oligodendrocytes from brain ischemia through Akt signal transduction
    Derrick D Rowe
    Department of Molecular Pharmacology and Physiology, School of Basic Biomedical Sciences, College of Medicine, University of South Florida, Tampa, Florida 33612, USA
    J Biol Chem 287:4177-87. 2012
    ..These results suggest that the soluble factors released from human umbilical cord blood cells converge on Akt to elevate peroxiredoxin 4 levels, and these effects contribute to oligodendrocyte survival...
  5. ncbi Versican and brevican are expressed with distinct pathology in neonatal hypoxic-ischemic injury
    Christopher C Leonardo
    Department of Molecular Pharmacology and Physiology, School of Basic Biomedical Sciences, College of Medicine, University of South Florida, Tampa, Florida, USA
    J Neurosci Res 86:1106-14. 2008
    ....
  6. ncbi Multimodal signaling by the ADAMTSs (a disintegrin and metalloproteinase with thrombospondin motifs) promotes neurite extension
    Michelle G Hamel
    University of South Florida College of Medicine, Department of Molecular Pharmacology and Physiology, 12901 Bruce B Downs Boulevard, Tampa, FL 33612 4799, USA
    Exp Neurol 210:428-40. 2008
    ....
  7. ncbi Blockade of adrenoreceptors inhibits the splenic response to stroke
    Craig T Ajmo
    Department of Molecular Pharmacology and Physiology, School of Basic Biomedical Sciences, College of Medicine, University of South Florida, Tampa, FL 33612, USA
    Exp Neurol 218:47-55. 2009
    ..05). These results demonstrate that circulating blood borne catecholamines regulate the splenic response to stroke through the activation of both alpha and beta adrenergic receptors...
  8. ncbi Lateral fluid percussion injury of the brain induces CCL20 inflammatory chemokine expression in rats
    Mahasweta Das
    Department of Internal Medicine, University of South Florida College of Medicine, 12901 Bruce B Downs Blvd, Tampa, FL 33612, USA
    J Neuroinflammation 8:148. 2011
    ..Due to the high incidence of head trauma in the sports field, battlefield and automobile accidents identification of the molecular signals involved in TBI progression is critical for the development of novel therapeutics...
  9. ncbi Dietary flavonoids are neuroprotective through Nrf2-coordinated induction of endogenous cytoprotective proteins
    Christopher C Leonardo
    Department of Anesthesiology, University of Florida, College of Medicine, Gainesville, FL, USA
    Nutr Neurosci 14:226-36. 2011
    ....