JOHN L LEAHY

Summary

Affiliation: University of Vermont
Country: USA

Publications

  1. ncbi Pathogenesis of type 2 diabetes mellitus
    Jack L Leahy
    University of Vermont College of Medicine, Burlington, VT 05405, USA
    Arch Med Res 36:197-209. 2005
  2. ncbi Insulin management of diabetic patients on general medical and surgical floors
    Jack L Leahy
    Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, University of Vermont College of Medicine, Burlington, Vermont, USA
    Endocr Pract 12:86-90. 2006
  3. ncbi Targeting beta-cell function early in the course of therapy for type 2 diabetes mellitus
    Jack L Leahy
    Endocrine Unit, University of Vermont College of Medicine Colchester Research Facility, 208 South Park Drive, Colchester, Vermont 05446, USA
    J Clin Endocrinol Metab 95:4206-16. 2010
  4. ncbi Thiazolidinediones in prediabetes and early type 2 diabetes: what can be learned about that disease's pathogenesis
    Jack L Leahy
    Colchester Research Facility, Colchester, VT 05446, USA
    Curr Diab Rep 9:215-20. 2009
  5. ncbi Physiologic and pharmacologic modulation of glucose-dependent insulinotropic polypeptide (GIP) receptor expression in beta-cells by peroxisome proliferator-activated receptor (PPAR)-gamma signaling: possible mechanism for the GIP resistance in type 2 diab
    Dhananjay Gupta
    Division of Endocrinology, Diabetes, and Metabolism and the Department of Medicine, University of Vermont, Burlington, Vermont, USA
    Diabetes 59:1445-50. 2010
  6. ncbi Enhanced beta-cell mass without increased proliferation following chronic mild glucose infusion
    Thomas L Jetton
    Division of Endocrinology, Diabetes, and Metabolism, University of Vermont, Burlington, VT 05405, USA
    Am J Physiol Endocrinol Metab 294:E679-87. 2008
  7. ncbi Peroxisome proliferator-activated receptor-gamma regulates expression of PDX-1 and NKX6.1 in INS-1 cells
    Jacob A Moibi
    Cross Cancer Institute, University of Alberta, Edmonton, Canada
    Diabetes 56:88-95. 2007
  8. ncbi Regulation of pancreatic beta-cell regeneration in the normoglycemic 60% partial-pancreatectomy mouse
    Mina Peshavaria
    University of Vermont College of Medicine, Department of Medicine, Given C331, Burlington, VT 05405, USA
    Diabetes 55:3289-98. 2006
  9. ncbi Basal-prandial insulin therapy: Scientific concept review and application
    Jack L Leahy
    Division of Endocrinology, Diabetes and Metabolism, University of Vermont College of Medicine, Burlington, Vermont 05405, USA
    Am J Med Sci 332:24-31. 2006
  10. ncbi Mechanisms of compensatory beta-cell growth in insulin-resistant rats: roles of Akt kinase
    Thomas L Jetton
    Division of Endocrinology, Diabetes and Metabolism, University of Vermont College of Medicine, Department of Medicine, Given C331, Burlington, VT 05405, USA
    Diabetes 54:2294-304. 2005

Research Grants

  1. Mechanisms of Beta cell Compensation and Failure
    John Leahy; Fiscal Year: 2007
  2. Beta-cell Compensation in Partial Pancreatectomy Mice
    John Leahy; Fiscal Year: 2007
  3. B-CELL COMPENSATION IN PARTIAL PANCREATECTOMY RATS
    John Leahy; Fiscal Year: 2003
  4. Beta-cell Compensation in Partial Pancreatectomy Mice
    JOHN L LEAHY; Fiscal Year: 2010

Collaborators

Detail Information

Publications15

  1. ncbi Pathogenesis of type 2 diabetes mellitus
    Jack L Leahy
    University of Vermont College of Medicine, Burlington, VT 05405, USA
    Arch Med Res 36:197-209. 2005
    ..This sequence also provides insight into how to better prevent or treat type 2 diabetes, by studying the molecular basis for the early defects, and developing targeted therapies against them...
  2. ncbi Insulin management of diabetic patients on general medical and surgical floors
    Jack L Leahy
    Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, University of Vermont College of Medicine, Burlington, Vermont, USA
    Endocr Pract 12:86-90. 2006
    ..CONCLUSION: Standardized protocols have been developed and implemented at the University of Vermont for patients receiving regular meals and continuous tube feedings or TPN...
  3. ncbi Targeting beta-cell function early in the course of therapy for type 2 diabetes mellitus
    Jack L Leahy
    Endocrine Unit, University of Vermont College of Medicine Colchester Research Facility, 208 South Park Drive, Colchester, Vermont 05446, USA
    J Clin Endocrinol Metab 95:4206-16. 2010
    ..In addition, it considers translation strategies to incorporate relevant scientific findings into educational initiatives targeting clinical practice behavior...
  4. ncbi Thiazolidinediones in prediabetes and early type 2 diabetes: what can be learned about that disease's pathogenesis
    Jack L Leahy
    Colchester Research Facility, Colchester, VT 05446, USA
    Curr Diab Rep 9:215-20. 2009
    ..Then it provides an overview of the current concepts regarding the beta-cell overwork and rest hypotheses, and the recent information about PPARgamma signaling effects in beta cells...
  5. ncbi Physiologic and pharmacologic modulation of glucose-dependent insulinotropic polypeptide (GIP) receptor expression in beta-cells by peroxisome proliferator-activated receptor (PPAR)-gamma signaling: possible mechanism for the GIP resistance in type 2 diab
    Dhananjay Gupta
    Division of Endocrinology, Diabetes, and Metabolism and the Department of Medicine, University of Vermont, Burlington, Vermont, USA
    Diabetes 59:1445-50. 2010
    ..Gene Bank blast for a homologous nucleotide sequence revealed the same PPRE within the rat glucose-dependent insulinotropic polypeptide receptor (GIP-R) promoter sequence. We investigated the role of PPARgamma in GIP-R transcription...
  6. ncbi Enhanced beta-cell mass without increased proliferation following chronic mild glucose infusion
    Thomas L Jetton
    Division of Endocrinology, Diabetes, and Metabolism, University of Vermont, Burlington, VT 05405, USA
    Am J Physiol Endocrinol Metab 294:E679-87. 2008
    ....
  7. ncbi Peroxisome proliferator-activated receptor-gamma regulates expression of PDX-1 and NKX6.1 in INS-1 cells
    Jacob A Moibi
    Cross Cancer Institute, University of Alberta, Edmonton, Canada
    Diabetes 56:88-95. 2007
    ..1. Additional studies are needed to determine whether there is a regulatory role for PPAR-gamma signaling in the beta-cell adaptation following a 60% Px in rats...
  8. ncbi Regulation of pancreatic beta-cell regeneration in the normoglycemic 60% partial-pancreatectomy mouse
    Mina Peshavaria
    University of Vermont College of Medicine, Department of Medicine, Given C331, Burlington, VT 05405, USA
    Diabetes 55:3289-98. 2006
    ..These data suggest that the IRS2-Akt pathway mediates compensatory beta-cell growth by activating beta-cell proliferation with an increase in the number of beta-cell clusters/small islets...
  9. ncbi Basal-prandial insulin therapy: Scientific concept review and application
    Jack L Leahy
    Division of Endocrinology, Diabetes and Metabolism, University of Vermont College of Medicine, Burlington, Vermont 05405, USA
    Am J Med Sci 332:24-31. 2006
    ....
  10. ncbi Mechanisms of compensatory beta-cell growth in insulin-resistant rats: roles of Akt kinase
    Thomas L Jetton
    Division of Endocrinology, Diabetes and Metabolism, University of Vermont College of Medicine, Department of Medicine, Given C331, Burlington, VT 05405, USA
    Diabetes 54:2294-304. 2005
    ....
  11. ncbi Chronic high glucose lowers pyruvate dehydrogenase activity in islets through enhanced production of long chain acyl-CoA: prevention of impaired glucose oxidation by enhanced pyruvate recycling through the malate-pyruvate shuttle
    Ye Qi Liu
    Division of Endocrinology, Diabetes, and Metabolism, University of Vermont, Burlington, Vermont 05405
    J Biol Chem 279:7470-5. 2004
    ..Also, a specialized trait of beta-cells is a long chain acyl-CoA-mediated defense mechanism that prevents a reduction in glucose oxidation and consequently in insulin secretion...
  12. ncbi Insulin therapy for type 2 diabetes
    Afshin Sasali
    Division of Endocrinology, Diabetes and Metabolism, and the Department of Medicine, University of Vermont College of Medicine, Given C-331, Burlington, VT 05405, USA
    Curr Diab Rep 3:378-85. 2003
    ..Finally, it provides a "hands on" approach on how to start basal insulin therapy and multishot insulin therapy in type 2 diabetes...
  13. ncbi beta-Cell adaptation to insulin resistance. Increased pyruvate carboxylase and malate-pyruvate shuttle activity in islets of nondiabetic Zucker fatty rats
    Ye Qi Liu
    Division of Endocrinology, Diabetes, and Metabolism, University of Vermont, Burlington, Vermont 05405, USA
    J Biol Chem 277:39163-8. 2002
    ....
  14. ncbi Is metformin cardioprotective?
    Afshin Sasali
    Diabetes Care 26:243-4. 2003
  15. ncbi Characterization of a novel metabolic strategy used by drug-resistant tumor cells
    Mary-Ellen Harper
    Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada
    FASEB J 16:1550-7. 2002
    ..In addition, drug-resistant cells express high levels of mitochondrial uncoupling protein 2 (UCP2). The discovery of this metabolic strategy potentially facilitates the design of novel therapeutic approaches to drug resistance...

Research Grants14

  1. Mechanisms of Beta cell Compensation and Failure
    John Leahy; Fiscal Year: 2007
    ..abstract_text> ..
  2. Beta-cell Compensation in Partial Pancreatectomy Mice
    John Leahy; Fiscal Year: 2007
    ..abstract_text> ..
  3. B-CELL COMPENSATION IN PARTIAL PANCREATECTOMY RATS
    John Leahy; Fiscal Year: 2003
    ..These studies will provide fundamental mechanistic information regarding beta-cell adaptive mechanisms and how they regulate glucose homeostasis. ..
  4. Beta-cell Compensation in Partial Pancreatectomy Mice
    JOHN L LEAHY; Fiscal Year: 2010
    ....