Research Topics
| G A LaughlinSummaryAffiliation: University of California Country: USA Publications
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Detail Information
Publications
Association of endogenous sex hormones and insulin resistance among postmenopausal women: results from the Postmenopausal Estrogen/Progestin Intervention TrialGrace Mariko Kalish
Yale University School of Medicine, New Haven, Connecticut 06510-8046, USA
J Clin Endocrinol Metab 88:1646-52. 2003..These results suggest that estrogen may be equally or more important than testosterone in the pathway to IR in healthy, young postmenopausal women, with differences not entirely explained by body size...- Sex differences in the association of Framingham Cardiac Risk Score with cognitive decline in community-dwelling elders without clinical heart diseaseGail A Laughlin
Department of Family and Preventive Medicine, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
Psychosom Med 73:683-9. 2011.... - Abdominal aortic diameter and vascular atherosclerosis: the Multi-Ethnic Study of AtherosclerosisG A Laughlin
Department of Family and Preventive Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, San Diego, CA 92093 0620, United States
Eur J Vasc Endovasc Surg 41:481-7. 2011.... - Extremes of endogenous testosterone are associated with increased risk of incident coronary events in older womenGail A Laughlin
University of California, San Diego, 9500 Gilman Drive, MC 0631C, La Jolla, California 92093, USA
J Clin Endocrinol Metab 95:740-7. 2010..Conclusions: An optimal range of testosterone may exist for cardiovascular health in women, with increased risk of CHD events at low levels of testosterone overall and at high levels of the bioavailable fraction of testosterone... - Endogenous oestrogens predict 4-year decline in verbal fluency in postmenopausal women: the Rancho Bernardo StudyGail A Laughlin
Department of Family and Preventive Medicine, School of Medicine, University of California, San Diego, CA 92093, USA
Clin Endocrinol (Oxf) 72:99-106. 2010..This study examines the association between endogenous oestrogen levels and subsequent 4-year decline in cognitive function test performance in community-dwelling older women... - Low serum testosterone and mortality in older menGail A Laughlin
Department of Family and Preventive Medicine, School of Medicine, University of California, San Diego, 9500 Gilman Drive, MC 0631C, La Jolla, California 92093, USA
J Clin Endocrinol Metab 93:68-75. 2008..Declining testosterone levels in elderly men are thought to underlie many of the symptoms and diseases of aging; however, studies demonstrating associations of low testosterone with clinical outcomes are few... - Association of adiponectin with coronary heart disease and mortality: the Rancho Bernardo studyGail A Laughlin
Department of Family and Preventive Medicine, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
Am J Epidemiol 165:164-74. 2007..001). These results suggest that use of adiponectin for cardiovascular disease risk stratification is premature... - Sex-specific determinants of serum adiponectin in older adults: the role of endogenous sex hormonesG A Laughlin
Department of Family and Preventive Medicine, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
Int J Obes (Lond) 31:457-65. 2007..To assess the sex-specific association of adiponectin with multiple factors thought to influence its levels, with a special emphasis on endogenous sex hormones... - Differences in association of bone mineral density with coronary artery calcification in men and women: the Rancho Bernardo StudyLudmila N Bakhireva
Department of Family and Preventive Medicine, Division of Epidemiology, University of California, San Diego, La Jolla, 92093-0607, USA
Menopause 12:691-8. 2005..1). CONCLUSION: Lack of association between BMD and CACS in men and women not using HT and the inverse association in women on HT suggest that the association between coronary and bone calcium might be mediated by estrogen... - The prospective association of serum insulin-like growth factor I (IGF-I) and IGF-binding protein-1 levels with all cause and cardiovascular disease mortality in older adults: the Rancho Bernardo StudyGail A Laughlin
Department of Family and Preventive Medicine, University of California San Diego School of Medicine, La Jolla, California 92093 0607
J Clin Endocrinol Metab 89:114-20. 2004..We conclude that low baseline levels of IGF-I and IGFBP-1 increase the risk of fatal IHD among elderly men and women independent of prevalent IHD and CVD risk factors... - The sex-specific association of serum osteoprotegerin and receptor activator of nuclear factor kappaB legend with bone mineral density in older adults: the Rancho Bernardo studyAnna Stern
Department of Family and Preventive Medicine, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093 0607, USA
Eur J Endocrinol 156:555-62. 2007..We examined the sex-specific associations of serum OPG, RANKL, and their ratio with bone mineral density (BMD) in older adults... - Ghrelin, adiponectin, and leptin do not predict long-term changes in weight and body mass index in older adults: longitudinal analysis of the Rancho Bernardo cohortClaudia Langenberg
Department of Family and Preventive Medicine, School of Medicine, University of California, San Diego, La Jolla, CA 92093-0607, USA
Am J Epidemiol 162:1189-97. 2005..From this analysis of Rancho Bernardo Study data, the authors conclude that ghrelin, adiponectin, and leptin do not predict weight gain beyond reflecting the influence of attained body size on future changes in weight or body mass index... - Sleep EEG studies during early and late partial sleep deprivation in premenstrual dysphoric disorder and normal control subjectsB L Parry
Department of Psychiatry, University of California, San Diego, La Jolla 92093 0804, USA
Psychiatry Res 85:127-43. 1999..LSD did not correlate with clinical response. Further sleep studies addressing additional circadian variables may serve to elucidate mechanisms mediating the therapeutic effects of sleep deprivation in PMDD... - Effects of dehydroepiandrosterone supplementation on cognitive function and quality of life: the DHEA and Well-Ness (DAWN) TrialDonna Kritz-Silverstein
Department of Family and Preventive Medicine, School of Medicine, University of California at San Diego, La Jolla, California 92093 0631, USA
J Am Geriatr Soc 56:1292-8. 2008..To examine the effects of dehydroepiandrosterone (DHEA) supplementation on cognitive function and quality of life in healthy older adults... - Reproductive steroid hormones and recurrence-free survival in women with a history of breast cancerCheryl L Rock
Cancer Prevention and Control Program, Moores UCSD Cancer Center, University of California San Diego, 3855 Health Sciences Drive, La Jolla, CA 92093 0901, USA
Cancer Epidemiol Biomarkers Prev 17:614-20. 2008.... - Insulin-like growth factor-I and cancer mortality in older menJacqueline M Major
Department of Family and Preventive Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093 0631C, USA
J Clin Endocrinol Metab 95:1054-9. 2010..These results suggest caution in the use of IGF-I-enhancing therapies to slow the adverse effects of aging... - Lipoprotein-associated phospholipase A2 is an independent predictor of incident coronary heart disease in an apparently healthy older population: the Rancho Bernardo StudyLori B Daniels
Division of Cardiology, Department of Medicine, University of California at San Diego, San Diego, California, USA
J Am Coll Cardiol 51:913-9. 2008..We examined whether the independent association was apparent in older adults... - Medical comorbidities predict mortality in women with a history of early stage breast cancerRuth E Patterson
Cancer Prevention and Control Program, Moores UCSD Cancer Center, University of California, San Diego, La Jolla, CA 92093 0901, USA
Breast Cancer Res Treat 122:859-65. 2010..Given that 85% of deaths were caused by breast cancer, these findings suggest that multiple comorbidities may reduce the likelihood of surviving additional breast cancer events... - Endogenous and exogenous estrogen, cognitive function, and dementia in postmenopausal women: evidence from epidemiologic studies and clinical trialsElizabeth Barrett-Connor
Departments of Family and Preventive Medicine and Medicine, University of California, San Diego School of Medicine, La Jolla, California 92093 0607, USA
Semin Reprod Med 27:275-82. 2009..Overall, the evidence does not convincingly support the prescription of early or late postmenopausal estrogen therapy to preserve cognitive function or prevent dementia... - Association between the ankle-brachial index and future coronary calcium (the Rancho Bernardo study)Matthew A Allison
The Department of Family and Preventive Medicine, University of California at San Diego, La Jolla, California, USA
Am J Cardiol 97:181-6. 2006..Men whose ABI was below this same cutpoint had a similar but nonsignificant increase in risk (odds ratio 2.1, p = 0.1). In conclusion, ABI was significantly associated with the presence and extent of future CAC measured 7 years later... - Coronary artery calcium versus intima-media thickness as a measure of cardiovascular disease among asymptomatic adults (from the Rancho Bernardo Study)Elizabeth Barrett-Connor
Department of Family and Preventive Medicine, School of Medicine, University of California, San Diego, La Jolla, California, USA
Am J Cardiol 99:227-31. 2007..In conclusion, IMT of the carotid arteries predicted the severity of CAC burden an average of 3 years later in community-dwelling asymptomatic older adults... - Hormone therapy and coronary artery calcification in asymptomatic postmenopausal women: the Rancho Bernardo StudyElizabeth Barrett-Connor
Department of Family and Preventive Medicine, School of Medicine, Mail Code 0607, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
Menopause 12:40-8. 2005.... - Association between the ankle-brachial index and carotid intimal medial thickness in the Rancho Bernardo StudyMatthew A Allison
Department of Family and Preventive Medicine, University of California, San Diego, San Diego, California, USA
Am J Cardiol 98:1105-9. 2006..05 for all). In conclusion, an ABI of 1.10 to 1.26 was associated with the lowest levels of cardiovascular disease risk factors and carotid atherosclerosis, suggesting that a new cut point for ABI risk stratification should be considered... - Sex-specific association of the androgen to oestrogen ratio with adipocytokine levels in older adults: the Rancho Bernardo StudyGail A Laughlin
Department of Family and Preventive Medicine, School of Medicine, University of California, San Diego, La Jolla, CA 92093-0607, USA
Clin Endocrinol (Oxf) 65:506-13. 2006.... - The Dehydroepiandrosterone And WellNess (DAWN) study: research design and methodsDenise von Muhlen
University of California, San Diego, United States
Contemp Clin Trials 28:153-68. 2007..Potential mechanisms of DHEA action, including the biotransformation of DHEA to active steroids and steroid metabolites, enhancement of IGF-I bioavailability, and inhibition of IL-6 production can also be evaluated... - Minimally elevated cardiac troponin T and elevated N-terminal pro-B-type natriuretic peptide predict mortality in older adults: results from the Rancho Bernardo StudyLori B Daniels
Division of Cardiology, Department of Medicine, University of California at San Diego, San Diego, California, USA
J Am Coll Cardiol 52:450-9. 2008..This study investigated the prognostic value of detectable cardiac troponin T (TnT) and elevated N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels in a population of community-dwelling older adults... - Clinically defined type 2 diabetes mellitus and prognosis in early-stage breast cancerKirsten Erickson
Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093 0901, USA
J Clin Oncol 29:54-60. 2011..Self-reported diabetes has been associated with poor breast cancer outcomes. Research is needed to investigate the relationship between biologically determined glycemic control and breast cancer prognosis... - Association of circulating C-reactive protein and interleukin-6 with longevity into the 80s and 90s: The Rancho Bernardo StudyChristina L Wassel
Division of Preventive Medicine, Department of Family and Preventive Medicine, University of California, San Diego, San Diego, California 92093, USA
J Clin Endocrinol Metab 95:4748-55. 2010..Few studies have examined whether the inflammatory markers IL-6 and C-reactive protein (CRP) are associated with exceptional longevity... - Visceral adiposity and subclinical coronary artery disease in elderly adults: Rancho Bernardo StudyDong Jun Kim
Department of Family and Preventive Medicine, School of Medicine, University of California San Diego, La Jolla, California, USA
Obesity (Silver Spring) 16:853-8. 2008..We examined this association in elderly, community-dwelling adults without clinically recognized CHD... - Aging and the adrenal cortexS S Yen
University of California, San Diego, La Jolla, USA
Exp Gerontol 33:897-910. 1998..The cortisol/DHEA-S ratio during the life span follows a U-shape curve, which may be telling us to explore these two critical adrenal steroids in tandem... - High-density lipoprotein subclasses are a potential intermediary between alcohol intake and reduced risk of cardiovascular disease: the Rancho Bernardo StudyNatalie D Muth
Department of Family and Preventive Medicine, University of California, San Diego, La Jolla, CA, USA
Br J Nutr 104:1034-42. 2010..These results suggest that one way that alcohol may decrease CVD is through potentially favourable changes in lipoprotein subclass composition... - Associations of estradiol and testosterone with serum phosphorus in older men: the Osteoporotic Fractures in Men studyJerry Meng
Division of Nephrology, Department of Medicine, University of California San Diego, San Diego, California, USA
Kidney Int 78:415-22. 2010..The mechanism responsible for the association of testosterone with serum phosphorus remains to be determined... - Does osteoprotegerin or receptor activator of nuclear factor-kappaB ligand mediate the association between bone and coronary artery calcification?Ludmila N Bakhireva
Division of Pharmacy Practice, College of Pharmacy, and Department of Family and Preventive Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
J Clin Endocrinol Metab 93:2009-12. 2008..Accumulating evidence indicates that vascular and bone mineralization may be related, although the exact mechanism remains unknown... - Electron beam computed tomography screening and heart disease risk factor modificationJulie C Sandwell
Department of Family and Preventive Medicine, Division of Epidemiology, School of Medicine, University of California, San Diego, La Jolla, CA 92093-0607, USA
Prev Cardiol 9:133-7. 2006..009), and multivitamins (p = 0.018). The authors conclude that electron beam computed tomography screening motivates initiation of measures to prevent clinical heart disease without causing undue alarm among older men and women... - Ghrelin and the metabolic syndrome in older adultsClaudia Langenberg
Department of Family and Preventive Medicine, School of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093 0607, USA
J Clin Endocrinol Metab 90:6448-53. 2005..Ghrelin may be one of the pathophysiological mechanisms underlying risk factor clustering observed in the metabolic syndrome, but this has not been investigated... - Effect of dehydroepiandrosterone supplementation on bone mineral density, bone markers, and body composition in older adults: the DAWN trialD Von Muhlen
Department of Family and Preventive Medicine, University of California, San Diego, La Jolla, CA 92093 0631, USA
Osteoporos Int 19:699-707. 2008.... - Dietary pattern influences breast cancer prognosis in women without hot flashes: the women's healthy eating and living trialEllen B Gold
Department of Public Health Sciences, University of California, Davis, Davis, CA, USA
J Clin Oncol 27:352-9. 2009..To determine whether a low-fat diet high in vegetables, fruit, and fiber differentially affects prognosis in breast cancer survivors with hot flashes (HF) or without HF after treatment... - The association of endogenous sex steroids and sex steroid binding proteins with mammographic density: results from the Postmenopausal Estrogen/Progestin Interventions Mammographic Density StudyGail A Greendale
Division of Geriatrics, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA 90095 1687, USA
Am J Epidemiol 162:826-34. 2005..These results suggest that some sex steroids may increase the risk of breast cancer by stimulating breast epithelial or stromal proliferation, which appears on a mammogram as higher density... - A longitudinal study of dehydroepiandrosterone sulphate (DHEAS) change in older men and women: the Rancho Bernardo StudyCara Tannenbaum
, Department of Medicine, , Quebec, Canada H3W 1W5
Eur J Endocrinol 151:717-25. 2004..006, P=0.008). CONCLUSION: In this sample, over 30% of the observed changes in DHEAS could be attributed to regression to the mean. Potential underlying mechanisms of change in DHEAS levels, and sex differences, are discussed... - Serum prolactin levels are positively associated with mammographic density in postmenopausal womenGail A Greendale
Division of Geriatrics, David Geffen School of Medicine at UCLA, 10945 Le Conte Avenue, Suite 2339, Los Angeles, CA 90095 1687, USA
Breast Cancer Res Treat 105:337-46. 2007..Mammographic density is a strong, independent predictor of breast cancer and, therefore, a potential surrogate indicator of breast cancer risk...