Research Topics
| ARTHUR LANDERSummaryAffiliation: University of California Country: USA Publications
Research Grants
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Detail Information
Publications
Glypican-1 controls brain size through regulation of fibroblast growth factor signaling in early neurogenesisYi Huei Linda Jen
Department of Developmental and Cell Biology, Developmental Biology Center and Center for Complex Biological Systems, University of California, Irvine, CA 92697 2300, USA
Neural Dev 4:33. 2009..Here we investigate the developmental role played by one particular HSPG, glypican-1 (Gpc1), which is especially abundant on neuronal cell membranes, and is the major HSPG of the adult rodent brain...- The elusive functions of proteoglycans: in vivo veritasA D Lander
Department of Developmental Biology, University of California, Irvine, California 92697, USA
J Cell Biol 148:227-32. 2000 - The edges of understandingArthur D Lander
Center for Complex Biological Systems, Department of Developmental and Cell Biology, University of California, Irvine, CA 92697, USA
BMC Biol 8:40. 2010..In the present, post-modern, 'systems biology' era, however, it is, arguably, the hairball... - Spatially distributed morphogen production and morphogen gradient formationArthur D Lander
Department of Developmental and Cell Biology, University of California, Irvine, CA 92697 3875
Math Biosci Eng 2:239-62. 2005..System A will be analyzed in considerable detail in [6], and the limitation of System R as an approximation of System F will also be delineated there... - The measure of success: constraints, objectives, and tradeoffs in morphogen-mediated patterningArthur D Lander
Department of Developmental and Cell Biology, University of California, Irvine, California 92697 2300, USA
Cold Spring Harb Perspect Biol 1:a002022. 2009..This work also provides new insights into the longstanding question of why morphogen gradients show a maximum range in vivo... - The 'stem cell' concept: is it holding us back?Arthur D Lander
Center for Complex Biological Systems, Department of Developmental and Cell Biology, and Department of Biomedical Engineering, University of California at Irvine, Irvine, CA 92697 2300, USA
J Biol 8:70. 2009..Yet recent work adds to a growing body of literature suggesting that 'stemness' cannot be reduced to the molecular features of cell types, and is instead an emergent property of cell lineages under feedback control... - Cell lineages and the logic of proliferative controlArthur D Lander
Department of Developmental and Cell Biology, University of California, Irvine, Irvine, California, USA
PLoS Biol 7:e15. 2009.... - Morpheus unbound: reimagining the morphogen gradientArthur D Lander
Department of Developmental and Cell Biology, Developmental Biology Center and Center for Complex Biological Systems, University of California, Irvine, CA 92697, USA
Cell 128:245-56. 2007..On close inspection, every morphogen gradient seems to use a rich array of regulatory mechanisms, suggesting that the tasks carried out by such systems are far more extensive than previously thought... - Pattern, growth, and controlArthur D Lander
Department of Developmental and Cell Biology, Center for Complex Biological Systems, University of California, Irvine, Irvine, CA 92697 2300, USA
Cell 144:955-69. 2011..By illuminating such principles, systems biology is helping to create a functional framework within which to make sense of the mechanistic complexity of organismal development... - Do morphogen gradients arise by diffusion?Arthur D Lander
Department of Developmental and Cell Biology, Developmental Biology Center, University of California, Irvine 92697, USA
Dev Cell 2:785-96. 2002..Moreover, we show that a class of experiments, endocytic blockade, thought to effectively distinguish between diffusive and nondiffusive transport models actually fails to draw useful distinctions... - A calculus of purposeArthur D Lander
Department of Developmental and Cell Biology, University of California, Irvine, USA
PLoS Biol 2:e164. 2004 - Identifying gene regulatory networks in schizophreniaSteven G Potkin
Department of Psychiatry and Human Behavior, 5251 California Avenue, Suite 240, University of California, Irvine, CA 92617, USA
Neuroimage 53:839-47. 2010..The model demonstrates epistatic interactions between FGF and glypican on brain development and may be a useful model of negative symptom schizophrenia... - Formation of the BMP activity gradient in the Drosophila embryoClaudia Mieko Mizutani
Section of Cell and Developmental Biology, University of California, San Diego, La Jolla, California 92093, USA
Dev Cell 8:915-24. 2005.... - Follistatin modulates a BMP autoregulatory loop to control the size and patterning of sensory domains in the developing tongueCrestina L Beites
Department of Anatomy and Neurobiology and Center for Complex Biological Systems, University of California, Irvine, CA 92697, USA
Development 136:2187-97. 2009.... - GDF11 controls the timing of progenitor cell competence in developing retinaJoon Kim
Department of Anatomy and Neurobiology, University of California, Irvine, CA 92697, USA
Science 308:1927-30. 2005..Thus, GDF11 governs the temporal windows during which multipotent progenitors retain competence to produce distinct neural progeny... - Computational analysis of BMP gradients in dorsal-ventral patterning of the zebrafish embryoYong Tao Zhang
Department of Mathematics, University of California, Irvine, CA 92697, USA
J Theor Biol 248:579-89. 2007.... - Widespread defects in the primary olfactory pathway caused by loss of Mash1 functionRichard C Murray
Department of Anatomy and Neurobiology, Developmental Biology Center, University of California, Irvine, Irvine, California 92697 2300, USA
J Neurosci 23:1769-80. 2003.... - Foxg1 promotes olfactory neurogenesis by antagonizing Gdf11Shimako Kawauchi
Department of Anatomy and Neurobiology, University of California, Irvine, CA 92697, USA
Development 136:1453-64. 2009..Thus, the pro-neurogenic effects of Foxg1 are likely to be mediated through different signaling pathways in different parts of the nervous system... - Feedback regulation in multistage cell lineagesWing Cheong Lo
Departments of Mathematics, University of California, Irvine, CA, United States
Math Biosci Eng 6:59-82. 2009..Our results suggest that two factors -- autoregulation of the proliferation of transit amplifying (TA) progenitor cells, and a low death rate of TD cells -- enhance the stability of this system... - Complex regulation of cyp26a1 creates a robust retinoic acid gradient in the zebrafish embryoRichard J White
Department of Developmental and Cell Biology, University of California Irvine, Irvine, California, United States of America
PLoS Biol 5:e304. 2007..Such control also provides an explanation for the fact that loss of an endogenous RA gradient can be compensated for by RA that is provided in a spatially uniform manner... - Multiple organ system defects and transcriptional dysregulation in the Nipbl(+/-) mouse, a model of Cornelia de Lange SyndromeShimako Kawauchi
Department of Anatomy and Neurobiology, University of California Irvine, Irvine, California, United States of America
PLoS Genet 5:e1000650. 2009..In addition, evidence is presented that reduced expression of genes involved in adipogenic differentiation may underlie the low amounts of body fat observed both in Nipbl+/- mice and in individuals with CdLS... - Cornelia de Lange syndrome is caused by mutations in NIPBL, the human homolog of Drosophila melanogaster Nipped-BIan D Krantz
Division of Human Genetics and Molecular Biology, The Children s Hospital of Philadelphia and the University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Nat Genet 36:631-5. 2004..The fly homolog of NIPBL, Nipped-B, facilitates enhancer-promoter communication and regulates Notch signaling and other developmental pathways in Drosophila melanogaster... - Growth factor-induced shedding of syndecan-1 confers glypican-1 dependence on mitogenic responses of cancer cellsKan Ding
Department of Developmental and Cell Biology, University of California, Irvine, Irvine, CA 92697
J Cell Biol 171:729-38. 2005..These results support a specific role for shed syndecan-1 or MMP7-syndecan-1 complexes in tumor progression and add to accumulating evidence that syndecans and glypicans have nonequivalent functions in vivo...
Research Grants
- Systems Biology of Morphogenesis and Spatial Information FlowARTHUR LANDER; Fiscal Year: 2007..Such insights will have a broad impact on a variety of health-related areas including human development and birth defects, stem cells and regeneration, normal and tumor cell growth, and basic physiology. ..
- TRAINING PROGRAM IN CELLULAR AND MOLECULAR NEUROSCIENCEARTHUR LANDER; Fiscal Year: 2007..Following completion of this program, trainees will be qualified for careers in Neuroscience research and/or teaching in basic science departments and medical schools, or for research careers in non-academic research laboratories. ..
- Transport and Complexity in Biological SystemsARTHUR LANDER; Fiscal Year: 2004..abstract_text> ..
- PROTEOGLYCANS AND BRAIN DEVELOPMENTARTHUR LANDER; Fiscal Year: 2004..These studies should provide insights into how an important and poorly understood class of molecules regulates basic developmental processes, particularly in the nervous system. ..
- GORDON RESEARCH CONFERENCE ON PROTEOGLYCANSARTHUR LANDER; Fiscal Year: 2002....