Research Topics
Species | S KyrkanidesSummaryAffiliation: University of Rochester Country: USA Publications
Research Grants
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Detail Information
Publications
Amelioration of pain and histopathologic joint abnormalities in the Col1-IL-1beta(XAT) mouse model of arthritis by intraarticular induction of mu-opioid receptor into the temporomandibular jointStephanos Kyrkanides
University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
Arthritis Rheum 56:2038-48. 2007..To evaluate opioid receptor function as a basis for novel antinociceptive therapy in arthritis...- Systemic FIV vector administration: transduction of CNS immune cells and Purkinje neuronsStephanos Kyrkanides
Department of Dentistry, School of Medicine and Dentistry, University of Rochester, Rochester, NY, USA
Brain Res Mol Brain Res 119:1-9. 2003..Our observations indicate that relatively low doses of FIV(lacZ) administered intraperitoneally resulted in the transduction of immune cells in the brain, as well as a specific subset of cerebellar neurons... - Transcriptional and posttranslational regulation of Cre recombinase by RU486 as the basis for an enhanced inducible expression systemStephanos Kyrkanides
Department of Dentistry, Rochester, New York 14620, USA
Mol Ther 8:790-5. 2003.... - Intraperitoneal inoculation of Sandhoff mouse neonates with an HIV-1 based lentiviral vector exacerbates the attendant neuroinflammation and disease phenotypeStephanos Kyrkanides
Eastman Dental Center, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, United States
J Neuroimmunol 188:39-47. 2007..We observed an increase and acceleration in the presence of MHC-II and CD45+ cells in their brains, along with neuroinflammation, but not in control heterozygous or wild type littermates that also received the same treatment... - Non-primate lentiviral vector administration in the TMJS Kyrkanides
Eastman Department of Dentistry, University of Rochester, 625 Elmwood Ave, Rochester, NY 14620, USA
J Dent Res 83:65-70. 2004..These findings suggest that lentiviral vectors can potentially serve as a platform for the transfer of anti-nociceptive genes for the management of temporomandibular joint pain... - beta-hexosaminidase lentiviral vectors: transfer into the CNS via systemic administrationStephanos Kyrkanides
Department of Dentistry, School of Medicine and Dentistry, University of Rochester Medical Center, Rochester NY 14642, United States
Brain Res Mol Brain Res 133:286-98. 2005..In conclusion, these results demonstrate the effective transfer of a beta-hexosaminidase lentiviral vector to the brain of Sandhoff mice and resolution of the GM2 gangliosidosis after neonatal intraperitoneal administration... - Temporomandibular joint nociception: effects of capsaicin on substance P-like immunoreactivity in the rabbit brain stemStephanos Kyrkanides
Craniofacial Research Core, University of Rochester Eastman Dental Center, 625 Elmwood Ave, Rochester, NY 14620, USA
J Orofac Pain 16:229-36. 2002.... - The cranial base in craniofacial development: a gene therapy studyS Kyrkanides
Departments of Dentistry, School of Medicine and Dentistry, University of Rochester Medical Center, 625 Elmwood Ave, Rochester NY 14620, USA
J Dent Res 86:956-61. 2007.... - Mandibular asymmetry and antigonial notching in individuals with unilateral cleft lip and palateStephanos Kyrkanides
Eastman Department of Dentistry, University of Rochester School of Medicine and Dentistry, Eastman Dental Center, Rochester, New York 14620, USA
Cleft Palate Craniofac J 39:30-5. 2002..To determine whether asymmetric antigonial notching is associated with the development of mandibular and lower facial asymmetry in individuals with unilateral cleft lip and palate (UCLP)... - Peripheral blood mononuclear cell infiltration and neuroinflammation in the HexB-/- mouse model of neurodegenerationStephanos Kyrkanides
Department of Neurobiology and Anatomy, School of Medicine and Dentistry, University of Rochester Rochester NY 14642, USA
J Neuroimmunol 203:50-7. 2008..There was no change in the level of GM2 storage and pro-apoptotic activity or astrocyte activation in HexB-/-; Ccr2-/- double knockout mice, which eventually succumbed secondary to GM2 gangliosidosis... - Cranial base and facial skeleton asymmetries in individuals with unilateral cleft lip and palateS Kyrkanides
Division of Orthodontics, University of Rochester Eastman Dental Center, New York, USA
Cleft Palate Craniofac J 37:556-61. 2000..The purpose of this study was to retrospectively investigate the development of cranial base asymmetries in patients with UCLP noted on posteroanterior cephalometric radiographs... - Comparison of skeletal and dental morphology in asymptomatic volunteers and symptomatic patients with bilateral degenerative joint diseaseIoanna K Gidarakou
Department of Dentistry, Division of Orthodontics, University of Rochester School of Medicine and Dentistry, NY 14620, USA
Angle Orthod 73:71-8. 2003..This study suggests that subjects with BDJD may manifest altered craniofacial morphology. Clinicians should be aware of this possibility, especially for patients who are growing children and orthognathic surgery candidates... - Association of nasomaxillary asymmetry in children with unilateral cleft lip and palate and their parentsYoung-Jooh Yoon
Eastman Department of Dentistry, School of Medicine and Dentistry, University of Rochester, Rochester, New York 14620, USA
Cleft Palate Craniofac J 40:493-7. 2003..Better understanding of the role of craniofacial form in cleft development will ultimately allow for the assessment of risk for cleft lip and palate... - Validity of panoramic radiographs for measuring mandibular asymmetryPanagiotis Kambylafkas
Department of Dentistry, Division of Orthodontics, University of Rochester School of Medicine and Dentistry, 625 Elmwood Avenue, Rochester, NY 14620, USA
Angle Orthod 76:388-93. 2006..62 and the specificity 1.0. This study suggests that the panoramic radiograph can be used to evaluate vertical posterior mandibular asymmetry, but there will be some underdiagnosis... - Comparison of skeletal and dental morphology in asymptomatic volunteers and symptomatic patients with bilateral disk displacement without reductionIoanna K Gidarakou
Department of Dentistry, Division of Orthodontics, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
Angle Orthod 74:684-90. 2004..This study suggests that subjects with BDDN may manifest altered craniofacial morphology. The clinician should be aware of that possibility, especially for the growing patients and the surgical candidates... - Comparison of skeletal and dental morphology in asymptomatic volunteers and symptomatic patients with bilateral disk displacement with reductionIoanna K Gidarakou
Department of Dentistry, Division of Orthodontics, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
Angle Orthod 72:541-6. 2002..This study suggests that subjects with BDDR may manifest altered craniofacial morphology. The clinician should be aware of this possibility especially for the growing patients and the orthognathic surgery candidates... - Nonsteroidal anti-inflammatory drugs in orthodontic tooth movement: metalloproteinase activity and collagen synthesis by endothelial cellsS Kyrkanides
Eastman Department of Dentistry, University of Rochester School of Medicine and Dentistry, Rochester, NY 14620, USA
Am J Orthod Dentofacial Orthop 118:203-9. 2000..Further studies are needed to establish novel pain relievers that do not interfere with orthodontic processes... - Mandibular asymmetry in adult patients with unilateral degenerative joint diseasePanagiotis Kambylafkas
Department of Dentistry, Division of Orthodontics, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
Angle Orthod 75:305-10. 2005..The results suggest that subjects with UDJD may manifest lower face asymmetry. This can be of clinical value when adult patients exhibiting asymmetry are to be treated... - Sequential down-regulation of E-cadherin with squamous cell carcinoma progression: loss of E-cadherin via a prostaglandin E2-EP2 dependent posttranslational mechanismSabine Brouxhon
Department of Emergency Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
Cancer Res 67:7654-64. 2007..Further understanding of how UV-PGE2-EP2 down-regulates E-cadherin may lead to novel chemopreventative strategies for the treatment of skin and other epithelial cancers... - Retrospective revelations: twenty orthodontically treated individuals with unilateral cleft lip and palateJ D Subtelny
Department of Orthodontics, Eastman Dental Center, University of Rochester School of Medicine and Dentistry, Rochester, New York 14620, USA
World J Orthod 5:152-63. 2004.... - The effect of esthetic consultation methods on acceptance of diastema-closure treatment plan: a pilot studyDov Almog
University of Rochester Eastman Dental Center, NY 14620, USA
J Am Dent Assoc 135:875-81; quiz 1035-6, 1038. 2004..The authors conducted a study to determine which of four consultation methods helped patients best understand a proposed treatment plan for maxillary anterior diastema closure... - Abnormal PGE(2) regulation of monocyte TNF-alpha levels in trauma patients parallels development of a more macrophage-like phenotypeKrzysztof Laudanski
Immunobiology and Stress Response Laboratories, Department of Surgery, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
Shock 22:204-12. 2004..Increased PGE2 levels still decreased patients' MO APC functions but failed to depress either MO TLR4 expression or mTNF-alpha levels, suggesting differential involvement of EP receptors in postinjury PGE2-mediated effects... - Cyclooxygenase-2 modulates brain inflammation-related gene expression in central nervous system radiation injuryStephanos Kyrkanides
Department of Neurobiology and Anatomy, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
Brain Res Mol Brain Res 104:159-69. 2002..These results indicate that COX-2 modulates the inflammatory response in brain following radiation injury, and suggest the use of COX-2 selective inhibitors for the management of CNS inflammation... - Comparison of skeletal and dental morphology in asymptomatic volunteers and symptomatic patients with normal temporomandibular jointsIoanna K Gidarakou
Department of Dentistry, University of Rochester School of Medicine and Dentistry, NY 14620, USA
Angle Orthod 73:116-20. 2003..This study showed that there are no alterations in skeletal morphology in SN individuals compared with AV... - Comparison of skeletal and dental morphology in asymptomatic volunteers and symptomatic patients with unilateral disk displacement without reductionIoanna K Gidarakou
Department of Dentistry, University of Rochester School of Medicine and Dentistry, NY 14620, USA
Angle Orthod 73:121-7. 2003..Presence of asymmetry and altered craniofacial morphology should alert the clinician especially while orthodontically treating children and surgical patients... - Association of distinct craniofacial features in nonsyndromic cleft lip and palate family membersMarja R Perkiomaki
University of Rochester School of Medicine and Dentistry, Rochester, New York 14620, USA
Cleft Palate Craniofac J 40:397-402. 2003..Mothers contribute more to their affected daughters' and fathers to their affected sons' distinct craniofacial morphology... - Transverse craniofacial features and their genetic predisposition in families with nonsyndromic unilateral cleft lip and palateYoung-Jooh Yoon
Eastman Department of Dentistry, School of Medicine and Dentistry, University of Rochester, Rochester, New York 14620, USA
Cleft Palate Craniofac J 41:256-61. 2004..CONCLUSION: Better understanding of the genetic inheritance of craniofacial features associated with cleft lip and palate may ultimately contribute to the development of cleft risk assessment methods... - Comparison of skeletal and dental morphology in asymptomatic volunteers and symptomatic patients with unilateral disk displacement with reductionIoanna K Gidarakou
Department of Dentistry, Division of Orthodontics, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
Angle Orthod 74:212-9. 2004..This study suggests that subjects with UDDR may manifest altered craniofacial morphology. The clinician should be aware of this possibility, especially for growing patients... - Spinal interleukin-1beta in a mouse model of arthritis and joint painPaolo M Fiorentino
University of Rochester School of Medicine and Dentistry, Rochester, New York 14620, USA
Arthritis Rheum 58:3100-9. 2008..This study was undertaken to determine whether the role of spinal interleukin-1beta (IL-1beta) in central processing of pain is important in the development of arthritis... - Chronic interleukin-1beta expression in mouse brain leads to leukocyte infiltration and neutrophil-independent blood brain barrier permeability without overt neurodegenerationSolomon S Shaftel
Department of Neurobiology and Anatomy, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
J Neurosci 27:9301-9. 2007..Knock-out of their sole receptor CXCR2 abrogated neutrophil infiltration but failed to reduce leakage of the blood-brain barrier... - Intraarticular induction of interleukin-1beta expression in the adult mouse, with resultant temporomandibular joint pathologic changes, dysfunction, and painYu Ching Lai
University of Rochester School of Medicine and Dentistry, Rochester, New York
Arthritis Rheum 54:1184-97. 2006..To examine the effects of intraarticular induction of interleukin-1beta (IL-1beta) expression in adult mice... - Sustained hippocampal IL-1 beta overexpression mediates chronic neuroinflammation and ameliorates Alzheimer plaque pathologySolomon S Shaftel
Department of Neurobiology and Anatomy, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
J Clin Invest 117:1595-604. 2007..These results demonstrate a possible adaptive role for IL-1 beta-driven neuroinflammation in AD and may help explain recent failures of antiinflammatory therapeutics for this disease... - Enhanced glial activation and expression of specific CNS inflammation-related molecules in aged versus young rats following cortical stab injuryS Kyrkanides
Department of Neurobiology and Anatomy, University of Rochester, 601 Elmwood Avenue, Box 603, Rochester, NY 14642, USA
J Neuroimmunol 119:269-77. 2001..Recognition of these age-specific differences may guide development of novel treatment regimes for older individuals... - Prevalence of missing posterior teeth and intraarticular temporomandibular disordersRoss H Tallents
Department of Dentistry, Division of Orthodonics and Prosthodonics, Eastman Dental Center, University of Rochester, Rochester, NY, USA
J Prosthet Dent 87:45-50. 2002..The association between missing mandibular posterior teeth and the development of intraarticular temporomandibular disorders (TMDs) remains unclear... - Cyclooxygenase-1 mediates prostaglandin E(2) elevation and contextual memory impairment in a model of sustained hippocampal interleukin-1beta expressionSarah B Matousek
Department of Neurobiology and Anatomy, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
J Neurochem 114:247-58. 2010..This data suggests a unique role for COX-1 in mediating chronic neuroinflammatory effects through PGE(2) production... - Selective inhibition of cyclooxygenase-2 attenuates expression of inflammation-related genes in CNS injuryStephanos Kyrkanides
Department of Neurology, Department of Neurobiology and Anatomy, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642 USA
Adv Exp Med Biol 507:155-60. 2002 - Comparison of Doppler sonography to magnetic resonance imaging and clinical examination for disc displacementPunkage Puri
Eastman Dental Center, Rochester, NY 14620, USA
Angle Orthod 76:824-9. 2006..Unfortunately, the specificity was low, producing many false-positive examinations... - The relationship of distinct craniofacial features between Turner syndrome females and their parentsMarja R Perkiomaki
Department of Oral Development and Orthodontics, Institute of Dentistry, University of Oulu, Finland
Eur J Orthod 27:48-52. 2005..01) measurement. The results suggest that maternal influences contribute to the growth of a distinct cranial base and to the magnitude of mandibular retrognathism of subjects with TS...
Research Grants
- NEURONAL FUNCTION IN CRANIOFACIAL DEVELOPMENTStephanos Kyrkanides; Fiscal Year: 2004..abstract_text> ..
- Gene therapy for treatment of craniofacial dysplasiaStephanos Kyrkanides; Fiscal Year: 2004..Completion of this study will aid in the development of novel therapies for the management of genetic disorders. ..
- Joint degeneration: Somatic mosaic analysis in a transgenic mouseStephanos Kyrkanides; Fiscal Year: 2007....
- Does peripheral localized chronic inflammation predispose to neurodegeneration?Stephanos Kyrkanides; Fiscal Year: 2007..Such information is critical to our understanding of the benefits of anti-inflammatory therapy in AD and other conditions and will guide the rational application and development of targeted interventions. ..
- Recombinant FIV vectors for the delivery of siRNA therapy to jointsStephanos Kyrkanides; Fiscal Year: 2007..Emphasis will be given in evaluating COX-2 and/or mPGES-1 expression as they are targets of our FIV(siRNA) therapy over time as well as assessing potential inflammatory responses elicited by this siRNA therapy. ..