Pawan Kumar

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. ncbi Arsenic trioxide enhances the therapeutic efficacy of radiation treatment of oral squamous carcinoma while protecting bone
    Pawan Kumar
    Department of Biologic and Materials Sciences, University of Michigan School of Dentistry, 1011 North University Avenue, Room no 5205, Ann Arbor, MI 48109, USA
    Mol Cancer Ther 7:2060-9. 2008
  2. ncbi Endothelial cells expressing Bcl-2 promotes tumor metastasis by enhancing tumor angiogenesis, blood vessel leakiness and tumor invasion
    Pawan Kumar
    Department of Biologic and Materials Sciences, University of Michigan School of Dentistry, Ann Arbor, MI 48109, USA
    Lab Invest 88:740-9. 2008
  3. ncbi Bcl-2 protects endothelial cells against gamma-radiation via a Raf-MEK-ERK-survivin signaling pathway that is independent of cytochrome c release
    Pawan Kumar
    Department of Biologic and Materials Sciences, University of Michigan School of Dentistry, 1011 North University Avenue, Ann Arbor, MI 48109, USA
    Cancer Res 67:1193-202. 2007
  4. ncbi Combination treatment significantly enhances the efficacy of antitumor therapy by preferentially targeting angiogenesis
    Pawan Kumar
    Department of Biological and Material Sciences, University of Michigan School of Dentistry, Ann Arbor, MI 48109, USA
    Lab Invest 85:756-67. 2005
  5. ncbi Rap1GAP inhibits tumor growth in oropharyngeal squamous cell carcinoma
    Zhaocheng Zhang
    Department of Oral Medicine, Pathology, and Oncology, University of Michigan, School of Dentistry, Ann Arbor, MI 48109 1078, USA
    Am J Pathol 168:585-96. 2006
  6. ncbi p38 MAPK mediates gamma-irradiation-induced endothelial cell apoptosis, and vascular endothelial growth factor protects endothelial cells through the phosphoinositide 3-kinase-Akt-Bcl-2 pathway
    Pawan Kumar
    Department of Oral Medicine, Pathology, and Oncology, University of Michigan School of Dentistry, Ann Arbor, Michigan 48109, USA
    J Biol Chem 279:43352-60. 2004
  7. ncbi Signal transduction pathways involved in rheumatoid arthritis synovial fibroblast interleukin-18-induced vascular cell adhesion molecule-1 expression
    Jacques C M Morel
    Department of Medicine, Northwestern University Medical School, Chicago, Illinois 60611, USA
    J Biol Chem 277:34679-91. 2002
  8. ncbi A scaleable manufacturing process for pro-EP-B2, a cysteine protease from barley indicated for celiac sprue
    Harmit Vora
    Department of Chemical Engineering, Stanford University, Stanford, California 94305, USA
    Biotechnol Bioeng 98:177-85. 2007
  9. ncbi Src and phosphatidylinositol 3-kinase mediate soluble E-selectin-induced angiogenesis
    Pawan Kumar
    Veterans Administration, Lakeside Division, Chicago Health Care System, Chicago, IL, USA
    Blood 101:3960-8. 2003
  10. ncbi Migration inhibitory factor mediates angiogenesis via mitogen-activated protein kinase and phosphatidylinositol kinase
    M Asif Amin
    Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Ill, USA
    Circ Res 93:321-9. 2003

Collaborators

Detail Information

Publications14

  1. ncbi Arsenic trioxide enhances the therapeutic efficacy of radiation treatment of oral squamous carcinoma while protecting bone
    Pawan Kumar
    Department of Biologic and Materials Sciences, University of Michigan School of Dentistry, 1011 North University Avenue, Room no 5205, Ann Arbor, MI 48109, USA
    Mol Cancer Ther 7:2060-9. 2008
    ..These results suggest a novel strategy to enhance the therapeutic efficacy of radiation treatment while protecting bone from the adverse effects of therapeutic radiation...
  2. ncbi Endothelial cells expressing Bcl-2 promotes tumor metastasis by enhancing tumor angiogenesis, blood vessel leakiness and tumor invasion
    Pawan Kumar
    Department of Biologic and Materials Sciences, University of Michigan School of Dentistry, Ann Arbor, MI 48109, USA
    Lab Invest 88:740-9. 2008
    ..These results suggest that Bcl-2, when expressed at higher levels in tumor-associated ECs, may promote tumor metastasis by enhancing tumor angiogenesis, blood vessel leakiness and tumor cell invasiveness...
  3. ncbi Bcl-2 protects endothelial cells against gamma-radiation via a Raf-MEK-ERK-survivin signaling pathway that is independent of cytochrome c release
    Pawan Kumar
    Department of Biologic and Materials Sciences, University of Michigan School of Dentistry, 1011 North University Avenue, Ann Arbor, MI 48109, USA
    Cancer Res 67:1193-202. 2007
    ....
  4. ncbi Combination treatment significantly enhances the efficacy of antitumor therapy by preferentially targeting angiogenesis
    Pawan Kumar
    Department of Biological and Material Sciences, University of Michigan School of Dentistry, Ann Arbor, MI 48109, USA
    Lab Invest 85:756-67. 2005
    ....
  5. ncbi Rap1GAP inhibits tumor growth in oropharyngeal squamous cell carcinoma
    Zhaocheng Zhang
    Department of Oral Medicine, Pathology, and Oncology, University of Michigan, School of Dentistry, Ann Arbor, MI 48109 1078, USA
    Am J Pathol 168:585-96. 2006
    ..Furthermore, SCC cells transfected with rap1GAP produced significantly smaller tumors in nude mice as compared to controls (P < 0.01). These novel findings suggest that rap1GAP acts as a tumor suppressor protein in SCC...
  6. ncbi p38 MAPK mediates gamma-irradiation-induced endothelial cell apoptosis, and vascular endothelial growth factor protects endothelial cells through the phosphoinositide 3-kinase-Akt-Bcl-2 pathway
    Pawan Kumar
    Department of Oral Medicine, Pathology, and Oncology, University of Michigan School of Dentistry, Ann Arbor, Michigan 48109, USA
    J Biol Chem 279:43352-60. 2004
    ....
  7. ncbi Signal transduction pathways involved in rheumatoid arthritis synovial fibroblast interleukin-18-induced vascular cell adhesion molecule-1 expression
    Jacques C M Morel
    Department of Medicine, Northwestern University Medical School, Chicago, Illinois 60611, USA
    J Biol Chem 277:34679-91. 2002
    ..Targeting VCAM-1 signaling mechanisms may represent therapeutic approaches to inflammatory and angiogenic diseases characterized by adhesion molecule up-regulation...
  8. ncbi A scaleable manufacturing process for pro-EP-B2, a cysteine protease from barley indicated for celiac sprue
    Harmit Vora
    Department of Chemical Engineering, Stanford University, Stanford, California 94305, USA
    Biotechnol Bioeng 98:177-85. 2007
    ..15 h(-1). A lyophilization procedure was developed that yielded protein with 85% recoverable activity after 7 weeks of storage at room temperature. The process was successfully scaled up to 100 L with comparable purity and recovery...
  9. ncbi Src and phosphatidylinositol 3-kinase mediate soluble E-selectin-induced angiogenesis
    Pawan Kumar
    Veterans Administration, Lakeside Division, Chicago Health Care System, Chicago, IL, USA
    Blood 101:3960-8. 2003
    ..Taken together, our data clearly show that sE-selectin-induced angiogenesis is predominantly mediated through the Src-PI3K pathway...
  10. ncbi Migration inhibitory factor mediates angiogenesis via mitogen-activated protein kinase and phosphatidylinositol kinase
    M Asif Amin
    Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Ill, USA
    Circ Res 93:321-9. 2003
    ..Our findings support a role for MIF as an angiogenic factor and provide a rationale for the use of MIF as a therapeutic inducer of neovascularization in the development of collateral circulation in coronary artery disease...
  11. ncbi Epstein-Barr virus lytic infection is required for efficient production of the angiogenesis factor vascular endothelial growth factor in lymphoblastoid cell lines
    Gregory K Hong
    Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, Chapel Hill, NC 27599, USA
    J Virol 79:13984-92. 2005
    ..In addition, as VEGF is a pleiotropic factor with effects other than angiogenesis, lytically induced VEGF secretion may potentially contribute to viral pathogenesis...
  12. ncbi Role of macrophage inflammatory protein-3alpha and its ligand CCR6 in rheumatoid arthritis
    Jeffrey H Ruth
    Department of Medicine, Northwestern University Medical School, Chicago, Illinois 60611, USA
    Lab Invest 83:579-88. 2003
    ..These results further indicate that expression of CCR6, the receptor for MIP-3alpha, can be correlated with RA development...
  13. ncbi Radiation processed amniotic membranes in the treatment of non-healing ulcers of different etiologies
    Rita Singh
    Defence Laboratory, Jodhpur, India
    Cell Tissue Bank 5:129-34. 2004
    ..Ulcers with duration of minimum 3 weeks to maximum 12 months were found to heal in 2-6 weeks by the application of amniotic membranes...
  14. ncbi Interleukin-13 gene therapy reduces inflammation, vascularization, and bony destruction in rat adjuvant-induced arthritis
    James M Woods
    Department of Medicine, Northwestern University Medical School, Chicago, IL 60611, USA
    Hum Gene Ther 13:381-93. 2002
    ..Thus, increasing IL-13 levels significantly ameliorates the course of rat AIA, suggesting that similar strategies for the treatment of human RA are worthy of further study...