Research Topics
Genomes and Genes | HELMUT KRAMERSummaryAffiliation: University of Texas Southwestern Medical Center Country: USA Publications
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Publications
The Golgi-associated hook3 protein is a member of a novel family of microtubule-binding proteinsJ H Walenta
Center for Basic Neuroscience and Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
J Cell Biol 152:923-34. 2001..Because overexpression of Hook3 caused fragmentation of the Golgi complex, we propose that Hook3 participates in defining the architecture and localization of the mammalian Golgi complex...- Mutations in the Drosophila hook gene inhibit endocytosis of the boss transmembrane ligand into multivesicular bodiesH Kramer
Department of Cell Biology and Neuroscience, University of Texas Southwestern Medical Center, Dallas 75235 9111, USA
J Cell Biol 133:1205-15. 1996.... - Genetic analysis of hook, a gene required for endocytic trafficking in drosophilaH Kramer
Center for Basic Neuroscience, Department of Cell Biology and Neuroscience, University of Texas Southwestern Medical Center, Dallas, Texas 75235 9111, USA
Genetics 151:675-84. 1999..The importance of all three domains for Hook function was confirmed by their conservation between two Drosophila and two human Hook proteins... - RIPping notch apart: a new role for endocytosis in signal transduction?H Kramer
Center for Basic Neuroscience and Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75235 9111, USA
Sci STKE 2000:pe1. 2000..This trans-endocytosis event contributes to the cleavage and release of the active Notch intracellular domain. The Perspective is accompanied by a movie illustrating the trans-endocytosis of Notch... - Sorting out signals in fly endosomesHELMUT KRAMER
Center for Basic Neuroscience, UT Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9111, USA
Traffic 3:87-91. 2002..This review discusses some intriguing links between these findings, the sorting of proteins in endocytic trafficking, and the regulation of signaling pathways in Drosophila... - The SM protein Car/Vps33A regulates SNARE-mediated trafficking to lysosomes and lysosome-related organellesMohammed A Akbar
Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390 9111, USA
Mol Biol Cell 20:1705-14. 2009..Consistent with a role in Car-mediated fusion, dSyntaxin16 is not restricted to Golgi membranes but also present on lysosomes... - Drosophila Vps16A is required for trafficking to lysosomes and biogenesis of pigment granulesSuprabha Pulipparacharuvil
Center for Basic Neuroscience, UT Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9111, USA
J Cell Sci 118:3663-73. 2005..Ubiquitous knockdown of dVps16A was lethal. Together, these findings demonstrate that Drosophila Vps16A is essential for lysosomal trafficking. Furthermore, metazoans have two types of Vps-C complexes with non-redundant functions... - Drosophila acinus encodes a novel regulator of endocytic and autophagic traffickingAdam S Haberman
Department of Neuroscience, UT Southwestern Medical Center, Dallas, TX 75390 9111, USA
Development 137:2157-66. 2010..Taken together, our data show that dacn encodes a regulator of endosomal and autophagosomal dynamics, modulating developmental signaling and the cellular response to starvation... - Hook2 contributes to aggresome formationGyörgyi Szebenyi
Center for Basic Neuroscience, University of Texas, Southwestern Medical Center, Dallas, Texas 75390 9111, USA
BMC Cell Biol 8:19. 2007..Hook proteins have been proposed to serve as adaptors for the association of cargos with dynein for transport on microtubules. Hook2 was shown to localize to the centrosome, bind centriolin, and contribute to centrosomal function... - The full-of-bacteria gene is required for phagosome maturation during immune defense in DrosophilaMohammed Ali Akbar
Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
J Cell Biol 192:383-90. 2011..These findings suggest that defects in phagosome maturation may contribute to symptoms of ARC patients including recurring infections... - A mutation in dVps28 reveals a link between a subunit of the endosomal sorting complex required for transport-I complex and the actin cytoskeleton in DrosophilaEvgueni A Sevrioukov
Center for Basic Neuroscience and Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9111, USA
Mol Biol Cell 16:2301-12. 2005.... - Acinus: a nuclear regulator of autophagy and endocytic traffickingHELMUT KRAMER
Department of Neuroscience, UT Southwestern Medical Center, Dallas, TX, USA
Autophagy 6:974-5. 2010..The increase in autophagy upon Acinus overexpression and its location to the nucleus are consistent with Acinus being a novel regulator of autophagy... - Hook2 localizes to the centrosome, binds directly to centriolin/CEP110 and contributes to centrosomal functionGyörgyi Szebenyi
Center for Basic Neuroscience, University of Texas, Southwestern Medical Center, 6000 Harry Hines Blvd, Dallas, TX 75390 9111, USA
Traffic 8:32-46. 2007..Thus, we propose that hook2 contributes to the establishment and maintenance of centrosomal structure and function... - Dynamin-independent synaptic vesicle retrieval?HELMUT KRAMER
Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390 9111, USA
Nat Neurosci 11:6-8. 2008..A new study proposes that synaptic vesicle endocytosis at a large synaptic terminal is partly independent of dynamin and GTP hydrolysis, suggesting a new mechanism leading to vesicle fission and maintenance of neurotransmission...