Research Topics
| Douglas S KondziolkaSummaryAffiliation: University of Pittsburgh Country: USA Publications
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Detail Information
Publications
The effect of radiosurgery during management of aggressive meningiomasAnthony E Harris
Department of Neurosurgery, The Center for Image-Guided Neurosurgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
Surg Neurol 60:298-305; discussion 305. 2003..Aggressive use of early boost radiosurgery following craniotomy and radiation therapy is recommended for patients with malignant meningiomas...- The application of stereotactic radiosurgery to disorders of the brainDouglas Kondziolka
Department of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213 2582, USA
Neurosurgery 62:707-19; discussion 719-20. 2008..The combination of high-resolution imaging, high-speed computer workstations, robotics, patient fixation techniques, and radiobiological research has put radiosurgery into the practice of almost all neurosurgeons... - Citation measures in stereotactic radiosurgery: publication across a disciplineDouglas Kondziolka
Department of Neurological Surgery, University of Pittsburgh, Center for Image Guided Neurosurgery, Pittsburgh, PA 15213, USA
Stereotact Funct Neurosurg 89:56-61. 2011..We identified the most cited works in the field of stereotactic radiosurgery to study the evolution of this field from the perspective of publication... - Radiobiology of radiosurgeryDouglas Kondziolka
Department of Neurological Surgery, University of Pittsburgh, UPMC Presbyterian 1, Pennsylvania 15213 2582, USA
Prog Neurol Surg 20:16-27. 2007..Effects are dose, volume, time, and tumor histology dependent. In this report, we discuss data from resected specimens after radiosurgery, and work to develop a classification method for radiosurgery effects... - Radiosurgery and radiotherapy: observations and clarificationsDouglas Kondziolka
Departments of Neurological Surgery and Radiation Oncology, University of Pittsburgh, Pennsylvania 15213, USA
J Neurosurg 101:585-9. 2004..Radiosurgery and radiation therapy represent important but unique treatment paradigms for patients with certain neoplasms, vascular lesions, or functional disorders. The authors discuss their differences... - The principles of skull base radiosurgeryDouglas Kondziolka
Department of Neurological Surgery, University of Pittsburgh, Pennsylvania 15213, USA
Neurosurg Focus 24:E11. 2008..In this report, the authors discuss technical concepts and dose selection in skull base radiosurgery... - Evaluation of surgical techniques for neuronal cell transplantation used in patients with strokeDouglas Kondziolka
Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA
Cell Transplant 13:749-54. 2004..Surgical cell delivery did not lead to new neurological deficits, and imaging studies showed no adverse effects. The cannula used allowed precise injection of the clinical cell dose within a time period that maintained cell viability... - Radiosurgery with or without whole-brain radiotherapy for brain metastases: the patients' perspective regarding complicationsDouglas Kondziolka
Department of Neurological Surgery and Radiation Oncology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Am J Clin Oncol 28:173-9. 2005..To assess the patients' perspective regarding current therapeutic options, we retrospectively surveyed 200 consecutive patients who underwent radiosurgery with or without WBRT... - Stroke repair with cell transplantation: neuronal cells, neuroprogenitor cells, and stem cellsDouglas Kondziolka
Department of Neurological Surgery, University of Pittsburgh, Pennsylvania, USA
Neurosurg Focus 24:E13. 2008..In this report the authors review several current concepts for cellular repair, discuss important patient selection and surgical technique issues, and discuss plans for future experiments... - Radiosurgery as definitive management of intracranial meningiomasDouglas Kondziolka
Department of Neurological Surgery, The Center for Image Guided Neurosurgery, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
Neurosurgery 62:53-8; discussion 58-60. 2008..We evaluated clinical and imaging outcomes of meningiomas stratified by histological tumor grade... - Neurotransplantation for patients with subcortical motor stroke: a phase 2 randomized trialDouglas Kondziolka
Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
J Neurosurg 103:38-45. 2005.... - Long-term survivors after gamma knife radiosurgery for brain metastasesDouglas Kondziolka
Department of Neurological Surgery, University of Pittsburgh School of Medicine, University of Pittsburgh Medical Center, PA 15213, USA
Cancer 104:2784-91. 2005..The authors evaluated all brain metastasis in patients who lived for > or = 4 years after radiosurgery to determine clinical and treatment patterns potentially responsible for their outcome... - Gamma Knife thalamotomy for essential tremorDouglas Kondziolka
Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
J Neurosurg 108:111-7. 2008..The purpose of this study was to evaluate the results following Gamma Knife thalamotomy (GKT) for medically refractory essential tremor in a series of patients in whom open surgical techniques were not desirable... - Improving the informed consent process for surgeryDouglas S Kondziolka
Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Neurosurgery 58:1184-9; discussion 1184-9. 2006..We developed a procedure-based consent form that facilitates patient discussion and validated this process by surveying the patient regarding elements of the consent process, using an independent evaluator... - Radiosurgery for cavernous malformationsDouglas Kondziolka
Department of Neurological Surgery, Center for Image Guided Neurosurgery, University of Pittsburgh, Pittsburgh, PA 15213, USA
Prog Neurol Surg 20:220-30. 2007..We have used Gamma Knife radiosurgery for selected patients with symptomatic, hemorrhagic malformations in high-risk brain locations. Indications, techniques, and results are presented... - Long-lasting microthalamotomy effect after temporary placement of a thalamic stimulating electrodeDouglas Kondziolka
Department of Neurological Surgery, University of Pittsburgh, PA 15213, USA
Stereotact Funct Neurosurg 82:127-30. 2004..By recognizing the benefit obtained from small lesions with minimal tissue manipulation, surgeons can continue to refine the target for movement disorder surgery... - Acoustic neuroma radiosurgery. Origins, contemporary use and future expectationsD Kondziolka
Department of Neurological Surgery, The Center for Image Guided Neurosurgery, University of Pittsburgh, Pittsburgh, Pennsylvania, PA 15213, USA
Neurochirurgie 50:427-35. 2004..We discuss the indications for and expectations with the different treatments. The literature on radiosurgery and radiotherapy is reviewed. It is expected that clinical and basic studies will further improve results... - Future perspectives in acoustic neuroma managementDouglas Kondziolka
Departments of Neurological Surgery and Radiation Oncology, Center for Image Guided Neurosurgery, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA 15213, USA
Prog Neurol Surg 21:247-54. 2008..Patient decisions must be based on quality information from the peer-reviewed literature. Future concepts for radiosurgery are discussed... - Stereotactic radiosurgery as primary and salvage treatment for brain metastases from breast cancer. Clinical articleDouglas Kondziolka
Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania15213, USA
J Neurosurg 114:792-800. 2011..To evaluate the role of stereotactic radiosurgery (SRS) in the management of brain metastases from breast cancer, the authors assessed clinical outcomes and prognostic factors for survival... - Gamma Knife stereotactic radiosurgery for idiopathic trigeminal neuralgiaDouglas Kondziolka
Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
J Neurosurg 112:758-65. 2010..Since different medical and surgical options have different rates of pain relief and morbidity, it is important to evaluate longer-term outcomes... - Results following gamma knife radiosurgical anterior capsulotomies for obsessive compulsive disorderDouglas Kondziolka
Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Neurosurgery 68:28-32; discussion 23-3. 2011..Obsessive compulsive disorder (OCD), in its severe form, can cause tremendous disability for affected patients... - Clinical research in stereotactic radiosurgery: lessons learned from over 10,000 casesDouglas Kondziolka
Departments of Neurological Surgery and Radiation Oncology, University of Pittsburgh, USA
Neurol Res 33:792-802. 2011..From case series to randomized trials, the safety and efficacy of radiosurgery is well documented. In this report, we discuss the key indications for radiosurgery and the kinds of research performed in this field... - Stereotactic radiosurgery for radiation-induced meningiomasDouglas Kondziolka
Department of Neurological Surgery, Center for Image Guided Neurosurgery, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
Neurosurgery 64:463-9; discussion 469-70. 2009..Stereotactic radiosurgery (SRS) has become an important primary or adjuvant management for patients with intracranial meningiomas, but the value of this approach for radiation-induced tumors is unclear... - Stereotactic radiosurgery for convexity meningiomasDouglas Kondziolka
Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA
J Neurosurg 111:458-63. 2009..Stereotactic radiosurgery has become an important primary or adjuvant treatment for patients with intracranial meningiomas. The authors evaluated clinical and imaging outcomes in patients with convexity meningiomas after radiosurgery... - Radiosurgical management of pediatric arteriovenous malformationsDouglas Kondziolka
Suite B 400, Department of Neurological Surgery, University of Pittsburgh Medical Center, 200 Lothrop St, Pittsburgh, PA 15213, USA
Childs Nerv Syst 26:1359-66. 2010..Management options for children include observation and medical management, surgical resection, endovascular embolization, or stereotactic radiosurgery, alone or in combination... - Long-term follow-up of acoustic schwannoma radiosurgery with marginal tumor doses of 12 to 13 GyRahul Chopra
Department of Radiation Oncology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Int J Radiat Oncol Biol Phys 68:845-51. 2007..To define long-term tumor control and clinical outcomes of radiosurgery with marginal tumor doses of 12 to 13 Gy for unilateral acoustic schwannoma... - Stereotactic radiosurgery for pediatric recurrent intracranial ependymomasHideyuki Kano
Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
J Neurosurg Pediatr 6:417-23. 2010.... - The role of palliative radiosurgery when cancer invades the cavernous sinusHideyuki Kano
Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Int J Radiat Oncol Biol Phys 73:709-15. 2009..We evaluated the role of stereotactic radiosurgery (SRS) in the treatment of patients who developed cavernous sinus metastases or direct invasion... - Long-term control of petroclival meningiomas through radiosurgeryThomas J Flannery
Department of Neurological Surgery, University of Pittsburgh, Pennsylvania 15213, USA
J Neurosurg 112:957-64. 2010..The authors evaluated outcomes in 168 patients with petroclival meningiomas who underwent Gamma Knife surgery (GKS) during a 21-year interval... - Gamma knife radiosurgery in younger patients with vestibular schwannomasJavier Lobato-Polo
Department of Neurological Surgery and the Center for Image Guided Neurosurgery, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
Neurosurgery 65:294-300; discussion 300-1. 2009..In younger patients, resection is often advocated because of concern regarding the long-term effects of radiation. We studied tumor response and clinical outcomes after SRS in such patients... - Gamma knife radiosurgery for benign tumors with symptoms from brainstem compressionKotaro Nakaya
Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA
Int J Radiat Oncol Biol Phys 77:988-95. 2010..This study evaluated the role of radiosurgery in the management of symptomatic patients with brainstem compression from benign basal tumors... - Radiosurgery for chordomas and chondrosarcomas of the skull baseJuan J Martin
Department of Neurological Surgery, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
J Neurosurg 107:758-64. 2007..The authors evaluated the effect of stereotactic radiosurgery (SRS) on local tumor control and survival... - Stereotactic radiosurgery for trigeminal schwannoma: tumor control and functional preservation Clinical articleHideyuki Kano
Departments of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
J Neurosurg 110:553-8. 2009.... - Boost Gamma Knife surgery during multimodality management of adult medulloblastomaAnand V Germanwala
Department of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
J Neurosurg 108:204-9. 2008..The aim of this paper was to determine prognostic factors for adult medulloblastoma treated with boost Gamma Knife surgery (GKS) following resection and craniospinal irradiation... - Long-term results after stereotactic radiosurgery for patients with cavernous malformationsToshinori Hasegawa
Department of Neurological Surgery and The Center for Image-Guided Neurosurgery, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
Neurosurgery 50:1190-7; discussion 1197-8. 2002..Given the difficulty of identifying high-risk patients, treatment after one major hemorrhage should be considered in selected younger patients. Such a strategy warrants further investigation... - Stereotactic radiosurgery providing long-term tumor control of cavernous sinus meningiomasJohn Y K Lee
Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pennsylvania, USA
J Neurosurg 97:65-72. 2002..We believe it is the preferred management strategy for tumors of suitable volume (average tumor diameter < or = 3 cm or volume < or = 15 cm3)... - Management of cystic craniopharyngiomas with phosphorus-32 intracavitary irradiationToshinori Hasegawa
Department of Neurological Surgery, University of Pittsburgh School of Medicine, Medical Center, 200 Lothrop Street, Pittsburgh, PA 15213, USA
Neurosurgery 54:813-20; discussion 820-2. 2004..CONCLUSION: For patients with cystic craniopharyngiomas, (32)P intracavitary irradiation proved effective, with a low risk of complications, for the control of tumor cysts but not of solid tumor components... - Gamma knife radiosurgery for intraventricular meningiomasIn Young Kim
Department of Neurological Surgery, Center for Image Guided Neurosurgery, University of Pittsburgh, Pittsburgh, PA, USA
Acta Neurochir (Wien) 151:447-52; discussion 452. 2009..We report our experience using gamma knife radiosurgery (GKR) for intraventricular meningiomas... - Prospective staged volume radiosurgery for large arteriovenous malformations: indications and outcomes in otherwise untreatable patientsSait Sirin
Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
Neurosurgery 58:17-27; discussion 17-27. 2006..After 5 years, this early experience suggests that AVM related symptoms can be stabilized and anticipated bleed rates can be reduced... - Experimental radiobiological investigations into radiosurgery: present understanding and future directionsAjay Niranjan
Department of Neurological Surgery, University of Pittsburgh, Center for Image-Guided Neurosurgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
Neurosurgery 55:495-504; discussion 504-5. 2004.... - Management of brain metastases from ovarian and endometrial carcinoma with stereotactic radiosurgeryEdward Monaco
Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
Cancer 113:2610-4. 2008..Stereotactic radiosurgery (SRS) has proven useful for the treatment of many benign and malignant brain tumors. In the current study, the authors evaluated outcomes after SRS in patients with ovarian and endometrial carcinoma... - Gamma Knife surgery for schwannomas originating from cranial nerves III, IV, and VIIn Young Kim
Department of Neurological Surgery, University of Pittsburgh, Center for Image Guided Neurosurgery, Pittsburgh, Pennsylvania 15213, USA
J Neurosurg 109:149-53. 2008..Schwannomas from the motor cranial nerves controlling eye movement are rare. The authors evaluated the role of Gamma Knife surgery (GKS) in the management of schwannomas originating from cranial nerves III, IV, and VI... - Repeat radiosurgery for refractory trigeminal neuralgiaToshinori Hasegawa
Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Neurosurgery 50:494-500; discussion 500-2. 2002.... - Optimizing intracranial metastasis detection for stereotactic radiosurgeryJohnathan A Engh
Department of Neurological Surgery, University of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
Stereotact Funct Neurosurg 85:162-8. 2007..The authors characterize the detection of additional intracranial metastases in cancer patients at the time of stereotactic radiosurgery (SRS) using a specialized high-resolution magnetic resonance imaging (MRI) protocol... - Outcome predictors for intracranial ependymoma radiosurgeryHideyuki Kano
Department of Neurological Surgery and Center for Image Guided Neurosurgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Neurosurgery 64:279-87; discussion 287-8. 2009.... - Long-term results after radiosurgery for benign intracranial tumorsDouglas Kondziolka
Departments of Neurological Surgery and Radiation Oncology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Neurosurgery 53:815-21; discussion 821-2. 2003..Evaluation of long-term outcomes more than 10 years after radiosurgery is needed... - Boost radiosurgery as a strategy after failure of initial management of pediatric primitive neuroectodermal tumorsThomas Flannery
Department of Neurological Surgery and Radiation Oncology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15123, USA
J Neurosurg Pediatr 3:205-10. 2009.... - The results of resection after stereotactic radiosurgery for brain metastasesHideyuki Kano
Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
J Neurosurg 111:825-31. 2009..In this paper the authors' goal was to evaluate prognostic factors that correlate with the survival of patients who require a resection of a brain metastasis after stereotactic radiosurgery (SRS)... - Radiobiological analysis of tissue responses following radiosurgeryJohn C Flickinger
Department of Radiation Oncology and Neurological Surgery, The Center for Image Guided Neurosurgery, Univ of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Technol Cancer Res Treat 2:87-92. 2003..Radiobiological analysis of clinical data from radiosurgery provides models for guiding treatment to achieve desired effects and provide reliable estimates of complications... - Energy sources in the posterior fossa: the role of radiosurgeryDouglas Kondziolka
Department of Neurological Surgery, Pittsburgh, Pennsylvania, USA
Clin Neurosurg 49:548-61. 2002 - Comparison of management options for patients with acoustic neuromasDouglas Kondziolka
Department of Neurological Surgery, Center for Image Guided Neurosurgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Neurosurg Focus 14:e1. 2003..Patient decisions must be based on quality information derived from peer-reviewed literature... - Neoplastic transformation after radiosurgery or radiotherapy: risk and realitiesAjay Niranjan
Department of Neurological Surgery, The Center for Image Guided Neurosurgery, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
Otolaryngol Clin North Am 42:717-29. 2009..All patients should be informed about the risks and consequences of radiation and microsurgery. The current practice standards for radiosurgery should not be modified because of this very low risk... - Percutaneous intracerebral navigation by duty-cycled spinning of flexible bevel-tipped needlesJohnathan A Engh
Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, USA
Neurosurgery 67:1117-22; discussion 1122-3. 2010..Current catheter placement techniques are limited to straight trajectories. The development of an inexpensive system for flexible percutaneous intracranial navigation may be of significant clinical benefit... - Neural transplantation for strokeDouglas Kondziolka
Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
J Clin Neurosci 9:225-30. 2002..We believe that cerebral infarction and selected neurodegenerative disorders are appropriate initial candidates for this research... - Analysis of repeat stereotactic radiosurgery for progressive primary and metastatic CNS tumorsAjay Bhatnagar
Department of Radiation Oncology, Center for Image-Guided Neurosurgery, University of Pittsburgh School of Medicine, 200 Lothrop Street, Pittsburgh, PA 15213, USA
Int J Radiat Oncol Biol Phys 53:527-32. 2002..0181). CONCLUSION: Repeat radiosurgery can be performed for recurrent tumors with minimal central nervous system toxicity, especially for benign tumors, with reasonable tumor control... - Radiosurgery for craniopharyngiomaAjay Niranjan
Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Int J Radiat Oncol Biol Phys 78:64-71. 2010..To analyze the outcomes of gamma knife stereotactic radiosurgery (SRS) for residual or recurrent craniopharyngiomas and evaluate the factors that optimized the tumor control rates... - Dosimetric comparison of the Leksell Gamma Knife Perfexion and 4CJosef Novotny
Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15213, USA
J Neurosurg 109:8-14. 2008..This comparison is important especially for the treatment of functional disorders when only a single shot with the 4- or 8-mm collimator is used... - Radiosurgery for intracanalicular vestibular schwannomasAjay Niranjan
Departments of Neurological Surgery, Radiology and Radiation Oncology, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA 15213, USA
Prog Neurol Surg 21:192-9. 2008..Radiosurgery is a minimally invasive management option for patients with intracanalicular tumors. Radiosurgery provides high rate of long-term hearing preservation with minimal morbidity... - Heritage of radiosurgical research, current trends and future perspectiveAjay Niranjan
Department of Neurological Surgery, The University of Pittsburgh, and Center for Image Guided Neurosurgery, PA 15213, USA
Prog Neurol Surg 20:359-74. 2007..The present review examines the state of radiobiological investigations into the nature of CNS effects, the newer techniques developed, and the use of radiosurgery as a tool for understanding basic CNS biology... - Stereotactic radiosurgery for vestibular schwannomas in patients with neurofibromatosis type 2: an analysis of tumor control, complications, and hearing preservation ratesDavid Mathieu
Department of Neurological Surgery, University of Pittsburgh School of Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
Neurosurgery 60:460-8; discussion 468-70. 2007..We evaluated the results of gamma knife radiosurgery for the management of these tumors, focusing on tumor response, hearing preservation, and other factors affecting outcomes... - Gamma knife radiosurgery in the management of malignant melanoma brain metastasesDavid Mathieu
Department of Neurological Surgery, University of Pittsburgh, School of Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
Neurosurgery 60:471-81; discussion 481-2. 2007..We reviewed our series of patients who underwent radiosurgery for melanoma brain metastases to assess clinical outcomes and identify prognostic factors for survival and cerebral disease control... - Emerging indications in stereotactic radiosurgeryDouglas Kondziolka
Department of Neurological Surgery, University of Pittsburgh, Pennsylvania, USA
Clin Neurosurg 52:229-33. 2005 - Cranial nerve preservation and outcomes after stereotactic radiosurgery for jugular foramen schwannomasJuan J Martin
Department of Neurological Surgery, University of Pittsburgh School of Medicine, The University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
Neurosurgery 61:76-81; discussion 81. 2007..We reviewed our clinical and imaging outcomes after patients underwent gamma knife radiosurgery for management of jugular foramen schwannomas... - Dose selection in stereotactic radiosurgeryJohn C Flickinger
Department of Radiation Oncology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Prog Neurol Surg 20:28-42. 2007..This paper reviews the radiobiological and physics principles that should be considered in dose selection as well as information from retrospective and prospective clinical investigations of radiosurgery... - Stereotactic radiosurgery for four or more intracranial metastasesAjay K Bhatnagar
Department of Radiation Oncology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Int J Radiat Oncol Biol Phys 64:898-903. 2006..Because total treatment volume was the most significant predictor of survival, the total volume of brain metastases, rather than the number of metastases, should be considered in identifying appropriate radiosurgery candidates... - The impact of whole-brain radiation therapy on the long-term control and morbidity of patients surviving more than one year after gamma knife radiosurgery for brain metastasesJohn M Varlotto
Department of Radiation Oncology, University of Pittsburgh Medical Center and the Center for Image Guided Neurosurgery, Pittsburgh, PA, USA
Int J Radiat Oncol Biol Phys 62:1125-32. 2005.... - Individualized treatment of pediatric craniopharyngiomasA Leland Albright
Department of Neurosurgery, Childrens Hospital of Pittsburgh, 3705 Fifth Avenue, Pittsburgh, PA 15213, USA
Childs Nerv Syst 21:649-54. 2005..We performed this study to correlate the clinical and radiographic features at the time of presentation with the multimodality treatments the children received... - Percutaneous retrogasserian glycerol rhizotomy for trigeminal neuralgia: technique and expectationsDouglas Kondziolka
Department of Neurological Surgery and the Center for Image Guided Neurosurgery, University of Pittsburgh, Pennsylvania, USA
Neurosurg Focus 18:E7. 2005..Percutaneous retrogasserian glycerol rhizotomy (PRGR) offers distinct advantages over other available procedures. The aim of this report was to provide details of the PRGR procedure and its expected outcome... - Establishing a benchmark for complications using frame-based stereotactic surgeryL Dade Lunsford
Department of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
Stereotact Funct Neurosurg 86:278-87. 2008..These results may serve as a benchmark against which free-hand or guided neuronavigation approaches may be measured, as both the advantages and risks of such procedures are assessed... - Gamma knife radiosurgery of imaging-diagnosed intracranial meningiomaJohn C Flickinger
Department of Radiation Oncology, Center for Image Guided Neurosurgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Int J Radiat Oncol Biol Phys 56:801-6. 2003..To evaluate tumor control and outcome from radiosurgery of meningiomas diagnosed by imaging without pathologic verification... - Radiosurgery techniques and current devicesAjay Niranjan
Department of Neurological Surgery, University of Pittsburgh, and Center for Image Guided Neurosurgery, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
Prog Neurol Surg 20:50-67. 2007..Its role as a tool for spine and body surgery is also under evaluation... - Radiosurgery for miscellaneous skull base tumorsL Dade Lunsford
Department of Neurological Surgery and the Center for Image Guided Neurosurgery, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
Prog Neurol Surg 20:192-205. 2007..Adjuvant radiosurgery is used for larger tumors after their initial partial resection. Gamma Knife radiosurgery becomes an adjuvant tool to provide longterm tumor growth control of a significantly reduced tumor volume... - Radiosurgery of vestibular schwannomas: summary of experience in 829 casesL Dade Lunsford
Department of Neurological Surgery and Radiation Oncology, The University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
J Neurosurg 102:195-9. 2005..Optimal outcomes reflect long-term tumor control, preservation of cranial nerve function, and retention of quality of life. The authors review their 15-year experience... - Analysis of tumor control and toxicity in patients who have survived at least one year after radiosurgery for brain metastasesJohn M Varlotto
Department of Radiation Oncology, University of Pittsburgh Medical Center and Center for Image Guided Neurosurgery, Pittsburgh, PA, USA
Int J Radiat Oncol Biol Phys 57:452-64. 2003..To better evaluate tumor control and toxicity from radiosurgery for brain metastases, we analyzed these outcomes in patients who had survived at least 1 year after radiosurgery... - Cell therapy: replacementLawrence R Wechsler
Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Stroke 34:2081-2. 2003 - External beam irradiation of craniopharyngiomas: long-term analysis of tumor control and morbidityJohn M Varlotto
Department of Radiation Oncology, University of Pittsburgh School of Medicine, Center for Image Guided Neurosurgery, and Pittsburgh Cancer Institute, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
Int J Radiat Oncol Biol Phys 54:492-9. 2002..To delineate the long-term control and morbidity with external beam radiotherapy (EBRT) of craniopharyngiomas... - Stereotactic radiosurgery for symptomatic solitary cerebral cavernous malformations considered high risk for resectionL Dade Lunsford
Department of Neurological Surgery and Center for Image Guided Neurosurgery, University of Pittsburgh, Pennsylvania 15213, USA
J Neurosurg 113:23-9. 2010..A retrospective study was conducted to reassess the benefit and safety of stereotactic radiosurgery (SRS) in patients with solitary cerebral cavernous malformations (CCMs) that bleed repeatedly and are poor candidates for surgical removal... - Radiosurgery for brain metastases from unknown primary cancersAjay Niranjan
Department of Neurological Surgery, University of Pittsburgh, UPMC Presbyterian, Pittsburgh, Pennsylvania 15213, USA
Int J Radiat Oncol Biol Phys 77:1457-62. 2010..We evaluated the role of Gamma Knife stereotactic radiosurgery in the multidisciplinary management of brain metastases from an undiagnosed primary cancer... - Hardware-related complications after placement of thalamic deep brain stimulator systemsDouglas Kondziolka
Department of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
Stereotact Funct Neurosurg 79:228-33. 2002..Surgeons who place DBS systems should be aware of the spectrum of problems that can be associated with the device and its placement... - Cellular transplantation for the nervous system: impact of time after preparation on cell viability and survivalGlenn T Gobbel
Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
J Neurosurg 113:666-72. 2010..Time can vary with cell preparation, delivery to the operating room, and surgical technique. This study was also designed to evaluate the sensitivity of various methods of assessing implant viability... - Efficiency and dose planning comparisons between the Perfexion and 4C Leksell Gamma Knife unitsAjay Niranjan
Department of Neurological Surgery, University of Pittsburgh, and Center for Image Guided Neurosurgery, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
Stereotact Funct Neurosurg 87:191-8. 2009..We analyzed the efficiency of the Leksell Gamma Knife Perfexion (LGK PFX) in the treatment of multiple metastases and benign tumors. We also compared treatment planning conformity between LGK PFX and LGK 4C for benign tumors... - Autologous glioma cell vaccine admixed with interleukin-4 gene transfected fibroblasts in the treatment of patients with malignant gliomasHideho Okada
Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
J Transl Med 5:67. 2007..The prognosis for malignant gliomas remains dismal. We addressed the safety, feasibility and preliminary clinical activity of the vaccinations using autologous glioma cells and interleukin (IL)-4 gene transfected fibroblasts...