Deanna Koepp

Summary

Affiliation: University of Minnesota
Country: USA

Publications

  1. ncbi The F-box protein Dia2 regulates DNA replication
    Deanna M Koepp
    Department of Genetics, Cell Biology, and Development, University of Minnesota Twin Cities, Minneapolis, MN 55455, USA
    Mol Biol Cell 17:1540-8. 2006
  2. ncbi The replication stress response and the ubiquitin system: a new link in maintaining genomic integrity
    Deanna M Koepp
    Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, MN 55455, USA
    Cell Div 5:8. 2010
  3. ncbi Activation of the S-phase checkpoint inhibits degradation of the F-box protein Dia2
    Andrew C Kile
    Department of Genetics, Cell Biology and Development, 6 160 Jackson Hall, 321 Church St, S E, Minneapolis, MN 55455, USA
    Mol Cell Biol 30:160-71. 2010
  4. ncbi Yra1 is required for S phase entry and affects Dia2 binding to replication origins
    Swarna Swaminathan
    Department of Genetics, Cell Biology and Development, University of Minnesota, 6 160 Jackson Hall, 321 Church St SE, Minneapolis, MN 55455, USA
    Mol Cell Biol 27:4674-84. 2007
  5. ncbi Fbw7 isoform interaction contributes to cyclin E proteolysis
    Wei Zhang
    Department of Genetics, Cell Biology and Development, University of Minnesota - Twin Cities, Minneapolis, MN, USA
    Mol Cancer Res 4:935-43. 2006
  6. ncbi Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex
    Ning Zheng
    Cellular Biochemistry and Biophysics Program, Memorial Sloan Kettering Cancer Center, New York 10021, USA
    Nature 416:703-9. 2002

Research Grants

  1. The Role of the F-box Protein Dia2 in Cell Cycle Control
    Deanna M Koepp; Fiscal Year: 2010
  2. The Role of the F-box Protein Dia2 in Cell Cycle Control
    Deanna Koepp; Fiscal Year: 2009

Collaborators

  • JEFFREY W HARPER
  • Andrew C Kile
  • Swarna Swaminathan
  • Wei Zhang
  • Ning Zheng
  • Elizabeth M MacDonald
  • Joan W Conaway
  • Claire Chu
  • Stephen J Elledge
  • Ronald C Conaway
  • Brenda A Schulman
  • Langzhou Song
  • Michele Pagano
  • Philip D Jeffrey
  • Nikola P Pavletich
  • Ping Wang
  • Julie J Miller

Detail Information

Publications6

  1. ncbi The F-box protein Dia2 regulates DNA replication
    Deanna M Koepp
    Department of Genetics, Cell Biology, and Development, University of Minnesota Twin Cities, Minneapolis, MN 55455, USA
    Mol Biol Cell 17:1540-8. 2006
    ..Interestingly, prolonging G1-phase in dia2 cells prevents the accumulation of DNA damage in S-phase. We propose that Dia2 is an origin-binding protein that plays a role in regulating DNA replication...
  2. ncbi The replication stress response and the ubiquitin system: a new link in maintaining genomic integrity
    Deanna M Koepp
    Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, MN 55455, USA
    Cell Div 5:8. 2010
    ..We think that this work will help to identify the mechanisms that function downstream of checkpoint activation and that intersect with cell cycle control pathways...
  3. ncbi Activation of the S-phase checkpoint inhibits degradation of the F-box protein Dia2
    Andrew C Kile
    Department of Genetics, Cell Biology and Development, 6 160 Jackson Hall, 321 Church St, S E, Minneapolis, MN 55455, USA
    Mol Cell Biol 30:160-71. 2010
    ..Together, our results suggest that Dia2 protein turnover does not involve an autocatalytic mechanism and that Dia2 proteolysis is inhibited by activation of the replication stress response...
  4. ncbi Yra1 is required for S phase entry and affects Dia2 binding to replication origins
    Swarna Swaminathan
    Department of Genetics, Cell Biology and Development, University of Minnesota, 6 160 Jackson Hall, 321 Church St SE, Minneapolis, MN 55455, USA
    Mol Cell Biol 27:4674-84. 2007
    ..Furthermore, Dia2 binding to replication origins is significantly reduced when association with Yra1 is compromised, suggesting that one aspect of the role of Yra1 in DNA replication may involve recruiting Dia2 to chromatin...
  5. ncbi Fbw7 isoform interaction contributes to cyclin E proteolysis
    Wei Zhang
    Department of Genetics, Cell Biology and Development, University of Minnesota - Twin Cities, Minneapolis, MN, USA
    Mol Cancer Res 4:935-43. 2006
    ..Overall, this study contributes to the current understanding of the regulation of the Fbw7 tumor-suppressor protein...
  6. ncbi Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex
    Ning Zheng
    Cellular Biochemistry and Biophysics Program, Memorial Sloan Kettering Cancer Center, New York 10021, USA
    Nature 416:703-9. 2002
    ..The structure suggests that Cul1 may contribute to catalysis through the positioning of the substrate and the ubiquitin-conjugating enzyme, and this model is supported by Cul1 mutations designed to eliminate the rigidity of the scaffold...

Research Grants5

  1. The Role of the F-box Protein Dia2 in Cell Cycle Control
    Deanna M Koepp; Fiscal Year: 2010
    ..When defective, these processes contribute to tumor formation. The goal is to understand how the processes work in normal cells so that anti-cancer therapies can be developed in the future. ..
  2. The Role of the F-box Protein Dia2 in Cell Cycle Control
    Deanna Koepp; Fiscal Year: 2009
    ..When defective, these processes contribute to tumor formation. The goal is to understand how the processes work in normal cells so that anti-cancer therapies can be developed in the future. ..