Alisa Koch

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. ncbi Dysregulated expression of MIG/CXCL9, IP-10/CXCL10 and CXCL16 and their receptors in systemic sclerosis
    Bradley J Rabquer
    Department of Internal Medicine, University of Michigan Medical School, 109 Zina Pitcher Dr, Ann Arbor, MI 48109, USA
    Arthritis Res Ther 13:R18. 2011
  2. ncbi Accelerated development of arthritis in mice lacking endothelial selectins
    Jeffrey H Ruth
    Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
    Arthritis Res Ther 7:R959-70. 2005
  3. ncbi Interleukin-18 as an in vivo mediator of monocyte recruitment in rodent models of rheumatoid arthritis
    Jeffrey H Ruth
    Department of Internal Medicine, University of Michigan Medical School, 109 Zina Pitcher Drive, Ann Arbor, MI 48109, USA
    Arthritis Res Ther 12:R118. 2010
  4. ncbi Chemokines and their receptors in rheumatoid arthritis: future targets?
    Alisa E Koch
    University of Michigan Medical School, Ann Arbor 48109-0680, USA
    Arthritis Rheum 52:710-21. 2005
  5. ncbi Vasculopathy and disordered angiogenesis in selected rheumatic diseases: rheumatoid arthritis and systemic sclerosis
    Alisa E Koch
    Veterans Hospital, and The University of Michigan Medical School, Zina Pitcher Place, Ann Arbor, Michigan 48109 2200, USA
    Arthritis Res Ther 9:S3. 2007
  6. ncbi CXCL16-mediated cell recruitment to rheumatoid arthritis synovial tissue and murine lymph nodes is dependent upon the MAPK pathway
    Jeffrey H Ruth
    University of Michigan Medical School, Ann Arbor 48109-0680, USA
    Arthritis Rheum 54:765-78. 2006
  7. ncbi Macrophage migration inhibitory factor: a mediator of matrix metalloproteinase-2 production in rheumatoid arthritis
    Angela Pakozdi
    University of Michigan Medical School, 109 Zina Pitcher Place, Ann Arbor, MI 48109, USA
    Arthritis Res Ther 8:R132. 2006
  8. ncbi Migration inhibitory factor up-regulates vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 via Src, PI3 kinase, and NFkappaB
    M Asif Amin
    Department of Medicine, University of Michigan Medical School, Ann Arbor, MI, USA
    Blood 107:2252-61. 2006
  9. ncbi Green tea extract inhibits chemokine production, but up-regulates chemokine receptor expression, in rheumatoid arthritis synovial fibroblasts and rat adjuvant-induced arthritis
    Hubert Marotte
    Department of Internal Medicine, University of Michigan Medical School, Department of Veterans Affairs, Ann Arbor, MI, USA
    Rheumatology (Oxford) 49:467-79. 2010
  10. ncbi Epigallocatechin-3-gallate inhibits IL-6 synthesis and suppresses transsignaling by enhancing soluble gp130 production
    Salahuddin Ahmed
    Division of Rheumatology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109 2200, USA
    Proc Natl Acad Sci U S A 105:14692-7. 2008

Research Grants

  1. IL-4 and IL-13 gene therapy for arthritis
    Alisa Koch; Fiscal Year: 2006
  2. NOVEL ANGIOGENIC CYTOKINE INDUCED ENDOTHELIAL ANTIGEN
    Alisa Koch; Fiscal Year: 2002
  3. IL 4 AND IL 13 GENE THERAPY FOR ARTHRITIS
    Alisa Koch; Fiscal Year: 2001
  4. IL-18 in rheumatoid inflammation and angiogenesis
    Alisa Koch; Fiscal Year: 2007

Collaborators

Detail Information

Publications62

  1. ncbi Dysregulated expression of MIG/CXCL9, IP-10/CXCL10 and CXCL16 and their receptors in systemic sclerosis
    Bradley J Rabquer
    Department of Internal Medicine, University of Michigan Medical School, 109 Zina Pitcher Dr, Ann Arbor, MI 48109, USA
    Arthritis Res Ther 13:R18. 2011
    ..In addition, CXCL16 promotes angiogenesis by binding its unique receptor CXCR6. In this study, we determined the expression of these chemokines and receptors in SSc skin and serum...
  2. ncbi Accelerated development of arthritis in mice lacking endothelial selectins
    Jeffrey H Ruth
    Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
    Arthritis Res Ther 7:R959-70. 2005
    ....
  3. ncbi Interleukin-18 as an in vivo mediator of monocyte recruitment in rodent models of rheumatoid arthritis
    Jeffrey H Ruth
    Department of Internal Medicine, University of Michigan Medical School, 109 Zina Pitcher Drive, Ann Arbor, MI 48109, USA
    Arthritis Res Ther 12:R118. 2010
    ..The function of interleukin-18 (IL-18) was investigated in pertinent animal models of rodent rheumatoid arthritis (RA) to determine its proinflammatory and monocyte recruitment properties...
  4. ncbi Chemokines and their receptors in rheumatoid arthritis: future targets?
    Alisa E Koch
    University of Michigan Medical School, Ann Arbor 48109-0680, USA
    Arthritis Rheum 52:710-21. 2005
  5. ncbi Vasculopathy and disordered angiogenesis in selected rheumatic diseases: rheumatoid arthritis and systemic sclerosis
    Alisa E Koch
    Veterans Hospital, and The University of Michigan Medical School, Zina Pitcher Place, Ann Arbor, Michigan 48109 2200, USA
    Arthritis Res Ther 9:S3. 2007
    ....
  6. ncbi CXCL16-mediated cell recruitment to rheumatoid arthritis synovial tissue and murine lymph nodes is dependent upon the MAPK pathway
    Jeffrey H Ruth
    University of Michigan Medical School, Ann Arbor 48109-0680, USA
    Arthritis Rheum 54:765-78. 2006
    ..CONCLUSION: Taken together, these results point to a unique role for CXCL16 as a premier MNC recruiter in RA and suggest additional therapeutic possibilities, targeting CXCL16, its receptor, or its signaling pathways...
  7. ncbi Macrophage migration inhibitory factor: a mediator of matrix metalloproteinase-2 production in rheumatoid arthritis
    Angela Pakozdi
    University of Michigan Medical School, 109 Zina Pitcher Place, Ann Arbor, MI 48109, USA
    Arthritis Res Ther 8:R132. 2006
    ..Consistent with these results, MIF induced phosphorylation of JNK, PKCdelta, and c-jun. These results indicate a potential novel role for MIF in tissue destruction in RA...
  8. ncbi Migration inhibitory factor up-regulates vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 via Src, PI3 kinase, and NFkappaB
    M Asif Amin
    Department of Medicine, University of Michigan Medical School, Ann Arbor, MI, USA
    Blood 107:2252-61. 2006
    ..MIF and MIF-dependent signaling pathways may be a potential target for treating diseases characterized by up-regulation of cell adhesion molecules...
  9. ncbi Green tea extract inhibits chemokine production, but up-regulates chemokine receptor expression, in rheumatoid arthritis synovial fibroblasts and rat adjuvant-induced arthritis
    Hubert Marotte
    Department of Internal Medicine, University of Michigan Medical School, Department of Veterans Affairs, Ann Arbor, MI, USA
    Rheumatology (Oxford) 49:467-79. 2010
    ..Evaluation of the efficacy of green tea extract (GTE) in regulating chemokine production and chemokine receptor expression in human RA synovial fibroblasts and rat adjuvant-induced arthritis (AIA)...
  10. ncbi Epigallocatechin-3-gallate inhibits IL-6 synthesis and suppresses transsignaling by enhancing soluble gp130 production
    Salahuddin Ahmed
    Division of Rheumatology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109 2200, USA
    Proc Natl Acad Sci U S A 105:14692-7. 2008
    ..The results of these studies provide previously undescribed evidence of IL-6 synthesis and transsignaling inhibition by EGCG with a unique mechanism of sgp130 up-regulation, and thus hold promise as a potential therapeutic agent for RA...
  11. ncbi Junctional adhesion molecule C mediates leukocyte adhesion to rheumatoid arthritis synovium
    Bradley J Rabquer
    University of Michigan Medical School, Department of Medicine, Ann Arbor, MI 48109, USA
    Arthritis Rheum 58:3020-9. 2008
    ..This study was undertaken to investigate the role of junctional adhesion molecule C (JAM-C) in mediating leukocyte recruitment and retention in the RA joint...
  12. ncbi Blocking ERK-1/2 reduces tumor necrosis factor alpha-induced interleukin-18 bioactivity in rheumatoid arthritis synovial fibroblasts by induction of interleukin-18 binding protein A
    Hubert Marotte
    University of Michigan, Ann Arbor, MI 48109 2200, USA
    Arthritis Rheum 62:722-31. 2010
    ..To examine the mechanism of regulation of interleukin-18 (IL-18) bioactivity by IL-18 binding protein (IL-18BP) induction...
  13. ncbi In vivo inhibition of angiogenesis by interleukin-13 gene therapy in a rat model of rheumatoid arthritis
    Christian S Haas
    University of Michigan Medical School, 109 Zina Pitcher Place, Ann Arbor, MI 48109, USA
    Arthritis Rheum 56:2535-48. 2007
    ..The purpose of this study was to use a gene therapy approach to investigate the role of IL-13 in angiogenesis in vivo, using a rat adjuvant-induced arthritis model of RA...
  14. ncbi Inhibition of angiogenesis by interleukin-4 gene therapy in rat adjuvant-induced arthritis
    Christian S Haas
    University of Michigan Medical School, Ann Arbor, MI 48109 0680, USA
    Arthritis Rheum 54:2402-14. 2006
    ..Interleukin-4 (IL-4) can modulate neovascularization. In this study, we used a gene therapy approach to investigate the role of IL-4 in angiogenesis in rat adjuvant-induced arthritis (AIA), a model for rheumatoid arthritis...
  15. ncbi Regulation of interleukin-1beta-induced chemokine production and matrix metalloproteinase 2 activation by epigallocatechin-3-gallate in rheumatoid arthritis synovial fibroblasts
    Salahuddin Ahmed
    University of Michigan Medical School, Ann Arbor, MI 48109 2200, USA
    Arthritis Rheum 54:2393-401. 2006
    ....
  16. ncbi ICOS and B7 costimulatory molecule expression identifies activated cellular subsets in rheumatoid arthritis
    Jeffrey H Ruth
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109 2200, USA
    Cytometry A 71:317-26. 2007
    ..Therefore, in the same joint, there may exist positive and negative influences on the inflammatory response, and perhaps, the negative signals dominate as joint inflammation resolves...
  17. ncbi Interleukin-18 induces angiogenic factors in rheumatoid arthritis synovial tissue fibroblasts via distinct signaling pathways
    Mohammad A Amin
    Department of Internal Medicine, Division of Rheumatology, University of Michigan Medical School, University of Michigan Health System, Ann Arbor, MI, USA
    Arthritis Rheum 56:1787-97. 2007
    ....
  18. ncbi The role of vascular cell adhesion molecule 1/ very late activation antigen 4 in endothelial progenitor cell recruitment to rheumatoid arthritis synovium
    Matthew D Silverman
    University of Michigan Health System, Internal Medicine Department, Ann Arbor, MI 48109 2200, USA
    Arthritis Rheum 56:1817-26. 2007
    ..This study was undertaken to investigate the hypothesis that EPCs selectively home to inflamed joint tissue and may perpetuate synovial neovascularization...
  19. ncbi H-2g, a glucose analog of blood group H antigen, mediates mononuclear cell recruitment via Src and phosphatidylinositol 3-kinase pathways
    M Asif Amin
    Department of Internal Medicine Division of Rheumatology, University of Michigan Medical School, Ann Arbor, MI 48109 2200, USA
    Arthritis Rheum 58:689-95. 2008
    ..We hypothesized that soluble Le(y)/H plays an important role in monocyte recruitment in RA...
  20. ncbi Down-regulation of myeloid cell leukemia 1 by epigallocatechin-3-gallate sensitizes rheumatoid arthritis synovial fibroblasts to tumor necrosis factor alpha-induced apoptosis
    Salahuddin Ahmed
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109 2200, USA
    Arthritis Rheum 60:1282-93. 2009
    ..This study was undertaken to evaluate the efficacy of epigallocatechin-3-gallate (EGCG) in down-regulating Mcl-1 expression and its mechanism of RA synovial fibroblast sensitization to TNFalpha-induced apoptosis...
  21. ncbi The proadhesive phenotype of systemic sclerosis skin promotes myeloid cell adhesion via ICAM-1 and VCAM-1
    Bradley J Rabquer
    Department of Internal Medicine, University of Michigan Medical School, AnnArbor, MI, USA
    Rheumatology (Oxford) 48:734-40. 2009
    ..The aim of this study was to examine adhesive interactions in SSc skin...
  22. ncbi Synovial inflammation in patients with osteonecrosis of the femoral head
    Bradley J Rabquer
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA
    Clin Transl Sci 2:273-8. 2009
    ..Our results suggest the presence of a previously unrecognized population of ON patients without a diagnosed inflammatory co-morbidity and a highly inflammed synovium consisting primarily of a macrophage and CD4(+) T-cell infiltrate...
  23. ncbi Expression and function of CXCL16 in a novel model of gout
    Jeffrey H Ruth
    University of Michigan Medical School, Division of Rheumatology, 109 Zina Pitcher Place, 4023 BSRB Box 2200, Ann Arbor, MI 48109 2200, USA
    Arthritis Rheum 62:2536-44. 2010
    ....
  24. ncbi Macrophage migration inhibitory factor promotes tumor growth in the context of lung injury and repair
    Douglas Arenberg
    Division of Pulmonary and Critical Care Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109 0642, USA
    Am J Respir Crit Care Med 182:1030-7. 2010
    ..We hypothesized that soluble factors released during the repair response to lung injury would promote orthotopic tumor growth...
  25. ncbi Junctional adhesion molecule-C is a soluble mediator of angiogenesis
    Bradley J Rabquer
    Department of Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Immunol 185:1777-85. 2010
    ..Moreover, sJAM-C-mediated HMVEC chemotaxis was dependent on Src, p38, and PI3K. Our results show that JAM-C exists in soluble form and suggest that modulation of sJAM-C may provide a novel route for controlling pathological angiogenesis...
  26. ncbi Interleukin 18 induces angiogenesis in vitro and in vivo via Src and Jnk kinases
    M Asif Amin
    Department of Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Ann Rheum Dis 69:2204-12. 2010
    ..Interleukin 18 (IL-18) is a novel mediator of angiogenesis in rheumatoid arthritis (RA)...
  27. ncbi Chemokine receptor expression in rat adjuvant-induced arthritis
    Christian S Haas
    University of Michigan Medical School, Ann Arbor, MI 48109 0680, USA
    Arthritis Rheum 52:3718-30. 2005
    ..In this study, we used rat adjuvant-induced arthritis (AIA), a model for RA, to define the temporospatial expression of chemokine receptors...
  28. ncbi Identification of genes modulated in rheumatoid arthritis using complementary DNA microarray analysis of lymphoblastoid B cell lines from disease-discordant monozygotic twins
    Christian S Haas
    University of Michigan Center, 1150 West Medical Center Drive, Ann Arbor, MI 48109 0680, USA
    Arthritis Rheum 54:2047-60. 2006
    ..To identify disease-specific gene expression profiles in patients with rheumatoid arthritis (RA), using complementary DNA (cDNA) microarray analyses on lymphoblastoid B cell lines (LCLs) derived from RA-discordant monozygotic (MZ) twins...
  29. ncbi Mcl-1 is essential for the survival of synovial fibroblasts in rheumatoid arthritis
    Hongtao Liu
    Division of Rheumatology, Northwestern University Feinberg School of Medicine and The Jesse Brown Veterans Affairs Chicago Heathcare System, IL 60611, USA
    J Immunol 175:8337-45. 2005
    ..These observations document a critical role for Mcl-1 in protecting against apoptosis in RA and suggest that Mc1-1 is a potential therapeutic target in this disease...
  30. ncbi A novel function for a glucose analog of blood group H antigen as a mediator of leukocyte-endothelial adhesion via intracellular adhesion molecule 1
    Kui Zhu
    Department of Medicine, Feinberg School of Medicine, Northwestern University, 303 E. Chicago Avenue, Chicago, IL 60611, USA
    J Biol Chem 278:21869-77. 2003
    ..Potential treatment strategies through the inhibition of JAK-dependent pathways to target H-2g signals may provide a useful approach in inflammation-driven diseases like rheumatoid arthritis...
  31. ncbi Role of macrophage inflammatory protein-3alpha and its ligand CCR6 in rheumatoid arthritis
    Jeffrey H Ruth
    Department of Medicine, Northwestern University Medical School, Chicago, Illinois 60611, USA
    Lab Invest 83:579-88. 2003
    ..These results further indicate that expression of CCR6, the receptor for MIP-3alpha, can be correlated with RA development...
  32. ncbi Immunoperoxidase histochemistry for the detection of cellular adhesion molecule, cytokine, and chemokine expression in the arthritic synovium
    Zoltan Szekanecz
    University of Debrecen, Hungary
    Methods Mol Biol 225:283-90. 2003
  33. ncbi CXCL16 functions as a novel chemotactic factor for prostate cancer cells in vitro
    Yi Lu
    Department of Medicine, Pittsburgh VA Healthcare System, Research and Development, University of Pittsburgh, Pittsburgh, PA 15240, USA
    Mol Cancer Res 6:546-54. 2008
    ..CXCL16 was found to promote prostate cancer cell migration and invasion in vitro. Therefore, we concluded that CXCL16 functions, through CXCR6, as a novel chemotactic factor for prostate cancer cells...
  34. ncbi The role of COX-2 in angiogenesis and rheumatoid arthritis
    James M Woods
    Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Exp Mol Pathol 74:282-90. 2003
    ..Our studies suggest that COX-2-induced angiogenic activity is an active mechanism within diseased synovium and may provide an additional rationale for the use of COX-2 inhibitors in RA...
  35. ncbi Migration inhibitory factor mediates angiogenesis via mitogen-activated protein kinase and phosphatidylinositol kinase
    M Asif Amin
    Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Ill, USA
    Circ Res 93:321-9. 2003
    ..Our findings support a role for MIF as an angiogenic factor and provide a rationale for the use of MIF as a therapeutic inducer of neovascularization in the development of collateral circulation in coronary artery disease...
  36. ncbi Src and phosphatidylinositol 3-kinase mediate soluble E-selectin-induced angiogenesis
    Pawan Kumar
    Veterans Administration, Lakeside Division, Chicago Health Care System, Chicago, IL, USA
    Blood 101:3960-8. 2003
    ..Taken together, our data clearly show that sE-selectin-induced angiogenesis is predominantly mediated through the Src-PI3K pathway...
  37. ncbi IL-6 and matrix metalloproteinase-1 are regulated by the cyclin-dependent kinase inhibitor p21 in synovial fibroblasts
    Harris Perlman
    Division of Rheumatology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA
    J Immunol 170:838-45. 2003
    ..These data suggest that alterations in p21 expression may activate AP-1 leading to enhanced proinflammatory cytokine and MMP production and development of autoimmune disease...
  38. ncbi Angiogenesis and chemokines in rheumatoid arthritis and other systemic inflammatory rheumatic diseases
    Edit Bodolay
    Division of Rheumatology, Third Department of Medicine, University of Debrecen Medical and Health Sciences Center, Debrecen, H-4004, Hungary
    J Cell Mol Med 6:357-76. 2002
    ....
  39. ncbi The effect of sulfasalazine on rheumatoid arthritic synovial tissue chemokine production
    Michael V Volin
    Department of Medicine, Nortwestern University Medical School, Chicago, Illinois 60611, USA
    Exp Mol Pathol 73:84-92. 2002
    ..These data suggest that SASP may function to reduce inflammation in RA through the effects of its metabolite SP to reduce the secretion of the inflammatory chemokines IL-8, GROalpha, and MCP-1...
  40. ncbi Signal transduction pathways involved in rheumatoid arthritis synovial fibroblast interleukin-18-induced vascular cell adhesion molecule-1 expression
    Jacques C M Morel
    Department of Medicine, Northwestern University Medical School, Chicago, Illinois 60611, USA
    J Biol Chem 277:34679-91. 2002
    ..Targeting VCAM-1 signaling mechanisms may represent therapeutic approaches to inflammatory and angiogenic diseases characterized by adhesion molecule up-regulation...
  41. ncbi Differential expression of the angiogenic Tie receptor family in arthritic and normal synovial tissue
    Shiva Shahrara
    Department of Medicine, Northwestern University Medical School, Chicago, IL 60611, USA
    Arthritis Res 4:201-8. 2002
    ..In conclusion, the dominance of Ang-1 mRNA and protein expression over Ang-2 is in agreement with an active neovascularization in RA synovial tissue...
  42. ncbi Interleukin-13 gene therapy reduces inflammation, vascularization, and bony destruction in rat adjuvant-induced arthritis
    James M Woods
    Department of Medicine, Northwestern University Medical School, Chicago, IL 60611, USA
    Hum Gene Ther 13:381-93. 2002
    ..Thus, increasing IL-13 levels significantly ameliorates the course of rat AIA, suggesting that similar strategies for the treatment of human RA are worthy of further study...
  43. ncbi Expression of mucin 3 and mucin 5AC in arthritic synovial tissue
    Michael V Volin
    Chicago College of Osteopathic Medicine, Midwestern University, Downers Grove, Illinois 60515, USA
    Arthritis Rheum 58:46-52. 2008
    ..MUC gene expression has been found to be altered in many cancers and inflammatory states. This study was undertaken to examine its expression in synovial tissue (ST) and role in arthritis...
  44. ncbi Mechanisms of Disease: angiogenesis in inflammatory diseases
    Zoltan Szekanecz
    Third Department of Medicine, Rheumatology Division, University of Debrecen Medical Center, 22 Moricz Zs Street, Debrecen, H 4012, Hungary
    Nat Clin Pract Rheumatol 3:635-43. 2007
    ..Furthermore, angiogenesis might be targeted by several specific approaches that could be therapeutically used to control inflammatory diseases...
  45. ncbi Mechanism by which H-2g, a glucose analog of blood group H antigen, mediates angiogenesis
    Kui Zhu
    Department of Medicine, Northwestern University of Feinberg School of Medicine, Chicago, IL, USA
    Blood 105:2343-9. 2005
    ..The critical role of Le(y)/H involvement in angiogenesis and its signaling pathways may provide new targets for therapy of diseases characterized by pathologic neovascularization...
  46. ncbi Local IL-13 gene transfer prior to immune-complex arthritis inhibits chondrocyte death and matrix-metalloproteinase-mediated cartilage matrix degradation despite enhanced joint inflammation
    Karin C A M Nabbe
    Department of Experimental Rheumatology and Advanced Therapeutics, University Medical Center Nijmegen, Nijmegen, The Netherlands
    Arthritis Res Ther 7:R392-401. 2005
    ..This study demonstrates that IL-13 overexpression during ICA diminished both chondrocyte death and MMP-mediated VDIPEN expression, even though joint inflammation was enhanced...
  47. ncbi Macrophages and their products in rheumatoid arthritis
    Zoltan Szekanecz
    Division of Rheumatology, Third Department of Medicine, University of Debrecen Medical and Health Sciences Center, Debrecen, Hungary
    Curr Opin Rheumatol 19:289-95. 2007
    ..Macrophages express adhesion molecules, chemokine receptors and other surface antigens. They also secrete a number of chemokines, cytokines, growth factors, proteases and other mediators...
  48. ncbi Therapeutic inhibition of leukocyte recruitment in inflammatory diseases
    Zoltan Szekanecz
    Division of Rheumatology, Third Department of Medicine, University of Debrecen Medical and Health Sciences Center, Debrecen, H 4004, Hungary
    Curr Opin Pharmacol 4:423-8. 2004
    ..In this review, the most recent advances in anti-chemokine and anti-adhesion therapeutic strategies are summarized...
  49. ncbi Amelioration of rat adjuvant-induced arthritis by Met-RANTES
    Shiva Shahrara
    Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Arthritis Rheum 52:1907-19. 2005
    ..The aim of this study was to investigate whether Met-RANTES could ameliorate adjuvant-induced arthritis (AIA) in the rat...
  50. ncbi Retinoblastoma suppression of matrix metalloproteinase 1, but not interleukin-6, through a p38-dependent pathway in rheumatoid arthritis synovial fibroblasts
    Kathleen Bradley
    Saint Louis University, School of Medicine, St Louis, Missouri 63104, USA
    Arthritis Rheum 50:78-87. 2004
    ..Therefore, we sought to determine if the tumor suppressor gene product retinoblastoma (Rb), a negative regulator of cell cycle activity, inhibits IL-6, MMP-1, and p38 in RA synovial fibroblasts...
  51. ncbi Chemokines in rheumatic diseases
    Zoltan Szekanecz
    Division of Rheumatology, Third Department of Medicine, University of Debrecen Medical and Health Sciences Center, Debrecen, H 4004, Hungary
    Curr Drug Targets 7:91-102. 2006
    ....
  52. ncbi Role of aggrecanase 1 in Lyme arthritis
    Aruna K Behera
    Tupper Research Institute, Tufts University School of Medicine, Boston, Massachusetts, USA
    Arthritis Rheum 54:3319-29. 2006
    ..The role of aggrecanases in Lyme arthritis has not yet been determined. We therefore sought to delineate the contribution of aggrecanases to joint destruction in Lyme arthritis...
  53. ncbi Endothelial cells in inflammation and angiogenesis
    Zoltan Szekanecz
    Division of Rheumatology, Third Department of Medicine, University of Debrecen Medical and Health Sciences Center, Debrecen H 4004, Hungary
    Curr Drug Targets Inflamm Allergy 4:319-23. 2005
    ..Specific targeting of pathological endothelial function including adhesion and angiogenesis, may be useful for the future management of various inflammatory diseases...
  54. ncbi Modifications in adenoviral coat fiber proteins and transcriptional regulatory sequences enhance transgene expression
    Harris Perlman
    Division of Rheumatology, Northwestern University Medical School, Chicago, Illinois 60611, USA
    J Rheumatol 29:1593-600. 2002
    ..CONCLUSION: Adenovirus attachment and uptake by cells and promoter strength limit transgene expression from conventional adenoviral vectors in models of rheumatoid arthritis...
  55. ncbi Porcine endothelial cells and iliac arteries transduced with AdenoIL-4 are intrinsically protected, through Akt activation, against immediate injury caused by human complement
    Sylvester M Black
    Department of Surgery, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    J Immunol 177:7355-63. 2006
    ....
  56. ncbi Differential expression of the FAK family kinases in rheumatoid arthritis and osteoarthritis synovial tissues
    Shiva Shahrara
    Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Arthritis Res Ther 9:R112. 2007
    ..Activation of the FAK family signaling cascade on RA and OA lining cells may be responsible for cell adhesion and migration into the diseased STs. Therapies targeting this novel signaling pathway may be beneficial in RA...
  57. ncbi Vascular endothelium and immune responses: implications for inflammation and angiogenesis
    Zoltan Szekanecz
    Division of Rheumatology, Third Department of Medicine, University of Debrecen Medical and Health Sciences Center, 22 Moricz Street, Debrecen H 4004, Hungary
    Rheum Dis Clin North Am 30:97-114. 2004
    ..Specific targeting of pathologic endothelial function may be useful for the future management of various inflammatory diseases...
  58. ncbi Chemokine receptor expression and in vivo signaling pathways in the joints of rats with adjuvant-induced arthritis
    Shiva Shahrara
    Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
    Arthritis Rheum 48:3568-83. 2003
    ..Furthermore, we investigated the signaling pathways associated with CC receptors as well as the cell type distribution of the receptors...
  59. ncbi Increased production of the soluble tumor-associated antigens CA19-9, CA125, and CA15-3 in rheumatoid arthritis: potential adhesion molecules in synovial inflammation?
    Eva Szekanecz
    Department of Oncology, University of Debrecen Medical and Health Science Center, Debrecen, Hungary
    Ann N Y Acad Sci 1108:359-71. 2007
    ..CEA, CA19-9, CA125, and CA15-3 contain carbohydrate motifs and thus they may be involved in synovitis-associated adhesive events. Furthermore, some TAAs, such as CEA, may also correlate with prognostic factors, such as serum RF levels...
  60. ncbi Gene therapy for rheumatoid arthritis: recent advances
    James M Woods
    Department of Microbiology and Immunology, Chicago College of Osteopathic Medicine, Midwestern University, Downers Grove, IL 60515, USA
    Curr Gene Ther 8:24-41. 2008
    ....

Research Grants18

  1. IL-4 and IL-13 gene therapy for arthritis
    Alisa Koch; Fiscal Year: 2006
    ..Currently it is a reality for patient care. The experiments proposed in this study should indicate the feasibility of IL-4 and IL-13 as new therapeutics for RA and explore the mechanisms by which they act in RA. ..
  2. NOVEL ANGIOGENIC CYTOKINE INDUCED ENDOTHELIAL ANTIGEN
    Alisa Koch; Fiscal Year: 2002
    ..These studies should broaden our understanding of the mode of action of this novel angiogenic mediator which may increase our ability to curb angiogenesis in conditions characterized by persistent neovascularization. ..
  3. IL 4 AND IL 13 GENE THERAPY FOR ARTHRITIS
    Alisa Koch; Fiscal Year: 2001
    ..The applicants hope that use of gene therapy employing IL-4 or IL-13 genes will result in a promising new therapy for RA, which afflicts many patients each year. ..
  4. IL-18 in rheumatoid inflammation and angiogenesis
    Alisa Koch; Fiscal Year: 2007
    ..Our proposal should answer some key questions, which may determine the ability of IL-18 to be a therapeutic target in RA. ..