P Kobbe

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi [Treatment of a shotgun fracture of the humerus]
    P Kobbe
    , , Freisestrasse 9, 38118, Braunschweig, Deutschland
    Unfallchirurg 111:256-9. 2008
  2. ncbi Local exposure of bone components to injured soft tissue induces Toll-like receptor 4-dependent systemic inflammation with acute lung injury
    Philipp Kobbe
    Department of Orthopaedic Surgery, McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Shock 30:686-91. 2008
  3. ncbi The role of fracture-associated soft tissue injury in the induction of systemic inflammation and remote organ dysfunction after bilateral femur fracture
    Philipp Kobbe
    Department of Orthopedic Surgery, University of Pittsburghm Kaufmann Medical Building, Pittsburgh, PA 15213, USA
    J Orthop Trauma 22:385-90. 2008
  4. ncbi [Treatment strategies for gunshot wounds of the extremities]
    P Kobbe
    Klinik für Unfallchirurgie, Städtisches Klinikum Braunschweig, Freisestrasse 9, 38118, Braunschweig, Deutschland
    Unfallchirurg 111:247-54; quiz 255. 2008
  5. ncbi [Voluminous bone graft harvesting of the femoral marrow cavity for autologous transplantation. An indication for the"Reamer-Irrigator-Aspirator-" (RIA-)technique]
    P Kobbe
    Department of Orthopaedic Surgery, Kaufmann Medical Building, University of Pittsburgh, 3471 Fifth Avenue, Suite 1010, Pittsburgh, PA 15213, USA
    Unfallchirurg 111:469-72. 2008
  6. ncbi Case report : recurrent piriformis syndrome after surgical release
    Philipp Kobbe
    Department of Orthopaedic Surgery, Division of Trauma, University of Pittsburgh School of Medicine, Kaufmann Building, Suite 1010, 3471 Fifth Avenue, Pittsburgh, PA 15213, USA
    Clin Orthop Relat Res 466:1745-8. 2008
  7. ncbi [Damage control orthopaedics in polytraumatised patients with lower leg injuries]
    P Kobbe
    Department of Orthopaedic Surgery, University of Pittsburgh, PA 15213, USA
    Z Orthop Unfall 146:580-5. 2008
  8. ncbi [Complex knee injury in polytraumatized patients]
    P Kobbe
    Department of Orthopaedic Surgery, University of Pittsburgh, Kaufmann Medical Building Suite 1010, 3471 Fifth Avenue, Pittsburgh, PA 15213, USA
    Unfallchirurg 110:235-42; quiz 243. 2007
  9. ncbi [Care of complex knee joint injuries in patients with polytrauma]
    P Kobbe
    Department of Orthopaedic Surgery, University of Pittsburgh, 3471 Fifth Avenue, Kaufmann Medical Building-Suite 1010, Pittsburgh, PA 15213, USA
    Unfallchirurg 110:245-9. 2007
  10. ncbi Patterns of cytokine release and evolution of remote organ dysfunction after bilateral femur fracture
    Philipp Kobbe
    Department of Orthopedic Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Shock 30:43-7. 2008

Collaborators

Detail Information

Publications18

  1. ncbi [Treatment of a shotgun fracture of the humerus]
    P Kobbe
    , , Freisestrasse 9, 38118, Braunschweig, Deutschland
    Unfallchirurg 111:256-9. 2008
  2. ncbi Local exposure of bone components to injured soft tissue induces Toll-like receptor 4-dependent systemic inflammation with acute lung injury
    Philipp Kobbe
    Department of Orthopaedic Surgery, McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Shock 30:686-91. 2008
    ..These findings suggest that bone components contribute to systemic inflammation and acute lung injury after long bone fractures via TLR-4 signaling and support the notion of a central role for TLR-4 in sensing tissue damage...
  3. ncbi The role of fracture-associated soft tissue injury in the induction of systemic inflammation and remote organ dysfunction after bilateral femur fracture
    Philipp Kobbe
    Department of Orthopedic Surgery, University of Pittsburghm Kaufmann Medical Building, Pittsburgh, PA 15213, USA
    J Orthop Trauma 22:385-90. 2008
    ..We hypothesized that fracture-associated soft tissue injury plays a pivotal role in the induction of systemic inflammation and remote organ dysfunction after fracture...
  4. ncbi [Treatment strategies for gunshot wounds of the extremities]
    P Kobbe
    Klinik für Unfallchirurgie, Städtisches Klinikum Braunschweig, Freisestrasse 9, 38118, Braunschweig, Deutschland
    Unfallchirurg 111:247-54; quiz 255. 2008
    ..Articular gunshot injuries are treated as open joint injuries and require irrigation, debridement, foreign body removal and antibiotic prophylaxis...
  5. ncbi [Voluminous bone graft harvesting of the femoral marrow cavity for autologous transplantation. An indication for the"Reamer-Irrigator-Aspirator-" (RIA-)technique]
    P Kobbe
    Department of Orthopaedic Surgery, Kaufmann Medical Building, University of Pittsburgh, 3471 Fifth Avenue, Suite 1010, Pittsburgh, PA 15213, USA
    Unfallchirurg 111:469-72. 2008
    ..The contralateral femur was reamed and the bone graft was applied to the nonunion. The patient showed clinical and radiological healing of the nonunion without donor site complications...
  6. ncbi Case report : recurrent piriformis syndrome after surgical release
    Philipp Kobbe
    Department of Orthopaedic Surgery, Division of Trauma, University of Pittsburgh School of Medicine, Kaufmann Building, Suite 1010, 3471 Fifth Avenue, Pittsburgh, PA 15213, USA
    Clin Orthop Relat Res 466:1745-8. 2008
    ..On revision surgery, polytetrafluoroethylene pledgets were placed around the sciatic nerve to avoid compression and entrapment by scar tissue. Both patients had satisfactory outcomes at 3 years followup...
  7. ncbi [Damage control orthopaedics in polytraumatised patients with lower leg injuries]
    P Kobbe
    Department of Orthopaedic Surgery, University of Pittsburgh, PA 15213, USA
    Z Orthop Unfall 146:580-5. 2008
    ..The decision for amputation is based on the patient's general condition and the soft-tissue and neurovascular status. Scoring systems are useful for decision making, however individual decisions should be made...
  8. ncbi [Complex knee injury in polytraumatized patients]
    P Kobbe
    Department of Orthopaedic Surgery, University of Pittsburgh, Kaufmann Medical Building Suite 1010, 3471 Fifth Avenue, Pittsburgh, PA 15213, USA
    Unfallchirurg 110:235-42; quiz 243. 2007
    ..To avoid further compromise to soft tissue and perfusion, temporary joint and fracture stabilization is required. Definitive surgery has to be delayed until the 2 week period, starting between the fifth and tenth day after trauma...
  9. ncbi [Care of complex knee joint injuries in patients with polytrauma]
    P Kobbe
    Department of Orthopaedic Surgery, University of Pittsburgh, 3471 Fifth Avenue, Kaufmann Medical Building-Suite 1010, Pittsburgh, PA 15213, USA
    Unfallchirurg 110:245-9. 2007
  10. ncbi Patterns of cytokine release and evolution of remote organ dysfunction after bilateral femur fracture
    Philipp Kobbe
    Department of Orthopedic Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Shock 30:43-7. 2008
    ....
  11. ncbi IL-10 administration attenuates pulmonary neutrophil infiltration and alters pulmonary iNOS activation following hemorrhagic shock
    P Kobbe
    Department of Orthopaedic Surgery, University of Pittsburgh, PA, USA
    Inflamm Res 58:170-4. 2009
    ..Several studies report immuno-modulatory effects of endogenous IL-10 after trauma. This study investigates the effect of IL-10 administration on systemic and pulmonary inflammation in hemorrhagic shock...
  12. ncbi [Impact of hypothermia on the severely injured patient]
    P Kobbe
    Klinik für Unfallchirurgie, Universitatsklinikum Essen, Essen, Deutschland
    Unfallchirurg 112:1055-61. 2009
    ..Therefore, hypothermic trauma patients with hemodynamic instability require aggressive rewarming...
  13. ncbi IL-10 deficiency augments acute lung but not liver injury in hemorrhagic shock
    Philipp Kobbe
    Department of Orthopaedic Surgery, University of Pittsburgh, Kaufmann Medical Building, Suite 1010, 3471 Fifth Avenue, Pittsburgh, PA 15213, USA
    Cytokine 45:26-31. 2009
    ..In contrast, no significant differences in any liver parameters were detected between IL-10 KO and C57/BL6 mice. Our data indicate that an endogenous IL-10 deficiency augments acute lung but not liver injury following hemorrhagic shock...
  14. ncbi Assessment of the clinical course with inflammatory parameters
    Hans Christoph Pape
    Department of Orthopaedic Surgery, University of Pittsburgh Medical Center, 3471 Fifth Avenue 1, 5213 Pittsburgh, PA, USA
    Injury 38:1358-64. 2007
    ..They precede the development of organ dysfunction and may be used for monitoring purposes. Among these, pro-inflammatory cytokines appear to be the most reliable parameters...
  15. ncbi New trends and techniques in open reduction and internal fixation of fractures of the tibial plateau
    V Musahl
    Department of Orthopaedic Surgery, University of Pittsburgh, Kaufmann Medical Building, Suite 1010, 3471 Fifth Avenue, Pittsburgh, Pennsylvania 15213, USA
    J Bone Joint Surg Br 91:426-33. 2009
    ..We review current surgical approaches and techniques, improved devices for internal fixation and the clinical outcome after utilisation of new methods for locked plating...
  16. ncbi [Bite injuries of the hand]
    P Lichte
    Klinik für Unfallchirurgie, Universitatsklinikum Essen, Universitat Duisburg Essen, Hufelandstrasse 55, 45147, Essen, Deutschland
    Unfallchirurg 112:719-26; quiz 727. 2009
    ..Common complications in cases of deficient primary therapy are flexor tenosynovitis, purulent arthritis, and phlegmons of the dorsal hand. These are emergencies and need immediate surgical intervention...
  17. ncbi Long term results of compartment syndrome of the lower limb in polytraumatised patients
    Michael Frink
    Department of Traumatology, Hannover Medical School, Carl Neuberg Str 1, Hannover, Germany
    Injury 38:607-13. 2007
    ..Polytraumatised patients did not suffer from worse long term effects regarding sensory or motor deficits. Associated injuries did not seem to influence the outcome of the compartment syndrome...
  18. ncbi Transgenic rat model of Huntington's disease
    Stephan von Horsten
    Department of Functional and Applied Anatomy, Hannover Medical School, Hannover, Germany
    Hum Mol Genet 12:617-24. 2003
    ..This model allows longitudinal in vivo imaging studies and is therefore ideally suited for the evaluation of novel therapeutic approaches such as neurotransplantation...