Research Topics
| Stephen A KlotzSummaryAffiliation: University of Arizona Country: USA Publications
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Publications
Antibodies to alpha5beta1 and alpha(v)beta3 integrins react with Candida albicans alcohol dehydrogenaseS A Klotz
Research Service, Southern Arizona Veterans Affairs Health Service System, Tucson, AZ, USA
Microbiology 147:3159-64. 2001..albicans and in spent growth medium. All four antibodies reacted with authentic ADH. The possible significance of these results in relation to C. albicans adherence is discussed...
Cat-scratch DiseaseStephen A Klotz
University of Arizona, Tucson, 85724, USA
Am Fam Physician 83:152-5. 2011..Infrequently, cat-scratch disease may present in a more disseminated form with hepatosplenomegaly or meningoencephalitis, or with bacillary angiomatosis in patients with AIDS...
Feeding behavior of triatomines from the southwestern United States: an update on potential risk for transmission of Chagas diseaseStephen A Klotz
Section of Infectious Diseases, University of Arizona School of Health Sciences, Tucson, AZ 85724, United States
Acta Trop 111:114-8. 2009..Thus, based on our observations, we do not believe that T. protracta and T. rubida pose an imminent risk for transmission of Chagas disease to residents of the southwestern United States...
Immune reconstitution inflammatory syndrome in a resource-poor settingStephen A Klotz
Section of Infectious Diseases, School of Health Sciences, University of Arizona, Tucson, Arizona 85724, USA
J Int Assoc Physicians AIDS Care (Chic) 8:122-7. 2009..In resource-poor settings where the primary goal is to initiate HAART, IRIS may go unrecognized and have fatal consequences...
Polymicrobial bloodstream infections involving Candida species: analysis of patients and review of the literatureStephen A Klotz
Department of Medicine, University of Arizona Health Sciences Center and Southern Arizona VA Health Care System, Tucson, AZ 85724, USA
Diagn Microbiol Infect Dis 59:401-6. 2007..This finding may have treatment implications for clinicians...
Clinical features of HIV/AIDS patients presenting to an inner city clinic in Ho Chi Minh City, VietnamStephen A Klotz
Section of Infectious Diseases, University of Arizona, Tucson, AZ 85724, USA
Int J STD AIDS 18:482-5. 2007..The various opportunistic infections seen in this resource-poor clinic setting is likely to be a pattern of presentation of HIV-infected Vietnamese for some time to come...
Candida albicans Als proteins mediate aggregation with bacteria and yeastsStephen A Klotz
University of Arizona and Southern Arizona VA Health Care System, Tucson, Arizona, USA
Med Mycol 45:363-70. 2007..cerevisiae also mediated these mixed microbial interactions. Thus the Als adhesins are potentially important for the co-adhesion of mixed microbial communities in biofilms and on mucus surfaces...
Oropharyngeal candidiasis: a new treatment optionStephen A Klotz
Section of Infectious Diseases, University of Arizona, Tucson, Arizona 85724, USA
Clin Infect Dis 42:1187-8. 2006
Inhibition of adherence and killing of Candida albicans with a 23-Mer peptide (Fn/23) with dual antifungal propertiesStephen A Klotz
Section of Infectious Diseases, Department of Medicine, University of Arizona, 1501 N Campbell Ave, Tucson, AZ 85724, USA
Antimicrob Agents Chemother 48:4337-41. 2004..albicans adherence to the peptide-coated PEG beads. This dual property of Fn/23, i.e., inhibition of adherence and killing of C. albicans, may provide important adjuvant effects in the treatment of disease caused by this fungus...
Degenerate peptide recognition by Candida albicans adhesins Als5p and Als1pStephen A Klotz
Department of Medicine, University of Arizona and Southern Arizona VA Health Care System, Tucson, Arizona 85724
Infect Immun 72:2029-34. 2004..A degenerate recognition system provides the fungi with the potential of adhering to a multitude of proteins and peptides, an advantage for any microorganism attempting to establish a commensal or pathogenic relationship with a host...
Candida albicans and Saccharomyces cerevisiae expressing ALA1/ALS5 adhere to accessible threonine, serine, or alanine patchesNand K Gaur
Research Service, VA Medical Center, Kansas City, MO, University of Kansas School of Medicine, Kansas City, KS, USA
Cell Commun Adhes 9:45-57. 2002..Thus, Ala1/Als5p recognizes patches of certain amino acids, which must be accessible before adherence will occur...
Accessibility of the peptide backbone of protein ligands is a key specificity determinant in Candida albicans SRS adherenceNand K Gaur
Research Service, University of Arizona, Tucson, AZ, USA
Microbiology 150:277-84. 2004..The proposed interactions in SRS adherence have striking similarities with those of the molecular chaperone Hsp70, which specifically binds to non-native proteins and resists denaturation...
Cat scratch disease and arthropod vectors: more to it than a scratch?Mark Mosbacher
Third World Veterinary, Fountain Hills, AZ, USA
J Am Board Fam Med 23:685-6. 2010..The absence of a vertebrate bite or scratch does not preclude infection with Bartonella henselae...
Postmortem candidaemia: marker of disseminated diseaseJennifer L Thorn
Department of Pathology, University of Arizona, Tucson, Arizona 85724, USA
J Clin Pathol 63:337-40. 2010..This article describes the findings of autopsy patients with postmortem candidaemia and it compares them with findings in autopsy patients with antemortem candidaemia...
Medical errors arising from outsourcing laboratory and radiology servicesBrian S Chasin
Section of Infectious Diseases, Department of Medicine, University of Arizona, Tucson, AZ 85724, USA
Am J Med 120:819.e9-11. 2007..Document errors and the nuisance factor inherent in the informational exchange that occurs with the outsourcing of laboratory and radiology examinations...
Abdominal and pelvic coccidioidomycosisGeoffrey Smith
Section of Infectious Diseases, University of Arizona College of Medicine, Tucson, Arizona, USA
Am J Med Sci 341:308-11. 2011..Pathologists played a critical role in the diagnosis of these presentations by recognizing spherules in tissue. In only 2 of the cases were Coccidioides species cultured...
The older HIV-positive adult: a critical review of the medical literatureClifford P Martin
Section of Infectious Diseases, University of Arizona Health Sciences Center, Tucson, AZ 85724, USA
Am J Med 121:1032-7. 2008..Despite these facts, there is mounting evidence that timely diagnosis and treatment of HIV in older adults leads to improved outcomes, similar to younger patients. This review evaluates the literature focusing on HIV and older adults...
Global cell surface conformational shift mediated by a Candida albicans adhesinJason M Rauceo
Department of Biology, Hunter College, 695 Park Ave, New York, NY 10021, USA
Infect Immun 72:4948-55. 2004..These results suggest a model for Als5p-mediated aggregation in which an adhesion-triggered change in the conformation of Als5p propagates around the cell surface, forming ordered aggregation-competent regions...
Threonine-rich repeats increase fibronectin binding in the Candida albicans adhesin Als5pJason M Rauceo
Dept. of Biology, Brooklyn College, 2900 Bedford Ave, Brooklyn, NY 11210, USA
Eukaryot Cell 5:1664-73. 2006..Thus, the TR region of Als5p modulated the structure of the Ig-T region, augmented cell adhesion activity through increased binding to mammalian ligands, and simultaneously promoted fungal cell-cell interactions...
