Jonathan Kipnis

Summary

Affiliation: University of Virginia
Country: USA

Publications

  1. ncbi Immunity and cognition: what do age-related dementia, HIV-dementia and 'chemo-brain' have in common?
    Jonathan Kipnis
    Department of Neuroscience, University of Virginia, Charlottesville, VA 22908, USA
    Trends Immunol 29:455-63. 2008
  2. ncbi Alternatively activated myeloid (M2) cells enhance cognitive function in immune compromised mice
    Noel C Derecki
    Graduate Program in Neuroscience, Department of Neuroscience, University of Virginia, Charlottesville, VA 22908, USA
    Brain Behav Immun 25:379-85. 2011
  3. ncbi Phagocytic activity of neuronal progenitors regulates adult neurogenesis
    Zhenjie Lu
    Department of Neuroscience, University of Virginia, Charlottesville, Virginia 22901, USA
    Nat Cell Biol 13:1076-83. 2011
  4. ncbi Regulatory T cells in CNS injury: the simple, the complex and the confused
    James T Walsh
    Neuroscience Graduate Program and Medical Scientist Training Program, Department of Neuroscience, University of Virginia, Charlottesville, VA 22908, USA
    Trends Mol Med 17:541-7. 2011
  5. ncbi Thrombospondin 1--a key astrocyte-derived neurogenic factor
    Zhenjie Lu
    Department of Neuroscience, University of Virginia, Charlottesville, VA 22908, USA
    FASEB J 24:1925-34. 2010
  6. ncbi Regulation of learning and memory by meningeal immunity: a key role for IL-4
    Noel C Derecki
    Department of Neuroscience, University of Virginia, Charlottesville, VA 22908, USA
    J Exp Med 207:1067-80. 2010

Research Grants

  1. Regulatory T cells in central nervous system injury
    Jonathan Kipnis; Fiscal Year: 2009
  2. Meninges-to-astrocyte communication in cognitive function
    Jonathan Kipnis; Fiscal Year: 2010
  3. Regulatory T cells in central nervous system injury
    Jonathan Kipnis; Fiscal Year: 2010

Collaborators

  • Zhenjie Lu
  • Noel C Derecki
  • James T Walsh
  • Kayla M Quinnies
  • Anastasia Crihfield
  • Chun Hui Yang
  • Kevin R Lynch
  • Amber N Cardani

Detail Information

Publications6

  1. ncbi Immunity and cognition: what do age-related dementia, HIV-dementia and 'chemo-brain' have in common?
    Jonathan Kipnis
    Department of Neuroscience, University of Virginia, Charlottesville, VA 22908, USA
    Trends Immunol 29:455-63. 2008
    ..We discuss candidate mechanisms underlying T cell-mediated control of cognitive function in human cognitive diseases associated with immune decline, such as age- and HIV-related dementias, 'chemo-brain' and others...
  2. ncbi Alternatively activated myeloid (M2) cells enhance cognitive function in immune compromised mice
    Noel C Derecki
    Graduate Program in Neuroscience, Department of Neuroscience, University of Virginia, Charlottesville, VA 22908, USA
    Brain Behav Immun 25:379-85. 2011
    ..These results might lead to development of new therapeutic approaches for cognitive pathologies associated with malfunction of adaptive immunity, such as chemo-brain, age-related dementia, HIV-dementia, and others...
  3. ncbi Phagocytic activity of neuronal progenitors regulates adult neurogenesis
    Zhenjie Lu
    Department of Neuroscience, University of Virginia, Charlottesville, Virginia 22901, USA
    Nat Cell Biol 13:1076-83. 2011
    ..Collectively, these findings indicate a paradigm wherein DCX(+) neuronal precursors also serve as phagocytes, and that their phagocytic activity critically contributes to neurogenesis in the adult brain...
  4. ncbi Regulatory T cells in CNS injury: the simple, the complex and the confused
    James T Walsh
    Neuroscience Graduate Program and Medical Scientist Training Program, Department of Neuroscience, University of Virginia, Charlottesville, VA 22908, USA
    Trends Mol Med 17:541-7. 2011
    ..In this piece, we explore how the immunology of neurodegeneration differs from that of cancer and autoimmunity and how these differences create confusion about the role of Tregs in neurodegenerative conditions...
  5. ncbi Thrombospondin 1--a key astrocyte-derived neurogenic factor
    Zhenjie Lu
    Department of Neuroscience, University of Virginia, Charlottesville, VA 22908, USA
    FASEB J 24:1925-34. 2010
    ..Our data demonstrate that TSP1 is a critical participant in maintenance of the adult NPC pool and in neuronal differentiation...
  6. ncbi Regulation of learning and memory by meningeal immunity: a key role for IL-4
    Noel C Derecki
    Department of Neuroscience, University of Virginia, Charlottesville, VA 22908, USA
    J Exp Med 207:1067-80. 2010
    ..These findings might lead to the development of new immune-based therapies for cognitive impairment associated with immune decline...

Research Grants3

  1. Regulatory T cells in central nervous system injury
    Jonathan Kipnis; Fiscal Year: 2009
    ..In this research proposal we aim to understand the role of regulatory T-lymphocytes in CNS injury, which might help to develop new therapeutic strategies for CNS injuries based on modulation of these cells. ..
  2. Meninges-to-astrocyte communication in cognitive function
    Jonathan Kipnis; Fiscal Year: 2010
    ..This understanding has the potential to define novel therapeutic targets for several forms of cognitive decline. ..
  3. Regulatory T cells in central nervous system injury
    Jonathan Kipnis; Fiscal Year: 2010
    ..In this research proposal we aim to understand the role of regulatory T-lymphocytes in CNS injury, which might help to develop new therapeutic strategies for CNS injuries based on modulation of these cells. ..