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Genomes and Genes | J KimbleSummaryAffiliation: University of Wisconsin Country: USA Publications
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Publications
The LIN-12/Notch signaling pathway and its regulationJ Kimble
Department of Biochemistry and Medical Genetics, University of Wisconsin Madison, USA
Annu Rev Cell Dev Biol 13:333-61. 1997..The existence of multiple ligands and receptors may have evolved from the stringent demands placed upon the regulation of genes encoding them...- Notch/LIN-12 signaling: transduction by regulated protein slicingJ Kimble
Dept of Biochemistry, University of Wisconsin Madison, USA
Trends Biochem Sci 23:353-7. 1998..Ligand binding appears to permit proteolysis of the receptor; as a result, the receptor's intracellular domain can enter the nucleus and function as a transcriptional co-activator... - gon-4, a cell lineage regulator required for gonadogenesis in Caenorhabditis elegansL Friedman
Department of Biochemistry, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
Dev Biol 228:350-62. 2000..We conclude that gon-4 is a regulator of the early lineage of Z1 and Z4 and suggest that it is a part of a genetic program common to the regulation of both hermaphrodite and male gonadogenesis... - The sys-1 gene and sexual dimorphism during gonadogenesis in Caenorhabditis elegansJ Miskowski
Department of Biochemistry, Howard Hughes Medical Institute, University of Wisconsin Madison, 433 Babcock Drive, Madison, Wisconsin 53706, USA
Dev Biol 230:61-73. 2001..We conclude that the primary role of sys-1 is to establish the shape and polarity of the hermaphrodite gonad... - LAG-3 is a putative transcriptional activator in the C. elegans Notch pathwayA G Petcherski
Howard Hughes Medical Institute and Department of Biochemistry, University of Wisconsin Madison, 53706, USA
Nature 405:364-8. 2000..elegans. We propose that GLP-1 and LIN-12 promote signalling by recruiting LAG-3 to target promoters, where it functions as a transcriptional activator... - Control of organ shape by a secreted metalloprotease in the nematode Caenorhabditis elegansR Blelloch
Program in Cell and Molecular Biology, University of Wisconsin Madison, 53706, USA
Nature 399:586-90. 1999..We speculate that GON-1 controls morphogenesis by remodelling basement membranes and that regulation of its activity is crucial for achieving organ shape... - CPEB proteins control two key steps in spermatogenesis in C. elegansC Luitjens
Program in Cell and Molecular Biology, University of Wisconsin, Madison, Wisconsin 53706, USA
Genes Dev 14:2596-609. 2000..In sum, our results demonstrate that, in C. elegans, two CPEB proteins have distinct functions in the germ line, both in spermatogenesis: FOG-1 specifies the sperm cell fate and CPB-1 executes that decision... - Mastermind is a putative activator for NotchA G Petcherski
Curr Biol 10:R471-3. 2000 - NANOS-3 and FBF proteins physically interact to control the sperm-oocyte switch in Caenorhabditis elegansB Kraemer
Department of Biochemistry University of Wisconsin Madison Madison, Wisconsin 53706, USA
Curr Biol 9:1009-18. 1999..In C. elegans, FBF is required for repression of fem-3 mRNA to achieve the hermaphrodite switch from spermatogenesis to oogenesis... - An ancient molecular mechanism for establishing embryonic polarity?J Kimble
Laboratory of Molecular Biology, Howard Hughes Medical Institute, University of Wisconsin, Madison 53706
Science 266:577-8. 1994 - More mog genes that influence the switch from spermatogenesis to oogenesis in the hermaphrodite germ line of Caenorhabditis elegansP L Graham
Department of CMS Biology, Northwestern University Medical School, Chicago, Illinois
Dev Genet 14:471-84. 1993..We further speculate that the mog-1-mog-6 mutations all interfere with translational controls of fem-3 and other maternal mRNAs... - A HECT domain ubiquitin ligase closely related to the mammalian protein WWP1 is essential for Caenorhabditis elegans embryogenesisK Huang
University of Wisconsin Medical School, Department of Pharmacology, Molecular and Cellular Pharmacology Program, 387 Medical Science Center, 1300 University Avenue, 53706, Madison, WI, USA
Gene 252:137-45. 2000..CeWWP1 must therefore have unique and nonredundant functions critical for embryogenesis... - gld-1, a tumor suppressor gene required for oocyte development in Caenorhabditis elegansR Francis
Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA
Genetics 139:579-606. 1995..This function of gld-1 is inferred from a haplo-insufficient phenotype and from the properties of gain-of-function gld-1 mutations that cause alterations in the sexual identity of germ cells... - The fog-3 gene and regulation of cell fate in the germ line of Caenorhabditis elegansR E Ellis
Howard Hughes Medical Institute, Laboratory of Molecular Biology, Madison, Wisconsin, USA
Genetics 139:561-77. 1995..Such a regulatory network would link the adoption of one germ-cell fate to the suppression of the other two... - Regulation of cell fate in Caenorhabditis elegans by a novel cytoplasmic polyadenylation element binding proteinS W Jin
Department of Biology, University of Michigan, Ann Arbor, Michigan, 48109
Dev Biol 229:537-53. 2001..Because CPEB proteins in Xenopus and Drosophila regulate gene expression at the level of translation, we propose that FOG-1 controls germ cell fates by regulating the translation of specific messenger RNAs... - Two homologous regulatory genes, lin-12 and glp-1, have overlapping functionsE J Lambie
Department of Biochemistry, College of Agriculture and Life Sciences, University of Wisconsin Madison 53706
Development 112:231-40. 1991..We speculate that the lin-12 and glp-1 proteins are biochemically interchangeable and that their divergent roles in development may rely largely on differences in gene expression...