Research Topics
| William KennedySummaryAffiliation: University of Minnesota Country: USA Publications
Research Grants
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Detail Information
Publications
A new device to quantify tactile sensation in neuropathyW R Kennedy
Department of Neurology, School of Medicine, University of Minnesota, Minneapolis, USA
Neurology 76:1642-9. 2011..To devise a rapid, sensitive method to quantify tactile threshold of finger pads for early detection and staging of peripheral neuropathy and for use in clinical trials...- A randomized, controlled, open-label study of the long-term effects of NGX-4010, a high-concentration capsaicin patch, on epidermal nerve fiber density and sensory function in healthy volunteersWilliam R Kennedy
Department of Neurology, University of Minnesota, Minneapolis, Minnesota 55455, USA
J Pain 11:579-87. 2010..The results help predict the long-term safety of NGX-4010 applications in patients... - Unmyelinated nerves, challenges, and opportunities: skin biopsy and beyondWilliam R Kennedy
Department of Neurology, University of Minnesota, MMC 187, 420 Delaware St. SE, Minneapolis, MI 55455, USA
Suppl Clin Neurophysiol 57:8-14. 2004 - Degranulated mast cells in the skin of adults with self-injurious behavior and neurodevelopmental disordersFrank J Symons
Department of Educational Psychology, University of Minnesota, 56 River Road, Minneapolis, MN 55455, USA
Brain Behav Immun 23:365-70. 2009..Thus, nociceptive mechanisms and peripheral afferent sensitization may play a part in mediating and maintaining chronic self-injury... - Variation in quantitative sensory testing and epidermal nerve fiber density in repeated measurementsMona M Selim
Department of Neurology, University of Minnesota, Minneapolis, MN 55455, USA
Pain 151:575-81. 2010..18 ENFs/mm). Since some individuals had large unsystematic variations, unexpected test results should therefore alert clinicians to test additional locations... - Mucosal nerve deficiency in chronic childhood constipation: a postmigration defect?Gwen Wendelschafer-Crabb
Department of Neurology, University of Minnesota Medical School, Minneapolis, MN 55455, USA
J Pediatr Surg 44:773-82. 2009..These children are distinguished from those with Hirschsprung's disease (HSCR) by the presence of enteric ganglia in rectal biopsy specimens. We investigated potential autonomic dysfunction by examining nerves in rectal mucosa... - Skin blister and skin biopsy to quantify epidermal nerves: a comparative studyIoanna G Panoutsopoulou
Department of Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA
Neurology 72:1205-10. 2009..The suction skin blister is an alternative, less invasive method to visualize and quantify ENFs. The blister roof provides an integrated bird's eye view of all ENFs within one tissue specimen... - Stimulated growth of human and pig epidermal nerve fibers by tape strippingMona M Selim
Department of Neurology, University of Minnesota, Minneapolis, MN 55455, USA
Arch Dermatol Res 299:513-6. 2007..This study demonstrates that changing the cellular and chemical environment of nerves by tape stripping is a feasible method to study nerve fiber growth in a physiological manner... - Opportunities afforded by the study of unmyelinated nerves in skin and other organsWilliam R Kennedy
Department of Neurology, University of Minnesota Hospital, MMC 187, 420 Delaware Street SE, Minneapolis, Minnesota 55455 0374, USA
Muscle Nerve 29:756-67. 2004..The new ability to examine the great variety of nerves in different organs opens opportunities and creates challenges and responsibilities for neurologists and neuroscientists... - Concordance between epidermal nerve fiber density and sensory examination in patients with symptoms of idiopathic small fiber neuropathyDavid Walk
Department of Neurology, University of Minnesota, Minneapolis 55455, United States
J Neurol Sci 255:23-6. 2007..Our findings indicate that ENF density determination is a clinically relevant objective test in patients undergoing evaluation for possible SFN... - Re-organization of P2X3 receptor localization on epidermal nerve fibers in a murine model of cancer painLaura S Gilchrist
Physical Therapy Program, College of St. Catherine, Minneapolis, MN 55454, USA
Brain Res 1044:197-205. 2005..These studies demonstrate increased expression of P2X3 receptors on CGRP-ir ENFs during tumor growth and suggest a role for ATP in cancer-related pain... - Assessing function and pathology in familial dysautonomia: assessment of temperature perception, sweating and cutaneous innervationMax J Hilz
Department of Neurology, New York University Medical Center, 550 First Avenue, Suite NB 7W11, New York, NY, 10016, USA
Brain 127:2090-8. 2004..Decreased SP and CGRP-ir nerves suggest that the FD gene mutation causes secondary neurotransmitter depletions. Empty Schwann cell sheaths and VIP-ir nerves suggest active denervation and regeneration... - Confocal microscopy study of nerves and blood vessels in untreated and treated port wine stains: preliminary observationsMona M Selim
Department of Dermatology, University of Minnesota, Minneapolis, Minnesota, USA
Dermatol Surg 30:892-7. 2004..PWS blood vessel size correlated with pulsed dye laser response and may prove to be a useful prognostic indicator of therapeutic outcome... - Anatomical evidence for enteric neuroimmune interactions in Peyer's patchesLucy Vulchanova
Department of Veterinary and Biomedical Sciences, University of Minnesota, 1988 Fitch Avenue, St Paul, Minnesota 55108 6010, USA
J Neuroimmunol 185:64-74. 2007..The results suggest that nerve fibers in PP may participate in neuroimmune cross-talk within individual antigen-sampling sites as well as integrate information across multiple antigen-sampling sites... - Evidence of altered epidermal nerve fiber morphology in adults with self-injurious behavior and neurodevelopmental disordersFrank J Symons
Department of Educational Psychology, University of Minnesota, Minneapolis, MN 55455, USA
Pain 134:232-7. 2008..Additional empirical work is needed to clarify the relation between sensory innervation of the skin and self-injury to improve assessment and treatment outcomes... - Histopathologic findings in primary erythromelalgia are nonspecific: special studies show a decrease in small nerve fiber densityMark D P Davis
Department of Dermatology, Mayo Clinic, Rochester, MN 55905, USA
J Am Acad Dermatol 55:519-22. 2006..Histopathologic findings were nonspecific. Vascular thrombi were not identified. A relative decrease in small nerve fiber density was noted in specimens from 13 of 16 patients... - Distal spinal and bulbar muscular atrophy caused by dynactin mutationImke Puls
Neurogenetics Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892-1416, USA
Ann Neurol 57:687-94. 2005..This mutation of dynactin, a ubiquitously expressed protein, causes a unique pattern of motor neuron degeneration that is associated with the accumulation of dynein and dynactin in neuronal inclusions...
Research Grants
- A THERMAL PROBE METHOD FOR STAGING DIABETIC NEUROPATHYWilliam Kennedy; Fiscal Year: 2002..abstract_text> ..
- METHODS TO DIAGNOSE AND EVALUATE THERAPY FOR DIABETESWilliam Kennedy; Fiscal Year: 2001..If NGF can enhance reinnervation in the skin wound these methods may be useful to evaluate the results of clinical therapeutic trials. ..