Research Topics
| David A KaufmanSummaryAffiliation: University of Virginia Country: USA Publications
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Detail Information
Publications
Decreased superoxide production, degranulation, tumor necrosis factor alpha secretion, and CD11b/CD18 receptor expression by adherent monocytes from preterm infantsD Kaufman
Division of Neonatology, Department of Pediatrics, University of Pennsylvania School of Medicine, The Children s Hospital of Philadelphia, Joseph Stokes Jr Research Institute, Philadelphia, Pennsylvania 19104 4399, USA
Clin Diagn Lab Immunol 6:525-9. 1999..We speculate that monocyte adherence factors may be important in the modulation of immune responses in preterm infants...- Strategies to prevent invasive candidal infection in extremely preterm infantsDavid A Kaufman
Division of Neonatology, Department of Pediatrics, University of Virginia School of Medicine, Box 800386, Charlottesville, VA 22903, USA
Clin Perinatol 37:611-28. 2010..The greatest impact of antifungal prophylaxis preventing ICI and decreasing Candida-related mortality and neurodevelopmental impairment would be achieved with a universal approach in all NICUs... - Challenging issues in neonatal candidiasisDavid A Kaufman
Department of Pediatrics, Division of Neonatology, University of Virginia School of Medicine, Charlottesville, VA, USA
Curr Med Res Opin 26:1769-78. 2010..Evaluation of ICI incidence and mortality by gestational age and birth week should be followed in each NICU, to evaluate infection control and prevention... - Fluconazole prophylaxis: can we eliminate invasive Candida infections in the neonatal ICU?David A Kaufman
Department of Pediatrics, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
Curr Opin Pediatr 20:332-40. 2008.... - Fungal infections in neonates: update on prevention and treatmentD A Kaufman
Department of Pediatrics, University of Virginia School of Medicine Charlottesville, VA 22908, USA
Minerva Ginecol 59:311-29. 2007..Liposomal amphotericin formulations and echinochandins are currently being studied in neonates. Prevention for high risk patients is now feasible with fluconazole prophylaxis... - Patterns of fungal colonization in preterm infants weighing less than 1000 grams at birthDavid A Kaufman
Department of Pediatrics, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
Pediatr Infect Dis J 25:733-7. 2006..ELBW infants are at a higher risk than VLBW infants for fungal sepsis and its associated mortality, but few studies have examined fungal colonization exclusively in ELBW infants... - Veronate (Inhibitex)David Kaufman
University of Virginia Health System, Department of Pediatrics, Charlottesville 22908, USA
Curr Opin Investig Drugs 7:172-9. 2006..Phase III clinical trials of Veronate are ongoing... - Fluconazole prophylaxis in extremely low birth weight infants and neurodevelopmental outcomes and quality of life at 8 to 10 years of ageDavid A Kaufman
Pediatrics, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
J Pediatr 158:759-765.e1. 2011..To examine the long-term effects of fluconazole prophylaxis in extremely low birth weight infants... - Twice weekly fluconazole prophylaxis for prevention of invasive Candida infection in high-risk infants of <1000 grams birth weightDavid Kaufman
Department of Pediatrics, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
J Pediatr 147:172-9. 2005..We tested the hypothesis that twice weekly prophylactic dosing of fluconazole prevents invasive candidiasis without promoting resistant Candida species in high-risk, preterm infants... - Fluconazole prophylaxis against fungal colonization and infection in preterm infantsD Kaufman
Department of Pediatrics, University of Virginia School of Medicine, Charlottesville, USA
N Engl J Med 345:1660-6. 2001..We evaluated the efficacy of prophylactic fluconazole in preventing fungal colonization and invasive infection in extremely-low-birth-weight infants... - Population pharmacokinetics of fluconazole in young infantsK C Wade
Department of Pediatrics, Division of Neonatology, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
Antimicrob Agents Chemother 52:4043-9. 2008..This population PK model of fluconazole discriminated the impact of BGA, PNA, and creatinine on drug CL. Our data suggest that dosing in young infants will require adjustment for BGA and PNA to achieve targeted systemic drug exposures... - Clinical microbiology of bacterial and fungal sepsis in very-low-birth-weight infantsDavid Kaufman
Department of Pediatrics, Division of Neonatology, P O Box 800386, University of Virginia Health System, 3768 Old Medical School, Hospital Drive, Charlottesville, VA 22908, USA
Clin Microbiol Rev 17:638-80, table of contents. 2004..Identification of the differences in neonatal intensive care units with low and high infection rates and implementation of infection control measures remain paramount in each neonatal intensive care unit caring for preterm infants... - Fungal infection in the very low birthweight infantDavid Kaufman
Department of Pediatrics, Division of Neonatology, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
Curr Opin Infect Dis 17:253-9. 2004..A better understanding of the adherence factors, molecular diagnostics and risk factors for invasive fungal infection are important in treatment and prevention... - Strategies for prevention of neonatal invasive candidiasisDavid Kaufman
Department of Pediatrics, University of Virginia School of Medicine, Charlottesville, VA, USA
Semin Perinatol 27:414-24. 2003..Effective prophylaxis strategies will decrease the high mortality and morbidity associated with fungal infection in high risk infants... - Fluconazole dosing for the prevention or treatment of invasive candidiasis in young infantsKelly C Wade
Department of Pediatrics, Children s Hospital of Philadelphia, Philadelphia, PA, USA
Pediatr Infect Dis J 28:717-23. 2009..Fluconazole is increasingly used to prevent and treat invasive candidiasis in infants. Dosing guidance remains empiric and variable because limited pharmacokinetic data exist... - Moderate hypothermia in neonatal encephalopathy: efficacy outcomesDorothea J Eicher
Department of Pediatrics, Medical University of South Carolina, Charleston, South Carolina 29425, USA
Pediatr Neurol 32:11-7. 2005..019). Although these results need to be validated in a large clinical trial, this pilot trial provides important data for clinical trial design of hypothermia treatment in neonatal hypoxic-ischemic injury... - Cytokine elaboration in critically ill infants with bacterial sepsis, necrotizing entercolitis, or sepsis syndrome: correlation with clinical parameters of inflammation and mortalityMary Catherine Harris
Division of Neonatology, Department of Pediatrics, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine Philadelphia, Pennsylvania 19104, USA
J Pediatr 147:462-8. 2005.... - Prevention of invasive Candida infections in preterm infants: the time is nowDavid A Kaufman
Expert Rev Anti Infect Ther 6:393-9. 2008