Research Topics
Species | Jason H T KarlawishSummaryAffiliation: University of Pennsylvania Country: USA Publications
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Publications
How do AD patients and their caregivers decide whether to enroll in a clinical trial?J H Karlawish
Department of Medicine, The University of Pennsylvania, Philadelphia, USA
Neurology 56:789-92. 2001....- Diagnostic evaluation of elderly patients with mild memory problemsJason H T Karlawish
University of Pennsylvania, Philadelphia, Pennsylvania, USA
Ann Intern Med 138:411-9. 2003..In addition, symptoms of memory problems may be reported by an observer rather than by the patient. These challenges warrant stepwise evaluation of elderly patients who present with symptoms of memory loss... - The ability of persons with Alzheimer disease (AD) to make a decision about taking an AD treatmentJ H T Karlawish
Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA
Neurology 64:1514-9. 2005.... - Addressing the ethical, legal, and social issues raised by voting by persons with dementiaJason H Karlawish
Department of Medicine, Center for Bioethics, Institute on Aging, University of Pennsylvania, Philadelphia 19104, USA
JAMA 292:1345-50. 2004..In some instances, extrapolation from existing policies and research permits reasonable recommendations to guide policy and practice. However, in other instances, additional research is necessary... - Alzheimer's disease patients' and caregivers' capacity, competency, and reasons to enroll in an early-phase Alzheimer's disease clinical trialJason H T Karlawish
Department of Medicine, Division of Geriatrics, University of Pennsylvania, Philadelphia, USA
J Am Geriatr Soc 50:2019-24. 2002..To examine the capacity, competency, and reasons for enrolling of patients with Alzheimer's disease (AD) and of their caregivers in an early phase AD clinical trial... - Addressing the challenges of transforming laboratory advances into Alzheimer's Disease treatmentsJason H T Karlawish
Department of Medicine, Division of Geriatrics, Alzheimer s Disease Center, Center for Bioethics and Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia 19104, USA
Neurobiol Aging 23:1043-9. 2002..In this model, the patient and caregiver are seen as interrelated subjects of both treatment and research and outcome measures reflect biomarkers of the disease, the functional morbidity of AD and the distress of caregiving... - Competency in the age of assessmentJason H T Karlawish
Institute on Aging, Philadelphia, PA 19104, USA
Lancet 364:1383-4. 2004 - How changes in health care practices, systems, and research challenge the practice of informed consentJason H T Karlawish
Department of Medicine, Division of Geriatric Medicine, University of Pennsylvania, Alzheimer s Disease Center, Philadelphia, Pennsylvania, USA
Med Care 40:V12-9. 2002..As a result, efforts to promote patient choice should attend to the ethical decision-making processes of institutions that create and sustain this perspective... - Do persons with dementia vote?J H T Karlawish
Department of Medicine, Division of Geriatrics, University of Pennsylvania, Philadelphia 19104, USA
Neurology 58:1100-2. 2002..Further research is needed to understand how persons with dementia and their caregivers decide what activities the person can and cannot continue and how well these decisions correspond to measures of competency... - Why would caregivers not want to treat their relative's Alzheimer's disease?Jason H T Karlawish
Department of Medicine, University of Pennsylvania, Philadelphia, USA
J Am Geriatr Soc 51:1391-7. 2003..To determine family caregivers' willingness to use Alzheimer's disease (AD)-slowing medicines and to examine the relationships between this willingness, dementia severity, and caregiver characteristics... - How does an Alzheimer's disease patient's role in medical decision making change over time?Karen B Hirschman
Department of Medicine, School of Social Work, University of Pennsylvania, 3615 Chestnut Street, Philadelphia, PA 19104, USA
J Geriatr Psychiatry Neurol 17:55-60. 2004..These results provide clinicians with prognostic information that can help caregivers understand how their role in decision making will change over the course of a patient's dementing illness... - Would caregivers of Alzheimer disease patients involve their relative in a decision to use an AD-slowing medication?Karen B Hirschman
Division of Biobehavioral and Health Sciences, The Univ of Pennsylvania, School of Nursing, Philadelphia, PA, USA
Am J Geriatr Psychiatry 13:1014-21. 2005.... - Empirical assessment of whether moderate payments are undue or unjust inducements for participation in clinical trialsScott D Halpern
Department of Medicine, Centers for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, USA
Arch Intern Med 164:801-3. 2004..Paying patients to participate in clinical trials is ethically controversial. However, there has been no empirical documentation regarding whether payment represents an undue or unjust inducement... - Identifying ambulatory cancer patients at risk of impaired capacity to consent to researchDavid J Casarett
Center for Health Equity Research and Promotion, Philadelphia Veterans Affairs Medical Center and the Department of Medicine, Division of Geriatrics, Leonard Davis Institute of Health Economics, University of Pennsylvania School of Medicine, USA
J Pain Symptom Manage 26:615-24. 2003..These data suggest that several patient characteristics, such as age, education, and tests of cognitive functions, may help investigators to identify patients with impaired capacity to give consent for research... - Living with dementia: caregiver perspectivesJason H T Karlawish
University of Pennsylvania, USA
LDI Issue Brief 7:1-4. 2002..This Issue Brief summarizes a series of studies that describe how caregivers make decisions for AD patients, and caregiver perspectives on the quality of life for relatives with AD... - Relationship between Alzheimer's disease severity and patient participation in decisions about their medical careJason H T Karlawish
Department of Medicine, University of Pennsylvania, Philadelphia, USA
J Geriatr Psychiatry Neurol 15:68-72. 2002..Beyond mild-stage disease, the clinician can largely expect that the caregiver is making the final decisions. These results illustrate how and when caregivers can expect changes in their decision making role... - Hypertensive patients' willingness to participate in placebo-controlled trials: implications for recruitment efficiencyScott D Halpern
Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
Am Heart J 146:985-92. 2003.... - How do patients with Alzheimer disease rate their overall quality of life?Bryan D James
Department of Medicine, Institute on Aging, 3615 Chestnut Street, Philadelphia, PA 19104, USA
Am J Geriatr Psychiatry 13:484-90. 2005..The authors asked how Alzheimer disease (AD) patients assess their overall quality of life (QOL) and sought to determine the characteristics associated with this assessment... - Do Alzheimer's disease patients want to participate in a treatment decision, and would their caregivers let them?Karen B Hirschman
Institute on Aging, 3615 Chestnut Street, Philadelphia, PA 19104, USA
Gerontologist 45:381-8. 2005.... - Why doesn't a family member of a person with advanced dementia use a substituted judgment when making a decision for that person?Karen B Hirschman
School of Nursing, Division of Biobehavioral and Health Sciences, Institute on Aging, University of Pennsylvania, 3615 Chestnut Street, Philadelphia, PA 19104, USA
Am J Geriatr Psychiatry 14:659-67. 2006..The objective of this study was to identify what standard of decision making a family member uses when making medical decisions for their relative with advanced dementia... - Identifying the barriers and challenges to voting by residents in nursing homes and assisted living settingsJason H T Karlawish
University of Pennsylvania Institute of Aging, Philadelphia, PA 19104, USA
J Aging Soc Policy 20:65-79. 2008.... - Identifying the factors that facilitate or hinder advance planning by persons with dementiaKaren B Hirschman
School of Nursing, Division of Biobehavioral and Health Sciences, University of Pennsylvania, Philadelphia, PA 19104, USA
Alzheimer Dis Assoc Disord 22:293-8. 2008..The most common form of active avoidance was avoiding the discussion (53%). These data suggest potentially remediable strategies to address barriers to advance planning discussions... - Rate of decline in Alzheimer disease measured by a Dementia Severity Rating ScaleSharon X Xie
Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, 423 Guardian Drive, Philadelphia, PA 19104 6021, USA
Alzheimer Dis Assoc Disord 23:268-74. 2009..To measure clinically relevant change in Alzheimer disease (AD) using a family member-completed Dementia Severity Rating Scale (DSRS) questionnaire... - Must patients with advanced cancer choose between a Phase I trial and hospice?David J Casarett
Center for Health Equity Research and Promotion at the Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania, USA
Cancer 95:1601-4. 2002..However, it is not known whether dual enrollment in a Phase I trial and hospice is feasible... - The development of a rapid screen for caregiver burdenKaren B Hirschman
School of Nursing, University of Pennsylvania, Philadelphia, Pennsylvania, USA
J Am Geriatr Soc 52:1724-9. 2004..To develop a shortened screen for burden associated with caring for a patient with Alzheimer's disease (AD)... - Conducting research that involves subjects at the end of life who are unable to give consentJason H T Karlawish
Department of Medicine, Division of Geriatric Medicine, Ralston-Penn Center, University of Pennsylvania, Rm. 234, 3615 Chestnut Street, Philadelphia, PA 19104-2676, USA
J Pain Symptom Manage 25:S14-24. 2003..These conditions are: (1) acceptable research risks, (2) proxy decision making, (3) subject assent and dissent, and (4) subject advance consent... - Alzheimer disease: current concepts and emerging diagnostic and therapeutic strategiesChristopher M Clark
Memory Disorders Clinic, Penn-Ralston Center, University of Pennsylvania, 3615 Chestnut Street, Philadelphia, Pennsylvania 19104, USA
Ann Intern Med 138:400-10. 2003..If these new therapies are successful, they will represent a remarkable medical advance for patients and the families who care for them... - Are depressed patients more likely to share health care decisions with others?Molly Collins
School of Arts and Sciences, Philadelphia VA Medical Center, Philadelphia, Pennsylvania, USA
J Palliat Med 7:527-32. 2004..Health care providers should be alert to this possibility, particularly when the decision at hand is significant... - Advocacy and activism: missing pieces in the quest to improve end-of-life careDavid J Casarett
The Center for Health Equity Research and Promotion, Philadelphia Veterans Affairs Medical Center, University of Pennsylvania 19104, USA
J Palliat Med 5:3-12. 2002..We discuss some of the reasons for this lack of response, and propose ways in which providers and funding agencies can work with patients and their families to improve end-of-life care... - Hospital protocols for the inpatient care of older adults: results from a statewide surveyMark D Neuman
Robert Wood Johnson Foundation Clinical Scholars Program, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Am Geriatr Soc 58:1959-64. 2010..To assess the prevalence of protocols or guidelines for selected domains of inpatient care for older adults; to explore associations between hospital characteristics and adoption of these guidelines or protocols... - Observed association between antidepressant use and pneumonia risk was confounded by comorbidity measuresSean Hennessy
Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
J Clin Epidemiol 60:911-8. 2007..A prior study suggested that antidepressants might increase the risk of hospitalization for pneumonia in the elderly. This study sought to confirm or refute this hypothesis... - Caregivers' assessments of preference-based quality of life in Alzheimer's diseaseJason H Karlawish
Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA
Alzheimers Dement 4:203-11. 2008.... - Novel ubiquitin neuropathology in frontotemporal dementia with valosin-containing protein gene mutationsMark S Forman
Department of Pathology, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
J Neuropathol Exp Neurol 65:571-81. 2006..Our findings are consistent with the hypothesis that the pathology associated with VCP gene mutations is the result of impairment of ubiquitin-based degradation pathways... - Preference-based quality of life in patients with Alzheimer's diseaseJason H Karlawish
Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA
Alzheimers Dement 4:193-202. 2008.... - How should we use age to ration health care? Lessons from the case of kidney transplantationPETER P REESE
Renal Division, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
J Am Geriatr Soc 58:1980-6. 2010..This article argues that attempts to use HTA for healthcare rationing are likely to disadvantage older patients. Guiding principles to help ensure that resources such as kidneys are justly allocated across the life span are proposed... - Design of comprehensive Alzheimer's disease centers to address unmet national needsJohn Q Trojanowski
Institute on Aging, Philadelphia, PA, USA
Alzheimers Dement 6:150-5. 2010..The intent of this position paper is to stimulate thinking and foster the development of other or alternative models for a systematic approach to the study of dementia and movement disorders... - The relationship between short-term mortality and quality of care for hip fracture: a meta-analysis of clinical pathways for hip fractureMark D Neuman
Robert Wood Johnson Foundation Clinical Scholars Program, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Am Geriatr Soc 57:2046-54. 2009..To assess the association between use of clinical pathways for hip fracture and changes in the rates of five inpatient complications and short-term mortality... - The continuing unethical conduct of underpowered clinical trialsScott D Halpern
Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, 108 Blockley Hall, 423 Guardian Dr, Philadelphia, PA 19104 6021, USA
JAMA 288:358-62. 2002..In both cases, investigators must inform prospective subjects that their participation may only indirectly contribute to future health care benefits... - Cognitive function assessment in individuals at risk for Alzheimer's diseaseValerie T Cotter
Adult Health and Gerontology Nurse Practitioner Programs, School of Nursing, Alzheimer's Disease Center, University of Pennsylvania, USA
J Am Acad Nurse Pract 15:79-86. 2003.... - Research involving cognitively impaired adultsJason H T Karlawish
Department of Medicine, Division of Geriatric Medicine, The Institute on Aging, The Leonard Davis Institute of Health Economics, the Center for Bioethics, University of Pennsylvania, Philadelphia, USA
N Engl J Med 348:1389-92. 2003 - Who can speak for the emergently ill? Testing a method to identify communities and their leadersRaina M Merchant
Department of Emergency Medicine, Leonard Davis Institute of Health Economics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Acad Emerg Med 15:581-3. 2008..We sought to determine if people could identify communities and leaders of those communities who researchers should consult with to represent their views about research that requires an exception from informed consent... - Frontotemporal dementia: clinicopathological correlationsMark S Forman
Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-4283, USA
Ann Neurol 59:952-62. 2006.... - Self-reported distress after cognitive testing in patients with Alzheimer's diseaseJames M Lai
University of Pennsylvania Institute on Aging, 3615 Chestnut Street, Philadelphia, PA 19104, USA
J Gerontol A Biol Sci Med Sci 63:855-9. 2008..It is also unknown whether this level of distress is at all related to specific patient factors, test performance, or awareness of test performance... - Decisional capacity for research participation in individuals with mild cognitive impairmentAngela L Jefferson
Department of Neurology, Alzheimer s Disease Center, School of Medicine, University of Massachusetts at Boston, Boston, Massachusetts 02118, USA
J Am Geriatr Soc 56:1236-43. 2008..To assess decisional capacity performance and the neuropsychological correlates of such performance to better understand higher-level instrumental activities of daily living in individuals with mild cognitive impairment (MCI)... - Trends in the prevalence and mortality of cognitive impairment in the United States: is there evidence of a compression of cognitive morbidity?Kenneth M Langa
Division of General Medicine, Department of Medicine, University of Michigan, Ann Arbor, MI, USA
Alzheimers Dement 4:134-44. 2008..To assess the impact of these multiple trends, we compared the prevalence and 2-year mortality of cognitive impairment (CI) consistent with dementia in the United States in 1993 to 1995 and 2002 to 2004... - Characterization of activities of daily living in individuals with mild cognitive impairmentAngela L Jefferson
Department of Neurology, Alzheimer s Disease Center, Boston University School of Medicine, Boston, MA 02118 2526, USA
Am J Geriatr Psychiatry 16:375-83. 2008.... - Current state of research on decision-making competence of cognitively impaired elderly personsScott Y H Kim
Department of Psychiatry, Division of Medical Humanities, University of Rochester School of Medicine, NY 14642, USA
Am J Geriatr Psychiatry 10:151-65. 2002..It is beginning to yield findings with practical implications for preserving the autonomy and welfare of this group of vulnerable elderly patients... - A taxonomy of value in clinical researchDavid J Casarett
VA Center for Health Equity Research and Promotion, USA
IRB 24:1-6. 2002 - Donepezil delay to nursing home placement study is flawedJason H T Karlawish
J Am Geriatr Soc 52:845; author reply 845-6. 2004 - Informed consent for Alzheimer's disease clinical trials: a survey of clinical investigatorsJason H T Karlawish
Internal Ethics Committee of the Alzheimer's Disease Cooperative Study
IRB 24:1-5. 2002 - Ethics and politics of research involving subjects with impaired decision-making abilitiesScott Y H Kim
Neurology 61:1645-6. 2003 - Re: "Ethics and sample size"Scott D Halpern
Am J Epidemiol 162:195-6; author reply 196. 2005 - Ignoring the controversies: newspaper reports on Alzheimer's disease treatmentsEric E Adelman
J Am Geriatr Soc 51:1821-2. 2003