SHAM KAKAR

Summary

Affiliation: University of Louisville
Country: USA

Publications

  1. ncbi Regulation of angiogenesis and invasion by human Pituitary tumor transforming gene (PTTG) through increased expression and secretion of matrix metalloproteinase-2 (MMP-2)
    Mohammad T Malik
    Department of Biochemistry and Molecular Biology, University of Louisville, Louisville, KY, USA
    Mol Cancer 5:61. 2006
  2. ncbi PTTG/securin activates expression of p53 and modulates its function
    Tariq Hamid
    Department of Medicine, University of Louisville, Louisville, KY 40202, USA
    Mol Cancer 3:18. 2004
  3. ncbi Ectopic expression of PTTG1/securin promotes tumorigenesis in human embryonic kidney cells
    Tariq Hamid
    Department of Medicine, University of Louisville, Louisville, KY 40202, USA
    Mol Cancer 4:3. 2005
  4. ncbi Effect of PTTG on endogenous gene expression in HEK 293 cells
    Siva K Panguluri
    Department of Physiology and Biophysics, James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA
    BMC Genomics 10:577. 2009
  5. ncbi Ovarian cancer mouse models: a summary of current models and their limitations
    Miranda Y Fong
    Department of Physiology and Biophysics, James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA
    J Ovarian Res 2:12. 2009
  6. ncbi Emerging role of microRNAs in diagnosis and treatment of various diseases including ovarian cancer
    Parag P Shah
    Department of Physiology and Biophysics, James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA
    J Ovarian Res 2:11. 2009
  7. ncbi Characterization of a polyclonal antibody to human pituitary tumor transforming gene 1 (PTTG1) protein
    S S Kakar
    James Graham Brown Cancer Center, University of Louisville, Kentucky 40202, USA
    J Histochem Cytochem 49:1537-46. 2001
  8. ncbi Suppression of lung cancer with siRNA targeting PTTG
    Sham S Kakar
    Department of Medicine, James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA
    Int J Oncol 29:387-95. 2006
  9. ncbi MicroRNA signature of cis-platin resistant vs. cis-platin sensitive ovarian cancer cell lines
    Smriti Kumar
    James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA
    J Ovarian Res 4:17. 2011
  10. ncbi Gonadotropin-releasing hormone receptor: cloning, expression and transcriptional regulation
    Sham S Kakar
    Department of Medicine, University of Louisville, Louisville, KY 40202, USA
    Prog Brain Res 141:129-47. 2002

Research Grants

  1. MOLECULAR CHARACTERIZATION OF GNRH RECEPTORS
    SHAM KAKAR; Fiscal Year: 2001
  2. PTTG Role in Ovarian Tumorigenesis and Matastasis
    SHAM KAKAR; Fiscal Year: 2007
  3. PTTG Role in Ovarian Tumorigenesis and Matastasis
    SHAM KAKAR; Fiscal Year: 2009
  4. PTTG Role in Ovarian Tumorigenesis and Matastasis
    Sham S Kakar; Fiscal Year: 2010

Collaborators

Detail Information

Publications19

  1. ncbi Regulation of angiogenesis and invasion by human Pituitary tumor transforming gene (PTTG) through increased expression and secretion of matrix metalloproteinase-2 (MMP-2)
    Mohammad T Malik
    Department of Biochemistry and Molecular Biology, University of Louisville, Louisville, KY, USA
    Mol Cancer 5:61. 2006
    ..In the present study, we investigated the effect of overexpression of PTTG on secretion and expression of metastasis-related metalloproteinase-2 (MMP-2) in HEK293 cells, cell migration, invasion and tubule formation...
  2. ncbi PTTG/securin activates expression of p53 and modulates its function
    Tariq Hamid
    Department of Medicine, University of Louisville, Louisville, KY 40202, USA
    Mol Cancer 3:18. 2004
    ..The relationship between PTTG and p53 remains unclear, however...
  3. ncbi Ectopic expression of PTTG1/securin promotes tumorigenesis in human embryonic kidney cells
    Tariq Hamid
    Department of Medicine, University of Louisville, Louisville, KY 40202, USA
    Mol Cancer 4:3. 2005
    ..To determine if PTTG1 functions similarly as an oncogene in humans, we have characterized its effects on human embryonic kidney (HEK293) cells...
  4. ncbi Effect of PTTG on endogenous gene expression in HEK 293 cells
    Siva K Panguluri
    Department of Physiology and Biophysics, James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA
    BMC Genomics 10:577. 2009
    ..For this purpose, we expressed PTTG in human embryonic kidney (HEK293) cells that do not express PTTG and analyzed the downstream genes using microarray analysis...
  5. ncbi Ovarian cancer mouse models: a summary of current models and their limitations
    Miranda Y Fong
    Department of Physiology and Biophysics, James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA
    J Ovarian Res 2:12. 2009
    ..This review focuses on the methods of various investigators and the limitations of each model in establishing a reproducible and inheritable line to study this disease...
  6. ncbi Emerging role of microRNAs in diagnosis and treatment of various diseases including ovarian cancer
    Parag P Shah
    Department of Physiology and Biophysics, James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA
    J Ovarian Res 2:11. 2009
    ..In this review, we focus on the miRNA signatures in different human diseases including cancers. Such signatures may be used as diagnostic and prognostic markers...
  7. ncbi Characterization of a polyclonal antibody to human pituitary tumor transforming gene 1 (PTTG1) protein
    S S Kakar
    James Graham Brown Cancer Center, University of Louisville, Kentucky 40202, USA
    J Histochem Cytochem 49:1537-46. 2001
    ....
  8. ncbi Suppression of lung cancer with siRNA targeting PTTG
    Sham S Kakar
    Department of Medicine, James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA
    Int J Oncol 29:387-95. 2006
    ....
  9. ncbi MicroRNA signature of cis-platin resistant vs. cis-platin sensitive ovarian cancer cell lines
    Smriti Kumar
    James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA
    J Ovarian Res 4:17. 2011
    ..abstract:..
  10. ncbi Gonadotropin-releasing hormone receptor: cloning, expression and transcriptional regulation
    Sham S Kakar
    Department of Medicine, University of Louisville, Louisville, KY 40202, USA
    Prog Brain Res 141:129-47. 2002
    ....
  11. ncbi Identification of distinct gene expression profiles associated with treatment of LbetaT2 cells with gonadotropin-releasing hormone agonist using microarray analysis
    Sham S Kakar
    Department of Medicine, University of Louisville, 570 South Preston Street, Baxter Building, Room 204 C, Louisville, KY 40202, USA
    Gene 308:67-77. 2003
    ....
  12. ncbi Characterization of the role of Sp1 and NF-Y in differential regulation of PTTG/securin expression in tumor cells
    Amy L Clem
    Department of Medicine and James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA
    Gene 322:113-21. 2003
    ..Our studies indicate an important role of Sp1 in transcription regulation of PTTG expression in tumors...
  13. ncbi Insulin and IGF-1 regulate the expression of the pituitary tumor transforming gene (PTTG) in breast tumor cells
    Alvin D Thompson
    Department of Biochemistry and Molecular Biology, James Graham Brown Cancer Center, University of Louisville, 580 South Preston, Baxter II, 324, Kentucky 40202, USA
    FEBS Lett 579:3195-200. 2005
    ..Taken together, our results suggest that insulin and IGF-1 regulate the expression of PTTG in MCF-7 cells primarily through the activation of PI3K/AKT cascade...
  14. ncbi Small interfering RNA against PTTG: a novel therapy for ovarian cancer
    Shahenda M El Naggar
    Department of Medicine, and the James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA
    Int J Oncol 31:137-43. 2007
    ..Taken together, these results strongly suggest that PTTG may serve as an important molecular target for the discovery of new anticancer agents and treatment strategies...
  15. ncbi Transcriptional regulation of follistatin expression by GnRH in mouse gonadotroph cell lines: evidence for a role for cAMP signaling
    Stephen J Winters
    Division of Endocrinology and Metabolism, University of Louisville, Louisville, KY 40202, United States
    Mol Cell Endocrinol 271:45-54. 2007
    ..These results provide a mechanism linking GnRH pulsatility to the differential control of FSH-beta and LH-beta gene expression through follistatin...
  16. ncbi Protein kinase A serves as a primary pathway in activation of Nur77 expression by gonadotropin-releasing hormone in the LbetaT2 mouse pituitary gonadotroph tumor cell line
    Tariq Hamid
    Department of Medicine and James Graham Brown Cancer Centre, University of Louisville, Louisville, KY 40202, USA
    Int J Oncol 33:1055-64. 2008
    ..Based on our results, we conclude that activation of protein kinase A is the major mechanism regulating the expression of Nur77 by GnRH which may serve as a down-stream signaling gene to mediate the antitumor effects of GnRH...
  17. ncbi Gonadotropin-releasing hormone receptors: structure, expression, and signaling transduction
    Sham S Kakar
    Department of Medicine, University of Louisville, Louisville, Kentucky 40202, USA
    Vitam Horm 69:151-207. 2004
  18. ncbi Development of cystic glandular hyperplasia of the endometrium in Mullerian inhibitory substance type II receptor-pituitary tumor transforming gene transgenic mice
    Shahenda M El Naggar
    Department of Biochemistry and Molecular Biology, University of Louisville, Kentucky 40202, USA
    J Endocrinol 194:179-91. 2007
    ....
  19. ncbi PTTG expression in different experimental and human prolactinomas in relation to dopaminergic control of lactotropes
    Carolina Cristina
    Instituto de Biologia y Medicina Experimental, Consejo Nacional de Investigaciones Cientificas y Tecnicas, V, Obligado 2490, 1428 Buenos Aires, Argentina
    Mol Cancer 6:4. 2007
    ..We also studied samples from human macroprolactinomas, which were characterized as responsive or resistant to dopamine agonist therapy...

Research Grants9

  1. MOLECULAR CHARACTERIZATION OF GNRH RECEPTORS
    SHAM KAKAR; Fiscal Year: 2001
    ..These studies have the potential to provide the basis for the development of a new class of drugs for treatments of hormone-responsive tumors. ..
  2. PTTG Role in Ovarian Tumorigenesis and Matastasis
    SHAM KAKAR; Fiscal Year: 2007
    ..In addition transgenic animal model developed from our studies could enhance efforts aimed at developing new methods for detection, prevention, and treatment of ovarian cancer. ..
  3. PTTG Role in Ovarian Tumorigenesis and Matastasis
    SHAM KAKAR; Fiscal Year: 2009
    ..In addition transgenic animal model developed from our studies could enhance efforts aimed at developing new methods for detection, prevention, and treatment of ovarian cancer. ..
  4. PTTG Role in Ovarian Tumorigenesis and Matastasis
    Sham S Kakar; Fiscal Year: 2010
    ..In addition transgenic animal model developed from our studies could enhance efforts aimed at developing new methods for detection, prevention, and treatment of ovarian cancer. ..