Research Topics
Genomes and Genes | Martin KagnoffSummaryAffiliation: University of California Country: USA Publications
Research Grants
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Publications
Mucosal immunology: new frontiersM F Kagnoff
Dept of Medicine, University of California, San Diego, La Jolla 92093 0623, USA
Immunol Today 17:57-9. 1996..Mucosal immunology is one of the most rapidly developing and exciting fields of immunological research. A recent meeting discussed advances in the fundamental knowledge of this area, and reviewed possibilities for its clinical application...- Overview and pathogenesis of celiac diseaseMartin F Kagnoff
Department of Medicine, Laboratory of Mucosal Immunology, University of California at San Diego, La Jolla, California 92093-0623, USA
Gastroenterology 128:S10-8. 2005 - Immunopathology of the gastrointestinal system. IntroductionMartin F Kagnoff
Department of Medicine and Pediatrics and The Laboratory of Mucosal Immunology, University of California, San Diego, La Jolla, CA, 92093, USA
Springer Semin Immunopathol 27:129-31. 2005 - Microbial-epithelial cell crosstalk during inflammation: the host responseMartin F Kagnoff
Departments of Medicine and Pediatrics, Laboratory of Mucosal Immunology, University of California at San Diego, La Jolla, CA 92093, USA
Ann N Y Acad Sci 1072:313-20. 2006..It further highlights the importance of intestinal epithelium in mediating host antimicrobial defense through the production of antimicrobial peptides of the defensin and cathelicidin families... - Celiac disease: pathogenesis of a model immunogenetic diseaseMartin F Kagnoff
Department of Medicine, Laboratory of Mucosal Immunology, and Wm K Warren Medical Research Center for Celiac Disease, UCSD, La Jolla, California 92093 0623, USA
J Clin Invest 117:41-9. 2007..This article focuses on the role of adaptive and innate immune mechanisms in the pathogenesis of celiac disease and how current concepts of immunopathogenesis might provide alternative approaches for treating celiac disease... - 2007 William K. Warren, Jr., prize for excellence in celiac disease research awarded to professor Ludvig M. Sollid of Oslo, NorwayMartin F Kagnoff
Medicine and Pediatrics, Wm. K. Warren Medical Research Center for Celiac Disease, University of California at San Diego, La Jolla, California, USA
Gastroenterology 133:9-10. 2007 - Analysis of host responses to microbial infection using gene expression profilingM F Kagnoff
University of California, San Diego, Laboratory of Mucosal Immunology, 9500 Gilman Drive, La Jolla, California 92093 0623, USA
Curr Opin Microbiol 4:246-50. 2001.... - Human immunodeficiency virus type 1 (HIV-1) infection and expression in intestinal epithelial cells: role of protein kinase A and C pathways in HIV-1 transcriptionM F Kagnoff
Department of Medicine, University of California, San Diego, La Jolla, CA 92093 0623, USA
J Infect Dis 179:S444-7. 1999.... - Nod2 mutation in Crohn's disease potentiates NF-kappaB activity and IL-1beta processingShin Maeda
Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0723, USA
Science 307:734-8. 2005..These effects are linked to increased susceptibility to bacterial-induced intestinal inflammation and identify NOD2 as a positive regulator of NF-kappaB activation and IL-1beta secretion... - Opposing functions of IKKbeta during acute and chronic intestinal inflammationLars Eckmann
Department of Medicine, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
Proc Natl Acad Sci U S A 105:15058-63. 2008..Our findings caution against the therapeutic use of IKKbeta/NF-kappaB inhibitors in acute inflammatory settings dominated by cell loss and ulceration... - Epithelial cell I kappa B-kinase beta has an important protective role in Clostridium difficile toxin A-induced mucosal injurySungwon Chae
Department of Medicine, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
J Immunol 177:1214-20. 2006..difficile toxin A exposure that is mediated, at least in part, through promoting epithelial cell survival by abrogating epithelial cell apoptosis... - The two faces of IKK and NF-kappaB inhibition: prevention of systemic inflammation but increased local injury following intestinal ischemia-reperfusionLee Wei Chen
Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, University of California, San Diego, California, USA
Nat Med 9:575-81. 2003..These results show the dual function of the NF-kappaB system, which is responsible for both tissue protection and systemic inflammation, and underscore the caution that should be exerted in using NF-kappaB and IKK inhibitors... - Central importance of immunoglobulin A in host defense against Giardia sppT Dianne Langford
Department of Medicine, University of California, San Diego, La Jolla, California 92093 0623, USA
Infect Immun 70:11-8. 2002..Moreover, B-cell-dependent but IgA-independent and B-cell-independent antigiardial host defenses exist but are less important for controlling infection... - IkappaB-kinasebeta-dependent NF-kappaB activation provides radioprotection to the intestinal epitheliumLaurence J Egan
Laboratory of Mucosal Immunology, University of California at San Diego, La Jolla, CA 92093, USA
Proc Natl Acad Sci U S A 101:2452-7. 2004..Selective preactivation of NF-kappaB through IKKbeta in intestinal epithelial cells could provide a therapeutic modality that allows higher doses of radiation to be tolerated during cancer radiotherapy... - Maintenance of colonic homeostasis by distinctive apical TLR9 signalling in intestinal epithelial cellsJongdae Lee
Department of Medicine, University of California, San Diego, La Jolla, CA 92093 0663, USA
Nat Cell Biol 8:1327-36. 2006..Our data provide a case for organ-specific innate immunity in which TLR expression in polarized IECs has uniquely evolved to maintain colonic homeostasis and regulate tolerance and inflammation... - Cathelicidin mediates innate intestinal defense against colonization with epithelial adherent bacterial pathogensMitsutoshi Iimura
Department of Medicine, University of California at San Diego, La Jolla, CA 92093 0623, USA
J Immunol 174:4901-7. 2005..Moreover, Cnlp+/+ mice were protected from oral infections with C. rodentium inocula that infected the majority of Cnlp-/- mice. These results establish cathelicidin as an important component of innate antimicrobial defense in the colon... - GM-CSF-facilitated dendritic cell recruitment and survival govern the intestinal mucosal response to a mouse enteric bacterial pathogenYoshihiro Hirata
Department of Medicine, University of California, San Diego, La Jolla, 92093 0623, USA
Cell Host Microbe 7:151-63. 2010..Thus, GM-CSF produced in the intestinal mucosa acts to enhance host protection against an enteric bacterial pathogen through regulating recruitment and survival of DCs... - IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancerFlorian R Greten
Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, University of California, San Diego, 9500 Gilman Drive, La Jolla 92093, USA
Cell 118:285-96. 2004..In addition to suppressing apoptosis in advanced tumors, IKKbeta may link inflammation to cancer... - Regulated production of the chemokine CCL28 in human colon epitheliumHiroyuki Ogawa
Department of Medicine, University of California at San Diego, La Jolla, CA 92093-0623, USA
Am J Physiol Gastrointest Liver Physiol 287:G1062-9. 2004..These findings indicate that CCL28 functions as an "inflammatory" chemokine in human colon epithelium and suggest the notion that CCL28 may act to counterregulate colonic inflammation... - Cell differentiation is a key determinant of cathelicidin LL-37/human cationic antimicrobial protein 18 expression by human colon epitheliumKoji Hase
Laboratory of Mucosal Immunology Histology Shared Resources, Department of Medicine, University of California, San Diego, La Jolla, California 92093 0623, USA
Infect Immun 70:953-63. 2002.... - Nod1 is an essential signal transducer in intestinal epithelial cells infected with bacteria that avoid recognition by toll-like receptorsJae Gyu Kim
Laboratory of Mucosal Immunology, University of California at San Diego, La Jolla, California 92093 0623, USA
Infect Immun 72:1487-95. 2004..Signaling through Nod1 provides the intestinal epithelium with a backup mechanism for rapidly activating innate immunity during infection with a group of highly invasive pathogenic gram-negative bacteria... - Ubiquitous production of macrophage migration inhibitory factor by human gastric and intestinal epitheliumChristian Maaser
Laboratory of Mucosal Immunology, Department of Medicine, University of California, San Diego, La Jolla, California 92093 0623, USA
Gastroenterology 122:667-80. 2002..MIF is produced by T cells, macrophages, and endothelial cells. Because intestinal epithelial cells produce mediators important for regulating mucosal immune and inflammatory responses, we sought to determine if these cells produce MIF... - Role of EHEC O157:H7 virulence factors in the activation of intestinal epithelial cell NF-kappaB and MAP kinase pathways and the upregulated expression of interleukin 8M Cecilia Berin
Laboratory of Mucosal Immunology, University of California at San Diego, La Jolla, CA 92093 0623, USA
Cell Microbiol 4:635-48. 2002..The activation of proinflammatory signals in human colon epithelial cells in response to this non-invasive pathogen appears to depend to a significant extent on H7 flagellin... - Nuclear factor-kappa B activation promotes restitution of wounded intestinal epithelial monolayersLaurence J Egan
Laboratory of Mucosal Immunology, Department of Medicine, University of California-San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0623, USA
Am J Physiol Cell Physiol 285:C1028-35. 2003.... - Activation of innate immune defense mechanisms by signaling through RIG-I/IPS-1 in intestinal epithelial cellsYoshihiro Hirata
Department of Medicine, University of California at San Diego, La Jolla, CA 92093, USA
J Immunol 179:5425-32. 2007..Virus replication and virus-induced cell death increased in IECs in which RIG-I was silenced, consistent with the importance of the RIG-I signaling pathway in IEC antiviral innate immune defense mechanisms... - Role of Shiga toxin versus H7 flagellin in enterohaemorrhagic Escherichia coli signalling of human colon epithelium in vivoYukiko Miyamoto
Laboratory of Mucosal Immunology, Department of Medicine, University of California at San Diego, La Jolla, CA, USA
Cell Microbiol 8:869-79. 2006..We conclude that EHEC H7 flagellin and not Stx is the major EHEC factor that directly upregulates proinflammatory chemokine production by human colon epithelium in vivo... - Intestinal mucosal responses to microbial infectionLars Eckmann
Department of Medicine, University of California at San Diego, La Jolla, CA 92093, USA
Springer Semin Immunopathol 27:181-96. 2005.... - Expression of Epstein-Barr virus-induced gene 3 and other interleukin-12-related molecules by human intestinal epitheliumChristian Maaser
Laboratory of Mucosal Immunology, Department of Medicine, University of California at San Diego, La Jolla, CA 92093, USA
Immunology 112:437-45. 2004.... - Chemokine receptor CCR6 transduces signals that activate p130Cas and alter cAMP-stimulated ion transport in human intestinal epithelial cellsCharles C Yang
Laboratory of Mucosal Immunology, Department of Medicine, University of California, San Diego, La Jolla, California 92093 0623, USA
Am J Physiol Cell Physiol 288:C321-8. 2005.... - Mucosal inflammation in celiac disease: interleukin-15 meets transforming growth factor beta-1Martin F Kagnoff
Gastroenterology 132:1174-6. 2007 - American Gastroenterological Association (AGA) Institute technical review on the diagnosis and management of celiac diseaseAlaa Rostom
Division of Gastroenterology, Foothills Medical Centre, University of Calgary, Calgary, Alberta, Canada
Gastroenterology 131:1981-2002. 2006 - Celiac disease pathogenesis: the plot thickensMartin F Kagnoff
Gastroenterology 123:939-43. 2002 - SDF-1/CXCL12 regulates cAMP production and ion transport in intestinal epithelial cells via CXCR4Michael B Dwinell
Dept of Microbiology and Molecular Genetics, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
Am J Physiol Gastrointest Liver Physiol 286:G844-50. 2004..Taken together, these data indicate that epithelial CXCR4 can transduce functional signals in human intestinal epithelial cells that modulate important cAMP-mediated cellular functions...
Research Grants
- INTESTINAL EPITHELIAL RESPONSES TO FOOD BORNE PATHOGENSMartin Kagnoff; Fiscal Year: 2004..Our experimental approaches will draw on in vitro and in vivo model systems established in this laboratory and a duality of hypothesis and discovery based experimental approaches. ..