Research Topics
Genomes and GenesSpecies | S JuulSummaryAffiliation: University of Washington Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Effects of neonatal stress and morphine on kappa opioid receptor signalingThuy N Vien
Department of Pediatrics, University of Washington, Seattle, WA 98195 6320, USA
Neonatology 96:235-43. 2009..However, the enduring effects of stress and opioids are not understood. The kappa opioid system is important in the mediation of stress in adults, but little is known about its function in neonates...- Microarray analysis of high-dose recombinant erythropoietin treatment of unilateral brain injury in neonatal mouse hippocampusSandra E Juul
Department of Pediatrics, University of Washington, Seattle, Washington 98195, USA
Pediatr Res 65:485-92. 2009.... - A phase I/II trial of high-dose erythropoietin in extremely low birth weight infants: pharmacokinetics and safetySandra E Juul
Department of Pediatrics, University of Washington, Seattle, Washington 98195, USA
Pediatrics 122:383-91. 2008..We designed a phase I/II trial to test the safety and determine the pharmacokinetics of high-dose recombinant erythropoietin in extremely low birth weight infants... - Recombinant erythropoietin is neuroprotective in a novel mouse oxidative injury modelSandra E Juul
Department of Pediatrics, University of Washington, Seattle, WA 98195 6320, USA
Dev Neurosci 30:231-42. 2008..01). The interleukin-10 expression was higher in the rEpo-treated animals. Apoptotic and proinflammatory gene expression persisted for 168 h. There was no increase in angiogenic gene expression at the time points studied... - Prenatal cord clamping in newborn Macaca nemestrina: a model of perinatal asphyxiaSandra E Juul
University of Washington, Department of Pediatrics, Division of Neonatology, Seattle, Wash 98195 6320, USA
Dev Neurosci 29:311-20. 2007..nemestrina newborns. This model, which combines structural, biochemical, and behavioral assessments over time can be used to assess the safety and efficacy of neuroprotective strategies... - Epo and other hematopoietic factorsSandra Juul
Department of Pediatrics, Division of Neonatology, Health Sciences Building, University of Washington, Box 356320, Seattle, WA 98195, USA
Semin Fetal Neonatal Med 12:250-8. 2007..They have clinical hematopoietic uses in neonatal populations and in experimental non-hematopoietic research, and clinical potential as neuroprotective or tissue-protective agents... - Recombinant erythropoietin as a neuroprotective treatment: in vitro and in vivo modelsSandra Juul
Division of Neonatology, Department of Pediatrics, University of Washington, PO Box 356320, Seattle, WA 98195, USA
Clin Perinatol 31:129-42. 2004..This article reviews the neuroprotective effects of erythropoietin in brain, emphasizing the progress made using in vitro and in vivo research models... - Erytropoietin concentrations in cerebrospinal fluid of nonhuman primates and fetal sheep following high-dose recombinant erythropoietinSandra E Juul
Department of Pediatrics, University of Washington, Seattle, Wash 98195, USA
Biol Neonate 85:138-44. 2004..We demonstrate that high-dose rEpo was well tolerated and results in neuroprotective concentrations in spinal fluid of adult and developing animal models by 2-2.5 h after injection... - Absorption of enteral recombinant human erythropoietin by neonatesSandra E Juul
Department of Pediatrics, Division of Neonatology, University of Washington, Seattle, WA 98195 6320, USA
Ann Pharmacother 37:782-6. 2003..One possible function of ingested EPO might be to stimulate erythropoiesis. However, it is unclear whether human neonates absorb recombinant human erythropoietin (rhEPO) after oral administration... - Zinc protoporphyrin/heme as an indicator of iron status in NICU patientsSandra E Juul
Department of Pediatrics, University of Washington, Seattle, Washington 98195, USA
J Pediatr 142:273-8. 2003..Gestational age, growth variables, iron supplementation, erythropoietin treatment, and blood transfusions were documented. Results are reported as mean +/- SD. A value of P <.05 was considered significant... - Erythropoietin in the central nervous system, and its use to prevent hypoxic-ischemic brain damageS Juul
Department of Pediatrics, Division of Neonatology, University of Washington, Seattle, Washington 98195, USA
Acta Paediatr Suppl 91:36-42. 2002..This review summarizes the current knowledge on the neurotrophic and neuroprotective functions of Epo in the developing and injured brain... - Enterally dosed recombinant human erythropoietin does not stimulate erythropoiesis in neonatesSandra E Juul
Department of Pediatrics, Division of Neonatology, University of Washington, Seattle, 1 98195, USA
J Pediatr 143:321-6. 2003..This study was designed to determine whether enterally dosed recombinant Epo (rEpo) stimulates erythropoiesis in preterm neonates... - Erythropoietin protects dopaminergic neurons and improves neurobehavioral outcomes in juvenile rats after neonatal hypoxia-ischemiaEric J Demers
Department of Pediatrics, University of Washington, Seattle, Washington 98195, USA
Pediatr Res 58:297-301. 2005..On the basis of these findings, we conclude that further studies investigating the safety and efficacy of high-dose rEpo as a neuroprotective strategy are indicated in neonatal models of hypoxic-ischemic brain injury... - Iron sulfate supplementation decreases zinc protoporphyrin to heme ratio in premature infantsSusan M Miller
Department of Pediatrics, University of Washington, Seattle, WA 98195, USA
J Pediatr 148:44-8. 2006..CONCLUSIONS: Iron sulfate supplementation (3-12 mg/kg/d) decreases ZnPP/H, is tolerated, and is not associated with increased oxidative injury... - Erythropoietin in human milk: physiology and role in infant healthRichard D Semba
Johns Hopkins School of Medicine, Baltimore, MD, USA
J Hum Lact 18:252-61. 2002..Current data suggest that erythropoietin in human milk may play a pleiomorphic role in erythropoiesis, neurodevelopment, maturation of the gut, apoptosis, and immunity in the infant... - Safety of high-dose recombinant erythropoietin in a neonatal rat modelRonald J McPherson
Department of Pediatrics, Division of Neonatology, University of Washington, Seattle, WA98195 6320, USA
Neonatology 91:36-43. 2007..High-dose recombinant erythropoietin (rEpo) is neuroprotective in neonatal animal models of brain injury, but the long-term consequences of neonatal exposure have not been studied... - A comparison of high-dose recombinant erythropoietin treatment regimens in brain-injured neonatal ratsBrian A Kellert
Department of Pediatrics, University of Washington, Seattle, Washington 98195, USA
Pediatr Res 61:451-5. 2007..rEpo provides dose-dependent neuroprotection. Of the regimens tested, three doses of 5,000 U/kg was optimal because it provided maximal benefit with limited total exposure... - A new model of neonatal stress which produces lasting neurobehavioral effects in adult ratsRonald J McPherson
Division of Neonatology, Department of Pediatrics, University of Washington, Seattle, WA 98195 6320, USA
Neonatology 92:33-41. 2007..An animal model simulating the NICU experience is needed to understand the impact of specific neonatal stressors... - Recent trends in erythropoietin-mediated neuroprotectionRonald J McPherson
Department of Pediatrics, University of Washington, Seattle, WA 98195, USA
Int J Dev Neurosci 26:103-11. 2008..Recent concerns that early erythropoietin might exacerbate the pathologic neovascularization associated with retinopathy of prematurity are addressed... - Characterization of developing bowel transplanted from transgenic erythropoietin receptor-deficient mouse embryosMarcella Mascher-Denen
Department of Pediatrics, University of Washington, WA 98195, USA
Neonatology 93:56-63. 2008..Transgenic mice with absent Epo function are embryonic lethal, so it is not known whether Epo function is required for bowel development... - High-dose erythropoietin inhibits apoptosis and stimulates proliferation in neonatal rat intestineRonald J McPherson
University of Washington, Seattle, WA 98195, USA
Growth Horm IGF Res 17:424-30. 2007..Erythropoietin (Epo) receptors are widely expressed in the small bowel of neonatal rats and evidence suggests Epo has important trophic effects in developing bowel... - Evaluation of neutropenia and neutrophilia in hospitalized preterm infantsSandra E Juul
Department of Pediatrics, University of Washington, Seattle, Washington 98195, USA
J Perinatol 24:150-7. 2004..CONCLUSIONS: The incidence and prevalence of neutrophil abnormalities increased with immaturity, and were more common than previously appreciated in hospitalized preterm infants... - Pharmacokinetics of high-dose recombinant erythropoietin in plasma and brain of neonatal ratsPamela A Statler
Department of Pediatrics, University of Washington, Seattle, Washington 98195, USA
Pediatr Res 61:671-5. 2007..We conclude that high-dose rEpo is detectable in brain for >20 h after a single systemic injection. These pharmacokinetic data are valuable for planning of rEpo neuroprotection experiments... - Effect of recombinant granulocyte colony-stimulating factor on blood neutrophil concentrations among patients with "idiopathic neonatal neutropenia": a randomized, placebo-controlled trialSandra E Juul
Department of Pediatrics, Division of Neonatology, University of Washington, Box 356320, Seattle, WA 98195, USA
J Perinatol 23:493-7. 2003..On that basis, we speculate that this variety of neonatal neutropenia does not constitute a significant deficiency in antibacterial defense... - Evaluation of eosinophilia in hospitalized preterm infantsSandra E Juul
Department of Pediatrics, University of Washington, Seattle, Washington 98195, USA
J Perinatol 25:182-8. 2005..CONCLUSIONS: The incidence and severity of eosinophilia increased with immaturity, and was temporally associated with infection, necrotizing enterocolitis, and packed red blood cell transfusion... - The effect of interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) on granulocyte macrophage-colony stimulating factor (GM-CSF) production by neuronal precursor cellsJ Benjamin Dame
Department of Pediatrics, University of Florida College of Medicine, Gainesville, FL 32610, USA
Eur Cytokine Netw 13:128-33. 2002..To determine whether granulocyte macrophage-colony stimulating factor (GM-CSF) production by neuronal precursor (NT2) cells can be regulated by IL-1beta and TNF-alpha...
Research Grants
- Optimizing Neuroprotection Following Perinatal AsphyxiaSandra E Juul; Fiscal Year: 2010..This work will produce important data with direct clinical application to perinatal asphyxia, and possibly to other mechanisms of brain injury in infants and children. ..
- Optimizing Neuroprotection Following Perinatal AsphyxiaSandra Juul; Fiscal Year: 2009..This work will produce important data with direct clinical application to perinatal asphyxia, and possibly to other mechanisms of brain injury in infants and children. ..
- Optimizing Neuroprotection Following Perinatal AsphyxiaSandra Juul; Fiscal Year: 2007..This work will produce important data with direct clinical application to perinatal asphyxia, and possibly to other mechanisms of brain injury in infants and children. ..
- Epo as a Rescue Agent for Perinatal Hypoxia-IschemiaSandra Juul; Fiscal Year: 2004....
- Nonhematopoietic Developmental Functions of EPOSandra Juul; Fiscal Year: 2004..We feel these experiments will provide important specific insights into the regulation of neonatal intestinal growth and injury. ..
- Optimizing Neuroprotection Following Perinatal AsphyxiaSandra Juul; Fiscal Year: 2009..This work will produce important data with direct clinical application to perinatal asphyxia, and possibly to other mechanisms of brain injury in infants and children. ..