Research Topics
Species | Emily M JutkiewiczSummaryAffiliation: University of Michigan Country: USA Publications
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Publications
The effects of CRF antagonists, antalarmin, CP154,526, LWH234, and R121919, in the forced swim test and on swim-induced increases in adrenocorticotropin in ratsEmily M Jutkiewicz
Department of Pharmacology, University of Michigan Medical School, 1301 MSRB 3, Ann Arbor, MI 48109 0632, USA
Psychopharmacology (Berl) 180:215-23. 2005..Therefore, compounds that block the effects of stress hormones were investigated as potential therapeutics for depression...- Behavioral and neurobiological effects of the enkephalinase inhibitor RB101 relative to its antidepressant effectsEmily M Jutkiewicz
Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI 48109 0632, USA
Eur J Pharmacol 531:151-9. 2006..v.) in rats. RB101 did not produce convulsions or seizures and did not alter BDNF mRNA expression. In conclusion, RB101 has the potential to produce antidepressant effects without convulsions... - The delta-opioid receptor agonist SNC80 [(+)-4-[alpha(R)-alpha-[(2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl]-(3-methoxybenzyl)-N,N-diethylbenzamide] synergistically enhances the locomotor-activating effects of some psychomotor stimulants, but not direct doEmily M Jutkiewicz
Department of Pharmacology, University of Michigan Medical School, 1301 Medical Science Research Building III, 1150 W Medical Center Drive, Ann Arbor, MI 48109 0632, USA
J Pharmacol Exp Ther 324:714-24. 2008.... - RB101-mediated protection of endogenous opioids: potential therapeutic utility?Emily M Jutkiewicz
Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan 48109 0632, USA
CNS Drug Rev 13:192-205. 2007.... - A bacterial cocaine esterase protects against cocaine-induced epileptogenic activity and lethalityEmily M Jutkiewicz
Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI 48109 0632, USA
Ann Emerg Med 54:409-20. 2009..The present study hypothesizes that a bacterial cocaine esterase with high catalytic efficiency would provide rapid and robust protection from cocaine-induced convulsions, epileptogenic activity, and lethality... - The antidepressant -like effects of delta-opioid receptor agonistsEmily M Jutkiewicz
Department of Pharmacology, University of Michigan Medical School, 1301 Medical Science Research Building III, 1150 W Medical Center Drive, Ann Arbor, MI 48109 0632, USA
Mol Interv 6:162-9. 2006..This review discusses the role of the DORs in depression and the antidepressant-like effects of delta-opioid agonists as well as their limitations... - The convulsive and electroencephalographic changes produced by nonpeptidic delta-opioid agonists in rats: comparison with pentylenetetrazolEmily M Jutkiewicz
Department of Pharmacology, 1301 Medical Science Research Bldg III, University of Michigan Medical School, Ann Arbor, MI 48109 0632, USA
J Pharmacol Exp Ther 317:1337-48. 2006..In terms of therapeutic development, these data suggest that it may be possible to develop delta-opioid agonists devoid of convulsive properties... - Differential behavioral tolerance to the delta-opioid agonist SNC80 ([(+)-4-[(alphaR)-alpha-[(2S,5R)-2,5-dimethyl-4-(2-propenyl)-1-piperazinyl]-(3-methoxyphenyl)methyl]-N,N-diethylbenzamide) in Sprague-Dawley ratsEmily M Jutkiewicz
1301 MSRB III, Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI 48109 0632, USA
J Pharmacol Exp Ther 315:414-22. 2005..Overall, the lack of observable tolerance to the antidepressant-like effects of SNC80 indicates that this class of compounds has potential as a novel antidepressant therapy... - Separation of the convulsions and antidepressant-like effects produced by the delta-opioid agonist SNC80 in ratsEmily M Jutkiewicz
Department of Pharmacology, University of Michigan Medical School, 1301 MSRB III, Ann Arbor, MI 48109 0632, USA
Psychopharmacology (Berl) 182:588-96. 2005..Therefore, determining how to separate the convulsive and antidepressant-like characteristics of these compounds is essential for their potential clinical use... - Endogenous opioids upregulate brain-derived neurotrophic factor mRNA through delta- and micro-opioid receptors independent of antidepressant-like effectsHuina Zhang
Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
Eur J Neurosci 23:984-94. 2006.... - Peptidic delta opioid receptor agonists produce antidepressant-like effects in the forced swim test and regulate BDNF mRNA expression in ratsMary M Torregrossa
Neuroscience Program, University of Michigan, Ann Arbor, MI 48109, USA
Brain Res 1069:172-81. 2006.... - Convulsant activity of a non-peptidic delta-opioid receptor agonist is not required for its antidepressant-like effects in Sprague-Dawley ratsDaniel C Broom
Department of Pharmacology, University of Michigan Medical School, 1301 Medical Science Research Building III, Ann Arbor, MI 48109-0632, USA
Psychopharmacology (Berl) 164:42-8. 2002..Therefore the convulsant activity of (+)BW373U86 and possibly other non-peptidic delta-agonists is not required for activity in the forced swim assay... - The selective delta opioid agonist SNC80 enhances amphetamine-mediated efflux of dopamine from rat striatumKELLY E BOSSE
Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
Neuropharmacology 55:755-62. 2008..The results of this study demonstrate that even though SNC80 does not stimulate dopamine efflux alone, it is able to augment amphetamine-mediated dopamine efflux through a delta opioid receptor mediated action locally in the striatum... - Dopamine D1/5 and D2/3 agonists differentially attenuate somatic signs of nicotine withdrawal in ratsYu Ohmura
Department of Pharmacology, University of Michigan, Ann Arbor, MI, 48109 5632, USA
Pharmacol Biochem Behav 99:552-6. 2011..These results indicate that a D(2)-selective agonist should be considered a candidate to relieve nicotine withdrawal symptoms... - Patterns of nicotinic receptor antagonism: nicotine discrimination studiesEmily M Jutkiewicz
Department of Pharmacology, University of Michigan, Ann Arbor, Michigan 48109 5632, USA
J Pharmacol Exp Ther 339:194-202. 2011.... - Behavioral effects of delta-opioid receptor agonists: potential antidepressants?Daniel C Broom
Department of Pharmacology, University of Michigan Medical School, Ann Arbor 48109-0632, USA
Jpn J Pharmacol 90:1-6. 2002..These studies propose that the delta-opioid receptor may provide a new therapeutic target for treating human depression... - Nicotine and amphetamine acutely cross-potentiate their behavioral and neurochemical responses in female Holtzman ratsEmily M Jutkiewicz
Department of Pharmacology, University of Michigan Medical School, 1150 W Medical Center Drive, 1301 Medical Science Research Building III, Ann Arbor, MI, 48109 0632, USA
Psychopharmacology (Berl) 200:93-103. 2008..Psychostimulants are often used in close temporal proximity to nicotine and have been reported to enhance acutely nicotine's desirability in humans... - Nonpeptidic delta-opioid receptor agonists reduce immobility in the forced swim assay in ratsDaniel C Broom
Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI 48109-0632, USA
Neuropsychopharmacology 26:744-55. 2002..Thus, delta-agonists differ from typical antidepressants in the forced swim assay... - The sensitizing effect of acute nicotine on amphetamine-stimulated behavior and dopamine efflux requires activation of ?2 subunit-containing nicotinic acetylcholine receptors and glutamate N-methyl-D-aspartate receptorsMyung N Kim
Department of Pharmacology, University of Michigan Medical School, 1301 Medical Science Research Building III, 1150 W Medical Center Drive, Ann Arbor, MI 48109 5632, USA
Neuropharmacology 60:1126-34. 2011..This article is part of a Special Issue entitled 'Trends in neuropharmacology: in memory of Erminio Costa'... - Rapid and robust protection against cocaine-induced lethality in rats by the bacterial cocaine esteraseZiva D Cooper
Department of Pharmacology, University of Michigan, 1301 MSRB III, 1150 West Med Cntr Dr, Ann Arbor, MI 48109-0632, USA
Mol Pharmacol 70:1885-91. 2006..p.), a cocaine analog that lacks the benzoyl ester moiety targeted by CocE. This characterization of CocE provides preliminary evidence that the enzyme could serve as a suitable antidote to cocaine toxicity in humans... - Delta-opioid agonists: differential efficacy and potency of SNC80, its 3-OH (SNC86) and 3-desoxy (SNC162) derivatives in Sprague-Dawley ratsEmily M Jutkiewicz
Department of Pharmacology 1301 MSRB 3, University of Michigan Medical School, Ann Arbor, MI 48109-0632, USA
J Pharmacol Exp Ther 309:173-81. 2004.... - Comparison of peptidic and nonpeptidic delta-opioid agonists on guanosine 5'-O-(3-[35S]thio)triphosphate ([35S]GTPgammaS) binding in brain slices from Sprague-Dawley ratsEmily M Jutkiewicz
Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI 48109-0632, USA
J Pharmacol Exp Ther 312:1314-20. 2005..Finally, these data also revealed that [(35)S]GTPgammaS autoradiography could be used to compare efficacy differences among agonists across various brain regions in rat brain slices... - 5-Hydroxytryptophan attenuates somatic signs of nicotine withdrawalYu Ohmura
Department of Pharmacology, University of Michigan, Ann Arbor, Michigan 48109 0632, USA
J Pharmacol Sci 117:121-4. 2011..Somatic signs were attenuated by the i.p. injection of 5-HTP, but not by NSD-1015, a centrally-acting L-aromatic amino acid decarboxylase inhibitor, indicating that 5-HTP mitigates somatic signs mainly through its conversion to 5-HT... - RGS inhibition at G(alpha)i2 selectively potentiates 5-HT1A-mediated antidepressant effectsJeffery N Talbot
Department of Pharmacology, University of Michigan, Ann Arbor, MI 48109, USA
Proc Natl Acad Sci U S A 107:11086-91. 2010..By selectively enhancing the beneficial effects of serotonin, inhibition of RGS proteins represents a therapeutic approach for the treatment of mood disorders... - L-DOPA attenuates nicotine withdrawal-induced behaviors in ratsYu Ohmura
Department of Pharmacology, University of Michigan, Ann Arbor, MI 48109 5632, USA
Pharmacol Biochem Behav 98:552-8. 2011..It did not mitigate nicotine withdrawal-induced locomotor suppression in the animals' home cages. These results indicate that L-DOPA could be a useful agent to alleviate some nicotine withdrawal symptoms... - Mu-opioid receptor coupling to G?(o) plays an important role in opioid antinociceptionJennifer T Lamberts
Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI, USA
Neuropsychopharmacology 36:2041-53. 2011..These results provide the first in vivo evidence that G?(o) contributes to maximally efficient MOR signaling and antinociception... - Conditional ablation and recovery of forebrain neurogenesis in the mouseBenjamin H Singer
Department of Neurology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
J Comp Neurol 514:567-82. 2009..The nestin-tk mouse should be useful for studying how reversible depletion of adult neurogenesis influences neurophysiology, other behaviors, and neural progenitor dynamics... - Effects of dopamine D1 ligands on eye blinking in monkeys: efficacy, antagonism, and D1/D2 interactionsEmily M Jutkiewicz
McLean Hospital, 115 Mill Street, Belmont MA 02478, USA
J Pharmacol Exp Ther 311:1008-15. 2004..Overall, eye blink rate appears to be a robust behavioral measure that can be used to measure changes in dopaminergic D1 signaling and as a functional assay of agonist efficacy at dopamine D1 receptors...