David E Joyner

Summary

Affiliation: University of Utah
Country: USA

Publications

  1. ncbi Desmoid cell motility is induced in vitro by rhEGF
    David E Joyner
    Department of Orthopaedics, University of Utah, Salt Lake City, Utah 84112, USA
    J Orthop Res 27:1258-62. 2009
  2. ncbi FAP-associated desmoid invasiveness correlates with in vitro resistance to doxorubicin
    David E Joyner
    Department of Orthopaedics, Sarcoma Services, SARC Laboratory, and Huntsman Cancer Institute, University of Utah, 2000 Circle of Hope, Salt Lake City, UT 84112, USA
    Fam Cancer 8:569-80. 2009
  3. ncbi Potential for functional redundancy in EGF and TGFalpha signaling in desmoid cells: a cDNA microarray analysis
    Sylvia H Trang
    SARC Laboratory, Sarcoma Services, Department of Orthopaedics and Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA
    Growth Factors 28:10-23. 2010
  4. ncbi G3139 antisense oligonucleotide directed against antiapoptotic Bcl-2 enhances doxorubicin cytotoxicity in the FU-SY-1 synovial sarcoma cell line
    David E Joyner
    SARC Laboratory, Sarcoma Services, Huntsman Cancer Institute, University of Utah, 2000 Circle of Hope, Salt Lake City, Utah 84112, USA
    J Orthop Res 24:474-80. 2006
  5. ncbi Doxorubicin induces cell senescence preferentially over apoptosis in the FU-SY-1 synovial sarcoma cell line
    David E Joyner
    SARC Laboratory, Sarcoma Services, Huntsman Cancer Institute, University of Utah, 2000 Circle of Hope, Salt Lake City, Utah 84112, USA
    J Orthop Res 24:1163-9. 2006
  6. ncbi Fas death pathway in sarcomas correlates with epidermal growth factor transcription
    David E Joyner
    Department of Orthopaedics, Sarcoma Services, Huntsman Cancer Institute, University of Utah School of Medicine, 2000 Circle of Hope, Salt Lake City, UT 84112, USA
    Clin Orthop Relat Res 466:2092-8. 2008
  7. ncbi Oncogene coexpression in mesenchymal neoplasia correlates with EGF transcription
    David E Joyner
    Huntsman Cancer Institute, Department of Orthopaedics, University of Utah School of Medicine, Salt Lake City, UT 84112, USA
    Clin Orthop Relat Res 459:14-21. 2007
  8. ncbi Diagnosis and management of synovial sarcoma
    R Lor Randall
    Sarcoma Services, Suite 4260, Huntsman Cancer Institute, 2000 Circle of Hope, Salt Lake City, UT 84112, USA
    Curr Treat Options Oncol 6:449-59. 2005
  9. ncbi Discriminate gene lists derived from cDNA microarray profiles of limited samples permit distinguishing mesenchymal neoplasia ex vivo
    David E Joyner
    SAR Lab, Sarcoma Services, Department of Orthopedics, Huntsman Cancer Institute and Primary Children's Medical Center, University of Utah, Salt Lake City, UT 84112, USA
    J Cancer Res Clin Oncol 131:137-46. 2005
  10. ncbi Potential for modulation of the fas apoptotic pathway by epidermal growth factor in sarcomas
    David E Joyner
    Department of Orthopaedics, Huntsman Cancer Institute, The University of Utah, Salt Lake City, UT 84112, USA
    Sarcoma 2011:847409. 2011

Detail Information

Publications10

  1. ncbi Desmoid cell motility is induced in vitro by rhEGF
    David E Joyner
    Department of Orthopaedics, University of Utah, Salt Lake City, Utah 84112, USA
    J Orthop Res 27:1258-62. 2009
    ..When EGF and TGFbeta1 receptors were inhibited simultaneously, the level of rhEGF-induced cell migration was reduced significantly beyond the level of cell migration generated by inhibition of EGFR alone...
  2. ncbi FAP-associated desmoid invasiveness correlates with in vitro resistance to doxorubicin
    David E Joyner
    Department of Orthopaedics, Sarcoma Services, SARC Laboratory, and Huntsman Cancer Institute, University of Utah, 2000 Circle of Hope, Salt Lake City, UT 84112, USA
    Fam Cancer 8:569-80. 2009
    ..Three genes associated with apoptosis were identified by microarray, two prosurvival genes overexpressed in FAP-associated cell cultures (NTN1, TNFRSF10C) and one proapoptosis gene overexpressed in sporadic tumor cell cultures (FOXL2)...
  3. ncbi Potential for functional redundancy in EGF and TGFalpha signaling in desmoid cells: a cDNA microarray analysis
    Sylvia H Trang
    SARC Laboratory, Sarcoma Services, Department of Orthopaedics and Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA
    Growth Factors 28:10-23. 2010
    ..Approximately 150 genes costimulated by rhEGF and rhTGFalpha were identified. This study suggests that EGF and TGFalpha retain some level of functional redundancy, possibly resulting from their divergence from a common ancestral gene...
  4. ncbi G3139 antisense oligonucleotide directed against antiapoptotic Bcl-2 enhances doxorubicin cytotoxicity in the FU-SY-1 synovial sarcoma cell line
    David E Joyner
    SARC Laboratory, Sarcoma Services, Huntsman Cancer Institute, University of Utah, 2000 Circle of Hope, Salt Lake City, Utah 84112, USA
    J Orthop Res 24:474-80. 2006
    ..G3139 anti-Bcl-2 intervention sensitized the FU-SY-1 SS to doxorubicin, due to increased apoptosis. G3139 intervention was ineffective in the two non-SS cell lines...
  5. ncbi Doxorubicin induces cell senescence preferentially over apoptosis in the FU-SY-1 synovial sarcoma cell line
    David E Joyner
    SARC Laboratory, Sarcoma Services, Huntsman Cancer Institute, University of Utah, 2000 Circle of Hope, Salt Lake City, Utah 84112, USA
    J Orthop Res 24:1163-9. 2006
    ..Likely, both apoptosis and cell senescence contribute to doxorubicin-induced cell death in this synovial sarcoma cell line...
  6. ncbi Fas death pathway in sarcomas correlates with epidermal growth factor transcription
    David E Joyner
    Department of Orthopaedics, Sarcoma Services, Huntsman Cancer Institute, University of Utah School of Medicine, 2000 Circle of Hope, Salt Lake City, UT 84112, USA
    Clin Orthop Relat Res 466:2092-8. 2008
    ..The results suggest ligand activity in the Fas death pathway correlates with EGF transcription in sarcomas...
  7. ncbi Oncogene coexpression in mesenchymal neoplasia correlates with EGF transcription
    David E Joyner
    Huntsman Cancer Institute, Department of Orthopaedics, University of Utah School of Medicine, Salt Lake City, UT 84112, USA
    Clin Orthop Relat Res 459:14-21. 2007
    ..EGF may enhance, or may indicate the presence of, oncogene coexpression in benign mesenchymal lesions, but counters gene synchronization in sarcomas...
  8. ncbi Diagnosis and management of synovial sarcoma
    R Lor Randall
    Sarcoma Services, Suite 4260, Huntsman Cancer Institute, 2000 Circle of Hope, Salt Lake City, UT 84112, USA
    Curr Treat Options Oncol 6:449-59. 2005
    ..Meanwhile, carefully designed clinical trials of these agents, with translational correlates, will provide in vivo data to complement the preclinical experience...
  9. ncbi Discriminate gene lists derived from cDNA microarray profiles of limited samples permit distinguishing mesenchymal neoplasia ex vivo
    David E Joyner
    SAR Lab, Sarcoma Services, Department of Orthopedics, Huntsman Cancer Institute and Primary Children's Medical Center, University of Utah, Salt Lake City, UT 84112, USA
    J Cancer Res Clin Oncol 131:137-46. 2005
    ..CONCLUSIONS: Linear discriminate analysis of cDNA gene expression profiles partitioned mesenchymal tumor classes, even when constrained by limited sample sizes...
  10. ncbi Potential for modulation of the fas apoptotic pathway by epidermal growth factor in sarcomas
    David E Joyner
    Department of Orthopaedics, Huntsman Cancer Institute, The University of Utah, Salt Lake City, UT 84112, USA
    Sarcoma 2011:847409. 2011
    ..Cells destined for elimination inhibit this prosurvival response via a presently undefined pathway. This scenario represents a novel role for EGF and CTGF as regulators of the Fas pathway in sarcomas...