Research Topics
| P A JonesSummaryAffiliation: University of Southern California Country: USA Publications
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Publications
The DNA methylation paradoxP A Jones
Department of Biochemistry and Molecular Biology, University of Southern, California Norris Comprehensive Cancer Center and Hospital, Los Angeles 90033 0800, USA
Trends Genet 15:34-7. 1999..The methylation paradox might be resolved if it is hypothesized that transcription through a CpG island facilitates de novo methylation...- Cancer epigenetics comes of ageP A Jones
Department of Biochemistry and Molecular Biology, University of Southern California School of Medicine, The Norris Comprehensive Cancer Center, Los Angeles 90033, USA
Nat Genet 21:163-7. 1999..We review here current mechanistic understanding of the role of DNA methylation in malignant transformation, and suggest Knudson's two-hit hypothesis should now be expanded to include epigenetic mechanisms of gene inactivation... - The endothelin receptor B (EDNRB) promoter displays heterogeneous, site specific methylation patterns in normal and tumor cellsM M Pao
Department of Biochemistry and Molecular Biology, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, CA 90089-9176, USA
Hum Mol Genet 10:903-10. 2001.... - Large scale mapping of methylcytosines in CTCF-binding sites in the human H19 promoter and aberrant hypomethylation in human bladder cancerD Takai
Department of Biochemistry and Molecular Biology, USC Norris Comprehensive Cancer Center, Keck School of Medicine of the University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA 90033, USA
Hum Mol Genet 10:2619-26. 2001..Loss of methylation imprinting of H19 is linked to hypomethylation of the paternal allele in human bladder cancer, unlike the situation in Wilms' tumor and colon cancer where the maternal allele becomes hypermethylated... - The gene for a novel transmembrane protein containing epidermal growth factor and follistatin domains is frequently hypermethylated in human tumor cellsG Liang
Department of Biochemistry and Molecular Biology, University of Southern California Norris Comprehensive Cancer Center, School of Medicine, Los Angeles 90033, USA
Cancer Res 60:4907-12. 2000..Our results suggest that potential tumor suppressor genes can be isolated from human tumors by virtue of their altered methylation patterns... - Expression of H19 does not influence the timing of replication of the Igf2/H19 imprinted regionC Q Windham
Department of Biochemistry and Molecular Biology, USC Norris Comprehensive Cancer Center, Los Angeles, USA
Dev Genet 20:29-35. 1997..This indicates that any differences in the timing of replication at the Igf2/H19 locus are of a lesser magnitude than those found in other imprinted regions... - Altered chromatin structure associated with methylation-induced gene silencing in cancer cells: correlation of accessibility, methylation, MeCP2 binding and acetylationC T Nguyen
Department of Biochemistry and Molecular Biology, USC/Norris Comprehensive Cancer Center, Keck School of Medicine of the University of Southern California, 1441 Eastlake Avenue, Room 8302L, Los Angeles, CA 90089-9181, USA
Nucleic Acids Res 29:4598-606. 2001.... - Susceptibility of nonpromoter CpG islands to de novo methylation in normal and neoplastic cellsC Nguyen
Department of Biochemistry and Molecular Biology, University of Southern California/Norris Comprehensive Cancer Center, Keck School of Medicine of the USC, Los Angeles, USA
J Natl Cancer Inst 93:1465-72. 2001..Subsequent selection of cells with a growth advantage conferred by spread of methylation into and inactivation of a particular promoter might then contribute to the genesis of a specific type of cancer... - Global and gene-specific epigenetic patterns in human bladder cancer genomes are relatively stable in vivo and in vitro over timeI D Markl
Department of Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA 90089, USA
Cancer Res 61:5875-84. 2001.... - Reduced rates of gene loss, gene silencing, and gene mutation in Dnmt1-deficient embryonic stem cellsM F Chan
Department of Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, 90089-9176, USA
Mol Cell Biol 21:7587-600. 2001..We conclude that Dnmt1 deficiency and the accompanying genomic DNA hypomethylation result in a reduction of three major pathways of gene inactivation in our model system... - Presence of p53 mutations in primary nasopharyngeal carcinoma (NPC) in non-Asians of Los Angeles, California, a low-risk population for NPCJ M Van Tornout
Department of Pediatrics, JSC Norris Comprehensive Cancer Center, University of Southern California School of Medicine, Los Angeles 90033 0800, USA
Cancer Epidemiol Biomarkers Prev 6:493-7. 1997..This is the first report investigating the presence of p53 missense mutations in NPC among a low-risk population. Our data indicate that p53 is also an infrequent event among NPC patients at low risk for the disease... - The role of DNA methylation in mammalian epigeneticsP A Jones
USC Norris Comprehensive Cancer Center, Departments of Biochemistry and Molecular Biology, Keck School of Medicine of the University of Southern California, 1441 Eastlake Avenue, MS 8302L, Los Angeles, CA 90089 9181, USA
Science 293:1068-70. 2001.... - Novel endothelin B receptor transcripts with the potential of generating a new receptorM Tsutsumi
Department of Biochemistry and Molecular Biology, Urologic Cancer Research Laboratory USC Norris Comprehensive Cancer Center, University of Southern California, School of Medicine, Los Angeles, CA 90033, USA
Gene 228:43-9. 1999..These transcripts are widely expressed in human tissues, but their expression patterns vary between different tissues... - Coordinate regulation of Igf-2 and H19 in cultured cellsP Eversole-Cire
Department of Biochemistry and Molecular Biology, USC Norris Comprehensive Cancer Center, University of Southern California, School of Medicine, Los Angeles 90033, USA
Cell Growth Differ 6:337-45. 1995..The data provide new experimental evidence for previously hypothesized mechanisms suggesting that Igf-2 and H19 are coordinately regulated... - Mismatch repair deficiency and CpG island hypermethylation in sporadic colon adenocarcinomasZ Xiong
Departments of Surgery, University of Southern California, Keck School of Medicine, Los Angeles, CA 90089-9176, USA
Cancer Epidemiol Biomarkers Prev 10:799-803. 2001.... - Multiple sites of interaction between the intracellular domains of an inwardly rectifying potassium channel, Kir6.2P A Jones
University Laboratory of Physiology, Parks Road, Oxford OX1 3PT, UK
FEBS Lett 508:85-9. 2001.... - Tissue-specific alternative splicing in the human INK4a/ARF cell cycle regulatory locusK D Robertson
USC Norris Comprehensive Cancer Center, Los Angeles, California 90033, USA
Oncogene 18:3810-20. 1999..The implications of the capacity of the INK4a/ARF locus to encode a third transcript, and for pancreatic cancer, in which the INK4a/ARF locus is nearly always altered, are considered... - The human DNA methyltransferases (DNMTs) 1, 3a and 3b: coordinate mRNA expression in normal tissues and overexpression in tumorsK D Robertson
University of Southern California, Norris Comprehensive Cancer Center, MS 83, 1441 Eastlake Avenue, Los Angeles, CA 90033, USA
Nucleic Acids Res 27:2291-8. 1999..Lastly, several novel alternatively spliced forms of DNMT3b, which may have altered enzymatic activity, were found to be expressed in a tissue-specific manner... - Zebularine: a new drug for epigenetic therapyC B Yoo
Department of Urology, USC/Norris Comprehensive Cancer Center, University of Southern California, Keck School of Medicine, 1441 Eastlake Ave, Los Angeles, CA 90089-9176, USA
Biochem Soc Trans 32:910-2. 2004..Further studies exploring the effectiveness of zebularine in a variety of settings could allow the development of novel therapies for cancer...