Research Topics
| Christine JohnstonSummaryAffiliation: University of Washington Country: USA Publications
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Publications
Standard-dose and high-dose daily antiviral therapy for short episodes of genital HSV-2 reactivation: three randomised, open-label, cross-over trialsChristine Johnston
Department of Medicine, University of Washington, Seattle, WA 98104, USA
Lancet 379:641-7. 2012..Skin and mucosal herpes simplex virus type 2 (HSV-2) shedding predominantly occurs in short subclinical episodes. We assessed whether standard-dose or high-dose antiviral therapy reduces the frequency of such shedding...- Herpes simplex virus type 2 serological testing and psychosocial harm: a systematic reviewKaile Ross
University of Washington Virology Research Clinic, Box 359928, 325 Ninth Avenue, Seattle, WA 98104, USA
Sex Transm Infect 87:594-600. 2011..Concerns about sustained emotional impact should not deter clinicians from offering HSV-2 serological testing to appropriate patients... - HSV-2: in pursuit of a vaccineChristine Johnston
Department of Medicine, University of Washington, Seattle, Washington, USA
J Clin Invest 121:4600-9. 2011.... - Herpes simplex virus viremia during primary genital infectionChristine Johnston
Department of Medicine, Universityof Washington, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
J Infect Dis 198:31-4. 2008..61%; P=.01). Viremia was detected more frequently and at a higher number of copies per milliliter early in infection. We conclude that HSV viremia during primary genital HSV infection is common, especially among women... - Impact of HIV infection and Kaposi sarcoma on human herpesvirus-8 mucosal replication and dissemination in UgandaChristine Johnston
Department of Medicine, University of Washington, Seattle, Washington, United States of America
PLoS ONE 4:e4222. 2009..Human herpesvirus-8 (HHV-8) replication is important both in transmission of HHV-8 and progression to KS. We characterized the sites and frequency of HHV-8 detection in Ugandans with and without HIV and KS... - Overlapping reactivations of herpes simplex virus type 2 in the genital and perianal mucosaSunitha Tata
Vaccine and Infectious Disease Institute, University of Washington, Seattle, USA
J Infect Dis 201:499-504. 2010..Genital shedding of herpes simplex virus (HSV) type 2 occurs frequently. Anatomic patterns of genital HSV-2 reactivation have not been intensively studied... - Genital shedding of herpes simplex virus among symptomatic and asymptomatic persons with HSV-2 infectionElizabeth Tronstein
Department of Medicine, University of Washington, Seattle, USA
JAMA 305:1441-9. 2011..The course of natural history of HSV-2 in asymptomatic, seropositive persons is uncertain... - Persistence of HIV-1 receptor-positive cells after HSV-2 reactivation is a potential mechanism for increased HIV-1 acquisitionJia Zhu
Vaccine and Infectious Disease Institute, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
Nat Med 15:886-92. 2009..The persistence and enrichment of HIV receptor-positive inflammatory cells in the genitalia help explain the inability of anti-HSV-2 therapy to reduce HIV acquisition... - Diversity in CD8(+) T cell function and epitope breadth among persons with genital herpesKerry J Laing
Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
J Clin Immunol 30:703-22. 2010..The diversity in T cell response in these ex vivo assessments offers the potential of defining immune correlates of HSV-2 reactivation in humans... - Clinician and patient recognition of anogenital herpes disease in HIV positive men who have sex with menMichael Isiah Sandlin
School of Medicine, University of Washington, Seattle, WA 98104, USA
Sex Transm Dis 38:833-6. 2011..When compared with clinician examination, HIV/HSV-2 coinfected men who have sex with men are frequently unaware of anogenital ulcers. These data highlight the importance of condom use and the need for new HSV-2 prevention strategies...