MARK LOUIS JOHNSON

Summary

Affiliation: University of Missouri-Kansas City
Country: USA

Publications

  1. ncbi How genomics has informed our understanding of the pathogenesis of osteoporosis
    Mark L Johnson
    Department of Oral Biology, University of Missouri Kansas City School of Dentistry, 650 East 25th Street, Kansas City, MO 64108, USA
    Genome Med 1:84. 2009
  2. ncbi Parameters of LRP5 from a structural and molecular perspective
    Mark L Johnson
    Creighton University School of Medicine, Osteoporosis Research Center, Omaha, NE 68131, USA
    Crit Rev Eukaryot Gene Expr 15:229-42. 2005
  3. ncbi The Wnt signaling pathway and bone metabolism
    Mark L Johnson
    Department of Oral Biology, University of Missouri Kansas City, School of Dentistry, Kansas City, Missouri 64108, USA
    Curr Opin Rheumatol 19:376-82. 2007
  4. ncbi Diseases of Wnt signaling
    Mark L Johnson
    Department of Oral Biology, UMKC School of Dentistry, 650 East 25th Street, Kansas City, MO 64108, USA
    Rev Endocr Metab Disord 7:41-9. 2006
  5. ncbi Osteocytes, mechanosensing and Wnt signaling
    Lynda F Bonewald
    University of Missouri, Kansas City School of Dentistry, Department of Oral Biology, 650 East 25th Street, Kansas City, MO 64108, USA
    Bone 42:606-15. 2008
  6. ncbi LRP5 and Wnt signaling: a union made for bone
    Mark L Johnson
    Osteoporosis Research Center, Creighton University School of Medicine, Omaha, Nebraska 68131, USA
    J Bone Miner Res 19:1749-57. 2004
  7. ncbi Identifying disease genes underlying complex traits
    Mark L Johnson
    Creighton University School of Medicine, Osteoporosis Research Center, 601 North 30th Street, Suite 6730, Omaha, NE 68131, USA
    Clin Rev Allergy Immunol 22:3-10. 2002
  8. ncbi A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait
    Randall D Little
    Department of Human Genetics, Genome Therapeutics Corporation, Waltham, MA 02453, USA
    Am J Hum Genet 70:11-9. 2002
  9. ncbi High bone density due to a mutation in LDL-receptor-related protein 5
    Randall D Little
    N Engl J Med 347:943-4; author reply 943-4. 2002
  10. ncbi Wnt/beta-catenin signaling is a normal physiological response to mechanical loading in bone
    John A Robinson
    Women s Health and Musculoskeletal Biology, Wyeth Research, Collegeville, Pennsylvania 19426, USA
    J Biol Chem 281:31720-8. 2006

Research Grants

  1. THE ROLE OF LRP5 IN BONE RESPONSE TO MECHANICAL LOADING
    Mark Johnson; Fiscal Year: 2009
  2. THE ROLE OF LRP5 IN BONE RESPONSE TO MECHANICAL LOADING
    MARK LOUIS JOHNSON; Fiscal Year: 2010

Detail Information

Publications10

  1. ncbi How genomics has informed our understanding of the pathogenesis of osteoporosis
    Mark L Johnson
    Department of Oral Biology, University of Missouri Kansas City School of Dentistry, 650 East 25th Street, Kansas City, MO 64108, USA
    Genome Med 1:84. 2009
    ....
  2. ncbi Parameters of LRP5 from a structural and molecular perspective
    Mark L Johnson
    Creighton University School of Medicine, Osteoporosis Research Center, Omaha, NE 68131, USA
    Crit Rev Eukaryot Gene Expr 15:229-42. 2005
    ..Ultimately, these interactions regulate the activity of the Wnt/beta-catenin signaling pathway and the role it plays in processes such as bone mass accrual and vision...
  3. ncbi The Wnt signaling pathway and bone metabolism
    Mark L Johnson
    Department of Oral Biology, University of Missouri Kansas City, School of Dentistry, Kansas City, Missouri 64108, USA
    Curr Opin Rheumatol 19:376-82. 2007
    ..This review will examine some of the seminal findings that have brought us to our current understanding of the role of this pathway in bone metabolism...
  4. ncbi Diseases of Wnt signaling
    Mark L Johnson
    Department of Oral Biology, UMKC School of Dentistry, 650 East 25th Street, Kansas City, MO 64108, USA
    Rev Endocr Metab Disord 7:41-9. 2006
    ..Our emerging understanding of Wnt signaling offers great hope that new molecular based screening tests and pharmaceutical agents that selectively target this pathway will be developed to diagnose and treat these diseases in the future...
  5. ncbi Osteocytes, mechanosensing and Wnt signaling
    Lynda F Bonewald
    University of Missouri, Kansas City School of Dentistry, Department of Oral Biology, 650 East 25th Street, Kansas City, MO 64108, USA
    Bone 42:606-15. 2008
    ..The study of osteocyte biology is becoming an intense area of research interest and this review will examine some of the recent findings that are reshaping our understanding of bone/bone cell biology...
  6. ncbi LRP5 and Wnt signaling: a union made for bone
    Mark L Johnson
    Osteoporosis Research Center, Creighton University School of Medicine, Omaha, Nebraska 68131, USA
    J Bone Miner Res 19:1749-57. 2004
  7. ncbi Identifying disease genes underlying complex traits
    Mark L Johnson
    Creighton University School of Medicine, Osteoporosis Research Center, 601 North 30th Street, Suite 6730, Omaha, NE 68131, USA
    Clin Rev Allergy Immunol 22:3-10. 2002
  8. ncbi A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait
    Randall D Little
    Department of Human Genetics, Genome Therapeutics Corporation, Waltham, MA 02453, USA
    Am J Hum Genet 70:11-9. 2002
    ..Our findings suggest that the HBM mutation confers a unique osteogenic activity in bone remodeling, and this understanding may facilitate the development of novel therapies for the treatment of osteoporosis...
  9. ncbi High bone density due to a mutation in LDL-receptor-related protein 5
    Randall D Little
    N Engl J Med 347:943-4; author reply 943-4. 2002
  10. ncbi Wnt/beta-catenin signaling is a normal physiological response to mechanical loading in bone
    John A Robinson
    Women s Health and Musculoskeletal Biology, Wyeth Research, Collegeville, Pennsylvania 19426, USA
    J Biol Chem 281:31720-8. 2006
    ....

Research Grants5

  1. THE ROLE OF LRP5 IN BONE RESPONSE TO MECHANICAL LOADING
    Mark Johnson; Fiscal Year: 2009
    ..into a paradigm that ultimately explains how bone responds to mechanical loading at the cellular and molecular level. This will lead to new approaches to treating and/or preventing osteoporosis. ..
  2. THE ROLE OF LRP5 IN BONE RESPONSE TO MECHANICAL LOADING
    MARK LOUIS JOHNSON; Fiscal Year: 2010
    ..into a paradigm that ultimately explains how bone responds to mechanical loading at the cellular and molecular level. This will lead to new approaches to treating and/or preventing osteoporosis. ..