Research Topics
| Karen C JohnsonSummaryAffiliation: University of Tennessee Country: USA Publications
Research Grants
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Detail Information
Publications
A prospective study of the effect of hypertension and baseline blood pressure on cognitive decline and dementia in postmenopausal women: the Women's Health Initiative Memory StudyKaren C Johnson
Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis, Tennesse 38163, USA
J Am Geriatr Soc 56:1449-58. 2008..To examine the relationship between baseline hypertension, blood pressure, and the development of cognitive decline in participants in the Women's Health Initiative Memory Study (WHIMS)...- Access of over-the-counter nicotine replacement therapy products to minorsKaren C Johnson
Department of Preventive Medicine, The University of Tennessee Health Science Center, Memphis 38163, USA
Arch Pediatr Adolesc Med 158:212-6. 2004..It is not clear how easily minors are able to purchase NRT products in retail markets... - Antiepileptic drug use, falls, fractures, and BMD in postmenopausal women: findings from the women's health initiative (WHI)Laura D Carbone
Department of Veterans Affairs Medical Center, Memphis, TN, USA
J Bone Miner Res 25:873-81. 2010..09-1.69, respectively). We conclude that in clinical practice, postmenopausal women who use AEDs should be considered at increased risk for fracture, and attention to fall prevention may be particularly important in these women... - Estimation of macular pigment optical density in the elderly: test-retest variability and effect of optical blur in pseudophakic subjectsKevin T Gallaher
Department of Ophthalmology, Hamilton Eye Institute, University of Tennessee Health Science Center, 930 Madison Avenue, Suite 731, Memphis, TN 38163, USA
Vision Res 47:1253-9. 2007..9+/-3.6) by comparing the baseline MPOD, obtained with an optimal correction, with MPODs obtained with a +/-1.00-diopter optical blur. This optical blur did not cause differences in the MPOD estimates, its accuracy, or test duration... - Family history of myocardial infarction predicts incident coronary heart disease in postmenopausal women with diabetes: the Women's Health Initiative Observational StudyRongling Li
University of Tennessee Health Science Center, Department of Preventive Medicine, Memphis, TN, USA
Diabetes Metab Res Rev 25:725-32. 2009..The goal of this study was to assess the relationship between family history of myocardial infarction (MI) and incident CHD in diabetic postmenopausal women... - Osteoporosis care in the United States after declines in reimbursements for DXABurton L Hayes
Department of Medicine, University of Tennessee Health Science Center, Memphis, TN, USA
J Clin Densitom 13:352-60. 2010.... - Use of nicotine replacement therapy in adolescent smokers and nonsmokersLisa M Klesges
Department of Preventive Medicine, University of Tennessee Health Science Center, 66 N. Pauline, Suite 633, Memphis, TN 38163, USA
Arch Pediatr Adolesc Med 157:517-22. 2003..Efforts are needed to discourage NRT use in nonsmoking youth and to encourage appropriate use of NRT in young smokers to maximize its potential for successful cessation... - Macular pigment optical density in the elderly: findings in a large biracial Midsouth population sampleAlessandro Iannaccone
Department of Ophthalmology, Hamilton Eye Institute, University of Tennessee Health Science Center, 930 Madison Avenue, Memphis, TN 38163, USA
Invest Ophthalmol Vis Sci 48:1458-65. 2007..5 degrees of eccentricity from the fovea in elderly subjects participating in ARMA, a study of aging and age-related maculopathy (ARM) ancillary to the Health, Aging, and Body Composition (Health ABC) Study... - Loop diuretic use and fracture in postmenopausal women: findings from the Women's Health InitiativeLaura D Carbone
Department of Veterans Affairs Medical Center, Memphis, TN, USA
Arch Intern Med 169:132-40. 2009..The relationship of loop diuretics to bone mineral density (BMD), falls, and fractures in postmenopausal women has not been established... - Effects of conjugated equine estrogen on stroke in the Women's Health InitiativeSusan L Hendrix
Department of Obstetrics and Gynecology, Wayne State University School of Medicine Hutzel Women s Hospital, Detroit, MI, USA
Circulation 113:2425-34. 2006..This report provides a thorough analysis of the stroke finding using the final results from the completed trial database... - Calcium/vitamin D supplementation and cardiovascular eventsJudith Hsia
Department of Medicine, George Washington University, Washington, DC, USA
Circulation 115:846-54. 2007..We evaluated the risk of coronary and cerebrovascular events in the Women's Health Initiative randomized trial of calcium plus vitamin D supplementation... - Estrogen plus progestin and the risk of coronary heart diseaseJoAnn E Manson
Division of Preventive Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
N Engl J Med 349:523-34. 2003..In this report, we provide the final results with regard to estrogen plus progestin and CHD from the Women's Health Initiative (WHI)... - Associations between age-related nuclear cataract and lutein and zeaxanthin in the diet and serum in the Carotenoids in the Age-Related Eye Disease Study, an Ancillary Study of the Women's Health InitiativeSuzen M Moeller
Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI 53726 2336, USA
Arch Ophthalmol 126:354-64. 2008..To evaluate associations between nuclear cataract (determined from slitlamp photographs between May 2001 and January 2004) and lutein and zeaxanthin in the diet and serum in patients between 1994 and 1998 and macula between 2001 and 2004... - Cigarette smoking and risk of benign proliferative epithelial disorders of the breast in the Women's Health InitiativeYan Cui
Department of Epidemiology and Population Health, Albert Einstein College of Medicine, 1300 Morris Park Ave, Belfer 1301, Bronx, NY 10461, USA
Cancer Causes Control 18:431-8. 2007..To investigate the association between cigarette smoking and risk of benign proliferative epithelial disorders (BPED) of the breast... - Relation of demographic factors, menstrual history, reproduction and medication use to sex hormone levels in postmenopausal womenAnne McTiernan
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Breast Cancer Res Treat 108:217-31. 2008..These results suggest that while age, oophorectomy status, and NSAID use may be associated with selected sex hormone concentrations, few menstrual or reproductive factors affect endogenous sex hormones in the postmenopausal period... - Calcium plus vitamin D supplementation and the risk of colorectal cancerJean Wactawski-Wende
Department of Social and Preventive Medicine, University at Buffalo, 270 Farber Hall, Buffalo, NY 14214, USA
N Engl J Med 354:684-96. 2006..However, randomized-trial evidence that calcium with vitamin D supplementation is beneficial in the primary prevention of colorectal cancer is lacking... - Calcium plus vitamin D supplementation and the risk of fracturesRebecca D Jackson
Division of Endocrinology, Ohio State University, 485 McCampbell, 1581 Dodd Dr, Columbus, OH 43210, USA
N Engl J Med 354:669-83. 2006..The efficacy of calcium with vitamin D supplementation for preventing hip and other fractures in healthy postmenopausal women remains equivocal... - Calcium plus vitamin D supplementation and the risk of incident diabetes in the Women's Health InitiativeIan H De Boer
Division of Nephrology, University of Washington, 1959 NE Pacific Street, Seattle, WA 98195, USA
Diabetes Care 31:701-7. 2008..We examined the effect of calcium plus vitamin D supplementation on the incidence of drug-treated diabetes in postmenopausal women... - Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women's Health Initiative randomized controlled trialJacques E Rossouw
Division of Women s Health Initiative, National Heart, Lung, and Blood Institute, 6705 Rockledge Dr, One Rockledge Ctr, Suite 300, Bethesda, MD 20817
JAMA 288:321-33. 2002..Despite decades of accumulated observational evidence, the balance of risks and benefits for hormone use in healthy postmenopausal women remains uncertain... - Effect of estrogen plus progestin on global cognitive function in postmenopausal women: the Women's Health Initiative Memory Study: a randomized controlled trialStephen R Rapp
Department of Psychiatry and Behavioral Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
JAMA 289:2663-72. 2003..On July 8, 2002, the estrogen plus progestin therapy in the WHI trial was discontinued because of certain increased health risks for women... - Calcium, vitamin D supplementation, and physical function in the Women's Health InitiativeRobert L Brunner
University of Nevada School of Medicine, PMB 251, MS 145, Reno, NV 89557, USA
J Am Diet Assoc 108:1472-9. 2008..Now we examine whether the treatment affected self-reported physical functioning and objective measures of physical functioning... - Effects of conjugated equine estrogen in postmenopausal women with hysterectomy: the Women's Health Initiative randomized controlled trialGarnet L Anderson
Fred Hutchinson Cancer Research Center, Seattle, Wash 98109 1024, USA
JAMA 291:1701-12. 2004..Despite decades of use and considerable research, the role of estrogen alone in preventing chronic diseases in postmenopausal women remains uncertain... - Low-fat dietary pattern and risk of cardiovascular disease: the Women's Health Initiative Randomized Controlled Dietary Modification TrialBarbara V Howard
MedStar Research Institute Howard University, Washington, DC, USA
JAMA 295:655-66. 2006..Multiple epidemiologic studies and some trials have linked diet with cardiovascular disease (CVD) prevention, but long-term intervention data are needed... - Abdominal aortic aneurysm events in the women's health initiative: cohort studyFrank A Lederle
VA Medical Center, Minneapolis, MN 55417, USA
BMJ 337:a1724. 2008..To assess the association between potential risk factors and subsequent clinically important abdominal aortic aneurysm events (repairs and ruptures) in women... - Statin use and incident frailty in women aged 65 years or older: prospective findings from the Women's Health Initiative Observational StudyAndrea Z LaCroix
Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
J Gerontol A Biol Sci Med Sci 63:369-75. 2008..This study examines associations between current use, duration, and potency of statin medications and incident frailty in initially nonfrail women 65 years old or older... - Effects of estrogen with and without progestin and obesity on symptomatic gastroesophageal refluxZongli Zheng
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
Gastroenterology 135:72-81. 2008..An association between female hormones and symptomatic gastroesophageal reflux disease (GERD) and may be modified by obesity is suggested but not proven. Factors affecting GERD progression, however, are largely unknown... - Fosinopril versus amlodipine comparative treatments study: a randomized trial to assess effects on plasminogen activator inhibitor-1Marco Pahor
Sticht Center on Aging, Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
Circulation 105:457-61. 2002..ACE inhibitors and calcium antagonists may modulate fibrinolysis. We conducted a randomized controlled trial to assess the effects of these drugs on plasminogen activator inhibitor-1 (PAI-1) antigen, an inhibitor of fibrinolysis... - Hip bone density predicts breast cancer risk independently of Gail score: results from the Women's Health InitiativeZhao Chen
Division of Epidemiology and Biostatistics, University of Arizona College of Public Health, Tucson, Arizona 85724 5211, USA
Cancer 113:907-15. 2008..The objective of the current study was to investigate whether hip BMD predicts postmenopausal breast cancer risk independently of the Gail score... - Usefulness of baseline lipids and C-reactive protein in women receiving menopausal hormone therapy as predictors of treatment-related coronary eventsPaul F Bray
Cardeza Foundation for Hematologic Research and Jefferson Medical College, Philadelphia, Pennsylvania, USA
Am J Cardiol 101:1599-1605. 2008..However, women with favorable lipid levels, especially LDL/HDL cholesterol ratio <2.5, did not have increased risk of coronary heart disease with CEE with or without MPA irrespective of hs-CRP... - Estrogen plus progestin and breast cancer detection by means of mammography and breast biopsyRowan T Chlebowski
Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA 90502, USA
Arch Intern Med 168:370-7; quiz 345. 2008..The effect of combined hormone therapy on breast cancer detection is not established... - Low-fat dietary pattern and risk of treated diabetes mellitus in postmenopausal women: the Women's Health Initiative randomized controlled dietary modification trialLesley F Tinker
Women s Health Initiative, Fred Hutchinson Cancer Research Center, PO Box 19024, Mail Stop M3 A410, Seattle, WA 98109, USA
Arch Intern Med 168:1500-11. 2008..This study was undertaken to assess the effects of a low-fat dietary pattern on incidence of treated diabetes among generally healthy postmenopausal women... - Tracking development of speech recognition: longitudinal data from hierarchical assessments in the Childhood Development after Cochlear Implantation StudyNae Yuh Wang
Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University, Baltimore, Maryland, USA
Otol Neurotol 29:240-5. 2008..To develop a speech recognition index that summarizes data collected through an array of age-appropriate hierarchical speech recognition tests in a longitudinal study... - Outcomes ascertainment and adjudication methods in the Women's Health InitiativeJ David Curb
Department of Geriatric Medicine, University of Hawaii, Honolulu, HI 96813, USA
Ann Epidemiol 13:S122-8. 2003 - Correlates of adherence with transdermal nicotineTheodore V Cooper
Department of Psychiatry and Human Behavior, The University of Mississippi Medical Center, GV Sonny Montgomery Veteran s Affairs Medical Center, 2500 North State Street, Jackson 39216, USA
Addict Behav 29:1565-78. 2004..421-4.832, P = .002). Noteworthy however, was the lack of association between level of income and patch adherence. These findings suggest characteristics of those more and less likely to adhere to TN in research and clinical settings... - A placebo controlled randomized trial of the effects of phenylpropanolamine and nicotine gum on cessation rates and postcessation weight gain in womenTheodore V Cooper
Department of Psychiatry and Human Behavior, G V Sonny Montgomery Veterans Affairs Medical Center, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USA
Addict Behav 30:61-75. 2005..Future efforts should focus on increasing adherence to behavioral program components, particularly session attendance... - Estrogen-plus-progestin use and mammographic density in postmenopausal women: Women's Health Initiative randomized trialAnne McTiernan
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98019, USA
J Natl Cancer Inst 97:1366-76. 2005..Increased mammographic density reduces the sensitivity of screening mammography, is associated with increased breast cancer risk, and may be hormone related. We assessed the effect of estrogen-plus-progestin therapy on mammographic density... - Low-fat dietary pattern and risk of invasive breast cancer: the Women's Health Initiative Randomized Controlled Dietary Modification TrialRoss L Prentice
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Wash 98109, USA
JAMA 295:629-42. 2006..The hypothesis that a low-fat dietary pattern can reduce breast cancer risk has existed for decades but has never been tested in a controlled intervention trial... - Low-fat dietary pattern and risk of colorectal cancer: the Women's Health Initiative Randomized Controlled Dietary Modification TrialShirley A A Beresford
Department of Epidemiology, University of Washington, Seattle, WA 98195 7236, USA
JAMA 295:643-54. 2006..Observational studies and polyp recurrence trials are not conclusive regarding the effects of a low-fat dietary pattern on risk of colorectal cancer, necessitating a primary prevention trial... - Conjugated equine estrogens and coronary heart disease: the Women's Health InitiativeJudith Hsia
Department of Medicine, George Washington University, Washington, DC, USA
Arch Intern Med 166:357-65. 2006..These trials did not address the role of unopposed estrogen for coronary protection... - Risk of fracture in women with type 2 diabetes: the Women's Health Initiative Observational StudyDenise E Bonds
M P H, Department of Epidemiology and Prevention, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, North Carolina 27157, USA
J Clin Endocrinol Metab 91:3404-10. 2006..Some but not all studies have shown higher rates of fracture in individuals with type 2 diabetes... - Varenicline for smoking cessation: definite promise, but no panaceaRobert C Klesges
JAMA 296:94-5. 2006 - Impact of inflammation on the relationship among alcohol consumption, mortality, and cardiac events: the health, aging, and body composition studyCinzia Maraldi
Department of Aging and Geriatric Research, College of Medicine, Institute on Aging, University of Florida, 1329 SW 16th St, Gainesville, FL 32608, USA
Arch Intern Med 166:1490-7. 2006..We investigated the relationship of alcohol intake with all-cause mortality and cardiac events and evaluated whether this relationship is mediated or modified by inflammatory markers... - Association of inflammatory markers with socioeconomic statusAnnemarie Koster
Department of Health Care Studies, Section of Medical Sociology, Universiteit Maastricht, P O Box 616, 6200 MD Maastricht, The Netherlands
J Gerontol A Biol Sci Med Sci 61:284-90. 2006.... - Cardiovascular disease, its risk factors and treatment, and age-related macular degeneration: Women's Health Initiative Sight Exam ancillary studyRonald Klein
Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, Wisconsin 53726, USA
Am J Ophthalmol 143:473-83. 2007..To examine the association of cardiovascular disease (CVD), CVD risk factors, and CVD treatment with age-related macular degeneration (AMD)... - Endogenous estrogen levels and the effects of ultra-low-dose transdermal estradiol therapy on bone turnover and BMD in postmenopausal womenAlison J Huang
Veterans Affairs Medical Center, San Francisco, California, USA
J Bone Miner Res 22:1791-7. 2007..This suggests that the protective effects of ultra-low-dose estrogen therapy on the postmenopausal skeletal health may depend critically on women's endogenous estrogen levels before treatment... - Daily coffee consumption and prevalence of nonmelanoma skin cancer in Caucasian womenErnest L Abel
Department of Obstetrics and Gynecology, Wayne State University, Detroit, Michigan, USA
Eur J Cancer Prev 16:446-52. 2007..Daily caffeinated coffee consumption was associated with a dose-related decreased prevalence of nonmelanoma skin cancer in Caucasian women... - Association of angiotensin-converting enzyme DD genotype with blood pressure sensitivity to weight lossJohn B Kostis
UMDNJ Robert Wood Johnson Medical School, New Brunswick, NJ 08903 0019, USA
Am Heart J 144:625-9. 2002..Salt sensitivity--the degree of blood pressure change in response to a change in sodium load--has been extensively explored. However, the determinants of the extent of blood pressure change after weight reduction have not been evaluated...
Research Grants
- The Look AHEAD Continuation: Action for Health in DiabetesKaren Johnson; Fiscal Year: 2007..These procedures will enable us to analyze the effects of the intervention on serious cardiovascular- related factors and complications, and cost-effectiveness of the intervention. ..