Research Topics
Species | Xia JinSummaryAffiliation: University of Rochester Country: USA Publications
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Publications
Human immunodeficiency virus type 1 (HIV-1)-specific CD8+-T-cell responses for groups of HIV-1-infected individuals with different HLA-B*35 genotypesXia Jin
Infectious Disease Unit, University of Rochester Medical Center, 601 Elmwood Avenue, Box 689, Rochester, NY 14642, USA
J Virol 76:12603-10. 2002..05). The data are consistent with the hypothesis that higher levels of virus-specific CTL contribute to protection against HIV disease progression in infected individuals with B*35-PY, but not in those with B*35-Px...- Dengue vaccine development and dengue viral neutralization and enhancement assaysXia Jin
Department of Medicine, University of Rochester Medical Center, Rochester, NY, USA
Antivir Ther 14:739-49. 2009..We conclude that modification of current neutralization assays is required to improve the correlation between neutralization end point determinations and protection against secondary heterotypic dengue infections... - APOBEC3G/CEM15 (hA3G) mRNA levels associate inversely with human immunodeficiency virus viremiaXia Jin
Department of Medicine, University of Rochester, NY 14682, USA
J Virol 79:11513-6. 2005..00012) in these patients. Furthermore, we discovered that the order of hA3G mRNA levels is LTNPs > HIV-uninfected subjects > progressors... - Interleukin-2 reconstitutes defective human immunodeficiency virus (HIV), and cytomegalovirus (CMV) specific CD8+ T cell proliferation in HIV infectionJie Yu
Department of Medicine, Infectious Diseases Unit, University of Rochester School of Medicine and Dentistry, New York 14642, USA
J Med Virol 78:1147-57. 2006..These defective proliferative responses of HIV- and CMV-specific CD8+ T cells were restored by the addition of IL-2 at the time of stimulation. These results may have implications for the design of immune modulation strategies in vivo... - APOBEC3G levels predict rates of progression to AIDSXia Jin
Departments of Medicine, University of Rochester, Rochester, New York 14642, USA
Retrovirology 4:20. 2007..These conflicting results indicate that a more comprehensive, conclusive investigation of hA3G expression levels in various patient cohorts is urgently needed... - Monocytes, but not T or B cells, are the principal target cells for dengue virus (DV) infection among human peripheral blood mononuclear cellsZhihua Kou
Department of Medicine, Infectious Diseases Division, University of Rochester, Rochester, New York 14642, USA
J Med Virol 80:134-46. 2008..They also demonstrate that using modern experimental technology, DV infection, and neutralization and enhancement of DV infection can be easily assessed simultaneously in multiple cell types... - Dengue virus neutralization is modulated by IgG antibody subclass and Fcgamma receptor subtypeW W Shanaka I Rodrigo
Department of Pathology and Laboratory Medicine, University of Rochester, Rochester, NY 14642, USA
Virology 394:175-82. 2009..Thus, the IgG antibody subclass profile generated by DENV infection or vaccination may independently influence the magnitude of the neutralizing response... - An automated Dengue virus microneutralization plaque assay performed in human Fc{gamma} receptor-expressing CV-1 cellsW W Shanaka I Rodrigo
Departments of Pathology and Laboratory Medicine, Microbiology and Immunology, and Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
Am J Trop Med Hyg 80:61-5. 2009.... - Primary human splenic macrophages, but not T or B cells, are the principal target cells for dengue virus infection in vitroShanley Blackley
Department of Biology, University of Rochester, Rochester, New York 14642, USA
J Virol 81:13325-34. 2007.... - Primary human endothelial cells support direct but not antibody-dependent enhancement of dengue viral infectionMaria T Arévalo
Department of Microbiology and Immunology, University of Rochester, New York 14642, USA
J Med Virol 81:519-28. 2009.... - Human antibodies against dengue enhance dengue viral infectivity without suppressing type I interferon secretion in primary human monocytesZhihua Kou
Department of Medicine, University of Rochester, Rochester, NY 14642, USA
Virology 410:240-7. 2011..These results demonstrate that the regulation of virus production in ADE infection of primary human monocytes is more complex than previously appreciated... - A tetravalent recombinant dengue domain III protein vaccine stimulates neutralizing and enhancing antibodies in miceOlivia K T Block
Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
Vaccine 28:8085-94. 2010..Vaccine strategies directed to DENV-dIII-targeted neutralizing antibody production remain attractive but will likely require further modifications to induce safe, protective immunity... - A novel HIV T helper epitope-based vaccine elicits cytokine-secreting HIV-specific CD4+ T cells in a Phase I clinical trial in HIV-uninfected adultsXia Jin
Infectious Diseases Division, University of Rochester Medical Center, Rochester, NY 14642, United States xia
Vaccine 27:7080-6. 2009..The responding CD4+ T cells made various combinations of IL-2, IL-4, IFN-gamma, and TNF-alpha. The study demonstrated that the EP-1043 vaccine is safe, well-tolerated, and immunogenic... - Statistical determination of threshold for cellular division in the CFSE-labeling assayDacheng Liu
Department of Biostatistics and Computational Biology, University of Rochester School of Medicine and Dentistry, Rochester, New York, NY 14642, USA
J Immunol Methods 312:126-36. 2006..071% (95% confidence) and 0.114% (99% confidence) of total CFSE-labeled cells under our laboratory conditions. We offer our methods presented here for other investigators to calculate a threshold in their own CFSE-labeling experiments... - Evaluation of a multiple-cycle, recombinant virus, growth competition assay that uses flow cytometry to measure replication efficiency of human immunodeficiency virus type 1 in cell cultureCarrie Dykes
Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
J Clin Microbiol 44:1930-43. 2006..This flow cytometry-based growth competition assay offers advantages over current assays for HIV replication efficiency and should prove useful for the evaluation of patient samples in clinical trials... - HIV-specific cytotoxic cell frequencies measured directly ex vivo by the Lysispot assay can be higher or lower than the frequencies of IFN-gamma-secreting cells: anti-HIV cytotoxicity is not generally impaired relative to other chronic virus responsesJennifer E Snyder-Cappione
David H. Smith Center for Vaccine Biology and Immunology, and Department of Microbiology and Immunology, University of Rochester Medical Center, NY 14642, USA
J Immunol 176:2662-8. 2006..Analysis of the frequency of directly cytotoxic HIV-specific T cells may be of considerable value in the assessment of disease progression and the potential efficacy of HIV vaccines... - A phase I trial of preventive HIV vaccination with heterologous poxviral-vectors containing matching HIV-1 inserts in healthy HIV-uninfected subjectsMichael C Keefer
Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA michael
Vaccine 29:1948-58. 2011..Thus, a heterologous poxvirus vector prime-boost regimen can induce HIV-specific CD8+ T-cell and CD4+ T-cell responses, which may be an important feature of an optimal regimen for preventive HIV vaccination... - Differential enhancement of dengue virus immune complex infectivity mediated by signaling-competent and signaling-incompetent human Fcgamma RIA (CD64) or FcgammaRIIA (CD32)W W Shanaka I Rodrigo
Division of Infectious Diseases, Department of Medicine, University of Rochester School of Medicine and Dentistry, Box 689, 601 Crittenden Avenue, Rochester, NY 14642, USA
J Virol 80:10128-38. 2006.... - HIV vaccine could use a little helpJiong Wang
Department of Medicine, University of Rochester, Rochester, NY, USA
Hum Vaccin 6:476-81. 2010..In the paper, we focus on reviewing the importance of CD4+ T helper cells and past experience of HIV vaccine clinical trials, as well as making some projections on the future development in HIV vaccine research field... - Evaluation of Multitype Mathematical Models for CFSE-Labeling Experiment DataHongyu Miao
Department of Biostatistics and Computational Biology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Box 630, Rochester, NY, 14642, USA
Bull Math Biol 74:300-26. 2012..This model was then employed to understand the proliferation pattern of CD4+ and CD8+ T cells under polyclonal stimulation... - Establishment of an alternative intracellular cytokine staining assay for HIV/AIDS clinical studiesHuiyuan Chen
Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, NY 14642, USA
J Virol Methods 123:131-40. 2005..The results suggest that this ICS assay format is sensitive and specific, and is amenable to standardization for screening for HIV-specific CD8+ T cells in clinical trials... - The associations between psychosocial stress and the frequency of illness, and innate and adaptive immune function in childrenMary T Caserta
Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
Brain Behav Immun 22:933-40. 2008.... - Association of family stress with natural killer cell activity and the frequency of illnesses in childrenPeter A Wyman
Department of Psychiatry, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, USA
Arch Pediatr Adolesc Med 161:228-34. 2007..To examine prospective associations between chronic stress in the parent-child and family systems and subsequent rates of illnesses and the activity of natural killer (NK) cells in children... - Simulation and prediction of the adaptive immune response to influenza A virus infectionHa Youn Lee
Department of Biostatistics and Computational Biology, University of Rochester, Rochester, New York 14642, USA
J Virol 83:7151-65. 2009..We further compared alternative model structures, for example, B-cell activation directly by the virus versus that through professional antigen-presenting cells or dendritic cell licensing of CD8 T cells... - Discontinuation of antiretroviral therapy commenced early during the course of human immunodeficiency virus type 1 infection, with or without adjunctive vaccinationMartin Markowitz
Aaron Diamond AIDS Research Center, Rockefeller University, New York, New York 10016, USA
J Infect Dis 186:634-43. 2002.... - Virological and immunological outcomes in HIV-1-infected Chinese patients treated with a combination of Efavirenz and Indinavir for 48 weeksLi Li
National Center for AIDS Prevention and Control, Beijing 100050, China
Chin Med J (Engl) 117:347-52. 2004..CONCLUSIONS: The combination of Efavirenz and Indinavir was generally well tolerated and efficient at reducing HIV-1 RNA. Furthermore, the treatment improved the immunological function... - The functional SNP in the matrix metalloproteinase-3 promoter modifies susceptibility and lymphatic metastasis in esophageal squamous cell carcinoma but not in gastric cardiac adenocarcinomaJianhui Zhang
Hebei Cancer Institute, Hebei Medical University, Jiankanglu 12, Shijiazhuang 050011, Hebei Province, China
Carcinogenesis 25:2519-24. 2004..The present study suggests that the MMP3 promoter SNP might be associated with a risk of development and lymphatic metastasis in ESCC but not in GCA... - Evidence for systemic immune system alterations in sporadic amyotrophic lateral sclerosis (sALS)Rongzhen Zhang
University of California, San Francisco, San Francisco General Hospital, 995 Potrero Avenue, Building 80, Ward 84, Box 0874, San Francisco, CA 94110, USA
J Neuroimmunol 159:215-24. 2005..These data are consistent with a disease model previously suggested for AD, wherein systemic immunologic activation plays an active role in sALS... - [Correlation of matrix metalloproteinase-3 polymorphism to genetic susceptibility and lymph node metastasis of non-small cell lung cancer]Shu Mei Fang
Lab of Molecular Biology, Hebei Provincial Cancer Institute, Shijiazhuang, Hebei, 050011, P R China
Ai Zheng 24:305-10. 2005..This study was to investigate correlation of the MMP-3 SNP with genetic susceptibility and lymph node metastasis of non-small cell lung cancer (NSCLC)... - [Single nucleotide polymorphism in the matrix metalloproteinases promoter is associated with susceptibility to endometriosis and adenomyosis]Shan Kang
Department of Obstetrics and Gynecology, Fourth Affiliated Hospital of Hebei Medical University, Shijiazhuang 050011, China
Zhonghua Fu Chan Ke Za Zhi 40:601-4. 2005..To investigate the association of the matrix metalloproteinases (MMP) 1, 3 promoter single nucleotide polymorphism (SNP) with the susceptibility to endometriosis (EM) and adenomyosis... - Evaluation of CD8+ T-cell and antibody responses following transient increased viraemia in rhesus macaques infected with live, attenuated simian immunodeficiency virusKarin J Metzner
Aaron Diamond AIDS Research Center and The Rockefeller University, New York, NY 10016, USA
J Gen Virol 86:3375-84. 2005.... - Safety and immunogenicity of ALVAC vCP1452 and recombinant gp160 in newly human immunodeficiency virus type 1-infected patients treated with prolonged highly active antiretroviral therapyXia Jin
Aaron Diamond AIDS Research Center, The Rockefeller University, 455 1st Avenue, 7th Floor, New York, NY 10016, USA
J Virol 76:2206-16. 2002..In summary, vaccination with vCP1452 and recombinant gp160 appears safe and immunogenic in newly HIV-1-infected patients on HAART...
Research Grants
- Standardizing Measurements of HIV-specific CD8+ T CellsXia Jin; Fiscal Year: 2004..Finally, we will revalidate the ICS assay in PBMC obtained from the HIV Vaccine Trials Network to assess levels of CD8+ T cell responses among recipients of HIV vaccines. ..