Research Topics
Genomes and Genes | Feng JiangSummaryAffiliation: University of Maryland Country: USA Publications
Research Grants
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Detail Information
Publications
Early detection of squamous cell lung cancer in sputum by a panel of microRNA markersLingxiao Xing
Department of Pathology, University of Maryland School of Medicine, Baltimore, MD 21201 1192, USA
Mod Pathol 23:1157-64. 2010..The sputum markers showed the potential to improve the early detection of lung squamous cell carcinomas...- Small nucleolar RNA signatures as biomarkers for non-small-cell lung cancerJipei Liao
Department of Pathology, University of Maryland School of Medicine, Baltimore, MD, USA
Mol Cancer 9:198. 2010.... - Aldehyde dehydrogenase 1 is a tumor stem cell-associated marker in lung cancerFeng Jiang
Department of Pathology, Greenbaum Cancer Center, University of Maryland School of Medicine, Baltimore, Maryland 21201 1192, USA
Mol Cancer Res 7:330-8. 2009..These findings offer an important new tool for the study of lung CSCs and provide a potential prognostic factor and therapeutic target for treatment of the patients with lung cancer... - Combined genetic analysis of sputum and computed tomography for noninvasive diagnosis of non-small-cell lung cancerFeng Jiang
Department of Pathology, University of Maryland School of Medicine, Baltimore, MD 21201 1192, USA
Lung Cancer 66:58-63. 2009..05). The integration of the genetic assay with CT led to improvements in noninvasive diagnosis of stage I NSCLCs, especially central tumors... - A panel of sputum-based genomic marker for early detection of lung cancerFeng Jiang
Department of Pathology, The University of Maryland School of Medicine, Baltimore, MD 21201, USA
Cancer Prev Res (Phila) 3:1571-8. 2010..The gene panel could provide sputum-based markers that have the potential to improve early detection of lung SCCs... - Early detection of lung adenocarcinoma in sputum by a panel of microRNA markersLei Yu
Department of Pathology, University of Maryland School of Medicine, Baltimore, MD 21201 1192, USA
Int J Cancer 127:2870-8. 2010..The sputum markers demonstrated the potential of translation to laboratory settings for improving the early detection of lung adenocarcinoma... - Up-regulation of 14-3-3zeta in lung cancer and its implication as prognostic and therapeutic targetTao Fan
Department of Pathology, University of Maryland Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, Maryland 21201 1192, USA
Cancer Res 67:7901-6. 2007..008). Our results suggest that 14-3-3zeta is a potential target for developing a prognostic biomarker and therapeutics that can enhance the antitumor activity of cisplatin for NSCLC... - Diagnosis of lung cancer in individuals with solitary pulmonary nodules by plasma microRNA biomarkersJun Shen
Department of Pathology, University of Maryland School of Medicine, 10 S, Pine St, Baltimore, MD 21201, USA
BMC Cancer 11:374. 2011..We previously demonstrated that microRNAs (miRNAs) could be used as biomarkers for lung cancer diagnosis. Here we investigate whether plasma microRNAs are useful in identifying lung cancer among individuals with CT-detected SPNs... - Altered miRNA expression in sputum for diagnosis of non-small cell lung cancerYing Xie
Department of Pathology, University of Maryland School of Medicine, Baltimore, MD, USA
Lung Cancer 67:170-6. 2010..82% sensitivity and 100.00% specificity by sputum cytology. The measurement of altered miRNA expression in sputum could be a useful noninvasive approach for the diagnosis of lung cancer... - Genetically abnormal circulating cells in lung cancer patients: an antigen-independent fluorescence in situ hybridization-based case-control studyRuth L Katz
Department of Pathology, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
Clin Cancer Res 16:3976-87. 2010.... - Plasma microRNAs as potential biomarkers for non-small-cell lung cancerJun Shen
Department of Pathology, University of Maryland School of Medicine, Baltimore, MD 21201 1192, USA
Lab Invest 91:579-87. 2011..67%) in diagnosis of lung adenocarcinomas compared with squamous cell carcinomas (82.35%) (P<0.05). Altered expressions of the miRNAs in plasma would provide potential blood-based biomarkers for NSCLC... - Magnetic enrichment of bronchial epithelial cells from sputum for lung cancer diagnosisQi Qiu
Department of Pathology, University of Maryland School of Medicine, 10 South Pine St, MSTF 7th Fl, Baltimore, MD 21201 1192, USA
Cancer 114:275-83. 2008..We propose to obtain concentrated and purified bronchial epithelial cells to improve early detection of lung cancer in sputum samples... - Surfactant protein A gene deletion and prognostics for patients with stage I non-small cell lung cancerFeng Jiang
Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Clin Cancer Res 11:5417-24. 2005..The present study was conducted to determine clinical relevance of surfactant protein A (SP-A) genetic aberrations in early-stage non-small cell lung cancer (NSCLC)... - Genetic deletions in sputum as diagnostic markers for early detection of stage I non-small cell lung cancerRuiYun Li
Department of Surgery, The University of Maryland School of Medicine, 10 South Pine Street, Baltimore, MD 21201, USA
Clin Cancer Res 13:482-7. 2007..The aim of this study was to determine whether the genetic changes can be used as markers in sputum specimen for the early detection of lung cancer... - Induction of ovarian cancer cell apoptosis by 1,25-dihydroxyvitamin D3 through the down-regulation of telomeraseFeng Jiang
Department of Pathology, University of South Florida College of Medicine, 12901 Bruce B Downs Blvd, Tampa, FL 33612 4799, USA
J Biol Chem 279:53213-21. 2004..Overall, the study suggests that the down-regulation of telomerase activity by 1,25(OH)(2)VD(3) and the resulting cell death are important components of the response of OCa cells to 1,25(OH)(2)VD(3)-induced growth suppression... - Genomic profiles in stage I primary non small cell lung cancer using comparative genomic hybridization analysis of cDNA microarraysFeng Jiang
Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
Neoplasia 6:623-35. 2004..The identified genomic aberrations may be involved in the initiation and progression of lung tumorigenesis and, most importantly, may be developed as new biomarkers for the early detection and classification of lung cancer... - Automated detection of genetic abnormalities combined with cytology in sputum is a sensitive predictor of lung cancerRuth L Katz
Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030 4009, USA
Mod Pathol 21:950-60. 2008..For diagnosing lung cancer in sputum, a combination of molecular and cytologic variables was superior to using conventional cytology alone... - RNA silencing of S-phase kinase-interacting protein 2 inhibits proliferation and centrosome amplification in lung cancer cellsFeng Jiang
Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Oncogene 24:3409-18. 2005..These results imply that SKP2 plays an oncogenic role in lung cancer and that SKP2 silencing may be useful in the treatment of lung cancer... - Overexpression of S100A2 protein as a prognostic marker for patients with stage I non small cell lung cancerHuijun Wang
Department of Pathology, University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA
Int J Cancer 116:285-90. 2005..Our results suggested that the expression of the S100A2 protein in stage I NSCLC indicates poor prognosis and may be used to identify patients with early-stage NSCLC who might benefit from adjuvant treatment... - ALDH1A1 is a marker for malignant prostate stem cells and predictor of prostate cancer patients' outcomeTing Li
Department of Pathology, University of Maryland School of Medicine, Baltimore, Maryland 21201 1192, USA
Lab Invest 90:234-44. 2010..00093 and 0.00017, respectively). ALDH1A1 could be a prostate CSC-related marker. Measuring its expression might provide a potential approach to study tumorigenesis of PCa and predict outcome of the disease... - A novel multiple FISH array for the detection of genetic aberrations in cancerRuiYun Li
Department of Surgery, The University of Maryland School of Medicine, Baltimore, 21201-1192, USA
Lab Invest 86:619-27. 2006..The technique may thus be a powerful laboratory strategy for cancer prevention and early detection and for improved patient management... - Kernel based methods for accelerated failure time model with ultra-high dimensional dataZhenqiu Liu
University of Maryland Greenebaum Cancer Center, 22 South Greene Street, Baltimore, MD 21201, USA
BMC Bioinformatics 11:606. 2010..This two-step procedure may introduce bias and inaccuracy and lead us to miss biologically important genes... - Suppression of beta-amyloid precursor protein signaling into the nucleus by estrogens mediated through complex formation between the estrogen receptor and Fe65Junying Bao
Department of Pathology, University of South Florida College of Medicine, 12901 Bruce B Downs Blvd, Tampa, FL 33612 4799, USA
Mol Cell Biol 27:1321-33. 2007..Our studies reveal a novel mechanism of estrogen action, which may explain the well-known neuroprotective functions of estrogens as well as the complex role of this female hormone in the pathogenesis of neuronal degeneration diseases... - Phospho-p70S6K/p85S6K and cdc2/cdk1 are novel targets for diffuse large B-cell lymphoma combination therapyMerry Y Zhao
Department of Pathology, University of Maryland School of Medicine, Marlene and Stewart Greenebaum Cancer Center, Baltimore, Maryland 21201, USA
Clin Cancer Res 15:1708-20. 2009..This study aimed to identify and evaluate molecular targets for the development of a novel combination chemotherapy to treat refractory and recurrent diffuse large B-cell lymphoma (DLBCL)... - Regularized F-measure maximization for feature selection and classificationZhenqiu Liu
Division of Biostatistics, University of Maryland Greenebaum Cancer Center, Baltimore, MD 21201, USA
J Biomed Biotechnol 2009:617946. 2009..Our experiments with the benchmark, methylation, and high dimensional microarray data show that the performance of proposed algorithm is better or equivalent compared with the other popular classifiers in limited experiments... - Gene identification and survival prediction with Lp Cox regression and novel similarity measureZhenqiu Liu
University of Maryland Greenebaum Cancer Center, Baltimore, MD 21201, USA
Int J Data Min Bioinform 3:398-408. 2009.... - Gene and pathway identification with Lp penalized Bayesian logistic regressionZhenqiu Liu
Division of Biostatistics, University of Maryland Greenebaum Cancer Center, 22 South Greene Street, Baltimore, MD 21201, USA
BMC Bioinformatics 9:412. 2008..Usually this parameter must be carefully tuned through cross-validation, which is time consuming... - Fluorescent metal nanoshell probe to detect single miRNA in lung cancer cellJian Zhang
Center for Fluorescence Spectroscopy, Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, 725 West Lombard Street, Baltimore, Maryland 21201, USA
Anal Chem 82:4464-71. 2010..The results may reflect a genomic signal change and provide a reference to lung cancer early diagnosis as well as other diseases... - Detecting genomic aberrations by fluorescence in situ hybridization with quantum dots-labeled probesZhengran Jiang
Department of Pathology, University of Maryland School of Medicine, Baltimore, MD, USA
J Nanosci Nanotechnol 7:4254-9. 2007..These results suggest that the QD-FISH probes may offer an effective approach to analyze cancer-related genomic aberrations in basic research and clinical applications... - Evaluation of peripheral blood involvement of mantle cell lymphoma by fluorescence in situ hybridization in comparison with immunophenotypic and morphologic findingsJun Gu
Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Mod Pathol 17:553-60. 2004.... - Centrosomal abnormality is common in and a potential biomarker for bladder cancerFeng Jiang
Department of Pathology, University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA
Int J Cancer 106:661-5. 2003..Centrosomal abnormalities appear to be intrinsic to aneuploidy and tumorigenesis and may be potential markers for early detection of bladder cancer... - G2/M arrest by 1,25-dihydroxyvitamin D3 in ovarian cancer cells mediated through the induction of GADD45 via an exonic enhancerFeng Jiang
Department of Pathology, University of South Florida College of Medicine and the Program of Molecular Oncology, H Lee Moffitt Cancer Center, Tampa, Florida 33612 4799, USA
J Biol Chem 278:48030-40. 2003..Taken together, these results identify GADD45 as an important mediator for the tumor-suppressing activity of 1,25-dihydroxyvitamin D3 in human ovarian cancer cells...
Research Grants
- New Diagnostic Assay for Early Detection of Lung CancerFeng Jiang; Fiscal Year: 2005..This project will be multidisciplinary, incorporating epidemiology, molecular biology, cytogenetics, pathology, bioinformatics, and statistics. ..