T L Jetton

Summary

Affiliation: University of Vermont
Country: USA

Publications

  1. ncbi Substrate-induced nuclear export and peripheral compartmentalization of hepatic glucokinase correlates with glycogen deposition
    T L Jetton
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232 0615, USA
    Int J Exp Diabetes Res 2:173-86. 2001
  2. ncbi Glucokinase gene locus transgenic mice are resistant to the development of obesity-induced type 2 diabetes
    M Shiota
    Department of Molecular Physiology and Biophysics, School of Medicine, Vanderbilt University, Nashville, Tennessee 37232 0615, USA
    Diabetes 50:622-9. 2001
  3. ncbi Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase
    C Postic
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Biol Chem 274:305-15. 1999
  4. ncbi Mice lacking alpha-calcitonin gene-related peptide exhibit normal cardiovascular regulation and neuromuscular development
    J T Lu
    Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Mol Cell Neurosci 14:99-120. 1999
  5. ncbi Ribozyme-mediated attenuation of pancreatic beta-cell glucokinase expression in transgenic mice results in impaired glucose-induced insulin secretion
    S Efrat
    Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461
    Proc Natl Acad Sci U S A 91:2051-5. 1994
  6. ncbi BRCA1 is secreted and exhibits properties of a granin
    R A Jensen
    Department of Pathology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 5310, USA
    Nat Genet 12:303-8. 1996
  7. ncbi Systemic treatment with sympatholytic dopamine agonists improves aberrant beta-cell hyperplasia and GLUT2, glucokinase, and insulin immunoreactive levels in ob/ob mice
    T L Jetton
    ErgoScience Corporation, N Andover, MA, USA
    Metabolism 50:1377-84. 2001
  8. ncbi Enhanced expression of insulin receptor substrate-2 and activation of protein kinase B/Akt in regenerating pancreatic duct epithelium of 60 %-partial pancreatectomy rats
    T L Jetton
    Division of Endocrinology, Diabetes and Metabolism, University of Vermont, College of Medicine, Burlington, VT 05405-0068, USA
    Diabetologia 44:2056-65. 2001

Collaborators

Detail Information

Publications8

  1. ncbi Substrate-induced nuclear export and peripheral compartmentalization of hepatic glucokinase correlates with glycogen deposition
    T L Jetton
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232 0615, USA
    Int J Exp Diabetes Res 2:173-86. 2001
    ..These data suggest that a compartmentalization exists of both active GK and the initial sites of glycogen deposition at the hepatocyte surface...
  2. ncbi Glucokinase gene locus transgenic mice are resistant to the development of obesity-induced type 2 diabetes
    M Shiota
    Department of Molecular Physiology and Biophysics, School of Medicine, Vanderbilt University, Nashville, Tennessee 37232 0615, USA
    Diabetes 50:622-9. 2001
    ..Together, these data indicate that increased GK levels dramatically lessen the development of both hyperglycemia and hyperinsulinemia associated with the feeding of an HF diet...
  3. ncbi Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase
    C Postic
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Biol Chem 274:305-15. 1999
    ..Interestingly, hepatic GK knock-out mice also have impaired insulin secretion in response to glucose. These studies indicate that deficiencies in both beta cell and hepatic GK contribute to the hyperglycemia of MODY-2...
  4. ncbi Mice lacking alpha-calcitonin gene-related peptide exhibit normal cardiovascular regulation and neuromuscular development
    J T Lu
    Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Mol Cell Neurosci 14:99-120. 1999
    ..These results suggest that alphaCGRP is not required for the systemic regulation of cardiovascular hemodynamics or development of the neuromuscular junction...
  5. ncbi Ribozyme-mediated attenuation of pancreatic beta-cell glucokinase expression in transgenic mice results in impaired glucose-induced insulin secretion
    S Efrat
    Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461
    Proc Natl Acad Sci U S A 91:2051-5. 1994
    ..They provide an animal model for studying the interaction of such factors with the reduced islet GK activity...
  6. ncbi BRCA1 is secreted and exhibits properties of a granin
    R A Jensen
    Department of Pathology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 5310, USA
    Nat Genet 12:303-8. 1996
    ..As a regulated secretory protein, BRCA1 appears to function by a mechanism not previously described for tumour suppressor gene products...
  7. ncbi Systemic treatment with sympatholytic dopamine agonists improves aberrant beta-cell hyperplasia and GLUT2, glucokinase, and insulin immunoreactive levels in ob/ob mice
    T L Jetton
    ErgoScience Corporation, N Andover, MA, USA
    Metabolism 50:1377-84. 2001
    ....
  8. ncbi Enhanced expression of insulin receptor substrate-2 and activation of protein kinase B/Akt in regenerating pancreatic duct epithelium of 60 %-partial pancreatectomy rats
    T L Jetton
    Division of Endocrinology, Diabetes and Metabolism, University of Vermont, College of Medicine, Burlington, VT 05405-0068, USA
    Diabetologia 44:2056-65. 2001
    ..The restricted staining pattern of phospho-Akt to cells of the common duct evaginations suggests that it has a role in regulating post-mitotic events related to cell-specific gene expression or survival or both...