Marc G Jeschke

Summary

Affiliation: University of Texas Medical Branch
Country: USA

Publications

  1. ncbi Inhalation injury in severely burned children does not augment the systemic inflammatory response
    Celeste C Finnerty
    Shriners Hospitals for Children and Department of Surgery, University of Texas Medical Branch, Galveston, TX, USA
    Crit Care 11:R22. 2007
  2. ncbi Are serum cytokines early predictors for the outcome of burn patients with inhalation injuries who do not survive?
    Gerd G Gauglitz
    Shriners Hospitals for Children, 815 Market Street, Galveston, Texas, 77550, USA
    Crit Care 12:R81. 2008
  3. ncbi The effect of oxandrolone on the endocrinologic, inflammatory, and hypermetabolic responses during the acute phase postburn
    Marc G Jeschke
    Shriners Hospital for Children, and Department of Surgery, University Texas Medical Branch, Galveston, Texas, USA
    Ann Surg 246:351-60; discussion 360-2. 2007
  4. ncbi Insulin decreases inflammatory signal transcription factor expression in primary human liver cells after LPS challenge
    Marc G Jeschke
    Shriners Hospitals for Children, Galveston Burns Unit, Galveston, TX 77550, USA
    Mol Med 14:11-9. 2008
  5. ncbi Combination of recombinant human growth hormone and propranolol decreases hypermetabolism and inflammation in severely burned children
    Marc G Jeschke
    Shriners Hospitals for Children and the Department of Surgery, University Texas Medical Branch, Galveston, TX, USA
    Pediatr Crit Care Med 9:209-16. 2008
  6. ncbi Glucose control in severely thermally injured pediatric patients: what glucose range should be the target?
    Marc G Jeschke
    Shriners Hospitals for Children, Biochemistry and Molecular Biology, Galveston, TX, USA
    Ann Surg 252:521-7; discussion 527-8. 2010
  7. ncbi Calcium and ER stress mediate hepatic apoptosis after burn injury
    Marc G Jeschke
    Shriners Hospitals for Children, University of Texas Medical Branch, Galveston, TX 77550, USA
    J Cell Mol Med 13:1857-65. 2009
  8. ncbi Age differences in inflammatory and hypermetabolic postburn responses
    Marc G Jeschke
    Galveston Burns Unit, Shriners Hospitals for Children, 815 Market St, Galveston, TX 77550, USA
    Pediatrics 121:497-507. 2008
  9. ncbi Intensive insulin therapy in severely burned pediatric patients: a prospective randomized trial
    Marc G Jeschke
    Shriners Hospitals for Children, Galveston, TX 77550, USA
    Am J Respir Crit Care Med 182:351-9. 2010
  10. ncbi Pathophysiologic response to severe burn injury
    Marc G Jeschke
    Shriners Hospitals for Children, University Texas Medical Branch, Galveston, Texas 77550, USA
    Ann Surg 248:387-401. 2008

Detail Information

Publications121 found, 100 shown here

  1. ncbi Inhalation injury in severely burned children does not augment the systemic inflammatory response
    Celeste C Finnerty
    Shriners Hospitals for Children and Department of Surgery, University of Texas Medical Branch, Galveston, TX, USA
    Crit Care 11:R22. 2007
    ..The aim of the present study was to determine the effect of inhalation injury on cytokine expression in severely burned children...
  2. ncbi Are serum cytokines early predictors for the outcome of burn patients with inhalation injuries who do not survive?
    Gerd G Gauglitz
    Shriners Hospitals for Children, 815 Market Street, Galveston, Texas, 77550, USA
    Crit Care 12:R81. 2008
    ..Early identification followed by appropriate management of these high-risk patients may lead to improved clinical outcome...
  3. ncbi The effect of oxandrolone on the endocrinologic, inflammatory, and hypermetabolic responses during the acute phase postburn
    Marc G Jeschke
    Shriners Hospital for Children, and Department of Surgery, University Texas Medical Branch, Galveston, Texas, USA
    Ann Surg 246:351-60; discussion 360-2. 2007
    ..The effects of oxandrolone on clinical outcome, body composition, endocrine system, and inflammation during the acute phase postburn in a large prospective randomized single-center trial have not been studied...
  4. ncbi Insulin decreases inflammatory signal transcription factor expression in primary human liver cells after LPS challenge
    Marc G Jeschke
    Shriners Hospitals for Children, Galveston Burns Unit, Galveston, TX 77550, USA
    Mol Med 14:11-9. 2008
    ..Based on our results, we suggest that primary hepatocyte cultures can be used to study the effect of LPS on the inflammatory cascade. Insulin decreases hepatic cytokine expression, which is associated with decreased STAT-5 expression...
  5. ncbi Combination of recombinant human growth hormone and propranolol decreases hypermetabolism and inflammation in severely burned children
    Marc G Jeschke
    Shriners Hospitals for Children and the Department of Surgery, University Texas Medical Branch, Galveston, TX, USA
    Pediatr Crit Care Med 9:209-16. 2008
    ..The aim of the present study was to determine whether rhGH plus propranolol improves hypermetabolism and the inflammatory and acute phase response after severe burn without causing adverse side effects...
  6. ncbi Glucose control in severely thermally injured pediatric patients: what glucose range should be the target?
    Marc G Jeschke
    Shriners Hospitals for Children, Biochemistry and Molecular Biology, Galveston, TX, USA
    Ann Surg 252:521-7; discussion 527-8. 2010
    ..To determine which glucose levels are associated with improved morbidity and mortality in thermally injured patients...
  7. ncbi Calcium and ER stress mediate hepatic apoptosis after burn injury
    Marc G Jeschke
    Shriners Hospitals for Children, University of Texas Medical Branch, Galveston, TX 77550, USA
    J Cell Mol Med 13:1857-65. 2009
    ..Our results reveal that thermal injury leads to dramatic hepatic disturbances in calcium homeostasis and resultant ER stress leading to mitochondrial abnormalities contributing to hepatic dysfunction and apoptosis after burn injury...
  8. ncbi Age differences in inflammatory and hypermetabolic postburn responses
    Marc G Jeschke
    Galveston Burns Unit, Shriners Hospitals for Children, 815 Market St, Galveston, TX 77550, USA
    Pediatrics 121:497-507. 2008
    ..The aim of this study was to identify contributors to morbidity and death in severely burned patients <4 years of age...
  9. ncbi Intensive insulin therapy in severely burned pediatric patients: a prospective randomized trial
    Marc G Jeschke
    Shriners Hospitals for Children, Galveston, TX 77550, USA
    Am J Respir Crit Care Med 182:351-9. 2010
    ..However, to date no prospective randomized study exists that determines whether intensive insulin therapy is associated with improved post-burn morbidity and mortality...
  10. ncbi Pathophysiologic response to severe burn injury
    Marc G Jeschke
    Shriners Hospitals for Children, University Texas Medical Branch, Galveston, Texas 77550, USA
    Ann Surg 248:387-401. 2008
    ..To improve clinical outcome and to determine new treatment options, we studied the pathophysiologic response postburn in a large prospective, single center, clinical trial...
  11. ncbi Burn size determines the inflammatory and hypermetabolic response
    Marc G Jeschke
    Shriners Hospitals for Children, 815 Market Street, Galveston, TX 77550, USA
    Crit Care 11:R90. 2007
    ..The purpose of the present study was to determine in a large prospective clinical trial whether different burn sizes are associated with differences in inflammation, body composition, protein synthesis, or organ function...
  12. ncbi Propranolol does not increase inflammation, sepsis, or infectious episodes in severely burned children
    Marc G Jeschke
    Department of Surgery, Shriners Hospitals for Children, University of Texas Medical Branch, TX 77550, USA
    J Trauma 62:676-81. 2007
    ..The purpose of the present study was to determine the effect of propranolol administration on infection, sepsis, and inflammation in severely burned pediatric patients...
  13. ncbi Gender differences in pediatric burn patients: does it make a difference?
    Marc G Jeschke
    Shriners Hospitals for Children, Galveston, Texas 77550, USA
    Ann Surg 248:126-36. 2008
    ..The aim of the present study was to compare hospital course and physiologic markers between severely burned pediatric females and males...
  14. ncbi Sex differences in the long-term outcome after a severe thermal injury
    Marc G Jeschke
    Shriners Hospital for Children and Department of Surgery, University of Texas Medical Branch, Galveston, Texas 77550, USA
    Shock 27:461-5. 2007
    ..Data indicate that girls have a reduced REE associated with changes in bone content and endogenous anabolic hormones...
  15. ncbi Changes in liver function and size after a severe thermal injury
    Marc G Jeschke
    Shriners Hospitals for Children and University of Texas Medical Branch, 815 Market Street, Galveston, TX 77550, USA
    Shock 28:172-7. 2007
    ..The treatment to prevent liver enlargement and the improved impaired function may result in a reduction of complications accompanied with liver hypertrophy and failure...
  16. ncbi The combination of IGF-I and KGF cDNA improves dermal and epidermal regeneration by increased VEGF expression and neovascularization
    M G Jeschke
    Shriners Hospitals for Children and Department of Surgery, University Texas Medical Branch Galveston, TX 77550, USA
    Gene Ther 14:1235-42. 2007
    ..In conclusion, exogenous administration of liposomal IGF-I plus KGF cDNA enhanced dermal and epidermal regeneration which is due to increased neovascularization...
  17. ncbi Gut mucosal homeostasis and cellular mediators after severe thermal trauma and the effect of insulin-like growth factor-I in combination with insulin-like growth factor binding protein-3
    Marc G Jeschke
    Shriners Hospitals for Children, The University of Texas Medical Branch, Galveston, Texas 77550, USA
    Endocrinology 148:354-62. 2007
    ..IGF-I/IGFBP-3 decreases small bowel epithelial cell apoptosis through down-regulation of the Fas pathway, which improves gut mucosal integrity after a severe thermal injury...
  18. ncbi The hepatic response to thermal injury: is the liver important for postburn outcomes?
    Marc G Jeschke
    Shriners Hospitals for Children and Department of Surgery, University Texas Medical Branch, Galveston, Texas, USA
    Mol Med 15:337-51. 2009
    ..This review discusses these studies and delineates the pivotal role of the liver in patients following severe thermal injury...
  19. ncbi Effect of insulin on the inflammatory and acute phase response after burn injury
    Marc G Jeschke
    Shriners Hospital for Children, Department of Surgery, University of Texas Medical Branch, Galveston, TX, USA
    Crit Care Med 35:S519-23. 2007
    ....
  20. ncbi Endogenous anabolic hormones and hypermetabolism: effect of trauma and gender differences
    Marc G Jeschke
    Shriners Hospital for Children and Department of Surgery, University Texas Medical Branch, Galveston, Texas 77550, USA
    Ann Surg 241:759-67; discussion 767-8. 2005
    ..The aims of the present study were to determine the pattern of anabolic hormones, resting energy expenditure and cytokines in severely thermally injured pediatric patients and to compare these parameters in female and male patients...
  21. ncbi The effect of growth hormone on gut mucosal homeostasis and cellular mediators after severe trauma
    Marc G Jeschke
    Shriners Hospital for Children and Department of Surgery, University Texas Medical Branch, Galveston, Texas 77550, USA
    J Surg Res 127:183-9. 2005
    ..The purpose of this study was to determine whether growth hormone can improve small bowel homeostasis after injury and by which cellular mechanisms these changes occur...
  22. ncbi Randomized controlled trial to determine the efficacy of long-term growth hormone treatment in severely burned children
    Ludwik K Branski
    Department of Surgery, University of Texas Medical Branch and Shriners Hospitals for Children, Galveston, TX 77550, USA
    Ann Surg 250:514-23. 2009
    ....
  23. ncbi Body composition changes with time in pediatric burn patients
    Rene Przkora
    Department of Surgery, University of Texas Medical Branch, Texas, USA
    J Trauma 60:968-71; discussion 971. 2006
    ..CONCLUSIONS: Body composition of severely burned children significantly improved in the second year compared with the first year after injury. This demonstrates a need for long-term rehabilitation in these burn patients...
  24. ncbi Abnormal insulin sensitivity persists up to three years in pediatric patients post-burn
    Gerd G Gauglitz
    Shriners Hospitals for Children, Galveston, Texas 77550, USA
    J Clin Endocrinol Metab 94:1656-64. 2009
    ..The acute hypermetabolic response post-burn is associated with insulin resistance and hyperglycemia, significantly contributing to adverse outcome of these patients...
  25. ncbi Insulin increases resistance to burn wound infection-associated sepsis
    Gerd G Gauglitz
    Shriners Hospitals for Children, University of Texas Medical Branch, Galveston, Texas, USA
    Crit Care Med 38:202-8. 2010
    ..This study was designed to determine the ability of insulin to improve outcome following a Pseudomonas aeruginosa wound infection in a rodent model of severe burn injury...
  26. ncbi Starvation-induced proximal gut mucosal atrophy diminished with aging
    Juquan Song
    Shriners Hospitals for Children, Galveston, Texas 77550, USA
    JPEN J Parenter Enteral Nutr 33:411-6. 2009
    ..Starvation induces small bowel atrophy with increased intestinal epithelial apoptosis and decreased proliferation. The authors examined these parameters after starvation in aged animals...
  27. ncbi The effect of hepatocyte growth factor on gut mucosal apoptosis and proliferation, and cellular mediators after severe trauma
    Marc G Jeschke
    Shriners Hospital for Children and Department of Surgery, Galveston, TX 77550, USA
    Surgery 138:482-9. 2005
    ..The purpose of this study was to determine whether HGF can improve small-bowel homeostasis after injury and the cellular mechanisms by which these changes occur...
  28. ncbi Retinol binding protein: marker for insulin resistance and inflammation postburn?
    Robert Kraft
    Shriners Hospitals for Children, and Department of Surgery, University of Texas Medical Branch Galveston, Texas, USA
    JPEN J Parenter Enteral Nutr 35:695-703. 2011
    ..The aim of this study was to determine RBP profiles and to test the hypothesis that elevated RBP levels are associated with both IR and the inflammatory response in burned patients...
  29. ncbi The use of exenatide in severely burned pediatric patients
    Gabriel A Mecott
    Department of Surgery, University of Texas Medical Branch, 301 University Blvd, Galveston, Texas 77555, USA
    Crit Care 14:R153. 2010
    ..We hypothesized that exenatide would decrease plasma glucose levels post-burn to levels similar to those achieved with IIT, and reduce the amount of exogenous insulin administered...
  30. ncbi Characterization of the inflammatory response during acute and post-acute phases after severe burn
    Gerd G Gauglitz
    Shriners Hospital for Children, Galveston, Texas 77550, USA
    Shock 30:503-7. 2008
    ....
  31. ncbi What, how, and how much should patients with burns be fed?
    Felicia N Williams
    Department of Surgery, Shriners Hospital for Children and University of Texas Medical Branch, 815 Market Street, Galveston, TX 77550, USA
    Surg Clin North Am 91:609-29. 2011
    ..This review focuses on the more recent advances in therapeutic strategies to attenuate the hypermetabolic response and its postburn-associated insulin resistance...
  32. ncbi Changes in cardiac physiology after severe burn injury
    Felicia N Williams
    Shriners Burn Hospital for Children, The University of Texas, Medical Branch, Galveston, Texas, USA
    J Burn Care Res 32:269-74. 2011
    ..Ejection fraction was within normal limits for 2 years. Cardiac stress persists for at least 2 years postburn, and the authors suggest that attenuation of these detrimental responses may improve long-term morbidity...
  33. ncbi Extent and magnitude of catecholamine surge in pediatric burned patients
    Gabriela A Kulp
    Shriners Hospitals for Children, Department of Surgery, University Texas Medical Branch Galveston, Texas 77550, USA
    Shock 33:369-74. 2010
    ..Inflammatory cytokines show a similar profile during the study period. Our study gives clinicians a useful insight into the extent and magnitude of CA elevation to better design treatment strategies...
  34. ncbi The leading causes of death after burn injury in a single pediatric burn center
    Felicia N Williams
    Department of Surgery, University of Texas Medical Branch, Galveston, Texas 77555, USA
    Crit Care 13:R183. 2009
    ..Despite these advances, death still occurs. Our aim was to determine the predominant causes of death in burned pediatric patients in order to develop new treatment avenues and future trajectories associated with increased survival...
  35. ncbi Insulin protects against hepatic damage postburn
    Marc G Jeschke
    Shriners Hospitals for Children, The University of Texas Medical Branch, Galveston, Texas, USA
    Mol Med 17:516-22. 2011
    ..These results support the use of insulin therapy after traumatic injury to improve patient outcomes...
  36. ncbi Second hit post burn increased proximal gut mucosa epithelial cells damage
    Juquan Song
    Shriners Hospitals for Children and Department of Surgery, The University of Texas Medical Branch, Galveston, TX 77550, USA
    Shock 30:184-8. 2008
    ..05) and significantly increased small intestinal epithelial apoptosis and mucosal atrophy, even after the first event, indicating a second detrimental effect of endotoxemia after the initial injury...
  37. ncbi Fibrin sealant improves graft adherence in a porcine full-thickness burn wound model
    Ludwik K Branski
    Shriners Hospital for Children and University of Texas Medical Branch, Galveston, TX, USA
    Burns 37:1360-6. 2011
    ..Slow-clotting fibrin sealant, applied with a spray-on device, has been shown to improve healing of skin grafts in large wounds. However, its use in burn wounds has not been studied so far...
  38. ncbi Metabolic and hormonal changes of severely burned children receiving long-term oxandrolone treatment
    Rene Przkora
    Department of Surgery, University of Texas Medical Branch, Shriners Hospitals for Children, Galveston, TX 77550, USA
    Ann Surg 242:384-9, discussion 390-1. 2005
    ..CONCLUSIONS: Oxandrolone improved body composition and strength in severely burned children during the 12 months of treatment. Its effect on height and weight continued after treatment was discontinued...
  39. ncbi Insulin prevents liver damage and preserves liver function in lipopolysaccharide-induced endotoxemic rats
    Marc G Jeschke
    Shriners Hospital for Children and Department of Surgery, The University Texas Medical Branch, Galveston Burns Unit, 815 Market Street, Galveston, TX 77550, USA
    J Hepatol 42:870-9. 2005
    ..The aim of the present study was to determine whether insulin exerts positive effects on hepatic homeostasis and function during endotoxemia...
  40. ncbi Long-term persistance of the pathophysiologic response to severe burn injury
    Marc G Jeschke
    Shriners Hospitals for Children, University of Texas Medical Branch, Galveston, Texas, United States of America
    PLoS ONE 6:e21245. 2011
    ....
  41. ncbi Identification of factors contributing to hepatomegaly in severely burned children
    Robert E Barrow
    Shriners Hospitals for Children, Galveston, Texas 77550, USA
    Shock 24:523-8. 2005
    ..Increases in extracellular protein, intracellular glycogen, and fluid accumulation may make a minor contribution to postburn hepatomegaly...
  42. ncbi Longitudinal assessment of Integra in primary burn management: a randomized pediatric clinical trial
    Ludwik K Branski
    Shriners Hospitals for Children, Galveston, TX, USA
    Crit Care Med 35:2615-23. 2007
    ..However, the suitability of its use in large burns (>50% total body surface area), its effects on postburn hypermetabolism, and the long-term cosmetic and functional results have not yet been evaluated...
  43. ncbi Burn size and survival probability in paediatric patients in modern burn care: a prospective observational cohort study
    Robert Kraft
    Shriners Hospitals for Children, Galveston, TX, USA
    Lancet 379:1013-21. 2012
    ..This study was designed to identify the burn size associated with significant increases in morbidity and mortality in paediatric patients...
  44. ncbi Proximal gut mucosal epithelial homeostasis in aged IL-1 type I receptor knockout mice after starvation
    Juquan Song
    Shriners Hospitals for Children, University of Texas Medical Branch, Galveston, Texas, USA
    J Surg Res 169:209-13. 2011
    ..In this experiment, we assessed whether starvation-induced atrophy of proximal gut mucosa is associated with the Interleukin-1 receptor (IL-1R) signaling pathway in aged mice...
  45. ncbi Long-term oxandrolone treatment increases muscle protein net deposition via improving amino acid utilization in pediatric patients 6 months after burn injury
    Demidmaa Tuvdendorj
    Department of Surgery, University of Texas Medical Branch, Galveston, TX 77555 1220, USA
    Surgery 149:645-53. 2011
    ..In the current study, we evaluated whether oxandrolone treatment affects mechanisms of protein turnover in skeletal muscle and whole-body protein breakdown in pediatric burn patients 6 months postinjury...
  46. ncbi The role of acute pancreatitis in pediatric burn patients
    Haidy G Rivero
    Department of Surgery, University of Texas Medical Branch, Galveston, TX, USA
    Burns 37:82-5. 2011
    ....
  47. ncbi Beneficial effects of extended growth hormone treatment after hospital discharge in pediatric burn patients
    Rene Przkora
    Department of Surgery, University of Texas Medical Branch and Shriners Hospitals for Children, 815 Market Street, Galveston, TX 77550, USA
    Ann Surg 243:796-801; discussion 801-3. 2006
    ..05). No side effects with rhGH were observed. CONCLUSIONS: Administration of rhGH for 1 year after burn was safe and improved recovery. These salutary effects continued after rhGH treatment was discontinued...
  48. ncbi Effects of exercise training on resting energy expenditure and lean mass during pediatric burn rehabilitation
    Ahmed M Al-Mousawi
    Department of Surgery, The University of Texas Medical Branch, Galveston, Texas 77550, USA
    J Burn Care Res 31:400-8. 2010
    ..Therefore, the use of exercise conditioning as a safe and effective component of pediatric burn rehabilitation is advocated...
  49. ncbi Intensive insulin treatment increases donor site wound protein synthesis in burn patients
    Demidmaa Tuvdendorj
    Metabolism Unit, Shriners Hospital for Children, Galveston, TX 77550 1220, USA
    Surgery 149:512-8. 2011
    ..We investigated whether intensive insulin treatment increases fractional synthesis rate (FSR) of the donor site wound protein and decreases the length of hospitalization normalized for total body surface area burned (LOS/TBSA)...
  50. ncbi Impact of anesthesia, analgesia, and euthanasia technique on the inflammatory cytokine profile in a rodent model of severe burn injury
    Ahmed M Al-Mousawi
    University of Texas Medical Branch, Galveston, TX, USA
    Shock 34:261-8. 2010
    ..Standardization across all experiments that are compared and awareness of these findings are essential for those investigating the pathophysiology of inflammation in animal models...
  51. ncbi Modulation of types I and II acute phase reactants with insulin-like growth factor-1/binding protein-3 complex in severely burned children
    Marcus Spies
    Shriners Hospital for Children and Department of Surgery, The University Texas Medical Branch, Galveston 77550, USA
    Crit Care Med 30:83-8. 2002
    ..CONCLUSIONS: Low-dose IGF-1/BP-3 effectively attenuated the type I and type II hepatic acute phase response, increased serum levels of constitutive proteins, and modulated the hypermetabolic response...
  52. ncbi Acute propranolol infusion stimulates protein synthesis in rabbit skin wound
    Xiao Jun Zhang
    Shriners Hospital for Children, Galveston, TX, USA
    Surgery 145:558-67. 2009
    ..Propranolol administration has been demonstrated to improve cardiac work, decrease energy expenditure, and attenuate lipolysis in burned patients; however, its effect on wound healing has not been reported...
  53. ncbi Is there a difference in clinical outcomes, inflammation, and hypermetabolism between scald and flame burn?
    Robert Kraft
    Department of Surgery, University of Texas Medical Branch, Galveston, TX, USA
    Pediatr Crit Care Med 12:e275-81. 2011
    ..The aim of the present study was to determine whether there is a difference in degree of inflammation, hypermetabolism, endocrine and acute-phase response, and clinical outcome between pediatric patients with scald and flame burns...
  54. ncbi Interaction of exogenous liposomal insulin-like growth factor-I cDNA gene transfer with growth factors on collagen expression in acute wounds
    Marc G Jeschke
    Shriners Hospital for Children, University Texas Medical Branch, Galveston, Texas 77550, USA
    Wound Repair Regen 13:269-77. 2005
    ..We conclude that liposomal IGF-I gene transfer can accelerate wound healing without causing an increase in types I and III collagen expression...
  55. ncbi Propranolol as a modulator of M2b monocytes in severely burned patients
    Makiko Kobayashi
    Department of Internal Medicine, The University of Texas Medical Branch, Galveston, Texas 77555 0435, USA
    J Leukoc Biol 89:797-803. 2011
    ..The increased susceptibility, to be associated with the appearance of M2b monocytes, of severely burned patients to opportunistic pathogens might be controlled by propranolol...
  56. ncbi Association between dietary fat content and outcomes in pediatric burn patients
    Jong O Lee
    Shriners Hospitals for Children, University of Texas Medical Branch, Galveston, Texas, USA
    J Surg Res 166:e83-90. 2011
    ..The aim of the study was to compare a low fat/high-carbohydrate diet and a high-fat diet on clinical outcomes by a retrospective cohort study...
  57. ncbi A porcine model of full-thickness burn, excision and skin autografting
    Ludwik K Branski
    Shriners Hospital for Children and University of Texas Medical Branch, Galveston, TX, USA
    Burns 34:1119-27. 2008
    ..The use of this standardized model provides burn researchers with a valuable tool for the comparison of different topical drug treatments and dressing materials in a setting that closely mimics clinical reality...
  58. ncbi Age-dependent differences in survival after severe burns: a unicentric review of 1,674 patients and 179 autopsies over 15 years
    Clifford T Pereira
    Department of Surgery, University of Texas Medical Branch, Galveston, TX, USA
    J Am Coll Surg 202:536-48. 2006
  59. ncbi Post-burn hepatic insulin resistance is associated with endoplasmic reticulum (ER) stress
    Gerd G Gauglitz
    Shriners Hospitals for Children, Galveston, Texas 77550, USA
    Shock 33:299-305. 2010
    ..Activation of ER-stress signaling cascades may explain metabolic abnormalities involving insulin action after burn...
  60. ncbi Propranolol decreases cardiac work in a dose-dependent manner in severely burned children
    Felicia N Williams
    Shriners Hospitals for Children, Galveston, TX, USA
    Surgery 149:231-9. 2011
    ..Four-hundred six patients with burns >30% total body surface area were enrolled and randomized to receive standard care (controls; n = 235) or standard care plus propranolol (n = 171)...
  61. ncbi Measurement of body composition in burned children: is there a gold standard?
    Ludwik K Branski
    Department of Surgery, University of Texas Medical Branch, Galveston, Texas, and Shriners Hospitals for Children, Galveston, Texas 77550, USA
    JPEN J Parenter Enteral Nutr 34:55-63. 2010
    ..The aim of this study was to compare 2 measurement methods for body composition, whole-body potassium counting (K count) and dual x-ray absorptiometry (DEXA), in a large prospective clinical trial in severely burned pediatric patients...
  62. ncbi The role of hyperglycemia in burned patients: evidence-based studies
    Gabriel A Mecott
    Department of Surgery, The University of Texas Medical Branch, Galveston, Texas, USA
    Shock 33:5-13. 2010
    ....
  63. ncbi Upper airway mucus deposition in lung tissue of burn trauma victims
    Robert A Cox
    Shriners Hospital for Children and the University of Texas Medical Branch, Galveston, Texas 77550, USA
    Shock 29:356-61. 2008
    ..Increased mucus synthesis and/or impaired mucociliary function may contribute to the pulmonary pathophysiology associated with burn injury...
  64. ncbi Insulin attenuates the cytokine response in a burn wound infection model
    Rene Przkora
    Shriners Hospital for Children and Department of Surgery, University of Texas Medical Branch, Galveston, TX 77550, USA
    Shock 27:205-8. 2007
    ..05). We conclude, that insulin treatment selectively modulates specific cytokines in a burn wound infection model...
  65. ncbi Cytokine expression profile over time in severely burned pediatric patients
    Celeste C Finnerty
    Galveston Burns Unit and Department of Surgery, Shriners Hospital for Children University of Texas Medical Branch, Galveston, TX 77550, USA
    Shock 26:13-9. 2006
    ..Furthermore, the elevation in most serum cytokine levels during the first week after burn may indicate a potential window of opportunity for therapeutic intervention...
  66. ncbi The factor age and the recovery of severely burned children
    Rene Przkora
    Shriners Hospital for Children and Department of Surgery, University of Texas Medical Branch, 815 Market Street, Galveston, TX 77550, USA
    Burns 34:41-4. 2008
    ..It is not known if the recovery of pediatric burn patients is age-dependent. The aim of this study was to investigate the effect of age on the recovery of body composition of severely burned children...
  67. ncbi The influence of age and gender on resting energy expenditure in severely burned children
    Ronald P Mlcak
    Shriners Hospital for Children and Department of Surgery, University Texas Medical Branch, Galveston, TX 77550, USA
    Ann Surg 244:121-30. 2006
    ..The purpose of this study was to analyze the influence of age and gender on resting energy expenditure (REE) in severely burned children from acute hospitalization through 12 months postburn...
  68. ncbi A review of gene and stem cell therapy in cutaneous wound healing
    Ludwik K Branski
    Department of Surgery, The University of Texas Medical Branch and Shriners Hospitals for Children, Galveston, TX 77550, United States
    Burns 35:171-80. 2009
    ..Recently, the combination of gene and stem cell therapy has emerged as a promising approach for treatment of chronic and acute wounds...
  69. ncbi Temporal cytokine profiles in severely burned patients: a comparison of adults and children
    Celeste C Finnerty
    Shriners Hospitals for Children, 815 Market Street, Galveston, TX 77550, USA
    Mol Med 14:553-60. 2008
    ....
  70. ncbi Blood transfusions are associated with increased risk for development of sepsis in severely burned pediatric patients
    Marc G Jeschke
    Shriners Hospitals for Children and Department of Surgery, University of Texas Medical Branch, Galveston, TX, USA
    Crit Care Med 35:579-83. 2007
    ..To determine the risk of developing sepsis following transfusion of blood products in severely burned pediatric patients...
  71. ncbi Severe burn-induced endoplasmic reticulum stress and hepatic damage in mice
    Juquan Song
    Shriners Hospitals for Children and Departments Surgery, University of Texas Medical Branch, Galveston, Texas, USA
    Mol Med 15:316-20. 2009
    ..In summary, thermal injury in mice causes long-term adaptive and deleterious hepatic function alterations characterized by significant upregulation of the ER stress response...
  72. ncbi Liposomal gene transfer of keratinocyte growth factor improves wound healing by altering growth factor and collagen expression
    Clifford T Pereira
    Shriners Hospitals for Children, University of Texas Medical Branch, Galveston, Texas 77550, USA
    J Surg Res 139:222-8. 2007
    ..In the present study, we thought to determine the interaction between keratinocyte growth factor (KGF) administered as liposomal cDNA with other dermal and epidermal growth factors and collagen synthesis in an acute wound...
  73. ncbi Metabolism modulators in sepsis: propranolol
    William B Norbury
    Department of Surgery, Shriners Hospitals for Children, Galveston, TX, USA
    Crit Care Med 35:S616-20. 2007
    ..In this article we attempt to demonstrate the effects of sepsis (SIRS plus infection) on whole body metabolism, outline the mediators of these changes, and then show the ability of propranolol to attenuate the changes seen...
  74. ncbi The structure and composition of liposomes can affect skin regeneration, morphology and growth factor expression in acute wounds
    M G Jeschke
    Galveston Burns Unit and Department of Surgery, Shriners Hospital for Children, University Texas Medical Branch, TX 77550, USA
    Gene Ther 12:1718-24. 2005
    ..For gene transfer in acute wounds, the administration of DOTAP/Chol liposomes appears to be beneficial...
  75. ncbi Amnion in the treatment of pediatric partial-thickness facial burns
    Ludwik K Branski
    Shriners Hospital for Children and University of Texas Medical Branch, 815 Market Street, Galveston, TX 77550, USA
    Burns 34:393-9. 2008
    ....
  76. ncbi Insulin resistance postburn: underlying mechanisms and current therapeutic strategies
    Gerd G Gauglitz
    Shriners Burns Hospital for Children, Galveston, Texas 77550, USA
    J Burn Care Res 29:683-94. 2008
    ..This review aims to discuss the mechanisms underlying insulin resistance induced hyperglycemia postburn and outlines current therapeutic strategies that are being used to modulate hyperglycemia after thermal trauma...
  77. ncbi The hypermetabolic response to burn injury and interventions to modify this response
    Felicia N Williams
    Department of Surgery, The University of Texas Medical Branch, Galveston, USA
    Clin Plast Surg 36:583-96. 2009
    ....
  78. ncbi Pre-clinical evaluation of liposomal gene transfer to improve dermal and epidermal regeneration
    L K Branski
    Shriners Hospitals for Children and University of Texas Medical Branch, Galveston, TX 77550, USA
    Gene Ther 17:770-8. 2010
    ..These data indicate that liposomal gene transfer can be a new therapeutic approach to improve wound healing in humans...
  79. ncbi Acute bronchial obstruction in sheep: histopathology and gland cytokine expression
    Robert A Cox
    Department of Pathology, University of Texas Medical Branch, Galveston, Texas 77550, USA
    Exp Lung Res 31:819-37. 2005
    ..05...
  80. ncbi Cytokine expression profile over time in burned mice
    Celeste C Finnerty
    Department of Surgery, University of Texas Medical Branch and Shriners Hospital for Children, 815 Market Street, Galveston, TX 77550, USA
    Cytokine 45:20-5. 2009
    ....
  81. ncbi Isolation and characterization of mesenchymal stem cells from the sub-amniotic human umbilical cord lining membrane
    Katsuhiro Kita
    Department of Surgery and Shriners Hospitals for Children, The University of Texas Medical Branch, Galveston, Texas 77550, USA
    Stem Cells Dev 19:491-502. 2010
    ..The cord lining membrane (subamniotic) MSCs isolated by our method maintain typical characteristics of MSCs in vitro, but also showed several specific features...
  82. ncbi Effect of growth factors as therapeutic drugs on hepatic metabolism during the systemic inflammatory response syndrome
    Marc G Jeschke
    Shriners Hospital for Children and Department of Surgery, University Texas Medical Branch, Galveston, Texas 77550, USA
    Curr Drug Metab 5:399-413. 2004
    ....
  83. ncbi Mortality related to gender, age, sepsis, and ethnicity in severely burned children
    Robert E Barrow
    Department of Surgery, University of Texas Medical Branch, Galveston, Texas 77550, USA
    Shock 23:485-7. 2005
    ..Burn mortality among infants and toddlers, children, and adolescents with greater than 40% total body surface area burns with or without identified sepsis could not be shown to be gender or ethnic origin dependent...
  84. ncbi Early release of third-degree eyelid burns prevents eye injury
    R E Barrow
    Department of Surgery at the University of Texas Medical Branch and the Shriners Hospitals for Children, Galveston, 77551, USA
    Plast Reconstr Surg 105:860-3. 2000
    ..We suggest that early release and grafting should be the treatment of choice for children and young adults with third-degree burns to the eyelids...
  85. ncbi Early fluid resuscitation improves outcomes in severely burned children
    R E Barrow
    Department of Surgery, University of Texas Medical Branch and Shriners Hospital for Children, Galveston 77550, USA
    Resuscitation 45:91-6. 2000
    ..We hypothesized that fluid resuscitation given within 2 h of a thermal injury attenuates renal failure, cardiac arrest, cardiac arrest deaths, incidence of sepsis, and overall mortality...
  86. ncbi Measurement of skin protein breakdown in a rat model
    E Volpi
    Department of Internal Medicine, University of Texas Medical Branch, Galveston, 77555, USA
    Am J Physiol Endocrinol Metab 279:E900-6. 2000
    ..mixed protein FSR). The tracee release method is a sensitive method for measurement of skin protein breakdown; however, given the high intersubject variability of FSR, the calculation of skin net balance is not advisable...
  87. ncbi Effect of varying burn sizes and ambient temperature on the hypermetabolic rate in thermally injured rats
    R E Barrow
    Shriners Hospital for Children, University of Texas Medical Branch, Galveston, TX 77550, USA
    J Surg Res 99:253-7. 2001
    ..The purpose of this study was to determine whether a smaller burn size can induce a similar hypermetabolic response with mortality rates lower than those of the 50% TBSA model...
  88. ncbi Enteral feeding intolerance: an indicator of sepsis-associated mortality in burned children
    S E Wolf
    Department of Surgery, University of Texas Medical Branch and the Shriners Burn Institute, Galveston 77550, USA
    Arch Surg 132:1310-3; discussion 1313-4. 1997
    ..To determine if enteral feeding intolerance (EFI) is associated with sepsis and increased mortality in children with severe burns...
  89. ncbi Gene therapy in wound healing: present status and future directions
    L K Branski
    Department of Surgery, The University of Texas Medical Branch, Shriners Hospitals for Children, Galveston, TX 77550, USA
    Gene Ther 14:1-10. 2007
    ..This article aims to review the research on gene therapy in wound healing and possible future directions in this exciting field...
  90. ncbi Biodistribution and feasibility of non-viral IGF-I gene transfers in thermally injured skin
    M G Jeschke
    Shriners Hospital for Children, and the Department of Surgery, University of Texas Medical Branch, Galveston, USA
    Lab Invest 80:151-8. 2000
    ..Liposomes containing the cDNA coding for IGF-I present an effective approach to gene therapy in the skin...
  91. ncbi Clinical microfluidics for neutrophil genomics and proteomics
    Kenneth T Kotz
    Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Nat Med 16:1042-7. 2010
    ....
  92. ncbi IGF-1 protects intestinal epithelial cells from oxidative stress-induced apoptosis
    Naira Baregamian
    Department of Surgery, The University of Texas Medical Branch, Galveston, Texas 77555 0353, USA
    J Surg Res 136:31-7. 2006
    ..The purpose of this study was to determine whether IGF-1 protects intestinal cells from ROS-induced apoptosis...
  93. ncbi Serum cytokine differences in severely burned children with and without sepsis
    Celeste C Finnerty
    Shriners Hospitals for Children, Galveston, TX 77550, USA
    Shock 27:4-9. 2007
    ..In addition, serum IL-6, IL-12 p70, and TNF can be used to identify burned patients who are at high risk of death from sepsis...
  94. ncbi IGF-I/BP-3 administration preserves hepatic homeostasis after thermal injury which is associated with increases in no and hepatic NF-kappa B
    M G Jeschke
    Shriners Hospital for Children and Department of Surgery, University Texas Medical Branch, Galveston, Texas, USA
    Shock 16:373-9. 2001
    ....
  95. ncbi Inflammation and the host response to injury, a large-scale collaborative project: patient-oriented research core--standard operating procedures for clinical care VII--Guidelines for antibiotic administration in severely injured patients
    Michael A West
    Department of Surgery, University of California, San Francisco, San Francisco, California 94110, USA
    J Trauma 65:1511-9. 2008
    ..It should also be noted that not all patients with increased temperature/WBC have an infection. Discontinuation of antibiotics is appropriate if cultures and other diagnostic studies are negative...
  96. ncbi Effects of incremental starvation on gut mucosa
    Vicky L Chappell
    Department of Surgery, The University of Texas Medical Branch, Galveston, Texas, USA
    Dig Dis Sci 48:765-9. 2003
    ..In conclusion, incremental starvation produces progressive small bowel atrophy. The mechanism involves both decreased gut epithelial cell proliferation and increased apoptosis...
  97. ncbi Serum TGF-beta in thermally injured rats
    M Varedi
    Department of Surgery and Shriners Hospital for Children, University of Texas Medical Branch, Galveston, Texas 77555, USA
    Shock 16:380-2. 2001
    ..6 pg/mL) throughout the experiment. Thermal injury induces a significant increase in serum TGF-beta, which may contribute to post-burn immunosuppression with an increased susceptibility to sepsis...
  98. ncbi Fatty infiltration of the liver in severely burned pediatric patients: autopsy findings and clinical implications
    J P Barret
    Department of Surgery, Division of Plastic Surgery, Shriners Burns Hospital and The University of Texas Medical Branch, Galveston, Texas, USA
    J Trauma 51:736-9. 2001
    ..It is notable that fatty infiltration of the liver occurred in the complete absence of parenteral nutrition...
  99. ncbi The effect of short-term growth hormone treatment on growth and energy expenditure in burned children
    J F Aili Low
    Shriners Hospital for Children, Department of Surgery, University of Texas Medical Branch at Galveston, 815 Market St, 77550, Galveston, TX, USA
    Burns 27:447-52. 2001
    ..Recombinant human GH, given during acute hospitalization, maintained growth in severely burned children who would otherwise experience a significant growth delay. Treatment with rhGH did not atttenuate their elevated REE...
  100. ncbi Differential expression of hepatocyte growth factor in liver, kidney, lung, and spleen following burn in rats
    Y Yamashita
    Shriners Burns Hospital, Galveston, Texas, USA
    Cytokine 12:1293-8. 2000
    ..These results suggest that burn induces the production of HGF in various organs, and that the induced HGF is activated according to the severity of tissue damage caused by burn...
  101. ncbi Beta-blockade in burns
    C T Pereira
    Shriners Hospitals for Children, 815 Market Street, Galveston, Texas 77550 2725, USA
    Novartis Found Symp 280:238-48; discussion 248-51. 2007
    ..This article aims to review the current understanding of catecholamines in postburn muscle wasting and focuses on the clinical and metabolic effects of beta-blockade in severe burns...