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Genomes and GenesSpecies | Randy L JensenSummaryAffiliation: University of Utah Country: USA Publications
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Publications
Cauda equina syndrome as a postoperative complication of lumbar spine surgeryRandy L Jensen
Department of Neurosurgery, University of Utah, Salt Lake City, Utah 84132, USA
Neurosurg Focus 16:e7. 2004..In this study the author describes two cases of CES that occurred following uneventful lumbar spine procedures--one microdiscectomy and one decompressive laminectomy...- Peritumoral edema after stereotactic radiosurgery for intracranial meningiomas and molecular factors that predict its developmentPeter Kan
Department of Neurosurgery, University of Utah Health Sciences Center, 175 N Medical Drive East, Salt Lake City, UT 84132, USA
J Neurooncol 83:33-8. 2007..Although uncommon, peritumoral edema can develop as a delayed complication after SRS. The purpose of the study was to evaluate the clinical and molecular risk factors for peritumoral edema after SRS for intracranial meningiomas... - Silencing of HIF-1alpha by RNA interference in human glioma cells in vitro and in vivoDavid L Gillespie
Department of Neurosurgery, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA
Methods Mol Biol 487:283-301. 2009..Here we present methods for investigating the role of HIF-1alpha in glioma growth in vivo and in vitro using RNA interference in U251, U87, and U373 glioma cells... - Silencing of hypoxia inducible factor-1alpha by RNA interference attenuates human glioma cell growth in vivoDavid L Gillespie
Department of Neurosurgery, Huntsman Cancer Institute in the Division of Pediatric Hematology Oncology, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA
Clin Cancer Res 13:2441-8. 2007..Hypoxia inducible factor-1alpha (HIF-1alpha) is a main responder to intracellular hypoxia and is overexpressed in many human cancers, including gliomas... - Hypoxia-regulated protein expression, patient characteristics, and preoperative imaging as predictors of survival in adults with glioblastoma multiformeJeannette R Flynn
Center for Children, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah, USA
Cancer 113:1032-42. 2008.... - Calcium channel antagonists augment hydroxyurea- and ru486-induced inhibition of meningioma growth in vivo and in vitroBrian T Ragel
Department of Neurosurgery, University of Utah, 30 North 1900 East, Suite 3B409, Salt Lake City, UT 84132, USA
Neurosurgery 59:1109-20; discussion 1120-1. 2006..These results suggest a possible role for these drugs as an additional adjuvant therapy for recurrent or unresectable meningiomas... - Celecoxib inhibits meningioma tumor growth in a mouse xenograft modelBrian T Ragel
Department of Neurosurgery, University of Utah, Salt Lake City, Utah 84132, USA
Cancer 109:588-97. 2007..We therefore tested the effects of celecoxib on meningioma growth in a mouse xenograft model... - A model-constrained Monte Carlo method for blind arterial input function estimation in dynamic contrast-enhanced MRI: II. In vivo resultsMatthias C Schabel
Utah Center for Advanced Imaging Research, Department of Radiology, University of Utah Health Sciences Center, 729 Arapeen Drive, Salt Lake City, UT 84108 1218, USA
Phys Med Biol 55:4807-23. 2010..These results demonstrate that the MCBE algorithm is a useful alternative to direct AIF measurement in cases where acquisition of high-quality arterial input function data is difficult or impossible... - Transient postictal MRI changes in patients with brain tumors may mimic disease progressionMichael A Finn
Department of Neurosurgery, University of Utah School of Medicine, Salt Lake City, UT 84132 2303, USA
Surg Neurol 67:246-50; discussion 250. 2007..Interval changes on repeat imaging can mimic disease progression or other pathologic processes... - Multimodality treatment of melanoma brain metastases incorporating stereotactic radiosurgery (SRS)Wolfram E Samlowski
Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah 84112, USA
Cancer 109:1855-62. 2007..We performed a retrospective analysis of our institutional experience of multimodality treatment utilizing linear accelerator (Linac)-based stereotactic radiosurgery (SRS)... - Stereotactic radiosurgery eligibility and selection bias in the treatment of glioblastoma multiformeChristopher J Anker
Department of Radiation Oncology, Huntsman Cancer Hospital, University of Utah School of Medicine, 1950 Circle of Hope, Rm 1570, Salt Lake City, UT, 581 2396, USA
J Neurooncol 98:253-63. 2010..It is possible inclusion of such patients in a series of SRS for GBM could mask a benefit in remaining patients. No significant difference in OS or PFS based on SRS-eligibility status was found... - Biochemotherapy of metastatic melanoma in patients with or without recently diagnosed brain metastasesMartin Majer
Multidisciplinary Melanoma Program, Huntsman Cancer Institute, Salt Lake City, Utah, USA
Cancer 110:1329-37. 2007.... - Overall and progression-free survival and visual and endocrine outcomes for patients with parasellar lesions treated with intensity-modulated stereotactic radiosurgeryRandy L Jensen
Department of Neurosurgery, Huntsman Cancer Institute, University of Utah Health Sciences Center, 5th Floor, Clinical Neurosciences Center, 175 North Medical Drive, Salt Lake City, UT, 84132, USA
J Neurooncol 98:221-31. 2010.... - Novalis intensity-modulated radiosurgery: methods for pretreatment planningRandy L Jensen
Department of Neurosurgery, The Huntsman Cancer Institute, University of Utah Health Sciences Center, Salt Lake City, Utah, USA
Neurosurgery 62:A2-9; discussion A9-10. 2008..We describe our methods and results of preprocedure planning for IMRS for patients with lesions in the cavernous sinus or parasellar regions in whom the dose to the optic nerve or chiasm might exceed our acceptable tolerance dose (8 Gy)... - Conformity of LINAC-based stereotactic radiosurgery using dynamic conformal arcs and micro-multileaf collimatorLisa J Hazard
Department of Radiation Oncology, Huntsman Cancer Hospital, University of Utah School of Medicine, Salt Lake City, UT, USA
Int J Radiat Oncol Biol Phys 73:562-70. 2009..To assess the conformity of dynamic conformal arc linear accelerator-based stereotactic radiosurgery and to describe a standardized method of isodose surface (IDS) selection... - Brain tumor hypoxia: tumorigenesis, angiogenesis, imaging, pseudoprogression, and as a therapeutic targetRandy L Jensen
Department of Neurosurgery, Huntsman Cancer Institute, University of Utah, Building 550, Fifth Floor, 175 North Medical Drive, Salt Lake City, UT 84132, USA
J Neurooncol 92:317-35. 2009..An understanding of the role of hypoxia in tumor development and growth is important for physicians involved in the care of patients with brain tumors... - Identification of hypoxia-induced genes in a malignant glioma cell line (U-251) by cDNA microarray analysisBrian T Ragel
Department of Neurosurgery, University of Utah, Salt Lake City, UT 84132, USA
Neurosurg Rev 30:181-7; discussion 187. 2007..Future studies will focus on the hypothesis that Depp is up-regulated in an autocrine fashion by the AKR1C3 enzyme in U-251 glioma cells under hypoxic conditions... - Hypoxia in the tumorigenesis of gliomas and as a potential target for therapeutic measuresRandy L Jensen
Department of Neurosurgery, University of Utah, Salt Lake City, Utah 84132, USA
Neurosurg Focus 20:E24. 2006..In this model, intratumoral hypoxia causes genetic changes that produce a microenvironment that selects for cells of a more aggressive phenotype... - Development of contrast enhancement after long-term observation of a dysembryoplastic neuroepithelial tumorRandy L Jensen
Department of Neurosurgery, University of Utah, Salt Lake City, Utah 84132 2303, USA
J Neurooncol 78:59-62. 2006..This case demonstrates the potential that DNETs may exhibit a changing MRI pattern over time. Natural history, imaging characteristics, and management are reviewed... - Inhibition of hypoxia inducible factor-1alpha (HIF-1alpha) decreases vascular endothelial growth factor (VEGF) secretion and tumor growth in malignant gliomasRandy L Jensen
Department of Neurosurgery, University of Utah, Salt Lake City, Utah 84132 2303, USA
J Neurooncol 78:233-47. 2006..We examined the effect of HIF-1alpha on VEGF secretion, tumor growth, and angiogenesis in malignant gliomas... - Dose fractionation in stereotactic radiotherapy for parasellar meningiomas: radiobiological considerations of efficacy and optic nerve toleranceDennis C Shrieve
Department of Radiation Oncology, The Huntsman Cancer Institute, University of Utah Health Sciences Center, Salt Lake City, Utah 84132, USA
J Neurosurg 101:390-5. 2004..An analysis of the expected efficacy of hypofractionation compared with the estimated optic tolerance to fractionated radiotherapy was undertaken... - Expression of hypoxia inducible factor-1 alpha and correlation with preoperative embolization of meningiomasRandy L Jensen
Department of Neurosurgery, University of Utah, Salt Lake City 84132 2303, USA
J Neurosurg 97:658-67. 2002..In this study, the authors examine the expression of HIF-1alpha and VEGF in meningiomas, with a special emphasis on conditions of hypoxia, such as preoperative embolization, and on in vitro studies in cultured cells... - Endolymphatic sac tumors in patients with and without von Hippel-Lindau disease: the role of genetic mutation, von Hippel-Lindau protein, and hypoxia inducible factor-1alpha expressionRandy L Jensen
Department of Neurosurgery, University of Utah, Salt Lake City, Utah 84132 2303, USA
J Neurosurg 100:488-97. 2004..In this study the authors examine the role of VHL and HIF-1 in ELS tumors... - Role of stereotactic radiosurgery in the treatment of brain metastasesLisa J Hazard
Department of Radiation Oncology, Huntsman Cancer Hospital, Salt Lake City, Utah 84112, USA
Am J Clin Oncol 28:403-10. 2005..The authors review the role of SRS in the treatment of brain metastases and discuss the use of SRS with or without whole-brain radiation therapy, optimal dose of SRS, SRS delivery methods, and selection of appropriate patients for SRS... - A comparison of the cell lines used in meningioma researchBrian T Ragel
Department of Neurosurgery, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
Surg Neurol 70:295-307; discussion 307. 2008..We address 2 criticisms of the mouse xenograft flank tumor model: Why are tumor induction rates derived from operative specimens low and inconsistent? Are flank tumors meningiomas?.. - Ubiquitous expression of cyclooxygenase-2 in meningiomas and decrease in cell growth following in vitro treatment with the inhibitor celecoxib: potential therapeutic applicationBrian T Ragel
Department of Neurosurgery, University of Utah; and Huntsman Cancer Institute, Salt Lake City, Utah 84132, USA
J Neurosurg 103:508-17. 2005..Celecoxib inhibits meningioma growth in vitro in a dose-dependent fashion, with evidence of apoptosis. Inhibitors of COX-2 may have a role in the treatment of recurrent meningiomas... - New approaches for the treatment of refractory meningiomasBrian Ragel
Department of Neurosurgery, University of Utah, Salt Lake City 84132, USA
Cancer Control 10:148-58. 2003 - Chronic suppressive therapy with calcium channel antagonists for refractory meningiomasBrian T Ragel
Department of Neurosurgery, University of Utah, Salt Lake City, Utah 84132, USA
Neurosurg Focus 23:E10. 2007..The use of CCAs is attractive as an adjunct treatment for unresectable or recurrent meningiomas because they are safe drugs with well-known side effect profiles that lend themselves to long-term chronic therapy... - Pleomorphic liposarcoma originating from intracranial dura materMichael L Mumert
Department of Neurosurgery, University of Utah, Salt Lake City, UT, USA
J Neurooncol 97:149-53. 2010..The authors review the few cases of primary or metastatic pleomorphic liposarcoma that have been reported involving the head... - Variations of disseminated choroid plexus papilloma: 2 case reports and a review of the literatureTodd McCall
Department of Neurosurgery, University of Utah, Salt Lake City, UT 84132, USA
Surg Neurol 66:62-7; discussion 67-8. 2006..The prognosis for patients with disseminated choroid plexus papilloma can range from prolonged stable disease and symptoms to death within months... - Hypophysial transposition (hypophysopexy) for radiosurgical treatment of pituitary tumors involving the cavernous sinus. Technical noteJames K Liu
Department of Neurosurgery, University of Utah, Salt Lake City, Utah 84132-2303, USA
Neurosurg Focus 14:e11. 2003..The increased distance between the normal pituitary gland and the residual tumor facilitates treatment of the tumor with radiosurgery and reduces radiation exposure to the normal pituitary gland... - Surgical strategies for recurrent craniofacial meningiomasGanesh Rao
Department of Neurosurgery, University of Utah, Salt Lake City 84132, USA
Neurosurgery 58:874-80; discussion 874-80. 2006..Although combined approaches may be necessary to achieve a gross total resection, these lesions can often be reached using standard transcranial techniques... - A novel model of intracranial meningioma in mice using luciferase-expressing meningioma cells. Laboratory investigationBrian T Ragel
Department of Neurosurgery, University of Utah, Salt Lake City 84132, USA
J Neurosurg 108:304-10. 2008..The authors describe a mouse model of intracranial meningioma that uses this novel BLI system... - Epidermal growth factor receptor gene amplification and protein expression in glioblastoma multiforme: prognostic significance and relationship to other prognostic factorsLester J Layfield
Department of Pathology, University of Utah Hospital and Clinics, Salt Lake City, Utah 84132, USA
Appl Immunohistochem Mol Morphol 14:91-6. 2006..p53 expression was also determined by immunohistochemistry and correlated with the other variables and survival... - Inflammatory response and meningioma tumorigenesis and the effect of cyclooxygenase-2 inhibitorsBrian T Ragel
Department of Neurosurgery, University of Utah, Salt Lake City, Utah 94132, USA
Neurosurg Focus 23:E7. 2007..In addition, celecoxib is well tolerated in humans, making its use as a chronic therapy for meningiomas attractive... - Molecular genetics of meningiomasBrian T Ragel
Department of Neurosurgery, University of Utah, Salt Lake City, Utah 84132, USA
Neurosurg Focus 19:E9. 2005..Ultimately, a better understanding of the molecular pathways of meningioma tumorigenesis will lead to new, successful treatments... - Primary spinal yolk sac tumor with brain metastasis: case report and review of the literaturePeter Kan
Department of Neurosurgery, University of Utah, Salt Lake City, Utah 84132, USA
J Neurooncol 78:249-53. 2006..The authors review the available literature on the treatment of intracranial malignant germ cell tumors, extrapolated to apply to the much rarer spinal lesions... - WHO Grade II and III supratentorial hemispheric ependymomas in adults: case series and review of treatment optionsToba N Niazi
Department of Neurosurgery, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84132, USA
J Neurooncol 91:323-8. 2009..All patients require initial close serial imaging and follow-up. The role of chemotherapy is still uncertain but may be necessary in younger patients who may have tumors that behave more like the pediatric ependymomas... - Multiinstitutional validation of the University of California at San Francisco Low-Grade Glioma Prognostic Scoring System. Clinical articleEdward F Chang
Brain Tumor Research Center, Department of Neurosurgery, University of California, San Francisco, California 94143, USA
J Neurosurg 111:203-10. 2009..The objective of this study was to validate the scoring system in a large patient group drawn from multiple external institutions... - Oligodendroglioma and juvenile pilocytic astrocytoma presenting as synchronous primary brain tumors. Case report with histological and molecular differentiation of the tumors and review of the literaturePeter Kan
Department of Neurosurgery, University of Utah, Salt Lake City, Utah 84132-2303, USA
J Neurosurg 100:700-5. 2004..They review the literature on multiple primary brain tumors with different histological characteristics and discuss potential mechanisms for the development of these lesions... - Multimodality management of brain metastases in metastatic melanoma patientsWolfram E Samlowski
Section of Melanoma, Renal Cancer and Immunotherapy, Nevada Cancer Institute, One Breakthrough Way, 10441 W Twain Ave, Las Vegas, NV 89135, USA
Expert Rev Anticancer Ther 7:1699-705. 2007..Current data suggest that aggressive treatment of patients with up to five brain melanoma brain metastases is capable of producing prolonged survival in many patients, including some long-term complete responses... - Meningioma of the jugular foramen: glomus jugulare mimic and surgical challengeM Erik Gilbert
Division of Otolaryngology Head and Neck Surgery, University of Utah Health Sciences Center, Salt Lake City 84123, USA
Laryngoscope 114:25-32. 2004..There is controversy regarding the selection of surgical approach, particularly with regard to management of the facial nerve. A reliable means of accurate preoperative diagnosis would help surgical planning and patient counseling... - Early growth response gene-1 regulates hypoxia-induced expression of tissue factor in glioblastoma multiforme through hypoxia-inducible factor-1-independent mechanismsYuan Rong
Department of Pathology and Laboratory Medicine, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Cancer Res 66:7067-74. 2006..We conclude that hypoxic up-regulation of tissue factor in glioblastoma multiforme cells depends largely on Egr-1 and is independent of HIF-1... - Safety and feasibility of convection-enhanced delivery of Cotara for the treatment of malignant glioma: initial experience in 51 patientsSunil J Patel
Department of Neurological Surgery, Medical University of South Carolina, Charleston, South Carolina, USA
Neurosurgery 56:1243-52; discussion 1252-3. 2005..This method of administration has an acceptable safety profile compared with literature reports of other therapeutics delivered by convection-enhanced delivery... - Intracerebral amyloidoma can mimic high-grade glioma on magnetic resonance imaging and spectroscopyBrian T Ragel
Arch Neurol 63:906-7. 2006