LARS FREDRIK JARSKOG

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. ncbi Schizophrenia: new pathological insights and therapies
    L Fredrik Jarskog
    Department of Psychiatry, Schizophrenia Research Center, University of North Carolina Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Annu Rev Med 58:49-61. 2007
  2. ncbi Apoptotic proteins in the temporal cortex in schizophrenia: high Bax/Bcl-2 ratio without caspase-3 activation
    L Fredrik Jarskog
    Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill 27599 7160, USA
    Am J Psychiatry 161:109-15. 2004
  3. ncbi Apoptotic mechanisms in the pathophysiology of schizophrenia
    L Fredrik Jarskog
    Department of Psychiatry, Schizophrenia Research Center, University of North Carolina Chapel Hill, CB 7160, Chapel Hill, NC 27599 7160, USA
    Prog Neuropsychopharmacol Biol Psychiatry 29:846-58. 2005
  4. ncbi Caspase-3 activation in rat frontal cortex following treatment with typical and atypical antipsychotics
    L Fredrik Jarskog
    Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7160, USA
    Neuropsychopharmacology 32:95-102. 2007
  5. ncbi Apoptosis in schizophrenia: pathophysiologic and therapeutic considerations
    L Fredrik Jarskog
    Department of Psychiatry, Schizophrenia Research Center, University of North Carolina, Chapel Hill 27599 7160, USA
    Curr Opin Psychiatry 19:307-12. 2006
  6. ncbi microRNA expression in the prefrontal cortex of individuals with schizophrenia and schizoaffective disorder
    Diana O Perkins
    Department of Psychiatry, University of North Carolina at Chapel Hill, CB 7160, Chapel Hill, NC 27599, USA
    Genome Biol 8:R27. 2007
  7. ncbi Maternal infection regulates BDNF and NGF expression in fetal and neonatal brain and maternal-fetal unit of the rat
    John H Gilmore
    Department of Psychiatry, CB 7160, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7160, USA
    J Neuroimmunol 138:49-55. 2003
  8. ncbi Maternal poly I:C exposure during pregnancy regulates TNF alpha, BDNF, and NGF expression in neonatal brain and the maternal-fetal unit of the rat
    John H Gilmore
    UNC Schizophrenia Research Center, Department of Psychiatry, CB 7160, University of North Carolina, Chapel Hill, NC 27599 7160, USA
    J Neuroimmunol 159:106-12. 2005
  9. ncbi Developmental regulation of the NMDA receptor subunits, NR3A and NR1, in human prefrontal cortex
    Maile A Henson
    Curriculum in Neurobiology, University of North Carolina, Chapel Hill, NC 27705, USA
    Cereb Cortex 18:2560-73. 2008
  10. ncbi Neuroprotection in schizophrenia
    L Fredrik Jarskog
    Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill, USA
    J Clin Psychiatry 67:e09. 2006

Research Grants

  1. Bcl-2 Family Protein and Apoptosis in Schizophrenia
    LARS JARSKOG; Fiscal Year: 2005

Collaborators

Detail Information

Publications16

  1. ncbi Schizophrenia: new pathological insights and therapies
    L Fredrik Jarskog
    Department of Psychiatry, Schizophrenia Research Center, University of North Carolina Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Annu Rev Med 58:49-61. 2007
    ..This review provides an update on developments in research on the neuropathology of schizophrenia and discusses recent advances in antipsychotic treatment and the potential impact on long-term outcomes...
  2. ncbi Apoptotic proteins in the temporal cortex in schizophrenia: high Bax/Bcl-2 ratio without caspase-3 activation
    L Fredrik Jarskog
    Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill 27599 7160, USA
    Am J Psychiatry 161:109-15. 2004
    ..It was hypothesized that the Bax/Bcl-2 ratio, but not caspase-3, would be high in the temporal cortex of patients with chronic schizophrenia...
  3. ncbi Apoptotic mechanisms in the pathophysiology of schizophrenia
    L Fredrik Jarskog
    Department of Psychiatry, Schizophrenia Research Center, University of North Carolina Chapel Hill, CB 7160, Chapel Hill, NC 27599 7160, USA
    Prog Neuropsychopharmacol Biol Psychiatry 29:846-58. 2005
    ..Although the exact role of apoptosis in schizophrenia remains uncertain, the potential involvement of non-lethal localized apoptosis is intriguing, especially in earlier stages of the illness...
  4. ncbi Caspase-3 activation in rat frontal cortex following treatment with typical and atypical antipsychotics
    L Fredrik Jarskog
    Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7160, USA
    Neuropsychopharmacology 32:95-102. 2007
    ..Although the association between antipsychotic treatment and increased pro-apoptotic caspase-3 is intriguing, further study is needed to understand its potential effects...
  5. ncbi Apoptosis in schizophrenia: pathophysiologic and therapeutic considerations
    L Fredrik Jarskog
    Department of Psychiatry, Schizophrenia Research Center, University of North Carolina, Chapel Hill 27599 7160, USA
    Curr Opin Psychiatry 19:307-12. 2006
    ..This paper will review studies of apoptotic regulatory proteins, DNA fragmentation, and gene microarrays to highlight the potential role of apoptosis in the pathophysiology and treatment of schizophrenia...
  6. ncbi microRNA expression in the prefrontal cortex of individuals with schizophrenia and schizoaffective disorder
    Diana O Perkins
    Department of Psychiatry, University of North Carolina at Chapel Hill, CB 7160, Chapel Hill, NC 27599, USA
    Genome Biol 8:R27. 2007
    ..They have been implicated in the etiology of a variety of complex diseases, including Tourette's syndrome, Fragile x syndrome, and several types of cancer...
  7. ncbi Maternal infection regulates BDNF and NGF expression in fetal and neonatal brain and maternal-fetal unit of the rat
    John H Gilmore
    Department of Psychiatry, CB 7160, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7160, USA
    J Neuroimmunol 138:49-55. 2003
    ..Abnormal expression of neurotrophic factors represents a potential mechanism through which maternal infection increases risk for neurodevelopmental disorders...
  8. ncbi Maternal poly I:C exposure during pregnancy regulates TNF alpha, BDNF, and NGF expression in neonatal brain and the maternal-fetal unit of the rat
    John H Gilmore
    UNC Schizophrenia Research Center, Department of Psychiatry, CB 7160, University of North Carolina, Chapel Hill, NC 27599 7160, USA
    J Neuroimmunol 159:106-12. 2005
    ..Changes in TNFalpha, BDNF, and NGF after maternal exposure to poly I:C represent a potential mechanism through which maternal infection increases risk for neurodevelopmental disorders...
  9. ncbi Developmental regulation of the NMDA receptor subunits, NR3A and NR1, in human prefrontal cortex
    Maile A Henson
    Curriculum in Neurobiology, University of North Carolina, Chapel Hill, NC 27705, USA
    Cereb Cortex 18:2560-73. 2008
    ..These data provide insights into NMDAR functions in the developing CNS and will contribute to designing pharmacotherapies for neurological disorders...
  10. ncbi Neuroprotection in schizophrenia
    L Fredrik Jarskog
    Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill, USA
    J Clin Psychiatry 67:e09. 2006
    ....
  11. ncbi Regulation of complexin 1 and complexin 2 in the developing human prefrontal cortex
    Kayvon Salimi
    Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Synapse 62:273-82. 2008
    ....
  12. ncbi Pro-apoptotic Par-4 and dopamine D2 receptor in temporal cortex in schizophrenia, bipolar disorder and major depression
    Leisa A Glantz
    Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Schizophr Res 118:292-9. 2010
    ..Changes in the Par-4/D2DR signaling pathway represent a novel mechanism that may link apoptotic and dopamine signaling pathways in major depression and schizophrenia...
  13. ncbi Apoptotic mechanisms and the synaptic pathology of schizophrenia
    Leisa A Glantz
    Department of Psychiatry, University of North Carolina-Chapel Hill, CB# 7160, Chapel Hill, NC 27599-7160, USA
    Schizophr Res 81:47-63. 2006
    ..This paper will review converging lines of data that implicate synaptic deficits in the pathophysiology of schizophrenia and propose an underlying role for apoptotic dysregulation...
  14. ncbi Secretin in a patient with treatment-resistant schizophrenia and prominent autistic features
    Sayed S Alamy
    Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill, NC 27599-7160, USA
    Schizophr Res 66:183-6. 2004
    ..The case illustrates the potential role of secretin as a novel adjunctive treatment strategy in schizophrenic patients with autistic features...
  15. ncbi Deficits in adult prefrontal cortex neurons and behavior following early post-natal NMDA antagonist treatment
    Leon G Coleman
    Curriculum in Neurobiology, Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7178, United States
    Pharmacol Biochem Behav 93:322-30. 2009
    ..These findings indicate that early brain insults affecting glutamatergic neurotransmission lead to persistent brain pathology that could contribute to impulsivity and cognitive dysfunction...
  16. ncbi Antipsychotic drugs for first-episode schizophrenia: a comparative review
    Kayvon Salimi
    Department of Psychiatry, University of North Carolina at Chapel Hill, USA
    CNS Drugs 23:837-55. 2009
    ..However, metabolic concerns associated with many atypical agents along with limited benefits in cognition and negative symptom domains highlight the persistent therapeutic needs of these patients...

Research Grants1

  1. Bcl-2 Family Protein and Apoptosis in Schizophrenia
    LARS JARSKOG; Fiscal Year: 2005
    ..Stereological neuronal cell counting and measurement of somal size will also be assessed. Finally, young adult rats will receive typical and atypical antipsychotics to assess their effect on the apoptotic regulatory proteins. ..