Research Topics
| R J JandacekSummaryAffiliation: University of Cincinnati Country: USA Publications
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Detail Information
Publications
Review of the effects of dilution of dietary energy with olestra on energy intakeRonald J Jandacek
Department of Pathology and Laboratory Medicine, University of Cincinnati, 2120 E Galbraith Road, Cincinnati, OH 45237, USA
Physiol Behav 105:1124-31. 2012..The data from animals and humans strongly suggest that the rodent is not a satisfactory model for the human in the determination of the extent of compensation by substitution of olestra for dietary fat...- A high throughput live transparent animal bioassay to identify non-toxic small molecules or genes that regulate vertebrate fat metabolism for obesity drug developmentKevin S Jones
Department of Genome Science, University of Cincinnati, Cincinnati, OH, 4523, USA
Nutr Metab (Lond) 5:23. 2008.... - Lymphatic and portal vein absorption of organochlorine compounds in ratsRonald J Jandacek
Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, OH 45237, USA
Am J Physiol Gastrointest Liver Physiol 296:G226-34. 2009..Portal absorption was a function of the octanol/water partition coefficients for four organochlorine compounds: hexachlorobenzene, pentachlorophenol, DDT, and its metabolite 1,1,1-trichloro-2,2-bischlorophenylethylene... - Enterohepatic circulation of organochlorine compounds: a site for nutritional interventionRonald J Jandacek
Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, OH 45237, USA
J Nutr Biochem 18:163-7. 2007..Data from animals and humans show that the presence of nonabsorbed lipid in the intestine can increase the rate of excretion in a clinically significant manner... - The effect of olestra on the absorption, excretion and storage of 2,2',5,5' tetrachlorobiphenyl; 3,3',4,4' tetrachlorobiphenyl; and perfluorooctanoic acidR J Jandacek
Department of Pathology and Laboratory Medicine, University of Cincinnati, 2120 E Galbraith Road, Cincinnati, OH 45237, United States
Environ Int 36:880-3. 2010..It did not, however, alter tissue concentrations of perfluorooctanoic acid. These data are consistent with previously observed effects of olestra on the absorption and storage of lipophilic compounds... - APD-356 (Arena)Ronald J Jandacek
The University of Cincinnati, Department of Pathology, Cincinnati, OH 45237, USA
Curr Opin Investig Drugs 6:1051-6. 2005..A phase IIb trial was initiated in June 2005, and preliminary results were expected at the end of 2005... - Rapid clearance of hexachlorobenzene from chylomicronsRonald J Jandacek
The University of Cincinnati, Department of Pathology, Cincinnati, Ohio 45237, USA
Lipids 39:993-5. 2004..This unexpected result raises questions about the manner in which hexachlorobenzene is delivered to tissues. The tissue distribution of the hexachlorobenzene is consistent with its rapid uptake... - Effects of yo-yo diet, caloric restriction, and olestra on tissue distribution of hexachlorobenzeneRonald J Jandacek
Department of Pathology and Laboratory Medicine, University of Cincinnati School of Medicine, Cincinnati, OH 45237, USA
Am J Physiol Gastrointest Liver Physiol 288:G292-9. 2005..Distribution of 14C into the brain resulting from the restricted diet was reduced by 50% by dietary olestra... - A novel, noninvasive method for the measurement of intestinal fat absorptionRonald J Jandacek
University of Cincinnati, College of Medicine, Department of Pathology, Ohio 45267, USA
Gastroenterology 127:139-44. 2004..The goal of the study was to facilitate fat balance measurements with an appropriate intestinal marker for the transit of dietary fat and thereby eliminate the need for complete diet and fecal collections... - Factors affecting the storage and excretion of toxic lipophilic xenobioticsR J Jandacek
The University of Cincinnati, Department of Pathology, Ohio 45267, USA
Lipids 36:1289-305. 2001..Areas for further research include optimizing regimens for body burden reductions, understanding the nature of nonbiliary excretion, and following the effects of tissue redistribution during loss of body fat... - CD36 is important for chylomicron formation and secretion and may mediate cholesterol uptake in the proximal intestineAndromeda M Nauli
Department of Pathology and Laboratory Medicine, Genome Research Institute, University of Cincinnati College of Medicine, 2120 Galbraith Road, Cincinnati, OH 45237, USA
Gastroenterology 131:1197-207. 2006..Studies are aimed to determine the role of CD36 in intestinal lipid absorption... - Cholecystokinin knockout mice are resistant to high-fat diet-induced obesityChun Min Lo
Cincinnati Obesity Research Center, Genome Research Institute, University of Cincinnati, Cincinnati, Ohio 45237, USA
Gastroenterology 138:1997-2005. 2010..We proposed that mice with a disruption in the CCK gene (CCK knockout [CCK-KO] mice) that were fed a diet of 20% butter fat would have altered fat metabolism... - Reduced absorption of saturated fatty acids and resistance to diet-induced obesity and diabetes by ezetimibe-treated and Npc1l1-/- miceEric D Labonté
Dept of Pathology, Genome Research Institute, Univ of Cincinnati, 2120 E Galbraith Rd, Cincinnati, OH 45237, USA
Am J Physiol Gastrointest Liver Physiol 295:G776-83. 2008..These unexpected beneficial results may be clinically important, given the focus on NPC1L1 as a target for the treatment of hypercholesterolemia... - Bypassing the duodenum does not improve insulin resistance associated with diet-induced obesity in rodentsTammy L Kindel
Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, Ohio, USA
Obesity (Silver Spring) 19:380-7. 2011..These data suggest that duodenal bypass alone is an insufficient mechanism to alter insulin sensitivity independent of weight loss in obese, nondiabetic rodents... - Weight loss through ileal transposition is accompanied by increased ileal hormone secretion and synthesis in ratsApril D Strader
Genome Research Institute, Department of Psychiatry, University of Cincinnati, 2071 E Galbraith Rd, Reading, OH 45237, USA
Am J Physiol Endocrinol Metab 288:E447-53. 2005..These findings support the importance of evaluating the contribution of gastrointestinal hormones to the weight loss seen with bariatric surgery... - One-year comparison of a high-monounsaturated fat diet with a high-carbohydrate diet in type 2 diabetesBonnie J Brehm
College of Nursing, University of Cincinnati, Cincinnati, Ohio, USA
Diabetes Care 32:215-20. 2009..The purpose of this study was to compare the effects of high-monounsaturated fatty acid (MUFA) and high-carbohydrate (CHO) diets on body weight and glycemic control in men and women with type 2 diabetes... - Olestra formulation and the gastrointestinal tractR J Jandacek
Procter and Gamble Miami Valley Laboratories and Winton Hill Technical Center, Cincinnati, Ohio 45253 8707, USA
Lipids 34:771-83. 1999.... - Characterization of mice lacking the gene for cholecystokininChun Min Lo
Department of Pathology and Laboratory Medicine, University of Cincinnati, Genome Research Institute, 2120 E Galbraith Rd, Bldg A, ML 0507, Cincinnati, OH 45237, USA
Am J Physiol Regul Integr Comp Physiol 294:R803-10. 2008..We conclude that CCK is involved in metabolic rate and is important for memory and exploration. CCK is intimately involved in multiple processes related to cognitive function and food intake regulation... - Postprandial lysophospholipid suppresses hepatic fatty acid oxidation: the molecular link between group 1B phospholipase A2 and diet-induced obesityEric D Labonté
Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, 2120 E Galbraith Rd, Cincinnati, OH 45237, USA
FASEB J 24:2516-24. 2010.... - Carboxyl ester lipase deficiency exacerbates dietary lipid absorption abnormalities and resistance to diet-induced obesity in pancreatic triglyceride lipase knockout miceDean Gilham
Department of Pathology and Laboratory Medicine, Genome Research Institute, University of Cincinnati College of Medicine, Cincinnati, Ohio 45237, USA
J Biol Chem 282:24642-9. 2007..The reduced lipid absorption efficiency due to PTL and CEL inactivation also resulted in protection against diet-induced obesity... - Pharmaceutical approaches to the treatment of obesityRonald J Jandacek
Department of Pathology, University of Cincinnati School of Medicine, Cincinnati, OH 45267, USA
Drug Discov Today 9:874-80. 2004..The multiplicity of targets illustrates not only the many potential approaches to the treatment of obesity but also the complexity and redundancy of the processes that regulate energy storage in the body... - The regulation of alcohol intake by melanin-concentrating hormone in ratsElizabeth A Duncan
Department of Psychiatry, University of Cincinnati, USA
Pharmacol Biochem Behav 85:728-35. 2006..Further, endogenous MCH does not seem to regulate alcohol drinking, however because the antagonist failed to attenuate MCH-induced alcohol intake this conclusion is tentative... - GOAT links dietary lipids with the endocrine control of energy balanceHenriette Kirchner
Departments of Psychiatry and Medicine, Obesity Research Centre and Genome Research Institute, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
Nat Med 15:741-5. 2009..These data implicate the ghrelin-GOAT system as a signaling pathway that alerts the central nervous system to the presence of dietary calories, rather than to their absence as is commonly accepted... - Alcohol drinking in MCH receptor-1-deficient miceElizabeth A Duncan
Department of Psychiatry, University of Cincinnati, Cincinnati, Ohio, USA
Alcohol Clin Exp Res 31:1325-37. 2007..However, because the physiological relevance of this finding is unclear, we tested the hypothesis that endogenous MCH signaling enhances alcohol consumption... - Treatment with a dietary fat substitute decreased Arochlor 1254 contamination in an obese diabetic maleTrevor G Redgrave
Department of Physiology, School of Biomedical and Chemical Sciences, University of Western Australia, Nedlands, Western Australia 6009, Australia
J Nutr Biochem 16:383-4. 2005.... - Using nutrition for intervention and prevention against environmental chemical toxicity and associated diseasesBernhard Hennig
Molecular and Cell Nutrition Laboratory, College of Agriculture, University of Kentucky, 900 S Limestone, Lexington, KY 40536, USA
Environ Health Perspect 115:493-5. 2007..It is becoming increasingly clear that nutrition can modulate the toxicity of environmental pollutants...