Chaim Jacob

Summary

Affiliation: University of Southern California
Country: USA

Publications

  1. ncbi Lupus-associated causal mutation in neutrophil cytosolic factor 2 (NCF2) brings unique insights to the structure and function of NADPH oxidase
    Chaim O Jacob
    The Lupus Genetic Group, Department of Medicine, University of Southern California, Los Angeles, CA 90089, USA
    Proc Natl Acad Sci U S A 109:E59-67. 2012
  2. ncbi Function2Gene: a gene selection tool to increase the power of genetic association studies by utilizing public databases and expert knowledge
    Don L Armstrong
    Department of Cell Biology and Neuroscience, University of California, Riverside, CA 92521, USA
    BMC Bioinformatics 9:311. 2008
  3. ncbi Identification of novel susceptibility genes in childhood-onset systemic lupus erythematosus using a uniquely designed candidate gene pathway platform
    Chaim O Jacob
    Department of Medicine, University of Southern California School of Medicine, 2011 Zonal Avenue, Los Angeles, CA 90033, USA
    Arthritis Rheum 56:4164-73. 2007
  4. ncbi Identification of IRAK1 as a risk gene with critical role in the pathogenesis of systemic lupus erythematosus
    Chaim O Jacob
    The Lupus Genetic Group, Department of Medicine, University of Southern California, 2011 Zonal Avenue, Los Angeles, CA 90033, USA
    Proc Natl Acad Sci U S A 106:6256-61. 2009
  5. ncbi Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci
    John B Harley
    Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, Oklahoma 73104, USA
    Nat Genet 40:204-10. 2008
  6. ncbi Pivotal role of Stat4 and Stat6 in the pathogenesis of the lupus-like disease in the New Zealand mixed 2328 mice
    Chaim O Jacob
    Department of Medicine, University of Southern California School of Medicine, Los Angeles, CA 90089, USA
    J Immunol 171:1564-71. 2003
  7. ncbi A functional variant of SUMO4, a new I kappa B alpha modifier, is associated with type 1 diabetes
    Dehuang Guo
    Center for Biotechnology and Genomic Medicine, Medical College of Georgia, 1120 15th Street, CA4098, Augusta, Georgia 30912, USA
    Nat Genet 36:837-41. 2004
  8. ncbi Paucity of clinical disease despite serological autoimmunity and kidney pathology in lupus-prone New Zealand mixed 2328 mice deficient in BAFF
    Chaim O Jacob
    Department of Medicine, Division of Gastrointestinal and Liver Diseases, Keck School of Medicine, University of Southern California, 2011 Zonal Avenue, Los Angeles, CA 90033, USA
    J Immunol 177:2671-80. 2006

Research Grants

  1. Cytokine mechanisms in systemic lupus erythematosus
    Chaim Jacob; Fiscal Year: 2007
  2. A new direction in studing sex hormone involovement in *
    Chaim Jacob; Fiscal Year: 2003
  3. GENETICS OF CHILDHOOD ONSET SLE
    Chaim Jacob; Fiscal Year: 2003
  4. Elucidation of novel gene variants predisposing to childhood and adult-onset SLE
    Chaim O Jacob; Fiscal Year: 2010

Collaborators

Detail Information

Publications8

  1. ncbi Lupus-associated causal mutation in neutrophil cytosolic factor 2 (NCF2) brings unique insights to the structure and function of NADPH oxidase
    Chaim O Jacob
    The Lupus Genetic Group, Department of Medicine, University of Southern California, Los Angeles, CA 90089, USA
    Proc Natl Acad Sci U S A 109:E59-67. 2012
    ..Our study completes the chain of evidence from genetic association to specific molecular function...
  2. ncbi Function2Gene: a gene selection tool to increase the power of genetic association studies by utilizing public databases and expert knowledge
    Don L Armstrong
    Department of Cell Biology and Neuroscience, University of California, Riverside, CA 92521, USA
    BMC Bioinformatics 9:311. 2008
    ..SNPs have been used to identify genetic components which are associated with a disease. Unfortunately, many studies using these methods suffer from low reproducibility due to lack of power...
  3. ncbi Identification of novel susceptibility genes in childhood-onset systemic lupus erythematosus using a uniquely designed candidate gene pathway platform
    Chaim O Jacob
    Department of Medicine, University of Southern California School of Medicine, 2011 Zonal Avenue, Los Angeles, CA 90033, USA
    Arthritis Rheum 56:4164-73. 2007
    ....
  4. ncbi Identification of IRAK1 as a risk gene with critical role in the pathogenesis of systemic lupus erythematosus
    Chaim O Jacob
    The Lupus Genetic Group, Department of Medicine, University of Southern California, 2011 Zonal Avenue, Los Angeles, CA 90033, USA
    Proc Natl Acad Sci U S A 106:6256-61. 2009
    ..This demonstration of an X chromosome gene as a disease susceptibility factor in human SLE raises the possibility that the gender difference in SLE may in part be attributed to sex chromosome genes...
  5. ncbi Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci
    John B Harley
    Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, Oklahoma 73104, USA
    Nat Genet 40:204-10. 2008
    ..Our results show that numerous genes, some with known immune-related functions, predispose to SLE...
  6. ncbi Pivotal role of Stat4 and Stat6 in the pathogenesis of the lupus-like disease in the New Zealand mixed 2328 mice
    Chaim O Jacob
    Department of Medicine, University of Southern California School of Medicine, Los Angeles, CA 90089, USA
    J Immunol 171:1564-71. 2003
    ..Furthermore, these results also question the apparent equation of the effect of Stat deficiency with loss of secretion or response to particular cytokines...
  7. ncbi A functional variant of SUMO4, a new I kappa B alpha modifier, is associated with type 1 diabetes
    Dehuang Guo
    Center for Biotechnology and Genomic Medicine, Medical College of Georgia, 1120 15th Street, CA4098, Augusta, Georgia 30912, USA
    Nat Genet 36:837-41. 2004
    ..5 times greater NF kappa B transcriptional activity and approximately 2 times greater expression of IL12B, an NF kappa B-dependent gene. These findings suggest a new pathway that may be implicated in the pathogenesis of T1D...
  8. ncbi Paucity of clinical disease despite serological autoimmunity and kidney pathology in lupus-prone New Zealand mixed 2328 mice deficient in BAFF
    Chaim O Jacob
    Department of Medicine, Division of Gastrointestinal and Liver Diseases, Keck School of Medicine, University of Southern California, 2011 Zonal Avenue, Los Angeles, CA 90033, USA
    J Immunol 177:2671-80. 2006
    ..These observations may have profound ramifications for the use of BAFF antagonists in human SLE and related diseases...

Research Grants12

  1. Cytokine mechanisms in systemic lupus erythematosus
    Chaim Jacob; Fiscal Year: 2007
    ..These studies should lead to better understanding of a number of characteristics of SLE and may lead to identification of new targets for therapy. ..
  2. A new direction in studing sex hormone involovement in *
    Chaim Jacob; Fiscal Year: 2003
    ..Stanczyk) and biochemistry of steroid hormones (Dr. Roberts). The project proposed represents a clear and distinct departure from the PI's and the other investigators ongoing research. ..
  3. GENETICS OF CHILDHOOD ONSET SLE
    Chaim Jacob; Fiscal Year: 2003
    ..They further state that this is a multi-center application from some of the largest pediatric lupus clinics in the country and, therefore, represents a major and unique resource for the study of the genetics of childhood-onset SLE. ..
  4. Elucidation of novel gene variants predisposing to childhood and adult-onset SLE
    Chaim O Jacob; Fiscal Year: 2010
    ....