Research Topics
Species | ANDREI IVANOVICH IVANOVSummaryAffiliation: University of Rochester Country: USA Publications
Research Grants
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Publications
Cytoskeletal regulation of epithelial barrier function during inflammationAndrei I Ivanov
Gastroenterology and Hepatology Division, Department of Medicine, University of Rochester, Rochester, New York, USA
Am J Pathol 177:512-24. 2010..Finally, we highlight signaling pathways induced by inflammatory mediators that regulate reorganization of actin filaments and junctional disassembly in mucosal epithelia...- Tumor suppressor scribble regulates assembly of tight junctions in the intestinal epitheliumAndrei I Ivanov
Gastroenterology and Hepatology Division, Department of Medicine, University of Rochester, 601 Elmwood Avenue, Box 646, Rochester, NY 14642, USA
Am J Pathol 176:134-45. 2010..We conclude that Scribble is an important regulator of TJ functions and plasticity in the intestinal epithelium. Down-regulation of Scribble may mediate mucosal barrier breakdown during intestinal inflammation... - Protein kinase C activation disrupts epithelial apical junctions via ROCK-II dependent stimulation of actomyosin contractilityAndrei I Ivanov
Department of Medicine, University of Rochester, Rochester, NY 14642, USA
BMC Cell Biol 10:36. 2009..In the present study we investigate mechanisms by which PKC activation induces disassembly of tight junctions (TJs) and adherens junctions (AJs) in a model pancreatic epithelium... - Actin motors that drive formation and disassembly of epithelial apical junctionsAndrei I Ivanov
Division Gastroenterology and Hepatology, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
Front Biosci 13:6662-81. 2008..The review focuses on the roles of these actin motors in the establishment, maintenance and disassembly of epithelial TJ and AJ during tissue morphogenesis and in pathology... - Myosin II regulates the shape of three-dimensional intestinal epithelial cystsAndrei I Ivanov
Epithelial Pathobiology Research Unit, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30322, USA
J Cell Sci 121:1803-14. 2008..We conclude that myosin II regulates the spherical shape of epithelial cysts by controlling actin polymerization at the cyst surface... - Differential roles for actin polymerization and a myosin II motor in assembly of the epithelial apical junctional complexAndrei I Ivanov
Epithelial Pathobiology Research Unit, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30322, USA
Mol Biol Cell 16:2636-50. 2005.... - c-Jun N-terminal kinase mediates disassembly of apical junctions in model intestinal epitheliaNayden G Naydenov
Department of Medicine, University of Rochester, Rochester, NY 14642, USA
Cell Cycle 8:2110-21. 2009..Taken together, our findings suggest a novel role for JNK in the signaling pathway that links ROCK and F-actin remodeling during disassembly of epithelial junctions... - A unique role for nonmuscle myosin heavy chain IIA in regulation of epithelial apical junctionsAndrei I Ivanov
Epithelial Pathobiology Research Unit, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia, United States of America
PLoS ONE 2:e658. 2007..These findings provide the first direct non-pharmacological evidence of myosin II-dependent regulation of AJC dynamics in mammalian epithelia and highlight a unique role of NMMIIA in junctional biogenesis... - Role for actin filament turnover and a myosin II motor in cytoskeleton-driven disassembly of the epithelial apical junctional complexAndrei I Ivanov
Epithelial Pathobiology Research Unit, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia 30322, USA
Mol Biol Cell 15:2639-51. 2004..Mechanisms of such reorganization involve cofilin-1-dependent depolymerization and Arp2/3-assisted repolymerization of actin filaments as well as myosin IIA-mediated contraction... - Mechanism of IFN-gamma-induced endocytosis of tight junction proteins: myosin II-dependent vacuolarization of the apical plasma membraneMarkus Utech
Epithelial Pathobiology Research Unit, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30322, USA
Mol Biol Cell 16:5040-52. 2005..These results, for the first time, suggest that IFN-gamma induces endocytosis of epithelial TJ proteins via RhoA/ROCK-mediated, myosin II-dependent formation of VACs... - Endocytosis of epithelial apical junctional proteins by a clathrin-mediated pathway into a unique storage compartmentAndrei I Ivanov
Epithelial Pathobiology Research Unit, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia 30322, USA
Mol Biol Cell 15:176-88. 2004..Such mechanisms may mediate the disruption of intercellular contacts during normal tissue remodeling and in pathology... - Microtubules regulate disassembly of epithelial apical junctionsAndrei I Ivanov
Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia 30322, USA
BMC Cell Biol 7:12. 2006..In the present study, we investigated the role of microtubules in disassembly of the AJC in intestinal epithelial cells using a model of extracellular calcium depletion... - Annexin 2 regulates intestinal epithelial cell spreading and wound closure through Rho-related signalingBrian A Babbin
Epithelial Pathobiology Research Unit, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia 30322, USA
Am J Pathol 170:951-66. 2007..These findings suggest that annexin 2 plays a role in targeting Rho to cellular membranes, thereby modulating Rho-related signaling events regulating cytoskeletal reorganization during epithelial cell migration... - Rho/Rho-associated kinase-II signaling mediates disassembly of epithelial apical junctionsStanislav N Samarin
Epithelial Pathobiology Research Unit, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30322, USA
Mol Biol Cell 18:3429-39. 2007..Thus, our findings demonstrate a central role of the GEF-H1/Rho/ROCK-II signaling pathway in the disassembly of AJC in epithelial cells... - Flotillin-1 stabilizes caveolin-1 in intestinal epithelial cellsElena V Vassilieva
Epithelial Pathobiology Research Unit, Department of Pathology and Laboratory Medicine, Emory University, Whitehead Research Building, 615 Michael Street, Atlanta, Georgia 30322, USA
Biochem Biophys Res Commun 379:460-5. 2009..Our data suggest that flotillin-1 regulates caveolin-1 level by preventing its lysosomal degradation in intestinal epithelial cells... - Endocytosis of the apical junctional complex: mechanisms and possible roles in regulation of epithelial barriersAndrei I Ivanov
Epithelial Pathobiology Research Unit, Department of Pathology and Laboratory Medicine, Emory University, Room 115, 615 Michael Street, Atlanta, GA 30322, USA
Bioessays 27:356-65. 2005..Potential biological roles for AJC endocytosis in maintaining functional apical junctions, reversible opening of epithelial barrier and disruption of intercellular adhesion are also discussed... - The epithelium in inflammatory bowel disease: potential role of endocytosis of junctional proteins in barrier disruptionAndrei I Ivanov
Epithelial Pathobiology Research Unit, Department of Pathology and Laboratory Medicine, Whitehead Research Building, Emory University, 615 Michael Street, Atlanta, GA 30322, USA
Novartis Found Symp 263:115-24; discussion 124-32, 211-8. 2004..A better understanding of the mechanisms of junctional internalization and recycling will likely provide new insights into the mechanisms of altered barrier function in IBD... - Coronin 1C negatively regulates cell-matrix adhesion and motility of intestinal epithelial cellsStanislav N Samarin
Epithelial Pathobiology Research Unit, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30322, USA
Biochem Biophys Res Commun 391:394-400. 2010..Thus, our findings provide the first evidence that Coronin 1C negatively regulates epithelial cell migration via FAK-mediated inhibition of cell-matrix adhesion... - Lipid rafts mediate internalization of beta1-integrin in migrating intestinal epithelial cellsElena V Vassilieva
Dept of Pathology and Laboratory Medicine, Emory Univ, Atlanta, GA 30322, USA
Am J Physiol Gastrointest Liver Physiol 295:G965-76. 2008..Such endocytosis is likely to be important for disassembly of integrin-based cell-matrix adhesions and therefore in regulating IEC migration and wound closure... - Non-muscle myosin IIA differentially regulates intestinal epithelial cell restitution and matrix invasionBrian A Babbin
Epithelial Pathobiology Research Unit, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia, USA
Am J Pathol 174:436-48. 2009..These observations indicate multiple functions for NM IIA, which, along with the regulation of the F-actin cytoskeleton and cell-matrix adhesions, involve previously unrecognized control of intracellular signaling and protein expression... - Exocytosis and endocytosis. PrefaceAndrei I Ivanov
Department of Medicine, Gastroenterology and Hepatology Division, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
Methods Mol Biol 440:v-vi. 2008 - Interferon-gamma induces internalization of epithelial tight junction proteins via a macropinocytosis-like processMatthias Bruewer
Epithelial Pathobiology Research Unit, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia 30322, USA
FASEB J 19:923-33. 2005..These results for the first time suggest that IFN-gamma produces a leaky epithelial barrier by inducing macropinoytosis of TJ proteins... - Interferon-gamma inhibits T84 epithelial cell migration by redirecting transcytosis of beta1 integrin from the migrating leading edgeQiao Tong
Epithelial Pathology Research Unit, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30322, USA
J Immunol 175:4030-8. 2005.... - Pharmacological inhibition of endocytic pathways: is it specific enough to be useful?Andrei I Ivanov
Department of Medicine, Gastroenterology and Hepatology Division, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
Methods Mol Biol 440:15-33. 2008..The most and the least-selective inhibitors of each major endocytic pathway are highlighted... - Formyl peptide receptor-1 activation enhances intestinal epithelial cell restitution through phosphatidylinositol 3-kinase-dependent activation of Rac1 and Cdc42Brian A Babbin
Epithelial Pathobiology Research Unit, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30322, USA
J Immunol 179:8112-21. 2007..Taken together, theses results support a novel role for FPR stimulation in enhancing intestinal epithelial cell restitution through PI3K-dependent activation of Rac1 and Cdc42... - Putative dual role of ephrin-Eph receptor interactions in inflammationAndrei I Ivanov
Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia, USA
IUBMB Life 58:389-94. 2006..Taking into consideration the abundance of ephrins and Eph receptors in tissues and the robustness of their signaling effects, the proposed involvement is likely to be substantial and may constitute a novel therapeutic target... - Expression of Eph receptors and their ligands, ephrins, during lipopolysaccharide fever in ratsAndrei I Ivanov
Systemic Inflammation Laboratory, Trauma Research, St Joseph s Hospital, Phoenix, Arizona 85013, USA
Physiol Genomics 21:152-60. 2005.... - Expression of genes controlling transport and catabolism of prostaglandin E2 in lipopolysaccharide feverAndrei I Ivanov
Trauma Research and Neurology Research, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, Arizona 85013, USA
Am J Physiol Regul Integr Comp Physiol 284:R698-706. 2003..By increasing the blood-brain gradient of PGE(2), this mechanism likely facilitates penetration of PGE(2) into the brain and prevents its elimination from the brain...
Research Grants
- Actin dynamics and regulation of epithelial barrier in intestinal inflammationANDREI IVANOVICH IVANOV; Fiscal Year: 2010..This may result in decreased morbidity and mortality of a large cohort of patients with inflammatory disorders. ..
- Junctional exocytosis and breakdown of the intestinal barrier in inflammationANDREI IVANOVICH IVANOV; Fiscal Year: 2010..This may result in decreased morbidity and mortality of a large cohort of patients with inflammatory disorders. ..