Research Topics
| A IshiyamaSummaryAffiliation: University of California Country: USA Publications
Research Grants
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Detail Information
Publications
Subcellular immunolocalization of NMDA receptor subunit NR-1 in the chinchilla vestibular peripheryG Ishiyama
Department of Neurology, UCLA School of Medicine, USA
Brain Res 851:270-6. 1999..The NMDA receptors on the type I hair cell are located in areas of synaptic specialization, and may play a role in autoregulation. The localization of the NMDA receptor subunit in type I but not type II hair cells is intriguing...- Unbiased quantification of the microdissected human Scarpa's ganglion neuronsAkira Ishiyama
Division of Head and Neck Surgery, UCLA School of Medicine, Los Angeles, CA 90095, USA
Laryngoscope 114:1496-9. 2004..The objective of the present study was to obtain unbiased estimates of the total number of Scarpa's vestibular ganglion neurons in individuals with normal vestibular function... - Aquaporins and Meniere's diseaseGail Ishiyama
Department of Neurology, Division of Head and Neck Surgery, David Geffen School of Medicine at the University of California, Los Angeles 90095, USA
Curr Opin Otolaryngol Head Neck Surg 14:332-6. 2006..Review of the role of aquaporins in inner ear homeostasis and potential role in the pathogenesis of Meniere's disease... - Unbiased stereological estimation of the spiral ligament and stria vascularis volumes in aging and Ménière's disease using archival human temporal bonesGail Ishiyama
Neurology Department, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA
J Assoc Res Otolaryngol 8:8-17. 2007.... - Histopathology of the vestibular end organs after intratympanic gentamicin failure for Meniere's diseaseGail Ishiyama
Department of Neurology, University of California School of Medicine, Los Angeles, CA 90095, USA
Acta Otolaryngol 127:34-40. 2007..Objective: To describe the histopathology and morphometry of the vestibular end organs from a 59-year-old Meniere's patient who underwent transmastoid labyrinthectomy for recurrent vertigo after failed intratympanic gentamicin... - Histopathological and ultrastructural analysis of vestibular endorgans in Meniere's disease reveals basement membrane pathologyAndrew A McCall
Surgery Department, Division of Head and Neck David Geffen School of Medicine, at UCLA, Los Angeles, California, USA
BMC Ear Nose Throat Disord 9:4. 2009..Other findings included hair cell and supporting cell microvessicles, increased intercellular clear spaces in the stroma, and endothelial cell vacuolization and stromal perivascular BM thickening... - Immunohistochemical localization and mRNA expression of aquaporins in the macula utriculi of patients with Meniere's disease and acoustic neuromaGail Ishiyama
Neurology Department, Division of Head and Neck, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA
Cell Tissue Res 340:407-19. 2010..Changes in AQP4 (decreased) and AQP6 (increased) expression in Meniere's disease specimens suggest that the supporting cell might be a cellular target... - Otological manifestations of Churg-Strauss syndromeA Ishiyama
Division of Head and Neck Surgery, University of California at Los Angeles School of Medicine, Los Angeles, California 90095, USA
Laryngoscope 111:1619-24. 2001..To describe the clinical features, pathogenesis, and management of the otological complications in Churg-Strauss syndrome (CSS)... - Temporal bone histopathology in dominantly inherited audiovestibular syndromeA Ishiyama
Division of Head and Neck Surgery, UCLA School of Medicine, Los Angeles, CA 90095-1769, USA
Neurology 63:1859-62. 2004..Finding the causative gene could have important implications for understanding the pathophysiology of presbycusis and dysequilibrium of aging... - Application of unbiased stereology on archival human temporal boneYong Tang
Department of Neurology, University of California Los Angeles School of Medicine, 90095, USA
Laryngoscope 112:526-33. 2002..The unbiased stereological technique presented in the current report thus would be invaluable for future studies on such specimens, including the study of the changes of neurons during aging and various pathological conditions... - Age-related change in the number of neurons in the human vestibular ganglionJ J Park
Division of Head and Neck Surgery, UCLA School of Medicine, Los Angeles, California 90095, USA
J Comp Neurol 431:437-43. 2001..This study confirmed the existence of an age-related decline in the primary neurons of the human vestibular system, thus providing one anatomical basis for the increased incidence of imbalance seen with age... - Unbiased stereological quantification of neurons in the human spiral ganglionA Ishiyama
Division of Head and Neck Surgery, UCLA School of Medicine, Los Angeles, CA 90095, USA
Neurosci Lett 304:93-6. 2001..The result of the present study provides the first unbiased baseline value of the human spiral ganglion neurons... - Drop attacks in older patients secondary to an otologic causeG Ishiyama
Department of Neurology, UCLA School of Medicine, Los Angeles, CA, USA
Neurology 57:1103-6. 2001..The salient clinical features of these cases are discussed. The patients underwent ablative vestibular surgery, and all compensated well and were free of vertigo and falls up to 10 years postoperatively... - Temporal dynamics of semicircular canal and otolith function following acute unilateral vestibular deafferentation in humansJun Ru Tian
Department of Ophthalmology, University of California, Los Angeles, CA 90095 7002, USA
Exp Brain Res 178:529-41. 2007..Most recovery of the human canal gain to high acceleration transients following UVD is for contralesional head rotation, occurring within 3 months as spontaneous nystagmus resolves... - Gentamicin ototoxicity: clinical features and the effect on the human vestibulo-ocular reflexGail Ishiyama
Department of Neurology, UCLA School of Medicine, Los Angeles, CA 90095, USA
Acta Otolaryngol 126:1057-61. 2006..Sinusoidal rotational stimuli with high accelerations such as the bedside head-thrust test or rotational step changes in velocity are useful to diagnose bilateral vestibulopathy... - Three dimensional kinematics of rapid compensatory eye movements in humans with unilateral vestibular deafferentationJun Ru Tian
Department of Ophthalmology, University of California, Los Angeles, CA 90095 7002, USA
Exp Brain Res 182:143-55. 2007..ADs have kinematics that neither conform to LL nor match the VOR axis, but appear instead programmed in 3D to correct VOR axis errors... - Effect of unilateral vestibular deafferentation on the initial human vestibulo-ocular reflex to surge translationJun Ru Tian
Department of Ophthalmology, University of California, Los Angeles, California 90095 7002, USA
Exp Brain Res 176:575-87. 2007..Chronic human UVD, on average, significantly impairs the surge LVOR for horizontally eccentric targets placed ipsilesionally, but this asymmetry is small relative to interindividual variation... - Unbiased quantification of Scarpa's ganglion neurons in aminoglycoside ototoxicityGail Ishiyama
Department of Neurology, UCLA School of Medicine, Los Angeles, CA 90095, USA
J Vestib Res 15:197-202. 2005..109). These findings may be consistent with either retrograde degeneration or a direct neurotoxic effect of the aminoglycosides on the vestibular ganglion neuron... - Regional estimates of hair cells and supporting cells in the human crista ampullarisIvan Lopez
Surgery Department, Division of Head and Neck, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
J Neurosci Res 82:421-31. 2005..34+/-0.10, and HC density was 0.63 cells/100 microm2. A significant decline in type I, type II, and total HC number and density was found in groups 2 and 3, with individuals exceeding the average human life span... - Time course of auditory impairment in mice lacking the electroneutral sodium bicarbonate cotransporter NBC3 (slc4a7)Ivan A Lopez
Department of Surgery, Division of Head and Neck, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
Brain Res Dev Brain Res 160:63-77. 2005..The vestibular sensory epithelia from slc4a7-/- mice were normal from P2 to P90. Damage of the sensory epithelia at the high frequency zone of the cochlea suggests that NBC3 may play an important physiological role in this region... - Spiral and vestibular ganglion estimates in archival temporal bones obtained by design based stereology and Abercrombie methodsGail Ishiyama
Department of Neurology, UCLA School of Medicine, Los Angeles, CA 90095, USA
J Neurosci Methods 196:76-80. 2011.... - Subcellular immunolocalization of NMDA receptor subunit NR1, 2A, 2B in the rat vestibular peripheryGail Ishiyama
Department of Neurology, UCLA School of Medicine, Los Angeles, CA 90095, USA
Brain Res 935:16-23. 2002..The receptor subtype(s) may be a combination of NR1/NR2A, NR1/NR2B, and/or NR1/NR2A/NR2B... - Canavan's leukodystrophy is associated with defects in cochlear neurodevelopment and deafnessGail Ishiyama
Department of Neurology, UCLA School of Medicine, Los Angeles, CA 90095, USA
Neurology 60:1702-4. 2003..The vestibular end organs and ganglia were normal. These findings implicate a role of aminoacylase II in the neurodevelopment of the organ of Corti... - Immunolocalization of voltage-gated calcium channel alpha1 subunits in the chinchilla cochleaIvan Lopez
Department of Surgery, Division of Head and Neck, 31 25 Rehabilitation Center, UCLA School of Medicine, 1000 Veteran Avenue, Los Angeles, CA 90095, USA
Cell Tissue Res 313:177-86. 2003..The presence of alpha1A, the pore-forming subunit of the P/Q type channels, has not previously been demonstrated in inner and outer hair cells, and its function in the cochlear hair cell is unknown... - Initiation and cancellation of the human heave linear vestibulo-ocular reflex after unilateral vestibular deafferentationBenjamin T Crane
Department of Surgery (Division of Otolaryngology, University of California, Los Angeles, CA, USA
Exp Brain Res 161:519-26. 2005..It is concluded that after UVD, the LVOR is bilaterally and symmetrically reduced but remains modulated by viewing distance and cancellation effort... - Dejerine-Sottas syndrome and vestibular loss due to a point mutation in the PMP22 geneJoanna Jen
Department of Neurology, School of Medicine, University of California, Los Angeles, CA 90095-1769, United States
J Neurol Sci 237:21-4. 2005..It is important to recognize this combination of peripheral nerve and vestibular deficits since rehabilitation strategies and prognosis are different... - Unbiased stereologic type I and type II hair cell counts in human utricular maculaQuinton Gopen
Division of Head and Neck Surgery, Medical Center, University of California-Los Angeles School of Medicine, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA
Laryngoscope 113:1132-8. 2003..The current data represent the first total type I and type II hair cell counts in human utricular neuroepithelium... - Blindness and auditory impairment caused by loss of the sodium bicarbonate cotransporter NBC3Dean Bok
Department of Neurobiology, Jules Stein Eye Institute, Los Angeles, California, 90095, USA
Nat Genet 34:313-9. 2003..Our results indicate that in certain sensory organs, in which the requirement to transduce specific environmental signals with speed, sensitivity and reliability is paramount, the choice of the H+ disposal mechanism used is limited... - Estimation of the number of nerve fibers in the human vestibular endorgans using unbiased stereology and immunohistochemistryIvan Lopez
Division of Head and Neck Surgery, CHS 62-132, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
J Neurosci Methods 145:37-46. 2005..These methods can be applied for studies of normal aging and pathological conditions of the vestibular periphery... - Endolymphatic hydrops in otologic syphilis: a temporal bone studyMia E Miller
University of California Los Angeles, Division of Head and Neck Surgery, Los Angeles, California 90095, USA
Otol Neurotol 31:681-6. 2010..Endolymphatic hydrops in temporal bones with otologic syphilis directly relates to osteitis, new bone formation, and/or resorption along the course of the endolymphatic system... - Drop attacks and vertigo secondary to a non-meniere otologic causeGail Ishiyama
Department of Neurology, University of California, Los Angeles, UCLA School of Medicine, Los Angeles, CA 90095, USA
Arch Neurol 60:71-5. 2003..The clinical description of the falls is similar to those associated with Meniere syndrome. Further studies are needed to understand the etiology of Tumarkin falls in these patients with normal hearing... - Immunohistochemical distribution of basement membrane proteins in the human inner ear from older subjectsAkira Ishiyama
Department of Surgery, Division of Head and Neck, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095 1769, USA
Hear Res 254:1-14. 2009..This information is critical to begin to unravel the role that BMs may play in human inner ear physiology and audiovestibular pathologies... - Immunolocalization of orphanin FQ in rat cochleaSoochuen T Kho
Surgery Department, Division of Head and Neck Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
Brain Res 1113:146-52. 2006..The findings are consistent with OFQ/N expression in lateral and medial olivocochlear efferents... - Immunohistochemical localization of aquaporins in the human inner earIvan A Lopez
Division of Head and Neck Surgery CHS 62 132, UCLA School of Medicine, Los Angeles, CA 90095, USA
Cell Tissue Res 328:453-60. 2007..The high degree of conservation of AQP expression in the human inner ear suggests that AQPs play a critical role in inner ear water homeostasis... - Drop attacks secondary to superior canal dehiscence syndromeKrister Brantberg
Department of Audiology, Karolinska University Hospital, Stockholm, Sweden
Neurology 64:2126-8. 2005..Neither had sound- or pressure-induced nystagmus. Repair of the dehiscence in one case stopped the drop attacks, supporting a causal relationship between the dehiscence and the drop attacks... - Unilateral deafferentation and eye position misdirect the initial vestibulo-ocular reflex: a model-based studyBenjamin T Crane
Department of Surgery Division of Otolaryngology Head and Neck Surgery, University of California, Los Angeles 90095 7002, USA
Invest Ophthalmol Vis Sci 48:5512-22. 2007..Orbital eye position and vestibular sensitivity have both been postulated to influence vestibulo-ocular reflex (VOR) axis direction. The interaction of these factors in unilateral vestibular deafferentation (UVD) was examined... - Human temporal bone consortium for research resource enhancementSaumil N Merchant
Otol Neurotol 29:271-4. 2008 - Calcitonin gene-related Peptide and choline acetyltransferase colocalization in the human vestibular peripheryPaul Popper
Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee, WI 53226, USA
Audiol Neurootol 7:298-302. 2002..As in the animal models, no CGRPi was found within Scarpa's ganglion. This study provides evidence for CGRPi in the human vestibular periphery and validates the biomedical relevance of the current animal models...
Research Grants
- Vestibular Pathology in Meniere's DiseaseAkira Ishiyama; Fiscal Year: 2007..or with alterations in neuronal number or size? 6) What are the morphometric correlates to abnormalities on traditional vestibular testing: caloric paresis, and decreased gain and time constant on step rotational testing? ..
- Modern Studies of the Human Temporal BoneAkira Ishiyama; Fiscal Year: 2007..We will collaborate with Dr. Kumar Alagramam in the development of RNA extraction using laser capture microdissection, and with Dr. Allen Ryan in the application of in situ hybridization on formalin-fixed paraffin-embedded sections. ..