Research Topics
| Raymond IdekerSummaryAffiliation: University of Alabama at Birmingham Country: USA Publications
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Detail Information
Publications
Reentry site during fibrillation induction in relation to defibrillation efficacy for different shock waveformsR E Ideker
Department of Medicine, University of Alabama at Birmingham, 35294 0019, USA
J Cardiovasc Electrophysiol 12:581-91. 2001..Unsuccessful defibrillation shocks may reinitiate fibrillation by causing postshock reentry...- Can the direct cardiac effects of the electric pulses generated by the TASER X26 cause immediate or delayed sudden cardiac arrest in normal adults?Raymond E Ideker
Department of Medicine, Division of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, Alabama 35294 0019, USA
Am J Forensic Med Pathol 28:195-201. 2007..Therefore, it is highly unlikely that the TASER X26 can cause ventricular fibrillation minutes to hours after its use through direct cardiac effects of the electric field generated by the TASER... - Ventricular fibrillation: how do we put the genie back in the bottle?Raymond E Ideker
Division of Cardiovascular Disease, Department of Medicine, University of Alabama, Birmingham, Alabama 35294 0019, USA
Heart Rhythm 4:665-74. 2007..I would be remiss if I did not thank the numerous colleagues, fellows, and students who performed most of the work leading to the papers of which I am a coauthor... - Our search for the porcine mother rotorRaymond E Ideker
Department of Medicine, Division of Cardiovascular Disease, University of Alabama Birmingham, Birmingham, Alabama 35294 0019, USA
Ann Noninvasive Electrocardiol 10:7-15. 2005..Indeed, a recent abstract by others reports that, after propranolol, a stable reentrant circuit is present on the endocardium at the insertion of the posterior papillary muscle into the LV free wall in pigs... - Ventricular fibrillation and defibrillation--what are the major unresolved issues?Raymond E Ideker
Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294-0019, USA
Heart Rhythm 2:555-8. 2005 - Measuring surface potential components necessary for transmembrane current computation using microfabricated arraysJ James Wiley
Cardiac Rhythm Management Laboratory, Univ. of Alabama at Birmingham, Volker Hall B140, 1670 Univ. Blvd, Birmingham, AL 35294, USA
Am J Physiol Heart Circ Physiol 289:H2468-77. 2005.... - Activation becomes highly organized during long-duration ventricular fibrillation in canine heartsLi Li
Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA
Am J Physiol Heart Circ Physiol 298:H2046-53. 2010..PFs appear to play an important role during this stage of VF... - Transmural and endocardial Purkinje activation in pigs before local myocardial activation after defibrillation shocksDerek J Dosdall
Department of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, Alabama, USA
Heart Rhythm 4:758-65. 2007..Earliest recorded postshock myocardial activations in pigs originate in the subepicardium of the apex and lateral free wall of the left ventricle (LV) 30-90 ms after the shock... - Impact of myocardial ischemia and reperfusion on ventricular defibrillation patterns, energy requirements, and detection of recoveryHao Qin
Department of Physiology and Biophysics, Medicine, University of Alabama at Birmingham, 35294-0019, USA
Circulation 105:2537-42. 2002..6+/-5.3 seconds. CONCLUSIONS: Spontaneous VF can be halted by a shock but then quickly restart before a standard ECG amplifier has recovered from postshock saturation, making it appear that the shock failed... - Estimated global transmural distribution of activation rate and conduction block during porcine and canine ventricular fibrillationJonathan C Newton
Department of Physiology and Biophysics, University of Alabama at Birmingham, Birmingham, Ala 35294, USA
Circ Res 94:836-42. 2004..Constancy of this pattern in pigs but its reversal by 2 minutes in dogs is consistent with the hypothesis that activation during later VF is driven by Purkinje fibers... - Identification of transmural necrosis along a linear catheter ablation lesion during atrial fibrillation and sinus rhythmJavier E Sanchez
Department of Internal Medicine, Division of Cardiovascular Diseases, Cardiac Rhythm Management Laboratory, University of Alabama at Birmingham, Birmingham, AL 35294, USA
J Interv Card Electrophysiol 8:9-17. 2003..Termination of atrial fibrillation may not be necessary to estimate the histologic characteristics of an ablation lesion... - New technologies of internal defibrillationDerek J Dosdall
Department of Biomedical Engineering, University of Alabama at Birmingham, 35294-0019, USA
J Interv Card Electrophysiol 13:67-70. 2005..Atrial defibrillation with ICDs is an area of considerable interest, but is not likely to gain widespread application unless acceptable methods of lowering pain associated with defibrillation shocks are implemented... - Development of an optrode for intramural multisite optical recordings of Vm in the heartJonathan L Byars
Department of Biomedical Engineering, University of Alabama at Birmingham, 1670 University Boulevard, Birmingham, AL 35294, USA
J Cardiovasc Electrophysiol 14:1196-202. 2003..This technique might become useful in studies of transmural impulse conduction during arrhythmias and defibrillation... - Chemical ablation of the Purkinje system causes early termination and activation rate slowing of long-duration ventricular fibrillation in dogsDerek J Dosdall
Volker Hall B140, 1670 Univ Blvd, Birmingham, AL 35294 0019, USA
Am J Physiol Heart Circ Physiol 295:H883-9. 2008..Ablation of the subendocardium hastens VF spontaneous termination and alters VF activation sequences, suggesting that Purkinje fibers are important in the maintenance of LDVF... - Evidence that activation following failed defibrillation is not caused by triggered activityXiangsheng Zheng
Division of Cardiovascular Diseases, Department of Medicine, University of Alabama at Birmingham, Alabama, USA
J Cardiovasc Electrophysiol 16:1200-5. 2005.... - Increased cycle length during long-duration ventricular fibrillation is caused by decreased upstroke velocity as well as prolonged refractorinessPeter G Robertson
Department of Medicine, Division of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, Alabama 35294 0007, USA
Heart Rhythm 6:378-84. 2009..Cycle length (CL) increases as ventricular fibrillation (VF) progresses... - High-resolution optical mapping of intramural virtual electrodes in porcine left ventricular wallOleg F Sharifov
Department of Biomedical Engineering, University of Alabama at Birmingham, 1670 University Boulevard, VH B126, Birmingham, AL 35294, USA
Cardiovasc Res 64:448-56. 2004..The occurrence of positive and negative polarizations during plateau and diastolic shocks at high but not low resolution provides evidence for microscopic nature of IVE in LV wall... - Intracardiac atrial defibrillationDerek J Dosdall
Department of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, Alabama 35294 0019, USA
Heart Rhythm 4:S51-6. 2007..Such electrode configurations would make the ICD more complicated, leading to greater difficulty and longer time required for implantation... - Guidelines for plunge needle recording for effective detection of purkinje activationDerek J Dosdall
Dept. of Biomed. Eng, Alabama Univ, Birmingham, AL 35294, USA
Conf Proc IEEE Eng Med Biol Soc 1:3915-8. 2006..Three guidelines were developed for effective Purkinje fiber recording: 1) use a minimum sampling rate of 4 KHz., 2) record near the endocardium, and 3) use bipolar rather than unipolar recording electrodes... - Regional differences in ventricular fibrillation in the open-chest porcine left ventricleKumaraswamy Nanthakumar
University of Alabama at Birmingham, Birmingham, Ala 35294-0019, USA
Circ Res 91:733-40. 2002..Although these differences are not totally consistent with the presence of a dominant domain within the LV free wall, the mean conduction velocity vector is consistent with one in the septum... - Intramural foci during long duration fibrillation in the pig ventricleLi Li
Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294 0019, USA
Circ Res 102:1256-64. 2008..Intramural foci may play an important role in later VF maintenance. It remains to be determined if these foci arise from Purkinje fibers attributable to abnormal automaticity, afterdepolarizations, or reentry... - Optical measurements of intramural action potentials in isolated porcine hearts using optrodesWei Kong
Department of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
Heart Rhythm 4:1430-6. 2007..Measurements of intramural membrane potential (Vm) would greatly increase knowledge of cardiac arrhythmias and defibrillation. Optrodes offer the possibility for three-dimensional Vm mapping, but their signal quality has been inadequate... - Epicardial mapping of ventricular fibrillation over the posterior descending artery and left posterior papillary muscle of the swine heartThomas D Nielsen
Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA
J Interv Card Electrophysiol 24:11-7. 2009..quot; The goal of this study was to obtain evidence to support or refute these possibilities... - Effect of shock-induced changes in transmembrane potential on reentrant waves and outcome during cardioversion of isolated rabbit heartsFrederick G Evans
Department of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, Alabama 35294-0019, USA
J Cardiovasc Electrophysiol 13:1118-27. 2002..CONCLUSION: These findings provide a direct mechanistic link between shock-induced changes in Vm and the effect of polarity, strength, and timing on cardioversion efficacy... - Regional variation in capture of fibrillating swine left ventricle during electrical stimulationKumaraswamy Nanthakumar
Department of Medicine, Division of Cardiovascular Diseases, University of Alabama- Birmingham, Birmingham, Alabama 35294, USA
J Cardiovasc Electrophysiol 16:425-32. 2005..A significant component of the variability in capture is related to the mean direction of VF wavefronts... - Activation patterns of Purkinje fibers during long-duration ventricular fibrillation in an isolated canine heart modelPaul B Tabereaux
Department of Medicine, Division of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, AL, USA
Circulation 116:1113-9. 2007..If wave fronts ever arise focally during VF, it should be possible to map them appearing de novo... - The transmural activation sequence in porcine and canine left ventricle is markedly different during long-duration ventricular fibrillationJ Scott Allison
Division of Cardiovascular Disease, Department of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama, USA
J Cardiovasc Electrophysiol 18:1306-12. 2007..We tested the hypothesis that the transmural activation sequence is similar in sinus rhythm (SR) and LDVF in dogs as well as pigs, but different between species... - Activation sequences following failed atrial defibrillationXiangsheng Zheng
Division of Cardiovascular Diseases, Department of Medicine, University of Alabama at Birmingham, 35294, USA
Heart Rhythm 1:616-23. 2004..4) The region of earliest postshock activation in the failed episodes without a focal postshock activation pattern exhibited regions of fragmented electrogram derivatives that may represent conduction block and possibly reentry... - Transmural recording of monophasic action potentialsXiaohong Zhou
Division of Cardiovascular Disease, Department of Medicine, University of Alabama, Birmingham, Alabama 35294-0019, USA
Am J Physiol Heart Circ Physiol 282:H855-61. 2002..It is possible to record transmural repolarization of the ventricles with KCl MAP electrodes on plunge needles. The MAP is caused by the KCl rather than being a nonspecific injury potential... - Burst stimulation improves hemodynamics during resuscitation after prolonged ventricular fibrillationGregory Walcott
University of Alabama at Birmingham, Birmingham, AL, USA
Circ Arrhythm Electrophysiol 2:57-62. 2009..We hypothesized that a similar series of electrical pulses could increase myocardial function and blood pressure during the early post-resuscitation period... - Right-sided vagus nerve stimulation inhibits induced spinal cord seizuresR Shane Tubbs
Department of Cell Biology, University of Alabama at Birmingham, Alabama 35233, USA
Clin Anat 20:23-6. 2007.... - Comparison of low-energy versus high-energy biphasic defibrillation shocks following prolonged ventricular fibrillationGregory P Walcott
Department of Medicine Division of Cardiovascular Diseases, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
Prehosp Emerg Care 14:62-70. 2010..This concern has been raised again with the development of the biphasic defibrillator... - Vagus nerve stimulation for induced spinal cord seizures: insights into seizure cessationR Shane Tubbs
Department of Cell Biology, Division of Pediatric Neurosurgery, University of Alabama at Birmingham, Alabama 35233, USA
J Neurosurg 102:213-7. 2005..To potentially elucidate a pathway in which vagus nerve stimulation aborts seizure activity, seizures were initiated not in the cerebral cortex but in the spinal cord and then vagus nerve stimulation was performed... - Decrease in fluoroscopic cardiac silhouette excursion precedes hemodynamic compromise in intraprocedural tamponadeKumaraswamy Nanthakumar
Division of Cardiovascular Disease, The University of Alabama at Birmingham, Birmingham, AL, USA
Heart Rhythm 2:1224-30. 2005..Survival depends on early recognition and treatment. A diagnostic test to detect pericardial fluid accumulation before a significant fall in blood pressure and without contamination of the sterile field would be valuable... - Chronic myocardial infarction is a substrate for bradycardia-induced spontaneous tachyarrhythmias and sudden death in conscious animalsCheryl R Killingsworth
Cardiac Rhythm Management Laboratory, Division of Cardiovascular Diseases, Department of Medicine, University of Alabama at Birmingham, 35294 0019, USA
J Cardiovasc Electrophysiol 17:189-97. 2006..We tested the hypothesis that MI and bradycardia cause more spontaneous sustained VT than does bradycardia alone... - Mechanisms of VF maintenance: wandering wavelets, mother rotors, or fociPaul B Tabereaux
Department of Medicine, Division of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, Alabama 35294 0019, USA
Heart Rhythm 6:405-15. 2009..Recent studies during the first 10 min of VF suggest that Purkinje fibers are important in maintaining VF after the first 1 to 2 min, either as a part of a reentrant circuit or as a source of focal activations... - In a swine model, chest compressions cause ventricular capture and, by means of a long-short sequence, ventricular fibrillationJose Osorio
Department of Medicine, Division of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, AL 35291 0007, USA
Circ Arrhythm Electrophysiol 1:282-9. 2008..During resuscitation, fibrillation often recurs. In swine, we studied refibrillation after long-duration ventricular fibrillation, investigating an association with chest compressions (CCs)... - Role of maximum rate of depolarization in predicting action potential duration during ventricular fibrillationJian Huang
Cardiac Rhythm Management Laboratory, Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294 0019, USA
Am J Physiol Heart Circ Physiol 293:H2530-6. 2007..During the first 20 s of VF in swine, V(max) is a more important determinant of APD than the previous DI (restitution) or the previous APD (memory). All variables together account for only one-half of APD variation during VF... - Effect of timing and duration of a single chest compression pause on short-term survival following prolonged ventricular fibrillationGregory P Walcott
University of Alabama, B140 Volker Hall, 1670 University Blvd, Birmingham, AL 35294, United States
Resuscitation 80:458-62. 2009..Previous animal studies have shown that multiple pauses of increasing duration decrease resuscitation success. We investigated the effect of varying the characteristics of a single pause near defibrillation on resuscitation outcome... - Printed circuit board electrodes for transmural cardiac mappingDerek J Dosdall
Dept of Biomed Eng, Alabama Univ, Birmingham, AL 35294, USA
Conf Proc IEEE Eng Med Biol Soc 1:3927-30. 2006..Tested PCB plunge needles recorded signals comparable to signals recorded by other plunge needles. PCB plunge needles provide an economical and rapid alternative to previously published techniques for plunge needle design... - Evaluation of a novel ventricular support device with defibrillation capabilities in canine and porcine animal modelsCheryl R Killingsworth
Cardiac Rhythm Management Laboratory, Division of Cardiovascular Diseases, Department of Medicine, University of Alabama at Birmingham, AL 35294 0019, USA
J Cardiovasc Electrophysiol 19:851-7. 2008..Sudden death is prevalent in heart failure patients. We tested an implantable ventricular support device consisting of a wireform harness with one or two pairs of integrated defibrillation electrode coils... - Transmural recording of shock potential gradient fields, early postshock activations, and refibrillation episodes associated with external defibrillation of long-duration ventricular fibrillation in swineJames D Allred
Department of Medicine, Division of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, Alabama, USA
Heart Rhythm 5:1599-606. 2008..Knowledge of the shock potential gradient (nablaV) and postshock activation is limited to internal defibrillation of short-duration ventricular fibrillation (SDVF)... - Mechanisms of defibrillationDerek J Dosdall
Departments of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
Annu Rev Biomed Eng 12:233-58. 2010..On the whole-heart level, shock field gradient and critical points determine whether a shock is successful or whether reentry causes initiation and continuation of fibrillation... - Design and initial evaluation of an implantable sonomicrometer and CW Doppler flowmeter for simultaneous recordings with a multichannel telemetry systemWei Kong
Biomedical Engineering Department, University of Alabama at Birmingham, Birmingham, AL 35294, USA
IEEE Trans Biomed Eng 52:1365-7. 2005..The ability to measure heart dimension and blood velocity will add significantly to our understanding of the sequence of events leading up to spontaneous sudden cardiac death... - Effects of heart isolation, voltage-sensitive dye, and electromechanical uncoupling agents on ventricular fibrillationHao Qin
Department of Physiology and Biophysics, University of Alabama, 1670 University Boulevard, Birmingham, AL 35294, USA
Am J Physiol Heart Circ Physiol 284:H1818-26. 2003..Most changes were broadly consistent with slowing and regularization due to loss of excitability. Heart isolation had the largest effect on VF patterns, followed by CytoD, DAM, and dye... - Three-dimensional mapping of earliest activation after near-threshold ventricular defibrillation shocksNipon Chattipakorn
Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294 0019, USA
J Cardiovasc Electrophysiol 14:65-9. 2003..To answer these questions, 3D electrical mapping was performed... - Sustained reentry in the left ventricle of fibrillating pig heartsJack M Rogers
Departments of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, Ala, USA
Circ Res 92:539-45. 2003..However, we found no evidence that these rotors were responsible for sustaining VF through the mechanisms outlined in the mother rotor hypothesis... - Defibrillation with a minimally invasive direct cardiac massage deviceGregory P Walcott
University of Alabama at Birmingham, 1530 3rd Ave So, Volker Hall B140, 35294 0019, USA
Resuscitation 55:301-7. 2002.... - Estimated global epicardial distribution of activation rate and conduction block during porcine ventricular fibrillationJonathan C Newton
Department of Physiology and Biophysics, University of Alabama at Birmingham, 35294, USA
J Cardiovasc Electrophysiol 13:1035-41. 2002.... - Defibrillation threshold and cardiac responses using an external biphasic defibrillator with pediatric and adult adhesive patches in pediatric-sized pigletsCheryl R Killingsworth
Cardiac Rhythm Management Laboratory, Department of Medicine, Division of Cardiovascular Diseases, University of Alabama at Birmingham, 1670 University Boulevard, B140 Volker Hall, Birmingham, AL 35294, USA
Resuscitation 55:177-85. 2002..These data suggest that there is a substantial safety margin above a DFT strength shock for this biphasic waveform in piglets... - Intramural virtual electrodes during defibrillation shocks in left ventricular wall assessed by optical mapping of membrane potentialVladimir G Fast
Department of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, Ala 35294, USA
Circulation 106:1007-14. 2002..Here, intramural shock-induced DeltaV(m) were measured for the first time in isolated preparations of left ventricle (LV) by an optical mapping technique... - The effects of acute and chronic amiodarone on activation patterns and defibrillation threshold during ventricular fibrillation in dogsJian Huang
Cardiac Rhythm Management Laboratory, Department of Medicine, University of Alabama at Birmingham, 1670 University Boulevard, Birmingham, AL 35294 0019, USA
J Am Coll Cardiol 40:375-83. 2002..The goal of this study was to evaluate the effects of acute and chronic amiodarone on activation patterns during ventricular fibrillation (VF), ventricular effective refractory period (VERP) and defibrillation threshold (DFT)... - Intelligent multichannel stimulator for the study of cardiac arrhythmiasPhilip L Johnson
Department of Biomedical Engineering, University of Alabama at Birmingham, 35294 0019, USA
Ann Biomed Eng 30:180-91. 2002..It was shown to be an effective research tool by demonstrating the ability to measure and respond to cardiac activations in real time using complex numerical algorithms and appropriately timed stimuli... - Effect of electrode location in great cardiac vein on the ventricular defibrillation thresholdJian Huang
Departments of Medicine, Biomedical Engineering and Physiology, University of Alabama at Birmingham, Birmingham, Alabama, USA
Pacing Clin Electrophysiol 25:42-8. 2002..001). Application of an auxiliary shock to the apical region, near the region where previous studies have indicated that the RV primary shock has its weakest effects, caused the greatest decrease in DFT... - Biphasic waveform external defibrillation thresholds for spontaneous ventricular fibrillation secondary to acute ischemiaGregory P Walcott
Cardiac Rhythm Management Laboratory, Division of Cardiovascular Diseases, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294 0019, USA
J Am Coll Cardiol 39:359-65. 2002.... - Effects of burst stimulation during ventricular fibrillation on cardiac function after defibrillationGregory P Walcott
Division of Cardiovascular Diseases, Department of Medicine, University of Alabama, 1670 University Blvd, Birmingham, AL 35294, USA
Am J Physiol Heart Circ Physiol 285:H766-74. 2003..beta-Blockade or reserpine pretreatment prevents most of this postshock increase in HR, arterial pressure, and LV pressure... - Endocardial wave front organization during ventricular fibrillation in humansGregory P Walcott
Division of Cardiovascular Diseases, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
J Am Coll Cardiol 39:109-15. 2002..This study was designed to characterize the organization of ventricular fibrillation (VF) on the endocardium of humans... - Discrimination of left atrial and pulmonary vein potentials in patients with paroxysmal atrial fibrillationNirav Patel
Department of Biomedical Engineering, University of Alabama at Birmingham, 1670 University Boulevard, Birmingham, AL 35294, USA
J Cardiovasc Electrophysiol 14:698-704. 2003..These additional parameters need to be included by physicians determining the preferential ablation site within PVs... - Quantification of activation patterns during ventricular fibrillation in open-chest porcine left ventricle and septumJian Huang
Department of Medicine, Cardiac Rhythm Management Laboratory, University of Alabama at Birmingham, Alabama 35294 0019, USA
Heart Rhythm 2:720-8. 2005..Previous studies have pointed to the ventricular septum as a possible location for a mother rotor in the pig heart... - Epicardial organization of human ventricular fibrillationKumaraswamy Nanthakumar
Division of Cardiovascular Medicine, University of Alabama at Birmingham, 35294, USA
Heart Rhythm 1:14-23. 2004..The objective of this study was to test the hypothesis that on the epicardium of the in vivo human heart, ventricular fibrillation (VF) consists of chaotic small wavefronts that constantly change paths... - Restitution properties during ventricular fibrillation in the in situ swine heartJian Huang
Cardiac Rhythm Management Laboratory, Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Volker Hall B140, 1530 3rd Ave S, Birmingham, AL 35294 0019, USA
Circulation 110:3161-7. 2004..Although restitution has been hypothesized to determine action potential duration (APD) during ventricular fibrillation (VF), cardiac memory may also be important... - Effects of electrical shocks on Cai2+ and Vm in myocyte culturesVladimir G Fast
Department of Biomedical Engineering, University of Alabama at Birmingham, 1670 University Blvd, VH B149, Birmingham, AL 35294, USA
Circ Res 94:1589-97. 2004..Outward flow of I(CaL) plays an important role in Ca(i)2+ decrease in the DeltaV+m areas. Very strong shocks caused smaller negative DeltaCa(i)2+ and postshock elevation of diastolic Ca(i)2+, likely caused by membrane electroporation... - Effects of shock strengths on ventricular defibrillation failureNipon Chattipakorn
Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294 0019, USA
Cardiovasc Res 61:39-44. 2004..We tested the hypothesis that both patterns can occur, but at different shock strengths... - Evolution of activation patterns during long-duration ventricular fibrillation in dogsJian Huang
Cardiac Rhythm Management Laboratory, Volker Hall B140, 1670 University Blvd, Birmingham, AL 35294 0019, USA
Am J Physiol Heart Circ Physiol 286:H1193-200. 2004..Further studies are warranted to determine whether these changes, particularly the increased organization of stage iii, have clinical consequences, such as an alteration in defibrillation efficacy... - Purkinje activation precedes myocardial activation following defibrillation after long-duration ventricular fibrillationDerek J Dosdall
Department of Medicine, Division of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, Alabama, USA
Heart Rhythm 7:405-12. 2010.... - Short-acting beta-adrenergic antagonist esmolol given at reperfusion improves survival after prolonged ventricular fibrillationCheryl R Killingsworth
Cardiac Rhythm Management Laboratory, Division of Cardiovascular Diseases, Department of Medicine, University of Alabama at Birmingham, AL 35294 0019, USA
Circulation 109:2469-74. 2004.... - Do clinically relevant transthoracic defibrillation energies cause myocardial damage and dysfunction?Gregory P Walcott
Cardiac Rhythm Management Laboratory, Division of Cardiovascular Diseases, Department of Medicine, University of Alabama at Birmingham, Volker Hall B140, 1670 University Blvd, Birmingham, AL 35294, USA
Resuscitation 59:59-70. 2003..Until those studies are completed, it seems reasonable to use the same 360 J (5 J/kg) energy limit for biphasic shocks as for monophasic shocks... - Delayed afterdepolarization inhibitor: a potential pharmacologic intervention to improve defibrillation efficacyNipon Chattipakorn
Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294 0019, USA
J Cardiovasc Electrophysiol 14:72-5. 2003..Delayed afterdepolarizations (DADs) have been suggested as a possible cause of this rapid repetitive postshock activity. The aim of this study was to test the hypothesis that DFT is decreased by application of a DAD inhibitor... - Adaptive pacing during ventricular fibrillationPhilip L Johnson
Department of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, Alabama, USA
Pacing Clin Electrophysiol 26:1824-36. 2003..Although it is possible to maintain capture while increasing the pacing rate during VF, the area of capture decreases... - Human ventricular fibrillation: wandering wavelets, mother rotors, or both?Raymond E Ideker
Circulation 114:530-2. 2006 - Types of ventricular fibrillation: 1,2,4,5, or 3000,000?Raymond E Ideker
J Cardiovasc Electrophysiol 15:1441-3. 2004 - Reduction of the internal atrial defibrillation threshold with balanced orthogonal sequential shocksXiangsheng Zheng
J Cardiovasc Electrophysiol 13:904-9. 2002.... - Comparison of six clinically used external defibrillators in swineRobert G Walker
Medtronic Physio Control Corporation, 11811 Willows Road NE, 98073 9706, Redmond, WA, USA
Resuscitation 57:73-83. 2003.... - The vortex at the apex of the left ventricle: a new twist to the story of the electrical induction of rotors?Nipon Chattipakorn
J Cardiovasc Electrophysiol 14:303-5. 2003
Research Grants
- VENTRICULAR FIBRILLATION AND ITS ALTERATION BY PACINGRaymond Ideker; Fiscal Year: 2004..Specific Aim 3: Determine if it is possible to capture myocardium by pacing during VF in patients. The most successful pacing techniques and most of the hypotheses of Specific Aim 2 will be tested in patients. ..
- COMPUTER ASSISTED MAPPING OF VENTRICULAR FIBRILLATIONRaymond Ideker; Fiscal Year: 2004..The hypotheses will be tested that heart failure caused by patchy fibrosis decreases VF organization while heart failure cause by rapid pacing increases it. ..
- CARDIAC MAPPING OF VENTRICULAR DEFIBRILLATIONRaymond Ideker; Fiscal Year: 2006..It is hoped that the basic knowledge gained about defibrillation mechanisms through these studies will lead to the improvement of defibrillation in patients. ..
- COMPUTER ASSISTED MAPPING OF VENTRICULAR FIBRILLATIONRaymond Ideker; Fiscal Year: 2007..This understanding will give us new information needed to develop therapies to counteract these mechanisms of VF maintenance to prevent sudden cardiac arrest, one of the leading health problems in the world today. ..
- VENTRICULAR FIBRILLATION AND ITS ALTERATION BY PACINGRaymond Ideker; Fiscal Year: 2007..We will test the hypotheses that pacing from the dominant domain (1) captures the maximum amount of tissue during VF and (2) halts the most organized types of VF. ..
- Mechanisms of Long Duration Fibrillation, Defibrillation and RefibrillationRaymond Ideker; Fiscal Year: 2007....
- COMPUTER ASSISTED MAPPING OF VENTRICULAR FIBRILLATIONRaymond Ideker; Fiscal Year: 2009..This understanding will give us new information needed to develop therapies to counteract these mechanisms of VF maintenance to prevent sudden cardiac arrest, one of the leading health problems in the world today. ..
- VENTRICULAR FIBRILLATION AND ITS ALTERATION BY PACINGRaymond E Ideker; Fiscal Year: 2010..We will test the hypotheses that pacing from the dominant domain (1) captures the maximum amount of tissue during VF and (2) halts the most organized types of VF. ..
- COMPUTER ASSISTED MAPPING OF VENTRICULAR FIBRILLATIONRaymond Ideker; Fiscal Year: 1999....
- CARDIAC MAPPING OF VENTRICULAR DEFIBRILLATIONRaymond Ideker; Fiscal Year: 2002....
- Mechanisms of Long Duration Fibrillation, Defibrillation and RefibrillationRaymond E Ideker; Fiscal Year: 2010....