Research Topics
| VIRGINIA HUXLEYSummaryAffiliation: University of Missouri Country: USA Publications
Research Grants
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Detail Information
Publications
Role of a glycocalyx on coronary arteriole permeability to proteins: evidence from enzyme treatmentsV H Huxley
Department of Physiology, University of Missouri School of Medicine, Columbia, Missouri 65212, USA
Am J Physiol Heart Circ Physiol 278:H1177-85. 2000..These data demonstrate that in intact coronary arterioles an enzyme-sensitive layer, most likely at the endothelial cell surface, contributes significantly to net barrier resistance to solute flux...- Cardiovascular sex differences influencing microvascular exchangeVirginia H Huxley
National Center for Gender Physiology, University of Missouri Columbia, Columbia, MO 65212, USA
Cardiovasc Res 87:230-42. 2010.... - Adaptation of coronary microvascular exchange in arterioles and venules to exercise training and a role for sex in determining permeability responsesVirginia H Huxley
Department of Medical Pharmacology and Physiology, University of Missouri School of Medicine, Columbia, MO 65212, USA
Am J Physiol Heart Circ Physiol 293:H1196-205. 2007.... - Sex and the cardiovascular system: the intriguing tale of how women and men regulate cardiovascular function differentlyVirginia H Huxley
Department of Medical Pharmacology and Physiology, Center for Gender Physiology and Environmental Adaptation, University of Missouri School of Medicine, Columbia, Missouri 65212, USA
Adv Physiol Educ 31:17-22. 2007.... - Lymphatic fluid: exchange mechanisms and regulationVirginia H Huxley
University of Missouri School of Medicine, Department of Physiology, MA 415 Medical Sciences Bldg, Columbia, MO 65212 0001, USA
J Physiol 589:2935-43. 2011.... - Sexual dimorphism in the permeability response of coronary microvessels to adenosineVirginia H Huxley
Dept of Medical Pharmacology and Physiology, University of Missouri School of Medicine, Columbia, MO 65212, USA
Am J Physiol Heart Circ Physiol 288:H2006-13. 2005.... - The microvasculature as a dynamic regulator of volume and solute exchangeV H Huxley
Department of Physiology and Internal Medicine, University of Missouri School of Medicine, Columbia 65212, USA
Clin Exp Pharmacol Physiol 27:847-54. 2000..5. We present data demonstrating that some dyes used widely in microvascular studies can alter the barrier under study and/or alter the physicochemical characteristics of the molecule to which they were bound... - Microvascular network remodeling in dura mater of ovariectomized pigs: role for angiopoietin-1 in estrogen-dependent control of vascular stabilityOlga V Glinskii
Department of Medical Pharmacology and Physiology, University of Missouri, Columbia, MO 65212, USA
Am J Physiol Heart Circ Physiol 293:H1131-7. 2007..We conclude that estrogen-dependent control of Ang-1 expression plays an important role in stabilizing meningeal microvessel and maintaining healthy microvascular networks... - Differential coronary microvascular exchange responses to adenosine: roles of receptor and microvessel subtypesJianJie Wang
Department of Physiology and Pharmacology, School of Medicine, University of Missouri, Columbia, Missouri, USA
Microcirculation 12:313-26. 2005..To assess the role of adenosine receptors in the regulation of coronary microvascular permeability to porcine serum albumin (P(s)(PSA))... - Continuous real time ex vivo epifluorescent video microscopy for the study of metastatic cancer cell interactions with microvascular endotheliumOlga V Glinskii
Department of Biochemistry, University of Missouri, Columbia, Missouri 65212, USA
Clin Exp Metastasis 20:451-8. 2003.... - Adenosine A2A receptor modulation of juvenile female rat skeletal muscle microvessel permeabilityJianJie Wang
Dept of Medical Pharmacology and Physiology, University of Missouri, Columbia, MO 65212, USA
Am J Physiol Heart Circ Physiol 291:H3094-105. 2006.... - PDGF/VEGF system activation and angiogenesis following initial post ovariectomy meningeal microvessel lossOlga V Glinskii
Department of Medical Pharmacology and Physiology, University of Missouri, Columbia, Missouri 65212, USA
Cell Cycle 7:1385-90. 2008..The implication of this study is that therapeutic interventions, including estrogen-based hormone replacement therapy, with physiological angioadaptation in postmenopausal or post OVX women need to be approached with the extreme caution... - Intravascular metastatic cancer cell homotypic aggregation at the sites of primary attachment to the endotheliumVladislav V Glinsky
Department of Biochemistry, University of Missouri, Columbia, Missouri 65211, USA
Cancer Res 63:3805-11. 2003.... - Synthetic galectin-3 inhibitor increases metastatic cancer cell sensitivity to taxol-induced apoptosis in vitro and in vivoVladislav V Glinsky
Harry S Truman Memorial Veterans Hospital, Columbia, MO 65201, USA
Neoplasia 11:901-9. 2009.... - Mechanical entrapment is insufficient and intercellular adhesion is essential for metastatic cell arrest in distant organsOlga V Glinskii
Department of Medical Pharmacology and Physiology, University of Missouri, Columbia, MO 65212, USA
Neoplasia 7:522-7. 2005..Efficient blocking of beta-galactoside-mediated adhesion precludes malignant cell lodging in target organs... - Evidence of porcine and human endothelium activation by cancer-associated carbohydrates expressed on glycoproteins and tumour cellsOlga V Glinskii
Medical Pharmacology and Physiology Biomedical Sciences Biochemistry, University of Missouri, Columbia, MO 65212, USA
J Physiol 554:89-99. 2004..Carbohydrate-mediated endothelial activation could be a process of physiological significance as it probably occurs in the interactions between a variety of circulating constituents and the vessel wall... - Permeability response of the rat mesenteric microvasculature to insulinRie Sasaki
Department of Medical Pharmacology and Physiology, University of Missouri Columbia, MA 415 HSC, USA
Clin Hemorheol Microcirc 34:259-63. 2006..We conclude that insulin reduces mesenteric venule permeability differently in males and females. Further studies are needed to differentiate the permeability responses with respect to age and gender... - Galectin-3 as a potential therapeutic target in tumors arising from malignant endotheliaKim D Johnson
Department of Veterinary Pathobiology, Hematology Oncology Division, University of Missouri Columbia, Columbia, MO 65211, USA
Neoplasia 9:662-70. 2007..7-fold and 3.6-fold, respectively. These results highlight the important role of Gal-3 in the biology of ASA and identify Gal-3 as a potential therapeutic target in tumors arising from malignant endothelial cells... - Fluorescent dyes modify properties of proteins used in microvascular researchSusan Bingaman
Department of Physiology, University of Missouri-Columbia, Columbia, MO, USA
Microcirculation 10:221-31. 2003..These findings may affect the interpretation of microvascular permeability experiments performed using fluorescent dyes, and they suggest care in the selection of dyes for such experiments... - In vivo determination of collecting lymphatic vessel permeability to albumin: a role for lymphatics in exchangeJoshua P Scallan
Department of Medical Pharmacology and Physiology, University of Missouri School of Medicine, Columbia, MO 65212, USA
J Physiol 588:243-54. 2010..As a consequence these data provide experimental support for the theory that prenodal lymphatic vessels concentrate intraluminal protein... - Similar permeability responses to nitric oxide synthase inhibitors of venules from three animal speciesRolando E Rumbaut
Department of Medicine and Department of Pediatrics, Baylor College of Medicine, Houston V A Medical Center, 2002 Holcombe Blvd, Building 109, Room 114, Houston, Texas 77030, USA
Microvasc Res 64:21-31. 2002..These data support a role of nitric oxide release on venular permeability to albumin that is conserved among the three animal species... - Inhibition of spontaneous breast cancer metastasis by anti-Thomsen-Friedenreich antigen monoclonal antibody JAA-F11Jamie Heimburg
Department of Microbiology and Immunology, The University at Buffalo, Buffalo, NY 14214, USA
Neoplasia 8:939-48. 2006..JAA-F11 significantly extended the median survival time of animals bearing metastatic 4T1 breast tumors and caused a > 50% inhibition of lung metastasis... - Macromolecule permeability of in situ and excised rodent skeletal muscle arterioles and venulesIngrid H Sarelius
Dept of Pharmacology and Physiology, Univ of Rochester Medical Center, Box 711, Rochester, NY 14642, USA
Am J Physiol Heart Circ Physiol 290:H474-80. 2006.... - Attenuation of endothelial dysfunction by exercise training in STZ-induced diabetic ratsDaroonwan Chakraphan
School of Sports Science, Chulalongkorn University, Bangkok, Thailand
Clin Hemorheol Microcirc 32:217-26. 2005..These findings support the notion that regular exercise training could be a fundamental form of therapy in preventing diabetic cardiovascular complications potentiated by endothelial dysfunction...
Research Grants
- Microvascular Permeability and SexVIRGINIA HUXLEY; Fiscal Year: 2007....