Research Topics
Genomes and Genes | Aliya N HusainSummaryAffiliation: University of Chicago Country: USA Publications
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Publications
Guidelines for pathologic diagnosis of malignant mesothelioma: a consensus statement from the International Mesothelioma Interest GroupAliya N Husain
Department of Pathology, University of Chicago, Chicago, IL 60631, USA
Arch Pathol Lab Med 133:1317-31. 2009..Malignant mesothelioma (MM) is an uncommon tumor that can be difficult to diagnose...- EphA2 mutation in lung squamous cell carcinoma promotes increased cell survival, cell invasion, focal adhesions, and mammalian target of rapamycin activationLeonardo Faoro
Section of Hematology and Oncology, Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA
J Biol Chem 285:18575-85. 2010..Further study of EphA2 as a therapeutic target is warranted... - Protein kinase C beta in malignant pleural mesotheliomaLeonardo Faoro
Section of Hematology Oncology, Department of Medicine, University of Chicago Pritzker School of Medicine, Chicago, Illinois 60637 1470, USA
Anticancer Drugs 19:841-8. 2008..Enzastaurin has preclinical activity against MPM, and exhibited synergism with cisplatin. PKCbeta inhibition in MPM might be able to reduce the invasiveness of MPM by affecting cytoskeletal function... - Expression patterns of PAX5, c-Met, and paxillin in neuroendocrine tumors of the lungJie Song
Department of Pathology, University of Chicago Medical Center, Chicago, IL, USA
Arch Pathol Lab Med 134:1702-5. 2010..The expression patterns of these functionally related proteins have not, to our knowledge, been systemically studied in neuroendocrine tumors of the lung... - Paxillin expression and amplification in early lung lesions of high-risk patients, lung adenocarcinoma and metastatic diseaseAlexander C MacKinnon
Department of Pathology, University of Chicago Medical Center, Chicago, Illinois 60637, USA
J Clin Pathol 64:16-24. 2011..A murine in vivo xenograft model of the most common paxillin mutation (A127T) showed increased cell proliferation and invasive tumour growth, establishing an important role for paxillin in the development of lung cancer... - MET and phosphorylated MET as potential biomarkers in lung cancerMaria Tretiakova
University of Chicago, Department of Pathology, Chicago, Illinois 60637, USA
J Environ Pathol Toxicol Oncol 30:341-54. 2011..12- 3.07; and P = .034; HR, 1.70; 95% CI, 1.04-2.78, respectively). In summary, MET, pMET, and HGF are highly expressed in both NSCLC and SCLC. Specific forms of pMET may serve as potential biomarkers in lung cancer... - Update in neoplastic lung diseases and mesotheliomaIlyssa O Gordon
Department of Pathology, University of Chicago, Chicago, Illinois 60637, USA
Arch Pathol Lab Med 133:1106-15. 2009..Identification of new molecular targets in pleural mesothelioma and in preneoplastic lesions may lead to improved therapeutic strategies... - PAX5 is expressed in small-cell lung cancer and positively regulates c-Met transcriptionRajani Kanteti
Department of Hematology Oncology, University of Chicago Medical Center, Chicago, IL 60637, USA
Lab Invest 89:301-14. 2009..Therefore, we propose that PAX5 could be an important regulator of c-Met transcription and a potential target for therapy in SCLC... - Epigenetic attenuation of mitochondrial superoxide dismutase 2 in pulmonary arterial hypertension: a basis for excessive cell proliferation and a new therapeutic targetStephen L Archer
Department of Medicine, Section of Cardiology, University of Chicago, 5841 S Maryland Avenue, Chicago, IL 60637, USA
Circulation 121:2661-71. 2010..Expression and activity of mitochondrial superoxide dismutase-2 (SOD2), the major generator of H(2)O(2), is known to be reduced in PAH; however, the mechanism and therapeutic relevance of this are unknown... - GADD45a is a novel candidate gene in inflammatory lung injury via influences on Akt signalingNuala J Meyer
Department of Medicine, W604, Pritzker School of Medicine, University of Chicago, 5841 S Maryland Ave, W604 Chicago, IL 60637, USA
FASEB J 23:1325-37. 2009..These studies validate GADD45a as a novel candidate gene in inflammatory lung injury and a significant participant in vascular barrier regulation via effects on Akt-mediated endothelial signaling... - Lymphatic vessel density is not associated with lymph node metastasis in non-small cell lung carcinomaLeonardo Faoro
Department of Medicine, Section of Hematology Oncology, University of Chicago, Chicago, IL, USA
Arch Pathol Lab Med 132:1882-8. 2008..Lymphatic metastasis is also an important means of tumor spread. In non-small cell lung carcinoma, the relationship of lymphangiogenesis with lymph node metastasis and, ultimately, patient prognosis is unknown... - MET/PKCbeta expression correlate with metastasis and inhibition is synergistic in lung cancerLeonardo Faoro
Section of Hematology Oncology, Department of Medicine, University of Chicago Pritzker School of Medicine, and University of Chicago Cancer Research Center, Chicago, IL 60637, USA
J Carcinog 8:15. 2009..Targeted inhibition of oncogenic proteins is promising. In this study, we evaluate the expression of MET and PKCbeta and in vitro effects of their inhibition using SU11274 and enzastaurin (LY317615.HCl) respectively... - Role of protein kinase C ? and vascular endothelial growth factor receptor in malignant pleural mesothelioma: Therapeutic implications and the usefulness of Caenorhabditis elegans model organismSivakumar Loganathan
Section of Hematology Oncology, University of Chicago, Chicago, IL 60637, USA
J Carcinog 10:4. 2011..To examine the role of both protein kinase C (PKC)-? and vascular endothelial growth factor receptor (VEGFR)-2 in malignant pleural mesothelioma (MPM) using respective inhibitors, enzastaurin and KRN633... - Simvastatin attenuates radiation-induced murine lung injury and dysregulated lung gene expressionBiji Mathew
Section of Pulmonary and Critical Care Medicine, Department of Medicine, University of Chicago, Illinois, USA
Am J Respir Cell Mol Biol 44:415-22. 2011..These studies identify the involvement of specific genes and gene networks in RILI pathobiology, and confirm that statins represent a novel strategy to limit RILI... - Increased rejection rates in cardiac transplant associated with dexamethasoneAdam B Cochrane
Department of Pharmacology, University of Chicago, Chicago, IL 60637, United States
Steroids 73:441-8. 2008..Methylprednisolone and dexamethasone are used interchangeably in many clinical settings; however, their equivalency has not been demonstrated... - Long-term effects of epoprostenol on the pulmonary vasculature in idiopathic pulmonary arterial hypertensionStuart Rich
Department of Medicine, University of Chicago, Section of Cardiology, 5841 S Maryland Ave, Ste LO 8 MC 5403, Chicago, IL 60637, USA
Chest 138:1234-9. 2010..Remarkably, the RV was able to sustain a normal cardiac output in the face of advanced vascular pathology. The mechanisms by which the RV adapts to chronic PAH need further study... - S100A12 in vascular smooth muscle accelerates vascular calcification in apolipoprotein E-null mice by activating an osteogenic gene regulatory programMARION A HOFMANN BOWMAN
Department of Medicine, Section of Cardiology, University of Chicago, 5841 S Maryland Avenue, Chicago IL 60637, USA
Arterioscler Thromb Vasc Biol 31:337-44. 2011..In the current study, we tested the hypothesis that S100A12 expressed in vascular smooth muscle in atherosclerosis-prone apolipoprotein E (ApoE)-null mice would accelerate atherosclerosis... - Immunohistochemistry staining of C4d to diagnose antibody-mediated rejection in cardiac transplantationSavitri E Fedson
Department of Medicine, University of Chicago Medical Center, Chicago, Illinois 60637, USA
J Heart Lung Transplant 27:372-9. 2008..There are few published data about hemodynamics and C4d staining. We prospectively performed C4d staining on endomyocardial biopsies (EMBs) and present the pattern of tissue staining and its correlation with intracardiac hemodynamics... - Functional variants of the sphingosine-1-phosphate receptor 1 gene associate with asthma susceptibilityXiaoguang Sun
Section of Pulmonary and Critical Care Medicine, Department of Medicine, University of Chicago, Chicago, Ill, USA
J Allergy Clin Immunol 126:241-9, 249.e1-3. 2010..Increased permeability of the microvasculature is a feature of asthma, and the sphingosine-1-phosphate receptor (S1PR1) is an essential participant regulating lung vascular integrity and responses to lung inflammation... - Essential role of pre-B-cell colony enhancing factor in ventilator-induced lung injurySang Bum Hong
Department of Medicine, University of Chicago Pritzker School of Medicine, 5841 S Maryland Avenue, W604, Chicago, IL 60637, USA
Am J Respir Crit Care Med 178:605-17. 2008..We previously demonstrated pre-B-cell colony enhancing factor (PBEF) as a biomarker in sepsis and sepsis-induced acute lung injury (ALI) with genetic variants conferring ALI susceptibility... - Diagnosis and management of pulmonary hypertension in systemic sclerosisNadera J Sweiss
Section of Rheumatology, University of Chicago, 5841 South Maryland Avenue MC6080, Chicago, IL 60637, USA
Curr Rheumatol Rep 12:8-18. 2010..Approved therapies include prostacyclins, endothelin antagonists, and phosphodiesterase type 5 inhibitors. Research is needed to define disease mechanisms and develop effective therapies... - Update in nonneoplastic lung diseasesIlyssa O Gordon
Department of Pathology, University of Chicago, Chicago, Illinois 60637, USA
Arch Pathol Lab Med 133:1096-105. 2009..It is important for the practicing pathologist to be aware of this new information and to understand how it impacts the diagnosis, treatment, and outcome of these diseases... - The presence of a CD21+ follicular dendritic cell network distinguishes invasive Quilty lesions from cardiac acute cellular rejectionHusain A Sattar
Department of Pathology, Section of Cardiology, University of Chicago Hospitals, Chicago, IL 60637, USA
Am J Surg Pathol 30:1008-13. 2006..We postulated that this organization is dependent on a follicular dendritic cell (FDC) network and that the presence of such a network would be useful in distinguishing invasive Quilty lesions from acute cellular rejection... - Multiple paragangliomata of the lungs and temporal boneHusain A Sattar
Department of Pathology, University of Chicago Hospitals, MC 1035, Chicago, IL 60637, USA
Ear Nose Throat J 87:E4-6. 2008..Before any chemotherapeutic regimen is initiated, a thorough physical examination of the head and neck should be performed, and biopsy material should be tested for markers of cell division... - Comparison of virulence in community-associated methicillin-resistant Staphylococcus aureus pulsotypes USA300 and USA400 in a rat model of pneumoniaChristopher P Montgomery
Department of Pediatrics, Section of Critical Care Medicine, University of Chicago, Illinois 60637, USA
J Infect Dis 198:561-70. 2008..The explanation for this shift is unclear. We hypothesized that USA300 must be more pathogenic--specifically, that USA300 would have increased virulence when compared with USA400 in an animal model... - Pathologic quiz case: multiple pulmonary nodules in a patient with stage IV, diffuse large B-cell lymphomaAtilla Omeroglu
Department of Pathology, Loyola University Medical Center, Maywood, Ill, USA
Arch Pathol Lab Med 126:747-8. 2002 - Urothelial neoplasms of the urinary bladder occurring in young adult and pediatric patients: a comprehensive review of literature with implications for patient managementGladell P Paner
Department of Pathology, Section of Urology, The University of Chicago Hospitals, 5841 S Maryland Avenue, Chicago, IL 60637, USA
Adv Anat Pathol 18:79-89. 2011.... - Pathologic quiz case: a 76-year-old woman with bilateral pulmonary nodulesNoman H Siddiqui
Department of Pathology, Loyola University Medical Center, Maywood, Ill, USA
Arch Pathol Lab Med 127:501-2. 2003 - Gefitinib response of erlotinib-refractory lung cancer involving meninges--role of EGFR mutationNicholas W Choong
Section of Hematology-Oncology, University of Chicago, Chicago, IL, USA
Nat Clin Pract Oncol 3:50-7; quiz 1 p following 57. 2006..MANAGEMENT: Carboplatin, paclitaxel and erlotinib, whole-brain radiotherapy, temozolomide with and without irinotecan, and gefitinib... - Paxillin is a target for somatic mutations in lung cancer: implications for cell growth and invasionRamasamy Jagadeeswaran
Department of Medicine, University of Chicago Cancer Research Center, University of Chicago Medical Center, Pritzker School of Medicine, Chicago, Illinois 60637, USA
Cancer Res 68:132-42. 2008..A murine in vivo xenograft model of A127T paxillin showed an increase in tumor growth, cell proliferation, and invasion. These results establish an important role for paxillin in lung cancer... - Cardiac tamponade mimicking tuberculous pericarditis as the initial presentation of chronic lymphocytic leukemia in a 58-year-old woman: a case reportElaine Lin
Section of Cardiology, Department of Medicine, University of Chicago, Chicago, IL, USA
J Med Case Reports 4:246. 2010..However, the signs, symptoms and laboratory findings of pericarditis related to chronic lymphocytic leukemia can mimic tuberculosis... - Genomic assessment of a multikinase inhibitor, sorafenib, in a rodent model of pulmonary hypertensionLiliana Moreno-Vinasco
Section of Pulmonary and Critical Care Medicine, Department of Medicine, Pritzker School of Medicine, University of Chicago, Chicago, Illinois 60637, USA
Physiol Genomics 33:278-91. 2008..In summary, sorafenib represents a novel potential treatment for severe PH with the MAPK cascade a potential canonical target... - Pathologic quiz case. A sinonasal mass in a 79-year-old African American womanAtilla Omeroglu
Department of Pathology, Loyola University Medical Center, Maywood, IL, USA
Arch Pathol Lab Med 126:493-4. 2002