Research Topics
Species | Steven J HughesSummaryAffiliation: University of Pittsburgh Country: USA Publications
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Publications
Laparoscopic repair of umbilical hernias in conjunction with other laparoscopic proceduresGeorge M Eid
Veteran Administration Pittsburgh Healthcare System, Pittsburgh, Pennsylvania, USA
JSLS 10:63-5. 2006..This study evaluates the feasibility of laparoscopic transfascial suture repair of umbilical hernias when combined with another laparoscopic procedure that potentially contaminates the peritoneal cavity...- A quantitative reverse transcription-PCR assay for rapid, automated analysis of breast cancer sentinel lymph nodesSteven J Hughes
Departments of Surgery, University of Pittsburgh, 497 Scaife Hall, 3550 Terrace St, Pittsburgh, PA 15261, USA
J Mol Diagn 11:576-82. 2009..Furthermore, the assay is not dependent on subjective interpretation, is reproducible across three clinical environments, and is rapid enough to allow intraoperative decision making... - Necrotizing pancreatitisSteven J Hughes
Section of Gastrointestinal Surgery, Department of Surgery, University of Pittsburgh School of Medicine, 497 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261, USA
Gastroenterol Clin North Am 36:313-23, viii. 2007..This article presents a multidisciplinary literature-based approach to the treatment of patients with necrotizing pancreatitis... - A rapid, fully automated, molecular-based assay accurately analyzes sentinel lymph nodes for the presence of metastatic breast cancerSteven J Hughes
Department of Surgery, Medical University of South Carolina, Charleston, USA
Ann Surg 243:389-98. 2006..This approach is superior to intraoperative SLN analysis and can provide standardized, objective results to assist in pathologic diagnosis... - Technology for automated, rapid, and quantitative PCR or reverse transcription-PCR clinical testingSiva Raja
Department of Surgery, Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA 15213, USA
Clin Chem 51:882-90. 2005..The GeneXpert can perform RNA isolation, reverse transcription, and quantitative PCR in approximately 35 min and could therefore be used for intraoperative testing when applicable... - Phase II study of gemcitabine and erlotinib as adjuvant therapy for patients with resected pancreatic cancerPhilip Q Bao
Department of Surgery, Stony Brook University Hospital, Stony Brook, NY, USA
Ann Surg Oncol 18:1122-9. 2011..This study was designed to evaluate the efficacy of gemcitabine and erlotinib as adjuvant therapy, and to explore potential biomarkers associated with response... - Cytoplasmic overexpression of CD95L in esophageal adenocarcinoma cells overcomes resistance to CD95-mediated apoptosisGregory A Watson
Department of Surgery, Division of Surgical Oncology, University of Pittsburgh, Pittsburgh, PA, USA
Neoplasia 13:198-205. 2011..We hypothesized that CD95L expression in esophageal adenocarcinoma confers advantages to the neoplasm other than immune privilege... - Inhibition of c-Met as a therapeutic strategy for esophageal adenocarcinomaGregory A Watson
Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA
Neoplasia 8:949-55. 2006..Factors other than receptor overexpression, such as c-Met-dependent PI3K/Akt signaling, may be predictive of an individual tumor's response to c-Met inhibition... - Inhibition of HGF/MET as therapy for malignancySanjay Naran
University of Pittsburgh School of Medicine, Division of Surgical Oncology, Department of Surgery, Pittsburgh, PA 15261, USA
Expert Opin Ther Targets 13:569-81. 2009..A number of MET inhibitor molecules are nearing completion of their development for clinical use... - Identification of mRNA markers for molecular staging of lymph nodes in colorectal cancerLiqiang Xi
Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15261, USA
Clin Chem 52:520-3. 2006..An automated, multimarker, quantitative reverse transcription-PCR assay for characterization of lymph nodes from colorectal cancer patients may be useful for improved staging and therapeutic decision making in colorectal cancer... - Can laparoscopic pancreaticoduodenectomy be safely implemented?Amer H Zureikat
Department of Surgery, Division of Surgical Oncology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
J Gastrointest Surg 15:1151-7. 2011..The implementation of laparoscopic pancreaticoduodenectomy (LPD) has been appropriately met with apprehension, and concerns exist regarding outcomes early in a program's experience. We reviewed our early experience and outcomes of LPD... - The HGF receptor c-Met is overexpressed in esophageal adenocarcinomaLuis J Herrera
Department of Surgery, University of Pittsburgh and the Hillman Cancer Center, Pittsburgh, PA 15261, USA
Neoplasia 7:75-84. 2005..Met dysregulation occurs early in Barrett's dysplasia to adenocarcinoma sequence. Future study of Met inhibition as a potential biologic therapy for EA is warranted... - Is occult lymph node disease in colorectal cancer patients clinically significant? A review of the relevant literatureDaniel G Nicastri
University of Pittsburgh, 3550 Terrace Street, Pittsburgh, PA 15261, USA
J Mol Diagn 9:563-71. 2007..The identification of occult disease by IHC techniques may also ultimately prove to be associated with worse outcome, but a number of inadequately powered studies have concluded conversely... - Short- and long-term costs of laparoscopic colectomy are significantly less than open colectomyDavid P Eisenberg
Division of Surgical Oncology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15261, USA
Surg Endosc 24:2128-34. 2010.... - Loss of heterozygosity predicts poor survival after resection of pancreatic adenocarcinomaJan Franko
UPMC Pancreatic Cancer Center, Division of Surgical Oncology, 497 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261, USA
J Gastrointest Surg 12:1664-72; discussion 1672-3. 2008..We hypothesized that genetic analysis of resected cancers would correlate with tumor biology and postoperative survival... - Ad-IRF-1 induces apoptosis in esophageal adenocarcinomaGregory A Watson
Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA
Neoplasia 8:31-7. 2006..In vivo administration of IRF-1 in a murine model of EA modestly inhibited tumor growth, but did not lead to tumor regression. Strategies aimed at increasing or restoring IRF-1 expression may have therapeutic benefits in EA... - Bile Salts Differentially Sensitize Esophageal Squamous Cells to CD95 (Fas/Apo-1 Receptor) Mediated ApoptosisSanjay Naran
Department of Surgery, Section of Gastrointestinal Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
J Surg Res 171:504-9. 2011.... - Molecular staging of lymph nodes from patients with esophageal adenocarcinomaLiqiang Xi
Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA
Clin Cancer Res 11:1099-109. 2005..The objective nature of QRT-PCR results, and the ability to detect occult metastases, make this an attractive alternative to routine pathology... - Clinical challenges and images in GI. Endometriosis of the sigmoid colon with endometriotic features within mesenteric lymph nodesClaudia Hriesik
Department of Surgery, The University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Gastroenterology 133:1768, 2078. 2007 - Laparoscopic colorectal surgery is safe in the high-risk patient: a NSQIP risk-adjusted analysisCarol A McCloskey
Department of Surgery, VA Pittsburgh Healthcare System and the University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Surgery 142:594-7; discussion 597.e1-2. 2007..We hypothesized that this procedure is safe to perform in high-risk patients, stratifying this risk using National VA Surgical Quality Improvement Program (NSQIP) algorithms... - Update for surgeons: recent and noteworthy changes in therapeutic regimens for cancer of the colon and rectumClaudia Hriesik
Department of Surgery, Division of Surgical Oncology, University of Pittsburgh School of Medicine, and University of Pittsburgh Cancer Institute, Pittsburgh, PA 15261, USA
J Am Coll Surg 205:468-78 (Quiz 524). 2007 - Minimal-access technique for distal catheter insertion during ventricular peritoneal shunt procedures: a review of 100 casesPawel G Ochalski
Department of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA
J Neurosurg 111:623-7. 2009..They conclude that intraperitoneal shunt catheter placement can be safely and effectively accomplished using a simplified percutaneous minimal-access insertion method that does not require direct laparoscopic visualization... - Increased interactive format for Morbidity & Mortality conference improves educational value and enhances confidenceJose M Prince
Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
J Surg Educ 64:266-72. 2007..We analyzed which features of M&M case reviews are associated with greater perceived educational value and enhanced confidence to deal with similar future clinical scenarios... - Minimally invasive treatment of pancreatic diseaseKenneth K Lee
Section of Gastrointestinal Surgery, Department of Surgery, University of Pittsburgh School of Medicine, 497 Scaife Hall, 3550 Lothrop Street, Pittsburgh, PA 15261, USA
Gastroenterol Clin North Am 36:441-54, xi. 2007..This article reviews the application of minimally invasive surgery to the management of both benign and malignant diseases of the pancreas... - Delayed operating room availability significantly impacts the total hospital costs of an urgent surgical procedureRajeev Dhupar
Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
Surgery 150:299-305. 2011..We examined how operating room use impacts efficiency and costs of treating an urgent surgical condition...
Research Grants
- Apoptosis in Barretts Metaplasia and Esophageal CancerSteven Hughes; Fiscal Year: 2007..This improved understanding may also alter the current management of gastroesophageal reflux disease, BE, and EA. ..