Research Topics
| Ke Qin HuSummaryAffiliation: University of California Country: USA Publications
Research Grants
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Detail Information
Publications
Barriers to screening for hepatitis B virus infection in asian americansKe Qin Hu
Division of GI Hepatology, University of California, Irvine, 101, The City Drive, Building 56, Rt 81, Rm 231, Orange, CA, 92868, USA
Dig Dis Sci 56:3163-71. 2011..Although the overall prevalence of HBV infection in the United States is low (<1%), it is high (~10%) in Asian Americans. However, HBV screening rates in this population have been reported to be low...- Impact of Hispanic or Asian ethnicity on the treatment outcomes of chronic hepatitis C: results from the WIN-R trialKe Qin Hu
Division of Gastroenterology and Hepatology, University of California Irvine, Orange, CA 92868, USA
J Clin Gastroenterol 45:720-6. 2011..The aim of this subanalysis of the Weight-based Dosing of PegINterferon ?-2b and Ribavirin (WIN-R) study was to assess the impact of Asian (n=118), Hispanic (n=289), and white (n=3919) ethnicity on CHC treatment outcomes... - Clinical implications of hepatic steatosis in patients with chronic hepatitis C: a multicenter study of U.S. veteransKe Qin Hu
Loma Linda VA Medical Center, Loma Linda, CA, USA
Dig Dis Sci 52:570-8. 2007..We found that steatosis is independently associated with stage III-IV fibrosis. However, only HCV genotype, and not steatosis, obesity, or stage III-IV fibrosis, was associated with SVR to interferon alpha-2b and ribavirin treatment... - Histologic evidence of active liver injury in chronic hepatitis B patients with normal range or minimally elevated alanine aminotransferase levelsKe Qin Hu
Division of GI Hepatology, University of California Irvine School of Medicine, Orange, CA 92868, USA
J Clin Gastroenterol 44:510-6. 2010..Sub-analysis was performed to determine whether HEALD based upon liver biopsy better correlates with ALT using modified ALT (30 men/19 women) upper limit of normal (ULN) criteria compared with local conventional laboratory... - Cyclooxygenase 2 (COX2)-prostanoid pathway and liver diseasesKe Qin Hu
Division of Gastroenterology and Hepatology and Chao Family Comprehensive Cancer Center, University of California Irvine Medical Center, Orange, CA 92868, USA
Prostaglandins Leukot Essent Fatty Acids 69:329-37. 2003..This provided rationale for further testing COX2 inhibitors as clinical agents for HCC chemoprovention. Further studies will be needed to examine how COX2 inhibitors affect pathogenesis of various liver diseases... - Overweight and obesity, hepatic steatosis, and progression of chronic hepatitis C: a retrospective study on a large cohort of patients in the United StatesKe Qin Hu
Division of Gastroenterology Hepatology, University of California Irvine, Orange, CA 92868, USA
J Hepatol 40:147-54. 2004..Hepatic steatosis has been associated with chronic hepatitis C (CHC), but its prevalence, risk factors, and clinical significance remain to be determined... - The clinical presentation of chronic hepatitis B virus infection in Asian Americans: a single center retrospective studyJonathan S Mellen
Department of Medicine parallel, Chao Comprehensive Digestive Disease Center, Irvine Medical Center, Orange, CA 92868, USA
J Clin Gastroenterol 44:364-70. 2010..The clinical course of chronic hepatitis B virus (HBV) infection varies with ethnicity. Little is known about the clinical presentation of chronic HBV infection in Asian Americans... - Intraoperative hypokalemia in pediatric liver transplantation: incidence and risk factorsVictor W Xia
Department of Anesthesiology, David Geffen School of Medicine, University of California, Los Angeles, California 90095 1778, USA
Anesth Analg 103:587-93. 2006..These findings support the use of K+ replacement to maintain normokalemia and avoid the potential complications related to hypokalemia in pediatric liver transplantation, especially in children with the risk factors for hypokalemia... - Effects and mechanisms of silibinin on human hepatoma cell linesJohn J Lah
Division of Gastroenterology, University of California, Irvine Medical Center, 101 The City Drive, Building 53, Suite 113, Orange, CA 92868, United States
World J Gastroenterol 13:5299-305. 2007..To investigate in vitro effects and mechanisms of silibinin on hepatocellular carcinoma (HCC) cell growth... - In-vivo effects and mechanisms of celecoxib-reduced growth of cyclooxygenase-2 (COX-2)-expressing versus COX-2-deleted human HCC xenografts in nude miceWei Cui
Division of Gastroenterology and Hepatology, University of California, Irvine Medical Center, Orange, CA, USA
Anticancer Drugs 19:891-7. 2008..In conclusion, celecoxib suppresses growth of HuH7 xenografts regardless of COX-2 expression, which may be mediated through different signaling... - Inhibited proliferation of cyclooxygenase-2 expressing human hepatoma cells by NS-398, a selective COX-2 inhibitorKe Qin Hu
Loma Linda University Medical Center, Loma Linda, CA 92354, USA
Int J Oncol 22:757-63. 2003..Our findings confirmed an effective inhibitory effect of NS-398 on proliferation of COX-2 expressing human hepatoma cells through a decreased COX-2/PG activity that is associated with altered cell cycle progression and apoptotic rate... - Preoperative characteristics and intraoperative transfusion and vasopressor requirements in patients with low vs. high MELD scoresVictor W Xia
Department of Anesthesiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095 1778, USA
Liver Transpl 12:614-20. 2006..In conclusion, these data suggest that pretransplant MELD scores provide important information for perioperative management of patients undergoing liver transplantation... - Factors associated with hepatic fibrosis in patients with chronic hepatitis C: a retrospective study of a large cohort of U.S. patientsShirley X Hu
Earl Warren College, University of California, San Diego, CA, USA
J Clin Gastroenterol 43:758-64. 2009..To determine the risk factors for stage 3 and 4 fibrosis in a large cohort of U.S. patients with chronic hepatitis C (CHC)... - Rationale and feasibility of chemoprovention of hepatocellular carcinoma by cyclooxygenase-2 inhibitorsKe Qin Hu
Transplantation Institute Division of Gastroenterology, Loma Linda University Medical Center, 11234 Anderson Street, Rm 1405, Loma Linda, CA 92354, USA
J Lab Clin Med 139:234-43. 2002.... - Occult hepatitis B virus infection and its clinical implicationsKe Qin Hu
Transplantation Institute and Division of Gastroenterology, Loma Linda University Medical Center and Jerry L Pettis Memorial VA Medical Center, Loma Linda, California 92354, USA
J Viral Hepat 9:243-57. 2002..Highly sensitive, quantitative, and functional molecular analyses of HBV, combined with a well-designed prospective clinical assessment will provide the best approach for the future study of occult HBV infection... - Nephrogenic fibrosing dermopathy after liver transplantation successfully treated with plasmapheresisPedro W Baron
Department of Surgery, Loma Linda University Medical Center, 11234 Anderson Street, Room 1405, PO Box 2000, Loma Linda, CA 92354, USA
Am J Dermatopathol 25:204-9. 2003..Preliminary studies (unpublished data) show that decreasing plasma levels of transforming growth factor-beta1 after plasmapheresis appear to correlate with the amelioration of this clinical condition... - Clinical significance of elevated alpha-fetoprotein (AFP) in patients with chronic hepatitis C, but not hepatocellular carcinomaKe-Qin Hu
Division of Gastroenterology, University of California, Irvine Medical Center, Orange, California 92868, USA
Am J Gastroenterol 99:860-5. 2004..5% specific for stage III/IV fibrosis. CONCLUSIONS: In patients with chronic hepatitis C, 23.0% had elevated serum AFP that is independently associated with stage III/IV hepatic fibrosis, elevated level of AST, and prolonged INR... - Clinical presentation of hepatocellular carcinoma (HCC) in Asian-Americans versus non-Asian-AmericansPhilip Y Wong
Department of Internal Medicine, University of California Irvine School of Medicine, Irvine, CA, USA
J Immigr Minor Health 13:842-8. 2011..8%, P = 0.001). Asian-American patients with HCC presented with a higher incidence of history and family history of HBV infection, lower incidence of hepatic decompensation, lower Child and MELD scores, and an early stage HCC disease... - Hepatitis B virus (HBV) infection in Asian and Pacific Islander Americans (APIAs): how can we do better for this special population?Ke Qin Hu
Division of Gastroenterology and Hepatology, University of California, Irvine School of Medicine, Irvine, California, USA
Am J Gastroenterol 103:1824-33. 2008.... - Predictors of hyperkalemia in the prereperfusion, early postreperfusion, and late postreperfusion periods during adult liver transplantationVictor W Xia
Department of Anesthesiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095 1778, USA
Anesth Analg 105:780-5. 2007..Hyperkalemia poses serious hazards to patients undergoing orthotopic liver transplantation (OLT), and its predictors have not been thoroughly examined... - Postliver transplant acute renal injury and failure by the RIFLE criteria in patients with normal pretransplant serum creatinine concentrations: a matched studyJie Chen
Department of Anesthesiology, Ronald Reagan UCLA Medical Center, Los Angeles, CA 90095 7430, USA
Transplantation 91:348-53. 2011..The aims of this study were to identify the incidence, risk factors, and impact of ARI and ARF in this patient population... - Clinical presentation of chronic hepatitis C in patients with end-stage renal disease and on hemodialysis versus those with normal renal functionKe-Qin Hu
Division of Gastroenterology and Hepatology, University of California, Irvine Medical Center, Orange, California 92868, USA
Am J Gastroenterol 100:2010-8. 2005..In patients with CHC and ESRD, stage III-IV fibrosis is not associated with a history of DM, but is independently associated with hepatic steatosis and thrombocytopenia... - Hepatobiliary manifestations of gastrointestinal and nutritional disordersJason B Samarasena
Division of Gastroenterology, University of California Irvine Medical Center, 101 The City Drive, City Tower, Suite 400, Zot 4092, Orange, CA 92868, USA
Clin Liver Dis 15:89-110. 2011.... - Quantification and mechanisms of oleic acid-induced steatosis in HepG2 cellsWei Cui
Division of Gastroenterology and Hepatology, Dept of Medicine, University of California Irvine, CA, USA
Am J Transl Res 2:95-104. 2010..In the absence of exogenous inflammatory mediators, OA-induced steatosis results in a series of pathophysilogical changes in HepG2 cells, indicating direct pathogenic roles of hepatocytes in NAFLD... - Effects and mechanisms of silibinin on human hepatocellular carcinoma xenografts in nude miceWei Cui
Division of Gastroenterology, University of California Irvine Medical Center, 101 The City Drive, Orange, CA 92868, USA
World J Gastroenterol 15:1943-50. 2009..To investigate the in vivo effects and mechanisms of silibinin on the growth of hepatocellular carcinoma (HCC) xenografts in nude mice... - Formal heparin anticoagulation protocol improves safety of charcoal-based liver-assist treatmentsDonald J Hillebrand
Division of Gastroenterology-Hepatology Scripps Clinic, Irvine, CA, USA
ASAIO J 52:334-42. 2006..3 vs 15.8 units/patient, p = 0.13) and fewer complications (16.7% vs 66.7%, p = 0.15) in group 2. Anticoagulation using ACT monitoring, heparin dose-response curves, and a target ACT of 300 seconds improves the safety of LDU treatments... - Charcoal-based hemodiabsorption liver support for episodic type C hepatic encephalopathyKevin Hill
Department of Internal Medicine, Transplantation Institute, Loma Linda University Medical Center, 11234 Anderson Street, Loma Linda, CA 92354, USA
Am J Gastroenterol 98:2763-70. 2003..CONCLUSIONS: Charcoal-based hemodiabsorption treatments in which a standardized anticoagulation protocol is used is safe and effective treatment for AHE not responding to standard medical therapy... - MELD score is a better prognostic model than Child-Turcotte-Pugh score or Discriminant Function score in patients with alcoholic hepatitisWichit Srikureja
Division of Gastroenterology, Loma Linda University Medical Center, Loma Linda, CA, USA
J Hepatol 42:700-6. 2005..MELD score is a more valuable model than CTP or DF score in patients admitted with alcoholic hepatitis... - Can we predict the degree of fibrosis in chronic hepatitis C patients using routine blood tests in our daily practice?Ramsey C Cheung
VA Palo Alto Healthcare System, Palo Alto, CA 94304, USA
J Clin Gastroenterol 42:827-34. 2008..To determine the validity of fibrosis indexes based on simple laboratory tests in daily practice... - Prospective multicenter study of eligibility for antiviral therapy among 4,084 U.S. veterans with chronic hepatitis C virus infectionEdmund J Bini
VA New York Harbor Healthcare System and NYU School of Medicine, New York, New York 10010, USA
Am J Gastroenterol 100:1772-9. 2005..Multidisciplinary collaboration is needed to overcome barriers to HCV therapy in this population... - Treatment eligibility and outcomes in elderly patients with chronic hepatitis C: results from the VA HCV-001 StudyJudith I Tsui
San Francisco VAMC, 4150 Clement St, San Francisco, CA 94121, USA
Dig Dis Sci 53:809-14. 2008..We undertook this study to determine if treatment candidacy and outcomes were similar between elderly and non-elderly patients... - Octreotide/Midodrine therapy significantly improves renal function and 30-day survival in patients with type 1 hepatorenal syndromeEric Esrailian
Division of Digestive Diseases, David Geffen School of Medicine at UCLA, USA
Dig Dis Sci 52:742-8. 2007..05). This large retrospective study suggests that octreotide/midodrine treatment appears to improve 30-day survival. A randomized, controlled trial is the next important step toward evaluating this treatment modality...
Research Grants
- Suppression of Hepatoma Cell Growth by CelecoxibKe Qin Hu; Fiscal Year: 2004..abstract_text> ..