Wei Hsu

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. ncbi Manipulating gene activity in Wnt1-expressing precursors of neural epithelial and neural crest cells
    Wei Hsu
    Department of Biomedical Genetics, Center for Oral Biology, James Wilmot Cancer Center, University of Rochester Medical Center, 601 Elmwood Avenue, Box 611, Rochester, NY 14642, USA
    Dev Dyn 239:338-45. 2010
  2. ncbi ?-catenin/cyclin D1 mediated development of suture mesenchyme in calvarial morphogenesis
    Anthony J Mirando
    Department of Biomedical Genetics, Center for Oral Biology, University of Rochester Medical Center, Rochester, NY 14642, USA
    BMC Dev Biol 10:116. 2010
  3. ncbi Gpr177/mouse Wntless is essential for Wnt-mediated craniofacial and brain development
    Jiang Fu
    Department of Biomedical Genetics, Center for Oral Biology, James Wilmot Cancer Center, University of Rochester Medical Center, Rochester, New York, USA
    Dev Dyn 240:365-71. 2011
  4. ncbi The balance of WNT and FGF signaling influences mesenchymal stem cell fate during skeletal development
    Takamitsu Maruyama
    Department of Biomedical Genetics, Center for Oral Biology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Sci Signal 3:ra40. 2010
  5. ncbi Development of a unique system for spatiotemporal and lineage-specific gene expression in mice
    Hsiao Man Ivy Yu
    Center for Oral Biology, Department of Biomedical Genetics, Abs Institute of Biomedical Sciences, School of Medicine and Dentistry, University of Rochester, 601 Elmwood Avenue, Box 611, Rochester, NY 14642, USA
    Proc Natl Acad Sci U S A 102:8615-20. 2005
  6. ncbi Craniosynostosis caused by Axin2 deficiency is mediated through distinct functions of beta-catenin in proliferation and differentiation
    Bo Liu
    Department of Biomedical Genetics, Center for Oral Biology, Abs Institute of Biomedical Sciences, University of Rochester Medical Center, Rochester, NY 14642, USA
    Dev Biol 301:298-308. 2007
  7. ncbi Axin2 controls bone remodeling through the beta-catenin-BMP signaling pathway in adult mice
    Ying Yan
    Department of Orthopaedics, Center for Musculoskeletal Research, University of Rochester School of Medicine, Rochester, NY 14642, USA
    J Cell Sci 122:3566-78. 2009
  8. ncbi Expression of Gpr177, a Wnt trafficking regulator, in mouse embryogenesis
    Hsiao Man Ivy Yu
    Department of Biomedical Genetics, Center for Oral Biology, James Wilmot Cancer Center, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Dev Dyn 239:2102-9. 2010
  9. ncbi Reciprocal regulation of Wnt and Gpr177/mouse Wntless is required for embryonic axis formation
    Jiang Fu
    Department of Biomedical Genetics, Center for Oral Biology, James P Wilmot Cancer Center, University of Rochester Medical Center, 601 Elmwood Avenue, Box 611, Rochester, NY 14642, USA
    Proc Natl Acad Sci U S A 106:18598-603. 2009
  10. ncbi SUMO-specific protease 2 is essential for modulating p53-Mdm2 in development of trophoblast stem cell niches and lineages
    Shang Yi Chiu
    Department of Biomedical Genetics, Center for Oral Biology, James P Wilmot Cancer Center, University of Rochester Medical Center, Rochester, New York, USA
    PLoS Biol 6:e310. 2008

Research Grants

  1. Genetic Regulatory Network in Mammary Tumorigenesis
    Wei Hsu; Fiscal Year: 2009
  2. GENETIC REGULATORY NETWORK IN CRANIOFACIAL DEVELOPMENT
    Wei Hsu; Fiscal Year: 2010
  3. GENETIC REGULATORY NETWORK IN CRANIOFACIAL DEVELOPMENT
    Wei Hsu; Fiscal Year: 2007
  4. Genetic Regulatory Network in Mammary Tumorigenesis
    Wei Hsu; Fiscal Year: 2006
  5. Genetic Regulatory Network in Mammary Gland Development and Tumorigenesis
    Wei Hsu; Fiscal Year: 2010

Collaborators

Detail Information

Publications12

  1. ncbi Manipulating gene activity in Wnt1-expressing precursors of neural epithelial and neural crest cells
    Wei Hsu
    Department of Biomedical Genetics, Center for Oral Biology, James Wilmot Cancer Center, University of Rochester Medical Center, 601 Elmwood Avenue, Box 611, Rochester, NY 14642, USA
    Dev Dyn 239:338-45. 2010
    ..This study demonstrated the versatility of our mouse models to achieve gene manipulation in early neural development...
  2. ncbi ?-catenin/cyclin D1 mediated development of suture mesenchyme in calvarial morphogenesis
    Anthony J Mirando
    Department of Biomedical Genetics, Center for Oral Biology, University of Rochester Medical Center, Rochester, NY 14642, USA
    BMC Dev Biol 10:116. 2010
    ..Haploid deficiency of ?-catenin alleviates the calvarial phenotype caused by Axin2 deficiency. This loss-of-function study provides evidence for the requirement of ?-catenin in exerting the downstream effects of Axin2...
  3. ncbi Gpr177/mouse Wntless is essential for Wnt-mediated craniofacial and brain development
    Jiang Fu
    Department of Biomedical Genetics, Center for Oral Biology, James Wilmot Cancer Center, University of Rochester Medical Center, Rochester, New York, USA
    Dev Dyn 240:365-71. 2011
    ..Our findings demonstrate the importance of Gpr177 in Wnt1-mediated development of the mouse embryo, suggesting an overlapping function of Wnt family members in the Wnt1-expressing cells...
  4. ncbi The balance of WNT and FGF signaling influences mesenchymal stem cell fate during skeletal development
    Takamitsu Maruyama
    Department of Biomedical Genetics, Center for Oral Biology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Sci Signal 3:ra40. 2010
    ..This study identifies endochondral ossification as a mechanism of suture closure during development and implicates this process in craniosynostosis...
  5. ncbi Development of a unique system for spatiotemporal and lineage-specific gene expression in mice
    Hsiao Man Ivy Yu
    Center for Oral Biology, Department of Biomedical Genetics, Abs Institute of Biomedical Sciences, School of Medicine and Dentistry, University of Rochester, 601 Elmwood Avenue, Box 611, Rochester, NY 14642, USA
    Proc Natl Acad Sci U S A 102:8615-20. 2005
    ..Gene expression can be manipulated in specific cell types and lineages with a flexibility that is difficult to achieve with conventional methods...
  6. ncbi Craniosynostosis caused by Axin2 deficiency is mediated through distinct functions of beta-catenin in proliferation and differentiation
    Bo Liu
    Department of Biomedical Genetics, Center for Oral Biology, Abs Institute of Biomedical Sciences, University of Rochester Medical Center, Rochester, NY 14642, USA
    Dev Biol 301:298-308. 2007
    ..Finally, haploid deficiency of beta-catenin alleviates the Axin2-null skeletal phenotypes. These findings support a model for disparate roles of beta-catenin in osteoblast proliferation and differentiation...
  7. ncbi Axin2 controls bone remodeling through the beta-catenin-BMP signaling pathway in adult mice
    Ying Yan
    Department of Orthopaedics, Center for Musculoskeletal Research, University of Rochester School of Medicine, Rochester, NY 14642, USA
    J Cell Sci 122:3566-78. 2009
    ..Taken together, our findings demonstrate that Axin2 is a key negative regulator in bone remodeling in adult mice and regulates osteoblast differentiation through the beta-catenin-BMP2/4-Osx signaling pathway in osteoblasts...
  8. ncbi Expression of Gpr177, a Wnt trafficking regulator, in mouse embryogenesis
    Hsiao Man Ivy Yu
    Department of Biomedical Genetics, Center for Oral Biology, James Wilmot Cancer Center, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Dev Dyn 239:2102-9. 2010
    ..The glycosylation of Gpr177 is necessary for proper transportation in the secretory pathway. Our findings suggest that the Gpr177-mediated regulation of Wnt is crucial for organogenesis in health and disease...
  9. ncbi Reciprocal regulation of Wnt and Gpr177/mouse Wntless is required for embryonic axis formation
    Jiang Fu
    Department of Biomedical Genetics, Center for Oral Biology, James P Wilmot Cancer Center, University of Rochester Medical Center, 601 Elmwood Avenue, Box 611, Rochester, NY 14642, USA
    Proc Natl Acad Sci U S A 106:18598-603. 2009
    ..A reciprocal regulation of Wnt and Gpr177 is essential for the patterning of the anterior-posterior axis during mammalian development...
  10. ncbi SUMO-specific protease 2 is essential for modulating p53-Mdm2 in development of trophoblast stem cell niches and lineages
    Shang Yi Chiu
    Department of Biomedical Genetics, Center for Oral Biology, James P Wilmot Cancer Center, University of Rochester Medical Center, Rochester, New York, USA
    PLoS Biol 6:e310. 2008
    ..Our data reveal a key genetic pathway, SENP2-Mdm2-p53, underlying trophoblast lineage development, suggesting its pivotal role in cell cycle progression of mitosis and endoreduplication...
  11. ncbi The role of Axin2 in calvarial morphogenesis and craniosynostosis
    Hsiao Man Ivy Yu
    Center for Oral Biology, Department of Biomedical Genetics, Abs Institute of Biomedical Sciences, School of Medicine and Dentistry, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Development 132:1995-2005. 2005
    ..The craniofacial anomalies caused by the Axin2 mutation are mediated through activation of beta-catenin signaling, suggesting a novel role for the Wnt pathway in skull morphogenesis...
  12. ncbi Co-opted JNK/SAPK signaling in Wnt/beta-catenin-induced tumorigenesis
    Bo Liu
    Department of Biomedical Genetics, University of Rochester Medical Center, 601 Elmwood Avenue, Box 611, Rochester, NY 14642, USA
    Neoplasia 10:1004-13. 2008
    ..Our finding may improve the usage of biomarkers to distinguish these two poorly differentiated tumor types, sharing similar histologic features...

Research Grants12

  1. Genetic Regulatory Network in Mammary Tumorigenesis
    Wei Hsu; Fiscal Year: 2009
    ..Using this novel approach, we will determine the role of the Wnt-Axin signaling network in the parity-induced mammary epithelial progenitors, reflecting their refractoriness to breast cancer. ..
  2. GENETIC REGULATORY NETWORK IN CRANIOFACIAL DEVELOPMENT
    Wei Hsu; Fiscal Year: 2010
    ..We will elucidate the mechanism underlying suture development mediated by this signaling network. These studies promise new insights into the molecular mechanism of craniofacial development and human diseases. ..
  3. GENETIC REGULATORY NETWORK IN CRANIOFACIAL DEVELOPMENT
    Wei Hsu; Fiscal Year: 2007
    ..We will elucidate the mechanism underlying suture development mediated by this signaling network. These studies promise new insights into the molecular mechanism of craniofacial development and human diseases. ..
  4. Genetic Regulatory Network in Mammary Tumorigenesis
    Wei Hsu; Fiscal Year: 2006
    ..Using this novel approach, we will determine the role of the Wnt-Axin signaling network in the parity-induced mammary epithelial progenitors, reflecting their refractoriness to breast cancer. ..
  5. Genetic Regulatory Network in Mammary Gland Development and Tumorigenesis
    Wei Hsu; Fiscal Year: 2010
    ..The results obtained in our study are highly relevant to the health of human breasts, and has outstanding potentials to gain important insights into potential therapeutic strategies for human diseases. ..