David Horwitz

Summary

Affiliation: University of Southern California
Country: USA

Publications

  1. ncbi Critical role of IL-2 and TGF-beta in generation, function and stabilization of Foxp3+CD4+ Treg
    David A Horwitz
    Division of Rheumatology and Immunology, Department of Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA
    Eur J Immunol 38:912-5. 2008
  2. ncbi Natural and TGF-beta-induced Foxp3(+)CD4(+) CD25(+) regulatory T cells are not mirror images of each other
    David A Horwitz
    Division of Rheumatology and Immunology, Department of Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA
    Trends Immunol 29:429-35. 2008
  3. ncbi Regulatory T cells in systemic lupus erythematosus: past, present and future
    David A Horwitz
    Department of Medicine, Division of Rheumatology and Immunology, University of Southern California, Keck School of Medicine, Los Angeles, CA 90033, USA
    Arthritis Res Ther 10:227. 2008
  4. ncbi Regulatory T cells generated ex vivo as an approach for the therapy of autoimmune disease
    David A Horwitz
    The Division of Rheumatology and Immunology, Department of Medicine, Keck School of Medicine of the University of Southern California, 2011 Zonal Avenue, HMR 711, Los Angeles, CA 90033, USA
    Semin Immunol 16:135-43. 2004
  5. ncbi Natural and induced CD4+CD25+ cells educate CD4+CD25- cells to develop suppressive activity: the role of IL-2, TGF-beta, and IL-10
    Song Guo Zheng
    Division of Rheumatology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    J Immunol 172:5213-21. 2004
  6. ncbi Generation ex vivo of TGF-beta-producing regulatory T cells from CD4+CD25- precursors
    Song Guo Zheng
    Division of Rheumatology and Immunology, Department of Medicine, Keck School of Medicine, University of Southern California, 2211 Zonal Avenue, Los Angeles, CA 90033, USA
    J Immunol 169:4183-9. 2002
  7. ncbi The role of the combination of IL-2 and TGF-beta or IL-10 in the generation and function of CD4+ CD25+ and CD8+ regulatory T cell subsets
    David A Horwitz
    Division of Rheumatology and Immunology, Department of Medicine, Keck School of Medicine of the University of Southern California, Los Angeles 90033 1034, USA
    J Leukoc Biol 74:471-8. 2003
  8. ncbi TGF-beta requires CTLA-4 early after T cell activation to induce FoxP3 and generate adaptive CD4+CD25+ regulatory cells
    Song Guo Zheng
    Division of Rheumatology and Immunology, Department of Medicine, University of Southern California, Keck School of Medicine, Los Angeles, CA 90033, USA
    J Immunol 176:3321-9. 2006
  9. ncbi Cutting edge: Foxp3+CD4+CD25+ regulatory T cells induced by IL-2 and TGF-beta are resistant to Th17 conversion by IL-6
    Song Guo Zheng
    Division of Rheumatology and Immunology, Department of Medicine, Keck School of Medicine at University of Southern California, Los Angeles, CA 90033, USA
    J Immunol 180:7112-6. 2008
  10. ncbi The potential of human regulatory T cells generated ex vivo as a treatment for lupus and other chronic inflammatory diseases
    David A Horwitz
    The Division of Rheumatology and Immunology, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    Arthritis Res 4:241-6. 2002

Research Grants

  1. IMMUNOREGULATORY MECHANISMS IN THE RHEUMATIC DISEASES
    David Horwitz; Fiscal Year: 1999
  2. FLOW CYTOMETER
    David Horwitz; Fiscal Year: 2002

Collaborators

  • Wei Shi
  • M L Barr
  • Y Chai
  • D D Brand
  • Toru Abo
  • William Stohl
  • Song Guo Zheng
  • Ling Lu
  • J Dixon Gray
  • Julie Wang
  • Ju Hua Wang
  • Feng Zhang
  • Xiaohui Zhou
  • Xuehao Wang
  • Juhua Wang
  • Xiu Hua Yang
  • Satoshi Yamagiwa
  • Bing Xu
  • Zhongmin Liu
  • Ge He
  • Huiming Fan
  • Hejian Zou
  • Jiangning Yu
  • Jilin Ma
  • Ning Kong
  • Pu Wang
  • Lingzhong Meng
  • Meguru Watanabe
  • Satoshi Sugahara
  • Yasunobu Matsuda
  • Yoshinobu Sato
  • Donald V Cramer
  • Yutaka Aoyagi
  • Takafumi Ichida
  • Hisami Watanabe
  • Kyoung Soo Kim
  • Harold Soucier
  • Kazuo Ohtsuka

Detail Information

Publications17

  1. ncbi Critical role of IL-2 and TGF-beta in generation, function and stabilization of Foxp3+CD4+ Treg
    David A Horwitz
    Division of Rheumatology and Immunology, Department of Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA
    Eur J Immunol 38:912-5. 2008
    ..Unlike mouse CD4+CD25(-) cells, which rapidly become polyclonal Foxp3+CD25+ Treg when activated appropriately with IL-2 and TGF-beta, human T cells require multiple stimulations to become similar suppressor cells...
  2. ncbi Natural and TGF-beta-induced Foxp3(+)CD4(+) CD25(+) regulatory T cells are not mirror images of each other
    David A Horwitz
    Division of Rheumatology and Immunology, Department of Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA
    Trends Immunol 29:429-35. 2008
    ..Thus, nTregs and iTregs may have different roles in the adaptive immune response...
  3. ncbi Regulatory T cells in systemic lupus erythematosus: past, present and future
    David A Horwitz
    Department of Medicine, Division of Rheumatology and Immunology, University of Southern California, Keck School of Medicine, Los Angeles, CA 90033, USA
    Arthritis Res Ther 10:227. 2008
    ..The role of immunogenic and tolerogenic dendritic cells in controlling Tregs is discussed, along with new strategies to normalize Treg function in systemic lupus erythematosus...
  4. ncbi Regulatory T cells generated ex vivo as an approach for the therapy of autoimmune disease
    David A Horwitz
    The Division of Rheumatology and Immunology, Department of Medicine, Keck School of Medicine of the University of Southern California, 2011 Zonal Avenue, HMR 711, Los Angeles, CA 90033, USA
    Semin Immunol 16:135-43. 2004
    ..These studies suggest that the adoptive transfer of CD4+ T regulatory cells generated ex vivo with IL-2 and TGF-beta as a treatment for autoimmune diseases may have sustained, long-term beneficial effects...
  5. ncbi Natural and induced CD4+CD25+ cells educate CD4+CD25- cells to develop suppressive activity: the role of IL-2, TGF-beta, and IL-10
    Song Guo Zheng
    Division of Rheumatology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    J Immunol 172:5213-21. 2004
    ..We suggest that the long-term effects of adoptively transferred natural-like CD4(+)CD25(+) regulatory cells induced ex vivo are due to their ability to generate new cytokine-producing CD4(+) regulatory T cells in vivo...
  6. ncbi Generation ex vivo of TGF-beta-producing regulatory T cells from CD4+CD25- precursors
    Song Guo Zheng
    Division of Rheumatology and Immunology, Department of Medicine, Keck School of Medicine, University of Southern California, 2211 Zonal Avenue, Los Angeles, CA 90033, USA
    J Immunol 169:4183-9. 2002
    ..The ability to induce CD4(+) and CD8(+) cells to become regulatory cells ex vivo has the potential to be useful in the treatment of autoimmune diseases and to prevent transplant rejection...
  7. ncbi The role of the combination of IL-2 and TGF-beta or IL-10 in the generation and function of CD4+ CD25+ and CD8+ regulatory T cell subsets
    David A Horwitz
    Division of Rheumatology and Immunology, Department of Medicine, Keck School of Medicine of the University of Southern California, Los Angeles 90033 1034, USA
    J Leukoc Biol 74:471-8. 2003
    ..Finally, the potential use of regulatory T cells generated ex vivo as an adoptive immunotherapy for certain autoimmune diseases, to prevent organ graft rejection, or to prevent pathologic host responses to infectious agents is discussed...
  8. ncbi TGF-beta requires CTLA-4 early after T cell activation to induce FoxP3 and generate adaptive CD4+CD25+ regulatory cells
    Song Guo Zheng
    Division of Rheumatology and Immunology, Department of Medicine, University of Southern California, Keck School of Medicine, Los Angeles, CA 90033, USA
    J Immunol 176:3321-9. 2006
    ..Although natural CD4+CD25+ cells develop normally in CTLA-4(-/-) mice, the lack of TGF-beta-induced, peripheral CD4+CD25+ suppressor cells in these mice may contribute to their rapid demise...
  9. ncbi Cutting edge: Foxp3+CD4+CD25+ regulatory T cells induced by IL-2 and TGF-beta are resistant to Th17 conversion by IL-6
    Song Guo Zheng
    Division of Rheumatology and Immunology, Department of Medicine, Keck School of Medicine at University of Southern California, Los Angeles, CA 90033, USA
    J Immunol 180:7112-6. 2008
    ..The resistance of iTregs to Th17 conversion suggests that they can function more effectively than nTregs in an inflammatory milieu and emphasizes the central role of IL-2 in combination with TGF-beta to maintain immunologic homeostasis...
  10. ncbi The potential of human regulatory T cells generated ex vivo as a treatment for lupus and other chronic inflammatory diseases
    David A Horwitz
    The Division of Rheumatology and Immunology, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    Arthritis Res 4:241-6. 2002
    ..This novel adoptive immunotherapy also has the potential to prevent the rejection of allogeneic transplants...
  11. ncbi Cutting edge: all-trans retinoic acid sustains the stability and function of natural regulatory T cells in an inflammatory milieu
    Xiaohui Zhou
    Division of Rheumatology, University of South California, Los Angeles, CA 90033, USA
    J Immunol 185:2675-9. 2010
    ..We suggest that nTregs treated with atRA may represent a novel treatment strategy to control established chronic immune-mediated inflammatory diseases...
  12. ncbi IL-2 is essential for TGF-beta to convert naive CD4+CD25- cells to CD25+Foxp3+ regulatory T cells and for expansion of these cells
    Song Guo Zheng
    Division of Rheumatology and Immunology, Department of Medicine, University of Southern California, Keck School of Medicine, Los Angeles, CA 90033, USA
    J Immunol 178:2018-27. 2007
    ....
  13. ncbi Transfer of regulatory T cells generated ex vivo modifies graft rejection through induction of tolerogenic CD4+CD25+ cells in the recipient
    Song Guo Zheng
    Division of Rheumatology and Immunology, Department of Medicine, 2011 Zonal Avenue, HMR 711
    Int Immunol 18:279-89. 2006
    ..Thus, Tregs generated ex vivo can act like a vaccine that generates host suppressor cells with the potential to protect MHC-mismatched organ grafts from rejection...
  14. ncbi Transforming growth factor-beta: taking control of T cells' life and death
    David A Horwitz
    Division of Rheumatology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Immunity 25:399-401. 2006
    ..2006) and Li et al. (2006a) created mice with T cells lacking TGF-beta signaling receptors. Both report that TGF-beta signaling by T cells is absolutely essential for tolerance and homeostasis...
  15. ncbi Role of SMAD and non-SMAD signals in the development of Th17 and regulatory T cells
    Ling Lu
    Division of Rheumatology, Department of Medicine, Saban Research Institute, Children s Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    J Immunol 184:4295-306. 2010
    ..Therefore, selective targeting of these intracellular TGF-beta signaling pathways during iTreg and Th17 cell development might lead to the development of therapies in treating autoimmune and other chronic inflammatory diseases...
  16. ncbi Synergistic effect of TGF-beta superfamily members on the induction of Foxp3+ Treg
    Ling Lu
    Division of Rheumatology, Department of Medicine, Keck School of Medicine, University of Southern California, and Developmental Biology Program, Department of Surgery, Children s Hospital Los Angeles, Los Angeles, CA 90033, USA
    Eur J Immunol 40:142-52. 2010
    ..In addition, the synergistic effect of BMP-2/4 and TGF-beta indicates that the simultaneous manipulation of TGF-beta and BMP signaling might have considerable effects in the clinical setting for the enhancement of Treg purity and yield...
  17. ncbi Increase of CD4+ CD25+ regulatory T-cells in the liver of patients with hepatocellular carcinoma
    Xiu Hua Yang
    Division of Gastroenterology and Hepatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    J Hepatol 45:254-62. 2006
    ..CONCLUSIONS: Our results suggest that CD4+ CD25+ T-cells in the marginal region of HCC may play a critical role in controlling CD8+ cytotoxic T-cell activity and, thereby, contribute to the progression of HCC...

Research Grants9

  1. IMMUNOREGULATORY MECHANISMS IN THE RHEUMATIC DISEASES
    David Horwitz; Fiscal Year: 1999
    ....
  2. FLOW CYTOMETER
    David Horwitz; Fiscal Year: 2002
    ..This new instrument will allow us the flexibility to develop new uses for the flow cytometer as dictated by our current and future users. ..