Research Topics
Genomes and Genes | M HortschSummaryAffiliation: University of Michigan Country: USA Publications
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Publications
The axonal localization of large Drosophila ankyrin2 protein isoforms is essential for neuronal functionalityMichael Hortsch
Department of Cell and Developmental Biology, University of Michigan, Ann Arbor 48109 0616, USA
Mol Cell Neurosci 20:43-55. 2002..We show that once polarization is established, it persists during later stages of Drosophila development. We also present genetic evidence that the absence of axonal Dank2 protein is lethal...- The interaction between L1-type proteins and ankyrins--a master switch for L1-type CAM functionMichael Hortsch
Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA
Cell Mol Biol Lett 14:57-69. 2009.... - Septate and paranodal junctions: kissing cousinsMichael Hortsch
Department of Cell and Developmental Biology, Departments of Biological Chemistry and Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA
Trends Cell Biol 13:557-61. 2003.... - Structural requirements for outside-in and inside-out signaling by Drosophila neuroglian, a member of the L1 family of cell adhesion moleculesM Hortsch
University of Michigan, Department of Anatomy and Cell Biology, Ann Arbor, Michigan 48109 0616, USA
J Cell Biol 142:251-61. 1998..We propose that the recruitment of ankyrin to cell contact sites depends on a physical rearrangement of neuroglian in response to cell adhesion, and that ankyrin binding plays a reciprocal role in stabilizing the adhesive interaction... - A conserved role for L1 as a transmembrane link between neuronal adhesion and membrane cytoskeleton assemblyM Hortsch
University of Michigan, Department of Anatomy and Cell Biology, Ann Arbor 48109 0616, USA
Cell Adhes Commun 5:61-73. 1998..These findings support a model of L1 function in which the phenotypes of human L1-CAM mutations results from a disruption of the link between the extracellular environment and the neuronal cytoskeleton... - The expression of MDP-1, a component of Drosophila embryonic basement membranes, is modulated by apoptotic cell deathM Hortsch
Department of Anatomy and Cell Biology, University of Michigan, Ann Arbor 48109 0616, USA
Int J Dev Biol 42:33-42. 1998.... - The L1-type cell adhesion molecule neuroglian influences the stability of neural ankyrin in the Drosophila embryo but not its axonal localizationM Bouley
University of Michigan, Department of Cell and Developmental Biology, Ann Arbor, Michigan 48109 0616, USA
J Neurosci 20:4515-23. 2000..In temperature-sensitive neuroglian mutants in which neuroglian protein is mislocated at the restrictive temperature to an intracellular location in the neuronal soma, Dank2 protein can still be detected along embryonic nerve tracts... - The analysis of genomic structures in the L1 family of cell adhesion molecules provides no evidence for exon shuffling events after the separation of arthropod and chordate lineagesG Zhao
University of Michigan, Department of Anatomy, Cell Biology, Ann Arbor, MI 48109 0616, USA
Gene 215:47-55. 1998..Nevertheless, exon shuffling or the generation of new exons by mutational changes might have been responsible for the generation of additional, alternatively spliced exons in L1-type genes... - The cytoplasmic domain of the Drosophila cell adhesion molecule neuroglian is not essential for its homophilic adhesive properties in S2 cellsM Hortsch
Department of Anatomy and Cell Biology, University of Michigan, Ann Arbor 48109, USA
J Biol Chem 270:18809-17. 1995.... - Cis-activation of L1-mediated ankyrin recruitment by TAG-1 homophilic cell adhesionJ D Malhotra
Department of Anatomy and Cell Biology, University of Michigan, Ann Arbor, Michigan 48109 0616, USA
J Biol Chem 273:33354-9. 1998..Furthermore, such interactions might ultimately result in the recruitment and the activation of other signaling molecules at sites of cell contacts... - Structural and functional evolution of the L1 family: are four adhesion molecules better than one?M Hortsch
Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, Michigan, 48109-0616, USA
Mol Cell Neurosci 15:1-10. 2000 - Sodium channel beta subunits mediate homophilic cell adhesion and recruit ankyrin to points of cell-cell contactJ D Malhotra
Department of Pharmacology, The University of Michigan, Ann Arbor, Michigan 48109, USA
J Biol Chem 275:11383-8. 2000..It is hypothesized that sodium channel beta subunits serve as a critical communication link between the extracellular and intracellular environments of the neuron and may play a role in sodium channel placement at nodes of Ranvier... - Ligation of 5' DNA overhangs to 3' DNA overhangs using short single-stranded oligonucleotide linkersG Zhao
University of Michigan, Ann Arbor 48109-0616, USA
Biotechniques 23:418-20. 1997 - The L1 family of neural cell adhesion molecules: old proteins performing new tricksM Hortsch
Department of Anatomy and Cell Biology, University of Michigan, Ann Arbor 48109-0616, USA
Neuron 17:587-93. 1996 - Sticky molecules in not-so-sticky cellsM Hortsch
Department of Anatomy and Cell Biology, University of Michigan, Ann Arbor 48109 0616
Trends Biochem Sci 16:283-7. 1991..As such, they have proved to be a useful tool for the functional characterization of putative cell-adhesion molecules... - Increased activity of Diaphanous homolog 3 (DIAPH3)/diaphanous causes hearing defects in humans with auditory neuropathy and in DrosophilaCynthia J Schoen
Neuroscience Graduate Program, Molecular and Behavioral Neuroscience Institute, Division of Pediatric Otolaryngology, Department of Otolaryngology Head and Neck Surgery, University of Michigan Health System, Ann Arbor, MI 48109, USA
Proc Natl Acad Sci U S A 107:13396-401. 2010..Genetic testing for DIAPH3 may be useful for individuals with recessive as well as dominant inheritance of nonsyndromic auditory neuropathy... - Neuroglian activates Echinoid to antagonize the Drosophila EGF receptor signaling pathwayRafique Islam
Department of Cell and Developmental Biology, University of Michigan, Medical School, Ann Arbor, MI 48109 0616, USA
Development 130:2051-9. 2003..Together, our results suggest a model in which Nrg acts as a heterophilic ligand and activator of Ed, which in turn antagonizes EGFR signaling... - Activation of EGF receptor kinase by L1-mediated homophilic cell interactionsRafique Islam
Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, Michigan 48109, USA
Mol Biol Cell 15:2003-12. 2004..Thus L1-type CAMs are able to promote the adhesion-dependent activation of EGF receptor signaling in vitro and in vivo... - Phosphorylation of L1-type cell-adhesion molecules--ankyrins away!Kakanahalli Nagaraj
Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA
Trends Biochem Sci 31:544-6. 2006.... - Pathogenic human L1-CAM mutations reduce the adhesion-dependent activation of EGFRKakanahalli Nagaraj
Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, 48109 2200, USA
Hum Mol Genet 18:3822-31. 2009..Either by reducing or abolishing L1-CAM protein expression, by interfering with L1-CAM's cell surface expression, by reducing L1-CAM's adhesive ability or by impeding further downstream adhesion-dependent signaling processes... - Structural requirements for interaction of sodium channel beta 1 subunits with ankyrinJyoti D Malhotra
Department of Pharmacology, The University of Michigan, Ann Arbor, Michigan 48109, USA
J Biol Chem 277:26681-8. 2002..beta 1 subunit-mediated cell adhesion and ankyrin recruitment may contribute to sodium channel placement at nodes of Ranvier. The phosphorylation state of beta 1Y181 may be a critical regulatory step in these developmental processes... - A conserved role for Drosophila Neuroglian and human L1-CAM in central-synapse formationTanja A Godenschwege
Department of Biology, Morrill Science Center, University of Massachusetts, Amherst, Amherst, Massachusetts 01003, USA
Curr Biol 16:12-23. 2006..Although the role of L1-CAMs in neurite extension and axon pathfinding has been extensively studied, much less is known about their role in synapse formation... - Genetic analysis of an overlapping functional requirement for L1- and NCAM-type proteins during sensory axon guidance in DrosophilaLars V Kristiansen
Instituto de Neurociencias CSIC UMH, Universidad Miguel Hernandez, Sant Joan d Alacant, 03550 Spain
Mol Cell Neurosci 28:141-52. 2005..Moreover, our findings demonstrate that this functionally redundant specificity to mediate axon guidance has been conserved in their vertebrate homologs, L1-CAM and NCAM... - Drosophila contactin, a homolog of vertebrate contactin, is required for septate junction organization and paracellular barrier functionCatherine Faivre-Sarrailh
Neurobiologie des Interactions Cellulaires et Neurophysiopathologie, UMR 6184 CNRS, Institut Jean Roche, Boulevard Pierre Dramard, 13916 Marseille Cedex 20, France
Development 131:4931-42. 2004..Hence, our data provide evidence that the organization of SJs is dependent on the interactions between these highly conserved cell-adhesion molecules... - Neuroglian stabilizes epithelial structure during Drosophila oogenesisJun Wei
Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA
Dev Dyn 230:800-8. 2004..Our data also suggest that Ig superfamily members have significant functional redundancy in maintaining epithelial polarity, with individual members playing subtle, unique roles during epithelial morphogenesis... - Drosophila Echinoid is an antagonist of Egfr signalling, but is not a member of the L1-type family of cell adhesion moleculesMichael Hortsch
Development 130:5295. 2003 - Neural cell adhesion molecules--brain glue and much more!Michael Hortsch
Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 4809-0616, USA
Front Biosci 8:d357-9. 2003....
Research Grants
- L1-MEDIATED RECRUITMENT OF THE MEMBRANE SKELETONMichael Hortsch; Fiscal Year: 2002..Finally, he will use this assay system to test whether mutant L1-CAM molecules from human patients will function in his assay. ..