T M Hooton

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. ncbi Fluoroquinolones and resistance in the treatment of uncomplicated urinary tract infection
    Thomas M Hooton
    Department of Medicine, Division of Allergy and Infectious Diseases, Harborview Medical Center, University of Washington School of Medicine, Box 359930, 325 Ninth Avenue, Seattle, WA 98104, USA
    Int J Antimicrob Agents 22:65-72. 2003
  2. ncbi Acute uncomplicated cystitis in an era of increasing antibiotic resistance: a proposed approach to empirical therapy
    Thomas M Hooton
    University of Washington, Seattle, WA, USA
    Clin Infect Dis 39:75-80. 2004
  3. ncbi Recurrent urinary tract infection in women
    T M Hooton
    University of Washington School of Medicine, Harborview Medical Center, Madison Clinic, 325 9th Avenue, Seattle, WA 98104 2499, USA
    Int J Antimicrob Agents 17:259-68. 2001
  4. ncbi Pathogenesis of urinary tract infections: an update
    T M Hooton
    Department of Medicine, University of Washington School of Medicine, Seattle, USA
    J Antimicrob Chemother 46:1-7; discussion 63-5. 2000
  5. ncbi A prospective study of asymptomatic bacteriuria in sexually active young women
    T M Hooton
    Department of Medicine, University of Washington School of Medicine and School of Public Health and Community Medicine, Seattle, USA
    N Engl J Med 343:992-7. 2000
  6. ncbi Amoxicillin-clavulanate vs ciprofloxacin for the treatment of uncomplicated cystitis in women: a randomized trial
    Thomas M Hooton
    Department of Medicine, School of Medicine, University of Washington, Seattle, USA
    JAMA 293:949-55. 2005
  7. ncbi Inverse association of H2O2-producing lactobacilli and vaginal Escherichia coli colonization in women with recurrent urinary tract infections
    K Gupta
    Department of Medicine, University of Washington, Seattle 98195, USA
    J Infect Dis 178:446-50. 1998
  8. ncbi Comparison of ciprofloxacin (7 days) and trimethoprim-sulfamethoxazole (14 days) for acute uncomplicated pyelonephritis pyelonephritis in women: a randomized trial
    D A Talan
    Department of Medicine, Olive View UCLA Medical Center, University of California, Los Angeles 91342, USA
    JAMA 283:1583-90. 2000
  9. ncbi Influence of the normal menstrual cycle on vaginal tissue, discharge, and microflora
    D A Eschenbach
    Department of Obstetrics University of Washington, Seattle, WA 98195 6460, USA
    Clin Infect Dis 30:901-7. 2000
  10. ncbi Prospective cohort study of microbial and inflammatory events immediately preceding Escherichia coli recurrent urinary tract infection in women
    C A Czaja
    Department of Medicine, University of Washington, Seattle, Washington, USA
    J Infect Dis 200:528-36. 2009

Collaborators

Detail Information

Publications53

  1. ncbi Fluoroquinolones and resistance in the treatment of uncomplicated urinary tract infection
    Thomas M Hooton
    Department of Medicine, Division of Allergy and Infectious Diseases, Harborview Medical Center, University of Washington School of Medicine, Box 359930, 325 Ninth Avenue, Seattle, WA 98104, USA
    Int J Antimicrob Agents 22:65-72. 2003
    ..Most women with acute uncomplicated pyelonephritis are now managed safely and effectively as outpatients...
  2. ncbi Acute uncomplicated cystitis in an era of increasing antibiotic resistance: a proposed approach to empirical therapy
    Thomas M Hooton
    University of Washington, Seattle, WA, USA
    Clin Infect Dis 39:75-80. 2004
  3. ncbi Recurrent urinary tract infection in women
    T M Hooton
    University of Washington School of Medicine, Harborview Medical Center, Madison Clinic, 325 9th Avenue, Seattle, WA 98104 2499, USA
    Int J Antimicrob Agents 17:259-68. 2001
    ..Exciting new approaches to prevent recurrent UTI include the use of probiotics and vaccines. Further understanding of the pathogenesis of UTI will lead to more effective and safer methods to prevent these frequent infections...
  4. ncbi Pathogenesis of urinary tract infections: an update
    T M Hooton
    Department of Medicine, University of Washington School of Medicine, Seattle, USA
    J Antimicrob Chemother 46:1-7; discussion 63-5. 2000
    ..Virulence determinants of uropathogens are much more important in the normal host than in the host who has a functional or anatomical abnormality of the genitourinary tract...
  5. ncbi A prospective study of asymptomatic bacteriuria in sexually active young women
    T M Hooton
    Department of Medicine, University of Washington School of Medicine and School of Public Health and Community Medicine, Seattle, USA
    N Engl J Med 343:992-7. 2000
    ..Asymptomatic bacteriuria is common in young women, but little is known about its pathogenesis, natural history, risk factors, and temporal association with symptomatic urinary tract infection...
  6. ncbi Amoxicillin-clavulanate vs ciprofloxacin for the treatment of uncomplicated cystitis in women: a randomized trial
    Thomas M Hooton
    Department of Medicine, School of Medicine, University of Washington, Seattle, USA
    JAMA 293:949-55. 2005
    ..One such antibiotic, amoxicillin-clavulanate, has not been well studied...
  7. ncbi Inverse association of H2O2-producing lactobacilli and vaginal Escherichia coli colonization in women with recurrent urinary tract infections
    K Gupta
    Department of Medicine, University of Washington, Seattle 98195, USA
    J Infect Dis 178:446-50. 1998
    ..5; P = .02). Thus, absence of H2O2-positive lactobacilli may be important in the pathogenesis of recurrent UTI by facilitating E. coli introital colonization...
  8. ncbi Comparison of ciprofloxacin (7 days) and trimethoprim-sulfamethoxazole (14 days) for acute uncomplicated pyelonephritis pyelonephritis in women: a randomized trial
    D A Talan
    Department of Medicine, Olive View UCLA Medical Center, University of California, Los Angeles 91342, USA
    JAMA 283:1583-90. 2000
    ..The optimal antimicrobial regimen and treatment duration for acute uncomplicated pyelonephritis are unknown...
  9. ncbi Influence of the normal menstrual cycle on vaginal tissue, discharge, and microflora
    D A Eschenbach
    Department of Obstetrics University of Washington, Seattle, WA 98195 6460, USA
    Clin Infect Dis 30:901-7. 2000
    ....
  10. ncbi Prospective cohort study of microbial and inflammatory events immediately preceding Escherichia coli recurrent urinary tract infection in women
    C A Czaja
    Department of Medicine, University of Washington, Seattle, Washington, USA
    J Infect Dis 200:528-36. 2009
    ..A prospective cohort study was conducted to characterize the temporal sequence of microbial and inflammatory events immediately preceding Escherichia coli recurrent urinary tract infection (rUTI)...
  11. ncbi Escherichia coli bacteriuria and contraceptive method
    T M Hooton
    Department of Medicine, University of Washington School of Medicine, Harborview Medical Center, Seattle 98104
    JAMA 265:64-9. 1991
    ....
  12. ncbi Effects of contraceptive method on the vaginal microbial flora: a prospective evaluation
    K Gupta
    Department of Medicine, Division of Allergy and Infectious Diseases, University of Washington, Seattle, WA 98195
    J Infect Dis 181:595-601. 2000
    ..coli, Enterococcus species, and anaerobic gram-negative rods. Thus, spermicidal methods of contraception are associated with alterations of the vaginal microflora that consequently may predispose women to genitourinary infections...
  13. ncbi Effects of oral contraceptive pill use on vaginal flora and vaginal epithelium
    D A Eschenbach
    Department of Obstetrics and Gynecology, University of Washington, Seattle, WA, USA
    Contraception 62:107-12. 2000
    ..04). The results indicate minimal effect of OC use on the vaginal epithelium and vaginal and cervical discharge, and a small effect on vaginal flora...
  14. ncbi Increasing antimicrobial resistance and the management of uncomplicated community-acquired urinary tract infections
    K Gupta
    Division of Allergy and Infectious Diseases, University of Washington School of Medicine, 1959 NE Pacific Street, BB1225, Box 356523, Seattle, WA 98195, USA
    Ann Intern Med 135:41-50. 2001
    ..Using a management strategy that takes these variables into account is essential for maintaining the safety and efficacy of treatment for acute UTI...
  15. ncbi Patient-initiated treatment of uncomplicated recurrent urinary tract infections in young women
    K Gupta
    Department of Medicine/Division of Allergy and Infectious Diseases, 1959 NE Pacific Street, Box 356523, University of Washington, Seattle, WA 98195, USA
    Ann Intern Med 135:9-16. 2001
    ..Clinical and microbiological cures occurred in 92% and 96%, respectively, of culture-confirmed episodes. No serious adverse events occurred. CONCLUSION: Adherent women can accurately self-diagnose and self-treat recurrent UTIs...
  16. ncbi Effects of vaginal intercourse with and without a condom on vaginal flora and vaginal epithelium
    D A Eschenbach
    Dept of Obstetrics and Gynecology, University of Washington, Seattle, WA 98195 6460, USA
    J Infect Dis 183:913-8. 2001
    ..coli (P=.06) and a significant increase in other enteric gram-negative rods (P=.001) after intercourse. Intercourse was not associated with gross, colposcopic, or histologic vaginal epithelial abnormalities...
  17. ncbi Fluoroquinolones in the treatment of acute uncomplicated urinary tract infections in adult women
    J Garrison
    Department of Pharmacy, University of Washington School of Medicine, Harborview Medical Center, Seattle 98104, USA
    Expert Opin Pharmacother 2:1227-37. 2001
    ..In light of these changing resistance patterns, prudent use of fluoroquinolones for the treatment of UTIs is warranted...
  18. ncbi Isolation of fluoroquinolone-resistant rectal Escherichia coli after treatment of acute uncomplicated cystitis
    Kalpana Gupta
    Department of Medicine Division of Allergy and Infectious Diseases, University of Washington, Seattle, 98195, USA
    J Antimicrob Chemother 56:243-6. 2005
    ....
  19. ncbi The effect of clarithromycin, fluconazole, and rifabutin on sulfamethoxazole hydroxylamine formation in individuals with human immunodeficiency virus infection (AACTG 283)
    Helen R Winter
    University of Washington, Seattle 98195, USA
    Clin Pharmacol Ther 76:313-22. 2004
    ....
  20. ncbi Ciprofloxacin compared with doxycycline for nongonococcal urethritis. Ineffectiveness against Chlamydia trachomatis due to relapsing infection
    T M Hooton
    Department of Medicine, Harborview Medical Center, University of Washington School of Medicine, Seattle 98104
    JAMA 264:1418-21. 1990
    ..We conclude that ciprofloxacin in dosages as high as 2 g daily is inadequate for treatment of chlamydial urethritis in men, often resulting in relapsing infections...
  21. ncbi Lower genitourinary tract sources of seminal HIV
    Robert W Coombs
    Department of Laboratory Medicine, University of Washington, Seattle, WA 98104 2499, USA
    J Acquir Immune Defic Syndr 41:430-8. 2006
    ..To investigate genital tract sources of HIV-1, we conducted extensive genitourinary sampling of 23 seropositive men without urethritis who shed HIV in their seminal plasma...
  22. ncbi Levofloxacin and ciprofloxacin decrease procainamide and N-acetylprocainamide renal clearances
    Larry A Bauer
    Department of Pharmacy, Box 357630, University of Washington, Seattle, WA 98195
    Antimicrob Agents Chemother 49:1649-51. 2005
    ..05). During ciprofloxacin treatment, only procainamide and NAPA renal clearances decreased significantly...
  23. ncbi Update on acute uncomplicated urinary tract infection in women
    Christopher A Czaja
    Department of Medicine, University of Washington School of Medicine, Seattle 98195, USA
    Postgrad Med 119:39-45. 2006
    ..Treatment of UTI has become more difficult because of the rising levels of resistance to commonly used antibiotics. Further research is needed to develop new antibiotic therapies and nonantibiotic prevention measures...
  24. ncbi Population-based epidemiologic analysis of acute pyelonephritis
    Christopher A Czaja
    Division of Allergy and Infectious Diseases, University of Washington, Seattle, WA 98195, USA
    Clin Infect Dis 45:273-80. 2007
    ..We performed a population-based analysis of trends in the incidence, microbial etiology, antimicrobial resistance, and antimicrobial therapy of outpatient and inpatient pyelonephritis...
  25. ncbi Electronic human immunodeficiency virus (HIV) clinical reminder system improves adherence to practice guidelines among the University of Washington HIV Study Cohort
    Mari M Kitahata
    Department of Medicine, University of Washington, Harborview Medical Center, Box 359931, 325 9th Ave, Seattle, WA 98104, USA
    Clin Infect Dis 36:803-11. 2003
    ..86; 95% CI, 1.05-3.27; P=.03) and syphilis infection (OR, 3.71; 95% CI, 2.37-5.81; P<.0001). HIV clinical reminders delivered at the time that HIV care is provided were associated with more timely initiation of recommended practices...
  26. ncbi A two-way messaging system to enhance antiretroviral adherence
    Peter J Dunbar
    Department of Anesthesiology, University of Washington, Seattle, Washington, USA
    J Am Med Inform Assoc 10:11-5. 2003
    ..The study suggests that it is feasible to use an automated wireless two-way messaging system to communicate with HIV-positive patients over an extended period of time...
  27. ncbi Risk factors associated with acute pyelonephritis in healthy women
    Delia Scholes
    Group Health Cooperative and University of Washington, Seattle, Washington, USA
    Ann Intern Med 142:20-7. 2005
    ..Although most cases of acute pyelonephritis occur in otherwise healthy women, data on risk factors for this condition are lacking...
  28. ncbi Short-course nitrofurantoin for the treatment of acute uncomplicated cystitis in women
    Kalpana Gupta
    Department of Medicine, Yale University and VA Connecticut Healthcare System, 950 Campbell Avenue, West Haven, CT 06516, USA
    Arch Intern Med 167:2207-12. 2007
    ..Evidence-based use of this drug is increasingly important as trimethoprim-sulfamethoxazole resistance among uropathogens increases...
  29. ncbi Toll-like receptor polymorphisms and susceptibility to urinary tract infections in adult women
    Thomas R Hawn
    Department of Medicine, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 4:e5990. 2009
    ..Although behavioral risk factors are strongly associated with urinary tract infection (UTI) risk, the role of genetics in acquiring this disease is poorly understood...
  30. ncbi Peer support and pager messaging to promote antiretroviral modifying therapy in Seattle: a randomized controlled trial
    Jane M Simoni
    Department of Psychology, University of Washington, 3909 W Stevens Way NE, Campus Box 351525, Seattle, WA 98195 1525, USA
    J Acquir Immune Defic Syndr 52:465-473. 2009
    ....
  31. ncbi Genetic variation of the human urinary tract innate immune response and asymptomatic bacteriuria in women
    Thomas R Hawn
    Department of Medicine, University of Washington, Seattle, Washington, USA
    PLoS ONE 4:e8300. 2009
    ..We examined whether candidate gene polymorphisms were associated with altered urine inflammatory profiles in asymptomatic women with or without bacteriuria...
  32. ncbi Antimicrobial resistance: a plan of action for community practice
    T M Hooton
    University of Washington School of Medicine, Seattle, USA
    Am Fam Physician 63:1087-98. 2001
    ..Antimicrobials intended for the treatment of bacterial infections should not be used to manage viral illnesses. Local resistance trends may be used to guide prescribing decisions...
  33. ncbi The current management strategies for community-acquired urinary tract infection
    Thomas M Hooton
    Department of Medicine, Division of Allergy and Infectious Diseases, University of Washington School of Medicine, Seattle, WA, USA
    Infect Dis Clin North Am 17:303-32. 2003
    ..The choice of antimicrobials is similar to that recommended for cystitis in women except that nitrofurantoin is not considered a good choice. Treatment duration should generally be longer than that recommended for women...
  34. ncbi Family history and risk of recurrent cystitis and pyelonephritis in women
    Delia Scholes
    Group Health Research Institute, Group Health Cooperative, Seattle, Washington 98101, USA
    J Urol 184:564-9. 2010
    ..Family history variables indicative of genetic risk merit further investigation. We evaluated the risk of recurrent cystitis and pyelonephritis in women with and those without a family history of urinary tract infection...
  35. ncbi Urinary tract infection risk factors and gender
    R D Harrington
    Department of Medicine and Division of Infectious Diseases, University of Washington School of Medicine, Seattle, USA
    J Gend Specif Med 3:27-34. 2000
    ....
  36. ncbi Association between culturable human immunodeficiency virus type 1 (HIV-1) in semen and HIV-1 RNA levels in semen and blood: evidence for compartmentalization of HIV-1 between semen and blood
    R W Coombs
    Department of Laboratory Medicine, University of Washington, School of Medicine, Seattle 98195 7110, USA
    J Infect Dis 177:320-30. 1998
    ....
  37. ncbi The effect of clarithromycin, fluconazole, and rifabutin on dapsone hydroxylamine formation in individuals with human immunodeficiency virus infection (AACTG 283)
    Helen R Winter
    University of Washington, Seattle, WA 98195, USA
    Clin Pharmacol Ther 76:579-87. 2004
    ..When dapsone is given in combination with rifabutin, dapsone dosage adjustment may be necessary in light of the increase in dapsone clearance...
  38. ncbi Differential stability and trade-off effects of pathoadaptive mutations in the Escherichia coli FimH adhesin
    Scott J Weissman
    Department of Microbiology, University of Washington School of Medicine, 1959 North Pacific Street, Seattle, WA 98195, USA
    Infect Immun 75:3548-55. 2007
    ..These functional trade-offs may determine the natural populational instability of this mutation or other pathoadaptive FimH mutations that confer dramatic increases in 1M binding strength...
  39. ncbi Life-threatening interactions between HIV-1 protease inhibitors and the illicit drugs MDMA and gamma-hydroxybutyrate
    R D Harrington
    Department of Medicine, School of Medicine, University of Washington, Seattle, USA
    Arch Intern Med 159:2221-4. 1999
    ..We also discuss the potential for HIV-1 protease inhibitors to alter the metabolism of other abusable prescribed and illicit substances...
  40. ncbi Etiology of nongonococcal nonchlamydial urethritis
    M A Schwartz
    Department of Medicine, University of Washington School of Medicine, Seattle, USA
    Dermatol Clin 16:727-33, xi. 1998
    ..In a majority of cases of acute NCNGU, no pathogen can be isolated. The etiology of chronic NCNGU is unknown...
  41. ncbi Evaluation of cerebrospinal fluid in Southeast Asian refugees with reactive serologic tests for syphilis
    D Buchwald
    Department of Medicine, Harborview Medical Center, University of Washington School of Medicine, Seattle, USA
    West J Med 165:289-93. 1996
    ....
  42. ncbi Thalidomide in low intermittent doses does not prevent recurrence of human immunodeficiency virus-associated aphthous ulcers
    J M Jacobson
    Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Infect Dis 183:343-346. 2001
    ..Thalidomide in lower intermittent doses is ineffective at preventing recurrence of aphthous ulcers in HIV-infected persons...
  43. ncbi Diagnosis, prevention, and treatment of catheter-associated urinary tract infection in adults: 2009 International Clinical Practice Guidelines from the Infectious Diseases Society of America
    Thomas M Hooton
    Department of Medicine, University of Miami, Florida 33136, USA
    Clin Infect Dis 50:625-63. 2010
    ..These guidelines are intended for use by physicians in all medical specialties who perform direct patient care, with an emphasis on the care of patients in hospitals and long-term care facilities...
  44. ncbi Infectious Diseases Society of America and the Society for Healthcare Epidemiology of America guidelines for developing an institutional program to enhance antimicrobial stewardship
    Timothy H Dellit
    Harborview Medical Center and the University of Washington, Seattle, USA
    Clin Infect Dis 44:159-77. 2007
  45. ncbi Multidrug-resistant Mycobacterium tuberculosis in HIV-infected persons, Peru
    Pablo E Campos
    University of Washington, Seattle, Washington 98104, USA
    Emerg Infect Dis 9:1571-8. 2003
    ..MDR-TB is an ongoing problem in HIV-infected persons receiving care in public hospitals in Lima and Callao; they represent sentinel cases for a potentially larger epidemic of nosocomial MDR-TB...
  46. ncbi Is acute uncomplicated urinary tract infection a foodborne illness, and are animals the source?
    Thomas M Hooton
    Clin Infect Dis 40:258-9. 2005
  47. ncbi Detection of intracellular bacterial communities in human urinary tract infection
    David A Rosen
    Department of Molecular Microbiology and Microbial Pathogenesis, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS Med 4:e329. 2007
    ..This IBC pathogenic cycle has not yet been investigated in humans. In this study we sought to determine whether evidence of an IBC pathway could be found in urine specimens from women with acute UTI...
  48. ncbi Maintenance fluconazole therapy for recurrent vulvovaginal candidiasis
    Jack D Sobel
    Division of Infectious Diseases, Wayne State University School of Medicine, Detroit, USA
    N Engl J Med 351:876-83. 2004
    ..No safe and convenient regimen has proved to be effective for the management of recurrent vulvovaginal candidiasis...
  49. ncbi Identification of genes subject to positive selection in uropathogenic strains of Escherichia coli: a comparative genomics approach
    Swaine L Chen
    Center for Genome Sciences, Washington University School of Medicine, St. Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 103:5977-82. 2006
    ..coli isolates from patients with UTI. These studies outline a computational approach that may be broadly applicable for studying strain-specific adaptation and pathogenesis in other bacteria...
  50. ncbi Duration of therapy for urinary tract infection: the long and the short of it
    Kalpana Gupta
    Clin Infect Dis 39:665-6. 2004
  51. ncbi Infectious Diseases Society of America guidelines for the diagnosis and treatment of asymptomatic bacteriuria in adults
    Lindsay E Nicolle
    University of Manitoba, Health Sciences Centre, Winnipeg, Manitoba, Canada
    Clin Infect Dis 40:643-54. 2005
  52. ncbi Escherichia coli from urine of female patients with urinary tract infections is competent for intracellular bacterial community formation
    Corinne K Garofalo
    Department of Molecular Microbiology, Box 8230, Washington University School of Medicine, 660 S Euclid Ave, St Louis, MO 63110, USA
    Infect Immun 75:52-60. 2007
    ..Although UPEC isolates differ genetically in their virulence factors, the majority of UPEC isolates from different types of UTI proceed through the IBC pathway, confirming the generality of IBCs in UTI pathogenesis in mice...
  53. ncbi Intracellular bacterial communities of uropathogenic Escherichia coli in urinary tract pathogenesis
    Gregory G Anderson
    Department of Molecular Microbiology, Washington University School of Medicine, Box 8230, 660 S. Euclid Ave, St Louis, MO 63110, USA
    Trends Microbiol 12:424-30. 2004
    ..Re-emergence of bacteria from this reservoir might be the source of recurrent infection...